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The Canadian veterinary journal = La revue veterinaire canadienne2015; 56(11); 1166-1171;

Acquired multiple acyl-CoA dehydrogenase deficiency and marked selenium deficiency causing severe rhabdomyolysis in a horse.

Abstract: This report describes a case of severe rhabdomyolysis in a pregnant mare associated with histopathologic and biochemical features of both selenium deficiency and acquired multiple acyl-CoA dehydrogenase deficiency (MADD) due to seasonal pasture myopathy (SPM). This case highlights the importance of assessing plasma selenium levels in horses with clinical signs of pasture myopathy as this deficiency may be a contributing or exacerbating factor. Déficience multiple acquise de déshydrogénase acyl-CoA et carence en sélénium marquée causant une rhabdomyolyse grave chez un cheval. Ce rapport décrit le cas d’une rhabdomyolyse grave chez une jument gravide associée à des caractéristiques histopathologiques et biochimiques de la carence en sélénium et d’une carence multiple acquise de déhydrogénase acyl-CoA (MADD) causées par la myopathie saisonnière des pâturages (SPM). Ce cas souligne l’importance d’évaluer les niveaux de sélénium dans le plasma des chevaux manifestant des signes cliniques de myopathie du pâturage car cette carence peut être un facteur contributif ou aggravant.(Traduit par Isabelle Vallières).
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Publication Date: 2015-11-06 PubMed ID: 26538673PubMed Central: PMC4608471
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article investigates a case of severe rhabdomyolysis in a pregnant horse and links it to both selenium and MADD deficiencies caused by a condition known as seasonal pasture myopathy. The article underscores the potential contribution of these nutritional deficiencies to the severe health decline of the horse, and the necessity of monitoring plasma selenium levels in horses showing symptoms of this condition.

Understanding the Research

  • The study observes a severe case of rhabdomyolysis, a condition characterized by the break-down of muscle cells that releases myoglobin into the bloodstream, ultimately causing potential kidney damage. In the article’s instance, this condition will be seen in a pregnant mare.
  • The researchers found characteristics associated with two specific deficiencies in the mare: selenium deficiency and Acquired Multiple Acyl-CoA Dehydrogenase Deficiency (MADD).
  • Selenium is a vital nutrient for many organisms, including horses, and its deficiency can lead to various health problems. The evidence of selenium deficiency in this case served as a primary study subject due to its potential role in causing or exacerbating the observed rhabdomyolysis.
  • MADD, on the other hand, is a metabolic disorder that disrupts the body’s ability to break down certain fats and proteins. This disorder was also found in the mare, contributing to the complexity of her health decline.

Findings from the Research

  • Both the selenium deficiency and MADD were attributed to a condition called seasonal pasture myopathy (SPM), a potentially fatal muscle disease found in horses grazed on certain pastures during specific seasons.
  • The report emphasizes the importance of assessing plasma selenium levels in horses, especially those showing clinical signs of pasture myopathy. Monitoring these levels could help identify deficiencies contributing to or exacerbating health issues such as rhabdomyolysis, thereby aiding in potential preventative measures or treatments.

Conclusion

  • The study’s observations have significant implications for the health and care of horses suffering from SPM. By linking selenium deficiency and MADD to the severe rhabdomyolysis encountered, the report furthers the need for nutritional and metabolic assessments in horses affected by this condition.
  • Particularly, monitoring and maintaining balanced plasma selenium levels might be a crucial aspect of effective veterinary care for horses displaying symptoms of SPM.

Cite This Article

APA
Gomez DE, Valberg SJ, Magdesian KG, Hanna PE, Lofstedt J. (2015). Acquired multiple acyl-CoA dehydrogenase deficiency and marked selenium deficiency causing severe rhabdomyolysis in a horse. Can Vet J, 56(11), 1166-1171.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 56
Issue: 11
Pages: 1166-1171

Researcher Affiliations

Gomez, Diego E
  • Department of Health Management (Gomez, Lofstedt) and Department of Pathology and Microbiology (Hanna), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA (Valberg); Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, California 95616, USA (Magdesian).
Valberg, Stephanie J
  • Department of Health Management (Gomez, Lofstedt) and Department of Pathology and Microbiology (Hanna), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA (Valberg); Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, California 95616, USA (Magdesian).
Magdesian, K Gary
  • Department of Health Management (Gomez, Lofstedt) and Department of Pathology and Microbiology (Hanna), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA (Valberg); Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, California 95616, USA (Magdesian).
Hanna, Paul E
  • Department of Health Management (Gomez, Lofstedt) and Department of Pathology and Microbiology (Hanna), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA (Valberg); Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, California 95616, USA (Magdesian).
Lofstedt, Jeanne
  • Department of Health Management (Gomez, Lofstedt) and Department of Pathology and Microbiology (Hanna), Atlantic Veterinary College, University of Prince Edward Island, 550 University Avenue, Charlottetown, Prince Edward Island C1A 4P3; Department of Veterinary Population Medicine, College of Veterinary Medicine, University of Minnesota, St. Paul, Minnesota, USA (Valberg); Department of Medicine and Epidemiology, School of Veterinary Medicine, University of California, 1 Shields Avenue, Davis, California 95616, USA (Magdesian).

MeSH Terms

  • Animals
  • Female
  • Horse Diseases / etiology
  • Horse Diseases / pathology
  • Horses
  • Malnutrition / complications
  • Malnutrition / veterinary
  • Multiple Acyl Coenzyme A Dehydrogenase Deficiency / blood
  • Multiple Acyl Coenzyme A Dehydrogenase Deficiency / veterinary
  • Muscle, Skeletal / enzymology
  • Muscular Diseases / complications
  • Muscular Diseases / etiology
  • Muscular Diseases / pathology
  • Muscular Diseases / veterinary
  • Pregnancy
  • Pregnancy Complications
  • Rhabdomyolysis / etiology
  • Rhabdomyolysis / veterinary
  • Seasons
  • Selenium / deficiency

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Citations

This article has been cited 1 times.
  1. Kruse CJ, Dieu M, Renaud B, François AC, Stern D, Demazy C, Burteau S, Boemer F, Art T, Renard P, Votion DM. New Pathophysiological Insights from Serum Proteome Profiling in Equine Atypical Myopathy. ACS Omega 2024 Feb 13;9(6):6505-6526.
    doi: 10.1021/acsomega.3c06647pubmed: 38371826google scholar: lookup
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