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Home / Equine Research Bank / Vet Surg / Acute phase response to surgery of varying intensity in hors...
Veterinary surgery : VS2009; 38(6); 762-769; doi: 10.1111/j.1532-950X.2009.00564.x

Acute phase response to surgery of varying intensity in horses: a preliminary study.

Abstract: To evaluate the postoperative inflammatory response of horses to elective surgery of varying intensity. Methods: Prospective longitudinal study. Methods: Horses referred to 2 hospitals for either arthroscopic removal of a unilateral osteochondritic lesion in the tibiotarsal joint (minimal surgical trauma, n=11), correction of recurrent laryngeal neuropathy by laryngoplasty and ventriculectomy (intermediate surgical trauma, n=10) or removal of an ovarian tumor by laparotomy (major surgical trauma, n=5). Methods: Horses had a thorough clinical examination every day. White blood cell (WBC) counts and concentrations of serum amyloid A (SAA), fibrinogen, and iron were assessed in blood samples obtained before, and 1-3, 5, 7, 9, and 11 days after surgery. Differences in levels of the inflammatory markers between the 3 surgical groups were analyzed using repeated measures ANOVA. Results: Postoperative concentrations of SAA and fibrinogen were significantly higher in horses that had laparotomy and ovariectomy than in horses that had laryngoplasty and ventriculectomy, or arthroscopy. Iron concentrations decreased to lower levels after intermediate and major surgical trauma than after small surgical trauma. WBC count did not differ between the 3 groups. Conclusions: Levels of SAA, fibrinogen, and iron reflected the intensity of the surgical trauma, whereas WBC count did not. Conclusions: Postoperative measurements of SAA, fibrinogen, and iron may be useful for comparing surgical trauma associated with new and established surgical techniques. Moreover, knowledge of the normal postoperative acute phase response is essential, if acute phase reactants are to be used for monitoring occurrence of postoperative infections.
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Publication Date: 2009-08-14 PubMed ID: 19674420DOI: 10.1111/j.1532-950X.2009.00564.xGoogle Scholar: Lookup
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  • Journal Article
  • Multicenter Study
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research examines the postoperative inflammation response in horses after different types of surgeries ranging from minimal to major surgical trauma. The study compares the levels of several inflammation markers such as serum amyloid A, fibrinogen, iron, and white blood cell counts. The findings show a distinct correlation between the severity of the surgical trauma and changes in the levels of certain markers; however, the white blood cell count wasn’t significantly varied.

Research Methodology

  • The researchers conducted a prospective longitudinal research involving horses who had been referred to two veterinary hospitals for different intensities of surgeries. These included arthroscopic removal of a unilateral osteochondritic lesion in the tibiotarsal joint (considered as minimal surgical trauma, with 11 horses), correction of recurrent laryngeal neuropathy by laryngoplasty and ventriculectomy (intermediate surgical trauma, with 10 horses), or removal of an ovarian tumor by laparotomy (major surgical trauma, with 5 horses).
  • Each horse was carefully examined on a daily basis. Blood samples were drawn before the surgeries and 1-3, 5, 7, 9, and 11 days afterward. These samples were used to assess white blood cell counts and concentration levels of serum amyloid A (SAA), fibrinogen, and iron.
  • Differences in the levels of inflammatory markers between the three groups were analyzed using repeated measures ANOVA (analysis of variance), a statistical method for comparing the means of three or more groups.

Results and Findings

  • In the postoperative period, horses that went through laparotomy and ovariectomy showed significantly higher concentrations of SAA and fibrinogen compared to horses who underwent laryngoplasty, ventriculectomy, or arthroscopy.
  • Iron concentrations declined to lower levels following intermediate and major surgical traumas than after small surgical trauma.
  • There was no significant variation in the white blood cell counts across the three groups regardless of the intensity of the surgical trauma.
  • The levels of SAA, fibrinogen, and iron mirrored the intensity of the surgical trauma, implying these markers could be accurately used to measure the level of surgical trauma.

Conclusions and Implications

  • Postoperative measurements of SAA, fibrinogen, and iron may prove useful in comparing the extent of surgical trauma associated with new and conventional surgical techniques.
  • Understanding the normal postoperative acute phase response is critical when using acute phase reactants such as SAA, fibrinogen, and iron for the monitoring of postoperative infections occurrence.

Cite This Article

APA
Jacobsen S, Nielsen JV, Kjelgaard-Hansen M, Toelboell T, Fjeldborg J, Halling-Thomsen M, Martinussen T, Thoefner MB. (2009). Acute phase response to surgery of varying intensity in horses: a preliminary study. Vet Surg, 38(6), 762-769. https://doi.org/10.1111/j.1532-950X.2009.00564.x

Publication

Veterinary surgery : VS
ISSN: 1532-950X
NlmUniqueID: 8113214
Country: United States
Language: English
Volume: 38
Issue: 6
Pages: 762-769

Researcher Affiliations

Jacobsen, Stine
  • Department of Large Animal Sciences, Faculty of Life Sciences, University of Copenhagen, DK-2630 Taastrup, Denmark. stj@life.ku.dk
Nielsen, Jon Vedding
    Kjelgaard-Hansen, Mads
      Toelboell, Trine
        Fjeldborg, Julie
          Halling-Thomsen, Maj
            Martinussen, Torben
              Thoefner, Martin Bang

                MeSH Terms

                • Acute-Phase Reaction / blood
                • Acute-Phase Reaction / veterinary
                • Animals
                • Biomarkers
                • Female
                • Fibrinogen / metabolism
                • Horse Diseases / blood
                • Horse Diseases / surgery
                • Horses
                • Iron / blood
                • Leukocyte Count / veterinary
                • Male
                • Serum Amyloid A Protein / metabolism
                • Surgical Procedures, Operative / adverse effects
                • Surgical Procedures, Operative / veterinary

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