Adverse reactions to veterinary drugs reported in Sweden during 1991-1995.
Abstract: The present article gives a summary of suspected adverse reactions reported by Swedish veterinarians during the period 1991-1995. The summary shows that severe adverse drug-reactions sometimes occur in Swedish veterinary practice. In horses, several cases of acute reactions in animals treated with procaine benzylpenicillin were reported and seven horses died within a few minutes after intramuscular injections of the drug. In cattle and swine most reports referred to the use of antimicrobial agents. In dogs reactions to vaccines were the most frequently reported adverse effects. The reactions were, however, usually rather mild. In dogs there were also several reports of severe reactions related to treatments with non-steroid anti-inflammatory drugs (NSAID) and alpha 2-receptor agonists. Amongst the reports six deaths were observed for each of these groups of drugs. In cats, as in dogs, adverse effects to vaccines were the most frequently reported reactions.
Publication Date: 1997-04-01 PubMed ID: 9131536DOI: 10.1046/j.1365-2885.1997.00050.xGoogle Scholar: Lookup
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- Journal Article
Summary
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This research paper provides a summary of recorded adverse reactions to veterinary drugs reported by Swedish veterinarians from 1991 to 1995, noting that severe drug reactions sometimes occur, resulting in deaths of animals from different species.
Overview of Research
- The research paper collates and analyzes reports of suspected adverse reactions to veterinary drugs made by Swedish veterinarians between the years 1991 and 1995.
- This overview offers insight into the types of drugs and animals involved in these reports, as well as the severity of the drug reactions.
Focused Findings on Horses, Cattle, and Swine
- In horses, many cases of acute reactions were reported for animals treated with procaine benzylpenicillin. According to the report, seven horses died within minutes of receiving intramuscular injections of the drug.
- For cattle and swine, most reports were related to the use of antimicrobial agents. The type and severity of reactions were not detailed in the abstract, but it can be inferred from the report that they were notable enough to be included.
Details on Reported Cases in Dogs and Cats
- In dogs, vaccines were most often reported as causing adverse reactions. However, these reactions were generally mild.
- There were also severe reactions in dogs linked to treatments with non-steroid anti-inflammatory drugs (NSAIDs) and alpha 2-receptor agonists. For both of these drug groups, six deaths were reported.
- In cats, as in dogs, adverse effects to vaccines were the most frequently reported reactions. The abstract doesn’t give detailed information about the severity of these reactions or whether any resulted in death.
Significance of the Findings
- The research provides important data on the risks associated with certain veterinary drugs. This information could help veterinarians make more informed decisions about treatment options and lead to changes in drug use policies or guidelines.
- It also highlights the importance of monitoring and reporting adverse drug reactions in veterinary medicine, allowing for potential improvements in animal health and welfare.
Cite This Article
APA
Tjälve H.
(1997).
Adverse reactions to veterinary drugs reported in Sweden during 1991-1995.
J Vet Pharmacol Ther, 20(2), 105-110.
https://doi.org/10.1046/j.1365-2885.1997.00050.x Publication
Researcher Affiliations
- Department of Pharmacology & Toxicology, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, Uppsala, Sweden.
MeSH Terms
- Animals
- Anti-Infective Agents / adverse effects
- Cats
- Cattle
- Dogs
- Horses
- Sweden
- Swine
- Vaccines / adverse effects
- Veterinary Drugs / adverse effects
Citations
This article has been cited 5 times.- Eichler J, Rulik B, Abazid A, Stope MB. Non-invasive physical plasma improves conventional wound management of cut and bite wounds in wild European hedgehogs. Sci Rep 2025 Jan 22;15(1):2744.
- Lallemand EA, Bousquet-Mélou A, Chapuis L, Davis J, Ferran AA, Kukanich B, Kuroda T, Lacroix MZ, Minamijima Y, Olsén L, Pelligand L, Portugal FR, Roques BB, Santschi EM, Wilson KE, Toutain PL. Pharmacokinetic-pharmacodynamic cutoff values for benzylpenicillin in horses to support the establishment of clinical breakpoints for benzylpenicillin antimicrobial susceptibility testing in horses. Front Microbiol 2023;14:1282949.
- Mount J, Sjöström K, Arthurson V, Kreuger S. A survey of veterinary professionals in Sweden: Adverse event reporting and access to product safety information. Vet Rec Open 2021 Dec;8(1):e18.
- Muijsers M, Martel A, Van Rooij P, Baert K, Vercauteren G, Ducatelle R, De Backer P, Vercammen F, Haesebrouck F, Pasmans F. Antibacterial therapeutics for the treatment of chytrid infection in amphibians: Columbus's egg?. BMC Vet Res 2012 Sep 25;8:175.
- Chon SK, Kim NS. Evaluation of silymarin in the treatment on asymptomatic Giardia infections in dogs. Parasitol Res 2005 Dec;97(6):445-51.
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