Aerosol deposition in equine lungs following ultrasonic nebulisation versus jet aerosol delivery system.
Abstract: Therapeutic aerosols pay an increasing role in the treatment of equine respiratory disorders. This route of delivery permits concentration of significant amounts of drugs at the site of action without unwanted high systemic concentration and resultant side effects. The efficiency of such a topical therapy depends on the quantity of inhaled drugs deposited in the lungs and, for some drugs, on the proportion retained in specific parts of the lungs. The objective of this study was to define and to compare quantitative (dose deposited) and qualitative (regional distribution) deposition of an aerosol in the equine lungs, using either a ultrasonic nebuliser (UN) currently used in human medicine or a high pressure jet nebuliser (JN) especially developed for the equine species. This comparison was possible owing to gamma-scintigraphy, a noninvasive technique ideally suited to give information about both total and regional deposition of inhaled drugs in the respiratory tract. The quantitative study did not point out any difference between the 2 systems concerning the activity released from the nebuliser proportionally to the initial loaded dose (mean +/- s.d. 45.95 +/- 4.93% for the UN vs. 46.47 +/- 8.49% for the JN). By contrast, the percentage of the dose released reaching the lungs was significantly lower with the UN compared to the JN (5.09 +/- 0.66% vs. 7.35 +/- 1.96%). The qualitative analysis did not show any significant difference in size of aerosol deposition image between the 2 nebulisers. However peripheral deposition was significantly higher with JN compared to UN. In conclusion, both nebulisers may be used for aerosol therapy in the equine species. The ultrasonic and pneumatic nebulisation achieved drug deposition in the peripheral part of the lungs (i.e. small airways and lung parenchyma).
Publication Date: 1997-11-05 PubMed ID: 9306067DOI: 10.1111/j.2042-3306.1997.tb03145.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research investigates the effectiveness of two different types of aerosol delivery systems, an ultrasonic nebuliser and a high-pressure jet nebuliser, on aerosol drug deposition in horse lungs. The researchers found that both systems achieved drug deposition without significant differences in the total dose, but the jet nebuliser resulted in higher peripheral lung deposit.
Objectives
- The researchers aim to explore how effective both an ultrasonic nebuliser (largely used in human medicine) and a high-pressure jet nebuliser (developed for horses) are at delivering aerosol medication to the lungs of horses.
- They mainly focus on the dosage and localization of the medication (aerosol) within the lungs.
Method
- Gamma-scintigraphy, a noninvasive technique, was used to pinpoint where and in what quantity the inhaled medication was deposited within the respiratory tract.
Findings
- The quantitative study revealed no significant difference between the two systems regarding the dose released from the nebulizer in relation to the initial loaded dose.
- However, the percentage of the dose that reached the lungs was shown to be noticeably lower with the ultrasonic nebuliser compared to the jet nebuliser.
- From a visual perspective, both nebulisers exhibited similar patterns of aerosol deposition in the horse lungs, but the jet nebuliser demonstrated a significantly higher peripheral deposition.
Conclusion
- This research suggests that both types of nebulisers are suitable for use in aerosol therapy for horses.
- Both systems were capable of depositing medication in the peripheral part of the lungs, which will aid in treating small airways and lung tissue (lung parenchyma).
Implications
- These findings have direct implications for the treatment of respiratory disorders in horses, offering a more thorough comparison between the different systems in terms of efficiency and localization of deposition.
- Furthermore, knowing which system delivers a higher percentage of medication to the lungs can help doctors and veterinarians to better decide which nebuliser to use based on the specific needs and condition of the horse.
Cite This Article
APA
Votion D, Ghafir Y, Munsters K, Duvivier DH, Art T, Lekeux P.
(1997).
Aerosol deposition in equine lungs following ultrasonic nebulisation versus jet aerosol delivery system.
Equine Vet J, 29(5), 388-393.
https://doi.org/10.1111/j.2042-3306.1997.tb03145.x Publication
Researcher Affiliations
- Laboratory for Functional Investigation, Faculty of Veterinary Medicine, University of Liege, Belgium.
MeSH Terms
- Administration, Inhalation
- Aerosols / standards
- Albumins / administration & dosage
- Albumins / analysis
- Animals
- Dose-Response Relationship, Drug
- Drug Delivery Systems / methods
- Drug Delivery Systems / standards
- Drug Delivery Systems / veterinary
- Horse Diseases / drug therapy
- Horse Diseases / physiopathology
- Horses / metabolism
- Horses / physiology
- Lung / chemistry
- Lung / diagnostic imaging
- Lung / physiology
- Lung Diseases / drug therapy
- Lung Diseases / physiopathology
- Lung Diseases / veterinary
- Nebulizers and Vaporizers / standards
- Nebulizers and Vaporizers / veterinary
- Radionuclide Imaging
- Technetium / administration & dosage
- Technetium / analysis
Citations
This article has been cited 1 times.- Arroyo MG, Couëtil LL, Nogradi N, Kamarudin MM, Ivester KM. Efficacy of Inhaled Levalbuterol Compared to Albuterol in Horses with Recurrent Airway Obstruction. J Vet Intern Med 2016 Jul;30(4):1333-7.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
