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Home / Equine Research Bank / Vet Res Commun / Age-dependent prevalence of equid herpesvirus 5 infection.
Veterinary research communications2010; 34(8); 703-708; doi: 10.1007/s11259-010-9443-9

Age-dependent prevalence of equid herpesvirus 5 infection.

Abstract: Equid herpesvirus 5 (EHV-5) infection was detected in a farm in Italy by the use of a semi-nested polymerase chain reaction (PCR) targeting glycoprotein B of EHV-5 on nasal swabs and blood samples of clinically healthy and randomly selected Lipizzaner horses (n = 55). Twenty-five horses at the age of 4-17 years and 30 at an age of 1-3 years were sampled once. The association of the infection with these age-groups and the gender of the horses was investigated. The apparent prevalence of EHV-5 infection was significantly different between age-cohorts: it was higher in the younger group of horses with 73,3% and 80% positives in nasal swabs and blood respectively, compared to 40% of nasal swabs and 20% of blood in the older horses. An age-dependence therefore was observed: the young age is more frequently associated with EHV-5 infection.
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Publication Date: 2010-09-15 PubMed ID: 20842426DOI: 10.1007/s11259-010-9443-9Google Scholar: Lookup
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research study investigates the prevalence of Equid herpesvirus 5 (EHV-5) infection in horses, specifically Lipizzaner horses in Italy, finding a higher rate of infection in younger horses compared to their older counterparts.

Objective and Methodology

  • The researchers aimed to understand the prevalence and age-dependent factors relating to EHV-5 infection in Lipizzaner horses in Italy.
  • To investigate this, the researchers conducted a semi-nested Polymerase Chain Reaction (PCR) test, targeting the glycoprotein B of EHV-5 in nasal swabs and blood samples from clinically healthy and randomly selected horses.
  • A total of 55 horses were included in the study, with 25 horses aged between 4-17 years and 30 horses aged between 1-3 years sampled once.

Findings

  • The study found a significant difference in the prevalence of EHV-5 infection between the two age cohorts: younger and older horses.
  • In the younger group of horses (1-3 years old), 73.3% positive infection was observed in nasal swabs and a higher rate at 80% was seen in blood samples.
  • On the other hand, in the older group of horses (4-17 years old), the infection prevalence was significantly lower with only 40% of nasal swabs and 20% of blood samples showing positive results.

Conclusion

  • The research suggests there is an age-dependence factor associated with EHV-5 infection in horses, with younger horses more prone to the infection.
  • This highlights the importance of age as a risk factor in considering prevention and treatment strategies for EHV-5 infections in horses.
  • The study does not mention the association of infection with gender, suggesting that further investigation into this factor might be needed.

Cite This Article

APA
Marenzoni ML, Coppola G, Maranesi M, Passamonti F, Cappelli K, Capomaccio S, Verini Supplizi A, Thiry E, Coletti M. (2010). Age-dependent prevalence of equid herpesvirus 5 infection. Vet Res Commun, 34(8), 703-708. https://doi.org/10.1007/s11259-010-9443-9

Publication

Veterinary research communications
ISSN: 1573-7446
NlmUniqueID: 8100520
Country: Switzerland
Language: English
Volume: 34
Issue: 8
Pages: 703-708

Researcher Affiliations

Marenzoni, Maria Luisa
  • Sports Horse Research Centre, Department of Experimental Science and Applied Biotechnology, Faculty of Veterinary Medicine, University of Perugia, via S. Costanzo 4, 06126, Perugia, Italy. marialuisa.marenzoni@unipg.it
Coppola, Giacomo
    Maranesi, Margherita
      Passamonti, Fabrizio
        Cappelli, Katia
          Capomaccio, Stefano
            Verini Supplizi, Andrea
              Thiry, Etienne
                Coletti, Mauro

                  MeSH Terms

                  • Age Factors
                  • Animals
                  • Base Sequence
                  • Cohort Studies
                  • DNA, Viral / chemistry
                  • DNA, Viral / genetics
                  • Female
                  • Gammaherpesvirinae / genetics
                  • Gammaherpesvirinae / isolation & purification
                  • Glycoproteins / chemistry
                  • Glycoproteins / genetics
                  • Herpesviridae Infections / blood
                  • Herpesviridae Infections / epidemiology
                  • Herpesviridae Infections / veterinary
                  • Herpesviridae Infections / virology
                  • Horse Diseases / blood
                  • Horse Diseases / epidemiology
                  • Horse Diseases / virology
                  • Horses
                  • Male
                  • Molecular Sequence Data
                  • Nasal Cavity / virology
                  • Polymerase Chain Reaction / veterinary
                  • Prevalence
                  • Sex Factors
                  • Viral Envelope Proteins / chemistry
                  • Viral Envelope Proteins / genetics

                  References

                  This article includes 26 references
                  1. Vannella KM, Moore BB. Viruses as co-factors for the initiation or exacerbation of lung fibrosis.. Fibrogenesis Tissue Repair 2008 Oct 13;1(1):2.
                    pubmed: 19014649doi: 10.1186/1755-1536-1-2google scholar: lookup
                  2. Dunowska M, Holloway SA, Wilks CR, Meers J. Genomic variability of equine herpesvirus-5.. Arch Virol 2000;145(7):1359-71.
                    pubmed: 10963342doi: 10.1007/s007050070095google scholar: lookup
                  3. Cho HJ, Kim S, Kwak SE, Kang TC, Kim HS, Kwon HJ, Kim YW, Kim YS, Choi EK, Song MJ. Age-dependent pathogenesis of murine gammaherpesvirus 68 infection of the central nervous system.. Mol Cells 2009 Jan 31;27(1):105-11.
                    pubmed: 19214440doi: 10.1007/s10059-009-0011-5google scholar: lookup
                  4. Dunowska M, Meers J, Wilks CR. Isolation of equine herpesvirus type 5 in New Zealand.. N Z Vet J 1999 Apr;47(2):44-6.
                    pubmed: 16032069doi: 10.1080/00480169.1999.36109google scholar: lookup
                  5. Kleiboeker SB, Schommer SK, Johnson PJ, Ehlers B, Turnquist SE, Boucher M, Kreeger JM. Association of two newly recognized herpesviruses with interstitial pneumonia in donkeys (Equus asinus).. J Vet Diagn Invest 2002 Jul;14(4):273-80.
                    pubmed: 12152805doi: 10.1177/104063870201400401google scholar: lookup
                  6. Dynon K, Black WD, Ficorilli N, Hartley CA, Studdert MJ. Detection of viruses in nasal swab samples from horses with acute, febrile, respiratory disease using virus isolation, polymerase chain reaction and serology.. Aust Vet J 2007 Jan-Feb;85(1-2):46-50.
                    pubmed: 17300454doi: 10.1111/j.1751-0813.2006.00096.xgoogle scholar: lookup
                  7. Dynon K, Varrasso A, Ficorilli N, Holloway S, Reubel G, Li F, Hartley C, Studdert M, Drummer H. Identification of equine herpesvirus 3 (equine coital exanthema virus), equine gammaherpesviruses 2 and 5, equine adenoviruses 1 and 2, equine arteritis virus and equine rhinitis A virus by polymerase chain reaction.. Aust Vet J 2001 Oct;79(10):695-702.
                    pubmed: 11712710doi: 10.1111/j.1751-0813.2001.tb10674.xgoogle scholar: lookup
                  8. Ptaschinski C, Rochford R. Infection of neonates with murine gammaherpesvirus 68 results in enhanced viral persistence in lungs and absence of infectious mononucleosis syndrome.. J Gen Virol 2008 May;89(Pt 5):1114-1121.
                    pubmed: 18420788doi: 10.1099/vir.0.83470-0google scholar: lookup
                  9. Buckles EL, Lowenstine LJ, DeLong RL, Melin SR, Vittore RK, Wong HN, Ross GL, St Leger JA, Greig DJ, Duerr RS, Gulland FM, Stott JL. Age-prevalence of Otarine Herpesvirus-1, a tumor-associated virus, and possibility of its sexual transmission in California sea lions.. Vet Microbiol 2007 Feb 25;120(1-2):1-8.
                    pubmed: 17208394doi: 10.1016/j.vetmic.2006.10.002google scholar: lookup
                  10. Bell SA, Balasuriya UB, Gardner IA, Barry PA, Wilson WD, Ferraro GL, MacLachlan NJ. Temporal detection of equine herpesvirus infections of a cohort of mares and their foals.. Vet Microbiol 2006 Sep 10;116(4):249-57.
                    pubmed: 16774810doi: 10.1016/j.vetmic.2006.05.002google scholar: lookup
                  11. Ataseven VS, Bilge-Dagalp S, Oguzoglu TC, Karapinar Z, Güzel M, Tan MT. Detection and sequence analysis of equine gammaherpesviruses from horses with respiratory tract disease in Turkey.. Transbound Emerg Dis 2010 Aug 1;57(4):271-6.
                    pubmed: 20553426doi: 10.1111/j.1865-1682.2010.01146.xgoogle scholar: lookup
                  12. Torfason EG, Thorsteinsdóttir L, Torsteinsdóttir S, Svansson V. Study of equid herpesviruses 2 and 5 in Iceland with a type-specific polymerase chain reaction.. Res Vet Sci 2008 Dec;85(3):605-11.
                    pubmed: 18336849doi: 10.1016/j.rvsc.2008.01.003google scholar: lookup
                  13. Holloway SA, Lindquester GJ, Studdert MJ, Drummer HE. Identification, sequence analysis and characterisation of equine herpesvirus 5 glycoprotein B.. Arch Virol 1999;144(2):287-307.
                    pubmed: 10470254doi: 10.1007/s007050050504google scholar: lookup
                  14. Nordengrahn A, Merza M, Ros C, Lindholmc A, Palfl V, Hannant D, Belák S. Prevalence of equine herpesvirus types 2 and 5 in horse populations by using type-specific PCR assays.. Vet Res 2002 May-Jun;33(3):251-9.
                    pubmed: 12056476doi: 10.1051/vetres:2002013google scholar: lookup
                  15. Fortier G, van Erck E, Pronost S, Lekeux P, Thiry E. Equine gammaherpesviruses: pathogenesis, epidemiology and diagnosis.. Vet J 2010 Nov;186(2):148-56.
                    pubmed: 19766026doi: 10.1016/j.tvjl.2009.08.017google scholar: lookup
                  16. Davison AJ, Eberle R, Ehlers B, Hayward GS, McGeoch DJ, Minson AC, Pellett PE, Roizman B, Studdert MJ, Thiry E. The order Herpesvirales.. Arch Virol 2009;154(1):171-7.
                    pubmed: 19066710doi: 10.1007/s00705-008-0278-4google scholar: lookup
                  17. Franchini M, Akens M, Bracher V, von Fellenberg R. Characterisation of gamma herpesviruses in the horse by PCR.. Virology 1997 Nov 10;238(1):8-13.
                    pubmed: 9375003doi: 10.1006/viro.1997.8825google scholar: lookup
                  18. Reubel GH, Crabb BS, Studdert MJ. Diagnosis of equine gammaherpesvirus 2 and 5 infections by polymerase chain reaction.. Arch Virol 1995;140(6):1049-60.
                    pubmed: 7611877doi: 10.1007/BF01315414google scholar: lookup
                  19. Fortier G, Pronost S, Miszczak F, Fortier C, Léon A, Richard E, Van Erck E, Thiry E, Lekeux P. Identification of equid herpesvirus-5 in respiratory liquids: a retrospective study of 785 samples taken in 2006-2007.. Vet J 2009 Nov;182(2):346-8.
                    pubmed: 18757217doi: 10.1016/j.tvjl.2008.07.004google scholar: lookup
                  20. Bell SA, Balasuriya UB, Nordhausen RW, MacLachlan NJ. Isolation of equine herpesvirus-5 from blood mononuclear cells of a gelding.. J Vet Diagn Invest 2006 Sep;18(5):472-5.
                    pubmed: 17037617doi: 10.1177/104063870601800509google scholar: lookup
                  21. Wang L, Raidal SL, Pizzirani A, Wilcox GE. Detection of respiratory herpesviruses in foals and adult horses determined by nested multiplex PCR.. Vet Microbiol 2007 Mar 31;121(1-2):18-28.
                    pubmed: 17208393doi: 10.1016/j.vetmic.2006.11.009google scholar: lookup
                  22. Browning GF, Studdert MJ. Genomic heterogeneity of equine betaherpesviruses.. J Gen Virol 1987 May;68 ( Pt 5):1441-7.
                    pubmed: 2883251doi: 10.1099/0022-1317-68-5-1441google scholar: lookup
                  23. Dunowska M, Wilks CR, Studdert MJ, Meers J. Equine respiratory viruses in foals in New Zealand.. N Z Vet J 2002 Aug;50(4):140-7.
                    pubmed: 16032260doi: 10.1080/00480169.2002.36300google scholar: lookup
                  24. Wong DM, Belgrave RL, Williams KJ, Del Piero F, Alcott CJ, Bolin SR, Marr CM, Nolen-Walston R, Myers RK, Wilkins PA. Multinodular pulmonary fibrosis in five horses.. J Am Vet Med Assoc 2008 Mar 15;232(6):898-905.
                    pubmed: 18341449doi: 10.2460/javma.232.6.898google scholar: lookup
                  25. Diallo IS, Hewitson GR, de Jong A, Kelly MA, Wright DJ, Corney BG, Rodwell BJ. Equine herpesvirus infections in yearlings in South-East Queensland.. Arch Virol 2008;153(9):1643-9.
                    pubmed: 18677574doi: 10.1007/s00705-008-0158-ygoogle scholar: lookup
                  26. Williams KJ, Maes R, Del Piero F, Lim A, Wise A, Bolin DC, Caswell J, Jackson C, Robinson NE, Derksen F, Scott MA, Uhal BD, Li X, Youssef SA, Bolin SR. Equine multinodular pulmonary fibrosis: a newly recognized herpesvirus-associated fibrotic lung disease.. Vet Pathol 2007 Nov;44(6):849-62.
                    pubmed: 18039898doi: 10.1354/vp.44-6-849google scholar: lookup

                  Citations

                  This article has been cited 11 times.
                  1. Stasiak K, Dunowska M, Rola J. Kinetics of the Equid Herpesvirus 2 and 5 Infections among Mares and Foals from Three Polish National Studs.. Viruses 2022 Mar 29;14(4).
                    doi: 10.3390/v14040713pubmed: 35458443google scholar: lookup
                  2. Scheurer L, Bachofen C, Hardmeier I, Lechmann J, Schoster A. Prevalence of Nasal Shedding of Equid Gammaherpesviruses in Healthy Swiss Horses.. Viruses 2021 Aug 25;13(9).
                    doi: 10.3390/v13091686pubmed: 34578268google scholar: lookup
                  3. Mira F, Canuti M, Di Bella S, Puleio R, Lavazza A, Lelli D, Vicari D, Purpari G, Cannella V, Chiaramonte G, Schirò G, Castronovo C, Guercio A. Detection and Molecular Characterization of Two Gammaherpesviruses from Pantesco Breed Donkeys during an Outbreak of Mild Respiratory Disease.. Viruses 2021 Aug 2;13(8).
                    doi: 10.3390/v13081527pubmed: 34452391google scholar: lookup
                  4. Stasiak K, Dunowska M, Trewick S, Rola J. Genetic Variation in the Glycoprotein B Sequence of Equid Herpesvirus 5 among Horses of Various Breeds at Polish National Studs.. Pathogens 2021 Mar 9;10(3).
                    doi: 10.3390/pathogens10030322pubmed: 33803246google scholar: lookup
                  5. Thorsteinsdóttir L, Jónsdóttir S, Stefánsdóttir SB, Andrésdóttir V, Wagner B, Marti E, Torsteinsdóttir S, Svansson V. The effect of maternal immunity on the equine gammaherpesvirus type 2 and 5 viral load and antibody response.. PLoS One 2019;14(6):e0218576.
                    doi: 10.1371/journal.pone.0218576pubmed: 31226153google scholar: lookup
                  6. Van Cleemput J, Poelaert KCK, Laval K, Nauwynck HJ. Unravelling the first key steps in equine herpesvirus type 5 (EHV5) pathogenesis using ex vivo and in vitro equine models.. Vet Res 2019 Feb 18;50(1):13.
                    doi: 10.1186/s13567-019-0630-6pubmed: 30777128google scholar: lookup
                  7. Miglio A, Morelli C, Gialletti R, Lauteri E, Sforna M, Marenzoni ML, Antognoni MT. Clinical and immunophenotypic findings in 4 forms of equine lymphoma.. Can Vet J 2019 Jan;60(1):33-40.
                    pubmed: 30651648
                  8. Marenzoni ML, Stefanetti V, Danzetta ML, Timoney PJ. Gammaherpesvirus infections in equids: a review.. Vet Med (Auckl) 2015;6:91-101.
                    doi: 10.2147/VMRR.S39473pubmed: 30155436google scholar: lookup
                  9. Smith FL, Watson JL, Spier SJ, Kilcoyne I, Mapes S, Sonder C, Pusterla N. Frequency of shedding of respiratory pathogens in horses recently imported to the United States.. J Vet Intern Med 2018 Jul;32(4):1436-1441.
                    doi: 10.1111/jvim.15145pubmed: 29761571google scholar: lookup
                  10. Rushton JO, Kolodziejek J, Tichy A, Nowotny N, Nell B. Clinical course of ophthalmic findings and potential influence factors of herpesvirus infections: 18 month follow-up of a closed herd of lipizzaners.. PLoS One 2013;8(11):e79888.
                    doi: 10.1371/journal.pone.0079888pubmed: 24278206google scholar: lookup
                  11. Marenzoni ML, Bietta A, Lepri E, Casagrande Proietti P, Cordioli P, Canelli E, Stefanetti V, Coletti M, Timoney PJ, Passamonti F. Role of equine herpesviruses as co-infecting agents in cases of abortion, placental disease and neonatal foal mortality.. Vet Res Commun 2013 Dec;37(4):311-7.
                    doi: 10.1007/s11259-013-9578-6pubmed: 24052369google scholar: lookup
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