Age-related changes in the central nervous system in selected domestic mammals and primates.
Abstract: Aging is a process which operates at many levels of physiological, genetic and molecular organization and leads inevitably to death. Brain macroscopic changes by MRI investigation during aging were observed in humans and dogs but chimpanzees did not display significant changes. This suggestion led to the statement that brain aging is different in various species. Although human brain changes, e.g. β-amyloid storage, neurofibrillary tangle formation, lipofuscin, are relatively well known, we are still looking for a suitable animal model to study the mechanisms of aging and neurodegenerative diseases. Therefore, this paper presents a comparative analysis of the changes described in the brains of senile dog, horse and gorilla. In addition we present the latest, non-invasive methods that can be applied in the diagnosis of old age in mammals. Our considerations have shown that the best animal model for further studies and observations on aging is the dog.
Publication Date: 2013-04-11 PubMed ID: 23619226DOI: 10.5604/17322693.1044490Google Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
- Review
Summary
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The research article investigates the impact of aging on the central nervous system of various animal species, including dogs, horses, and gorillas. The study concludes that dogs could be the best animal model for further studies on aging and neurodegenerative diseases.
About the Study
- The research focuses on understanding changes that occur in the central nervous system as a result of aging. Aging, according to the article, is a multi-faceted process involving physiological, genetic, and molecular changes that inevitably lead to death. The focus is on brain changes that can be assessed macroscopically via MRI.
- The researchers observed that brain changes due to aging occur in humans and dogs. However, such changes were not significant in chimpanzees. This led to the assertion that brain aging varies across different species.
- While human brain changes like β-amyloid storage, neurofibrillary tangle formation, and lipofuscin accumulation are relatively understood, the authors note there is still a search for an appropriate animal model that can be used to study aging and neurodegenerative diseases mechanisms.
Comparative Analysis
- The paper presents a comparative analysis of the observed changes in the brains of aged dogs, horses, and gorillas. This comparison is crucial to assess similarities and differences in brain changes due to aging, across different species.
- In addition, the researchers highlight the most up-to-date, non-invasive methods that could be utilized in diagnosing old age in mammals. Such methods are essential for improving understanding of aging and developing more effective strategies to deal with related diseases.
Findings and Conclusions
- The study concluded that the dog could be the most suitable animal model for further study and observations on aging. This conclusion is drawn from the comparative analysis carried out, which likely highlighted the similarity of age-related changes in dogs with those in humans.
Cite This Article
APA
Firląg M, Kamaszewski M, Gaca K, Bałasińska B.
(2013).
Age-related changes in the central nervous system in selected domestic mammals and primates.
Postepy Hig Med Dosw (Online), 67, 269-275.
https://doi.org/10.5604/17322693.1044490 Publication
Researcher Affiliations
- Department of Physiological Science, Faculty of Veterinary Medicine, Warsaw University of Life Science, 02-776 Warsaw, Poland. maciejfirlag@wp.pl
MeSH Terms
- Aging / pathology
- Aging / physiology
- Animals
- Brain / pathology
- Brain / physiology
- Disease Models, Animal
- Dogs / physiology
- Gorilla gorilla / physiology
- Histology, Comparative
- Horses / physiology
- Humans
- Lipofuscin / metabolism
- Magnetic Resonance Imaging
- Models, Animal
- Neurodegenerative Diseases / physiopathology
- Neurofibrillary Tangles / pathology
- Physiology, Comparative
- Species Specificity
Citations
This article has been cited 6 times.- Yang M, Liu C, Jiang N, Liu Y, Luo S, Li C, Zhao H, Han Y, Chen W, Li L, Xiao L, Sun L. Mitochondrial homeostasis: a potential target for delaying renal aging. Front Pharmacol 2023;14:1191517.
- Park DW, Jeon H, So R, Kang SC. Centella asiatica extract prevents visual impairment by promoting the production of rhodopsin in the retina. Nutr Res Pract 2020 Jun;14(3):203-217.
- Żak A, Siwińska N, Chełmecka E, Bażanów B, Romuk E, Adams A, Niedźwiedź A, Stygar D. Effects of Advanced Age, Pituitary Pars Intermedia Dysfunction and Insulin Dysregulation on Serum Antioxidant Markers in Horses. Antioxidants (Basel) 2020 May 21;9(5).
- Moreno-García A, Kun A, Calero O, Medina M, Calero M. An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration. Front Neurosci 2018;12:464.
- Carmeli E. Physical Therapy for Neurological Conditions in Geriatric Populations. Front Public Health 2017;5:333.
- Romanucci M, Della Salda L. Oxidative Stress and Protein Quality Control Systems in the Aged Canine Brain as a Model for Human Neurodegenerative Disorders. Oxid Med Cell Longev 2015;2015:940131.
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