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Aleurone supplementation enhances the metabolic benefits of training in Standardbred mares: impacts on glucose-insulin dynamics and gut microbiome composition.
Abstract: Aleurone, derived from the bran layer of grains like wheat and barley, has demonstrated positive effects on energy metabolism in pigs, mice, and untrained horses, influencing glucose-insulin dynamics and gut microbiome composition. Training itself enhances insulin sensitivity in horses, similar to the improvements in performance capacity observed in human athletes. This study aimed to investigate whether aleurone supplementation provides additional benefits to training by modulating insulin metabolism and gut microbiota in Standardbred mares. Unassigned: Sixteen Standardbred mares (aged 3-5 years) participated in a cross-over study with two 8-week training periods separated by 8 weeks of detraining. Each horse received either 200 g/day aleurone supplementation or a control diet. Insulin metabolism was evaluated using oral (OGTT) and intravenous (FSIGTT) glucose tolerance tests, measuring parameters such as Maximum, AUC, Maximum, AUC, Time to peak (OGTT), Acute Insulin Response to Glucose (AIRg), glucose effectiveness (Sg), and disposition index (DI) (FSIGTT). Fecal samples underwent metagenomic analysis to assess alpha and beta diversity and microbial composition. Unassigned: Training alone: Training significantly improved OGTT parameters by decreasing Maximum ( = 0.005) and AUC ( = 0.001), while increasing Time to peak ( = 0.03), indicating enhanced insulin sensitivity. FSIGTT results also showed a decrease in logAIRg ( = 0.044). Training with Aleurone: Aleurone supplementation further reduced FSIGTT AIRg ( = 0.030), logAIRg ( = 0.021) while increasing glucose effectiveness (Sg; = 0.031). These findings suggest aleurone improves insulin sensitivity, glucose disposal, and fasting glucose regulation beyond training. Microbiome analysis revealed training decreased , associated with dysbiosis, while aleurone reduced inflammation-associated . Beta diversity metrics showed no significant changes. Unassigned: Aleurone supplementation enhances training-induced improvements in glucose metabolism and fecal microbiota composition, which could offer potential benefits for equine athletes by optimizing metabolic flexibility. It also supports improvements in glucose and insulin dynamics, particularly by further enhancing insulin sensitivity and glucose-mediated disposal. Future studies should investigate the mechanisms of aleurone at the muscle and gut level and explore its potential applications for metabolic disorders such as Equine Metabolic Syndrome.
Copyright © 2025 Boshuizen, De Maré, Oosterlinck, Van Immerseel, Eeckhaut, De Meeus, Devisscher, Vidal Moreno de Vega, Willems, De Oliveira, Hosotani, Gansemans, Meese, Van Nieuwerburgh, Deforce, Vanderperren, Verdegaal and Delesalle.
Publication Date: 2025-04-10 PubMed ID: 40276369PubMed Central: PMC12018385DOI: 10.3389/fphys.2025.1565005Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
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This study researched the effects of aleurone supplementation alongside training in Standardbred mares, and found that it has potential benefits in improving insulin metabolism and gut microbiota composition.
Overview of the Study
- The study aimed to investigate the effects of aleurone supplementation, a substance derived from wheat and barley bran, in conjunction with training on insulin metabolism and gut microbiota in Standardbred mares.
- Standardbred mares aged between 3-5 years participated in a crossover study involving two separate 8-week training periods separated by 8 weeks of detraining, receiving either a control diet or a diet with 200g/day aleurone supplementation.
- The insulin metabolism of the horses was measured using oral (OGTT) and intravenous (FSIGTT) glucose tolerance tests, and various parameters such as Maximum, AUC, Time to peak (OGTT), Acute Insulin Response to Glucose (AIRg), glucose effectiveness (Sg), and disposition index (DI) (FSIGTT).
Findings of the Study
- Training improved insulin sensitivity in the horses as indicated by significant improvements in OGTT parameters, including a decrease in Maximum and AUC and an increase in Time to peak.
- Aleurone supplementation during training further reduced FSIGTT AIRg and logAIRg while increasing glucose effectiveness (Sg), suggesting that it aids in better insulin sensitivity, improved glucose disposal, and regulation of fasting glucose levels, beyond the effects of training alone.
- Microbiome analysis showed that training decreased certain microbiota associated with dysbiosis, whilst aleurone supplementation reduced inflammation-associated microbiota.
- However, beta diversity metrics of gut microbiota showed no significant changes.
Implications of the Study
- The results obtained suggest that aleurone supplementation, in conjunction with training, can further enhance improvements in glucose metabolism and gut microbiota composition induced by training.
- This could be beneficial for equine athletes by improving their metabolic flexibility and allowing for heightened performance and health.
- The combined effects of aleurone and training also imply potential improvements in insulin sensitivity and glucose-mediated disposal, which may have applications for metabolic disorders such as Equine Metabolic Syndrome.
- Future studies would be useful to further investigate the mechanisms behind aleurone’s effects at the muscle and gut level.
Cite This Article
APA
Boshuizen B, De Maré L, Oosterlinck M, Van Immerseel F, Eeckhaut V, De Meeus C, Devisscher L, Vidal Moreno de Vega C, Willems M, De Oliveira JE, Hosotani G, Gansemans Y, Meese T, Van Nieuwerburgh F, Deforce D, Vanderperren K, Verdegaal EL, Delesalle C.
(2025).
Aleurone supplementation enhances the metabolic benefits of training in Standardbred mares: impacts on glucose-insulin dynamics and gut microbiome composition.
Front Physiol, 16, 1565005.
https://doi.org/10.3389/fphys.2025.1565005 Publication
Researcher Affiliations
- Department of Translational Physiology, Infectiology and Public Health, Research Group of Comparative Physiology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Equine Hospital Wolvega, Oldeholtpade, Netherlands.
- Department of Translational Physiology, Infectiology and Public Health, Research Group of Comparative Physiology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Department of Large Animal Surgery, Anaesthesia and Orthopaedics, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Department of Pathobiology, Pharmacology and Special Animals Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Department of Pathobiology, Pharmacology and Special Animals Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Department of Translational Physiology, Infectiology and Public Health, Research Group of Comparative Physiology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Gut-Liver ImmunoPharmacology Unit, Department of Basic and Applied Medical Sciences, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium.
- Department of Translational Physiology, Infectiology and Public Health, Research Group of Comparative Physiology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Department of Translational Physiology, Infectiology and Public Health, Research Group of Comparative Physiology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Cargill Research and Development Centre Europe, Vilvoorde, Belgium.
- Cargill Research and Development Centre Europe, Vilvoorde, Belgium.
- Department of Pharmaceutics, Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.
- Department of Pharmaceutics, Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.
- Department of Pharmaceutics, Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.
- Department of Pharmaceutics, Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium.
- Department of Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Department of Translational Physiology, Infectiology and Public Health, Research Group of Comparative Physiology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Equine Health and Performance Centre, School of Animal and Veterinary Sciences, Roseworthy Campus, University of Adelaide, Adelaide, SA, Australia.
- Department of Translational Physiology, Infectiology and Public Health, Research Group of Comparative Physiology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium.
- Equine Health and Performance Centre, School of Animal and Veterinary Sciences, Roseworthy Campus, University of Adelaide, Adelaide, SA, Australia.
Conflict of Interest Statement
JD and GH are researchers employed by Cargill, which has exclusivity over distribution of aleurone for feed market in Europe produced according to patents held by Buhler Company. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
References
This article includes 88 references
- Almeida R, Gerbaba T, Petrof E O. Recurrent Clostridium difficile infection and the microbiome. J. Gastroenterol. 51, 1–10.
- Arfuso F, Assenza A, Fazio F, Rizzo M, Giannetto C, Piccione G. Dynamic change of serum levels of some branched-chain amino acids and tryptophan in athletic horses after different physical exercises. J. Equine Vet. Sci. 77, 12–16.
- Asplin K E, Sillence M N, Pollitt C C, McGowan C M. Induction of laminitis by prolonged hyperinsulinaemia in clinically normal ponies. Veterinary J. 174, 530–535.
- Assenza A, Arfuso F, Fazio F, Giannetto C, Rizzo M, Zumbo A. Effect of gender and jumping exercise on leukocyte number, dopamine and prolactin levels in horses. Thai J. Veterinary Med. 48, 95–101.
- Biddle A S, Tomb J F, Fan Z. Microbiome and blood analyte differences point to community and metabolic signatures in lean and obese horses. Front. Vet. Sci. 5, 225.
- Bohm A, Bogoni C, Behrens R, Otto T. Method for the extraction of aleurone from bran. .
- Bolyen E, Rideout J R, Dillon M R, Bokulich N A, Abnet C C, Al-Ghalith G A. Reproducible, interactive, scalable and extensible microbiome data science using QIIME 2. Nat. Biotechnol. 37, 852–857.
- Bonomini-Gnutzmann R, Plaza-Díaz J, Jorquera-Aguilera C, Rodríguez-Rodríguez A, Rodríguez-Rodríguez F. Effect of intensity and duration of exercise on gut microbiota in humans: a systematic review. Res. Public Health 19, 9518.
- Borghouts L B, Backx K, Mensink M F, Keizer H A. Effect of training intensity on insulin sensitivity as evaluated by insulin tolerance test. Eur. J. Appl. Physiol. Occup. Physiol. 80, 461–466.
- Boshuizen B, Moreno de Vega C V, De Maré L, de Meeûs C, de Oliveira J E, Hosotani G. Effects of aleurone supplementation on glucose-insulin metabolism and gut microbiome in untrained healthy horses. Front. Vet. Sci. 8, 642809.
- Boston R C, Stefanovski D, Moate P J, Sumner A E, Watanabe R M, Bergman R N. MINMOD Millennium: a computer program to calculate glucose effectiveness and insulin sensitivity from the frequently sampled intravenous glucose tolerance test. Diabetes Technol. Ther. 5, 1003–1015.
- Boytar A N, Skinner T L, Wallen R E, Jenkins D G, Dekker Nitert M. The effect of exercise prescription on the human gut microbiota and comparison between clinical and apparently healthy populations: a systematic review. Nutrients 15, 1534.
- Brouns F, Youna H, Ruth P, Anson N M. Wheat aleurone: separation, composition, health aspects, and potential food use. Crit. Rev. Food Sci. Nutr. 52, 553–568.
- Caporaso J G, Kuczynski J, Stombaugh J, Bittinger K, Bushman F D, Costello E K. QIIME allows analysis of high-throughput community sequencing data. Nat. Methods 7, 335–336.
- Carter R A, McCutcheon L J, Valle E, Meilahn E N, Geor R J. Effects of exercise training on adiposity, insulin sensitivity, and plasma hormone and lipid concentrations in overweight or obese, insulin-resistant horses. Am. J. Vet. Res. 71, 314–321.
- Caspi R, Billington R, Keseler I M, Kothari A, Krummenacker M, Midford P E. The MetaCyc database of metabolic pathways and enzymes-a 2019 update. Nucleic Acids Res. 48, D445–D453.
- Chen L, Collij V, Jaeger M, van den Munckhof I C L, Vich Vila A, Kurilshikov A. Gut microbial co-abundance networks show specificity in inflammatory bowel disease and obesity. Nat. Commun. 11, 4018.
- Clarke S F, Murphy E F, O’Sullivan O, Lucey A J, Humphreys M, Hogan A. Exercise and associated dietary extremes impact on gut microbial diversity. Gut 63, 1913–1920.
- Codella R, Luzi L, Terruzzi I. Exercise has the guts: how physical activity may positively modulate gut microbiota in chronic and immune-based diseases. Dig. Liver Dis. 50, 331–341.
- Cook M D, Allen J M, Pence B D, Wallig M A, Gaskins H R, White B A. Exercise and gut immune function: evidence of alterations in colon immune cell homeostasis and microbiome characteristics with exercise training. Immunol. Cell Biol. 94, 158–163.
- Costa M C, Stämpfli H R, Arroyo L G, Allen-Vercoe E, Gomes R G, Weese J S. Changes in the equine fecal microbiota associated with the use of systemic antimicrobial drugs. BMC Vet. Res. 11, 19.
- Costa M C, Weese J S. The equine intestinal microbiome. Anim. Health Res. Rev. 13, 121–128.
- Costabile G, Vitale M, Della Pepa G, Cipriano P, Vetrani C, Testa R. A wheat aleurone-rich diet improves oxidative stress but does not influence glucose metabolism in overweight/obese individuals: results from a randomized controlled trial. Nutr. Metabolism Cardiovasc. Dis. 32, 715–726.
- Dalby M J. Questioning the foundations of the gut microbiota and obesity. Philosophical Trans. R. Soc. B Biol. Sci. 378, 20220221.
- Daly K, Proudman C J, Duncan S H, Flint H J, Dyer J, Shirazi-Beechey S P. Alterations in microbiota and fermentation products in equine large intestine in response to dietary variation and intestinal disease. Br. J. Nutr. 107, 989–995.
- de Laat M A, McGree J M, Sillence M N. Equine hyperinsulinemia: Investigation of the enteroinsular axis during insulin dysregulation. Am. J. Physiol. Endocrinol. Metab. 310, E61–E72.
- De Maré L, Boshuizen B, Vidal Moreno de Vega C, de Meeûs C, Plancke L, Gansemans Y. Profiling the aerobic window of horses in response to training by means of a modified lactate minimum speed test: flatten the curve. Front. Physiol. 13, 792052.
- De Meeûs D’Argenteuil C, Boshuizen B, Oosterlinck M, Van De Winkel D, De Spiegelaere W, De Bruijn C M. Flexibility of equine bioenergetics and muscle plasticity in response to different types of training: an integrative approach, questioning existing paradigms. PLoS One 16, e0249922.
- DeSantis T Z, Hugenholtz P, Larsen N, Rojas M, Brodie E L, Keller K. Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB. Appl. Environ. Microbiol. 72, 5069–5072.
- Duncan G E, Perri M G, Theriaque D W, Hutson A D, Eckel R H, Stacpoole P W. Exercise training, without weight loss, increases insulin sensitivity and postheparin plasma lipase activity in previously sedentary adults. Diabetes Care 26, 557–562.
- Durham A E, Frank N, McGowan C M, Menzies-Gow N J, Roelfsema E, Vervuert I. ECEIM consensus statement on equine metabolic syndrome. J. Vet. Intern Med. 33, 335–349.
- Essén‐Gustavsson B, McMiken D, Karlström K, Lindholm A, Persson S, Thornton J. Muscular adaptation of horses during intensive training and detraining. Equine Vet. J. 21, 27–33.
- Estaki M, Pither J, Baumeister P, Little J P, Gill S K, Ghosh S. Cardiorespiratory fitness as a predictor of intestinal microbial diversity and distinct metagenomic functions. Microbiome 4, 42.
- Evans C C, LePard K J, Kwak J W, Stancukas M C, Laskowski S, Dougherty J. Exercise prevents weight gain and alters the gut microbiota in a mouse model of high fat diet-induced obesity. PLoS One 9, e92193.
- Fava F, Ulaszewska M M, Scholz M, Stanstrup J, Nissen L, Mattivi F. Impact of wheat aleurone on biomarkers of cardiovascular disease, gut microbiota and metabolites in adults with high body mass index: a double-blind, placebo-controlled, randomized clinical trial. Eur. J. Nutr. 61, 2651–2671.
- Filho H C M, Manso H E C C C, Watford M, McKeever K H. Abundance of the skeletal muscle Glut-4 glucose transport protein in Standardbred foals during development and exercise. Comp. Exerc. Physiol. 16, 395–402.
- Fitzgerald D M, Spence R J, Stewart Z K, Prentis P J, Sillence M N, De Laat M A. The effect of diet change and insulin dysregulation on the faecal microbiome of ponies. J. Exp. Biol. 223, jeb219154.
- Frank N, Geor R. Current best practice in clinical management of equine endocrine patients. Equine Vet. Educ. 26, 6–9.
- Franzosa E A, Sirota-Madi A, Avila-Pacheco J, Fornelos N, Haiser H J, Reinker S. Gut microbiome structure and metabolic activity in inflammatory bowel disease. Nat. Microbiol. 4, 293–305.
- García-Estévez D A, Araújo-Vilar D, Fiestras-Janeiro G, Saavedra-González Á, Cabezas-Cerrato J. Comparison of several insulin sensitivity indices derived from basal plasma insulin and glucose levels with minimal model indices. Hormone Metabolic Res. 35, 13–17.
- Gerber G K, Onderdonk A B, Bry L. Inferring dynamic signatures of microbes in complex host ecosystems. PLoS Comput. Biol. 8, e1002624.
- Górniak W, Cholewińska P, Szeligowska N, Wołoszyńska M, Soroko M, Czyż K. Effect of intense exercise on the level of bacteroidetes and firmicutes phyla in the digestive system of thoroughbred racehorses. Animals 11, 290–299.
- Henneke D R, Potter G D, Kreider J L, Yeates B F. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet. J. 15, 371–372.
- Ihaka R, Gentleman R. R: A language for data analysis and graphics. J. Comput. Graph. Stat. 5, 299–314.
- Janabi A, Biddle A, Klein D, McKeever K. Exercise training-induced changes in the gut microbiota of Standardbred racehorses. Comp. Exerc Physiol. 12, 119–130.
- Janabi A H D, Biddle A S, Klein D J, McKeever K H. The effects of acute strenuous exercise on the faecal microbiota in Standardbred racehorses. Comp. Exerc Physiol. 13, 13–24.
- Jeffcott L B, Field J R, McLean J G, O’Dea K. Glucose tolerance and insulin sensitivity in ponies and Standardbred horses. Equine Vet. J. 18, 97–101.
- Kang S S, Jeraldo P R, Kurti A, Miller M E B, Cook M D, Whitlock K. Diet and exercise orthogonally alter the gut microbiome and reveal independent associations with anxiety and cognition. Mol. Neurodegener. 9, 36.
- Karikoski N P, McGowan C M, Singer E R, Asplin K E, Tulamo R M, Patterson-Kane J C. Pathology of natural cases of equine endocrinopathic laminitis associated with hyperinsulinemia. Vet. Pathol. 52, 945–956.
- Keaveney E M, Price R K, Hamill L L, Wallace J M W, McNulty H, Ward M. Postprandial plasma betaine and other methyl donor-related responses after consumption of minimally processed wheat bran or wheat aleurone, or wheat aleurone incorporated into bread. Br. J. Nutr. 113, 445–453.
- Lacombe V A, Hinchcliff K W, Kohn C W, Devor S T, Taylor L E. Effects of feeding meals with various soluble-carbohydrate content on muscle glycogen synthesis after exercise in horses. Am. J. Vet. Res. 65, 916–923.
- Lacombe V A, Hinchcliff K W, Taylor L E. Interactions of substrate availability, exercise performance, and nutrition with muscle glycogen metabolism in horses. J. Am. Vet. Med. Assoc. 223, 1576–1585.
- Lambert J E, Myslicki J P, Bomhof M R, Belke D D, Shearer J, Reimer R A. Exercise training modifies gut microbiota in normal and diabetic mice. Appl. Physiology, Nutr. Metabolism 40, 749–752.
- Langille M G I, Zaneveld J, Caporaso J G, McDonald D, Knights D, Reyes J A. Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences. Nat. Biotechnol. 31, 814–821.
- Leschke D H, Muir G S, Hodgson J K, Coyle M, Horn R, Bertin F R. Immunoreactive insulin stability in horses at risk of insulin dysregulation. J. Vet. Intern Med. 33, 2746–2751.
- Lindenberg F, Krych L, Kot W, Fielden J, Frøkiær H, van Galen G. Development of the equine gut microbiota. Sci. Rep. 9, 14427.
- Mandal S, Van Treuren W, White R A, Eggesbø M, Knight R, Peddada S D. Analysis of composition of microbiomes: a novel method for studying microbial composition. Microb. Ecol. Health Dis. 26, 27663.
- Manso Filho H C, Betros C L, Gordon M E, Manso H E C C C, Watford M, McKeever K H. Exercise training, Glut-4 protein abundance and glutamine in skeletal muscle of mature and very old horses. Comp. Exerc Physiol. 13, 63–69.
- McCutcheon L J, Geor R J, Hinchcliff K W. Changes in skeletal muscle GLUT4 content and muscle membrane glucose transport following 6 weeks of exercise training. Equine Vet. J. Suppl. 34, 199–204.
- Menzies-Gow N J, Wray H, Bailey S R, Harris P A, Elliott J. The effect of exercise on plasma concentrations of inflammatory markers in normal and previously laminitic ponies. Equine Vet. J. 46, 317–321.
- Mohr A E, Jäger R, Carpenter K C, Kerksick C M, Purpura M, Townsend J R. The athletic gut microbiota. J. Int. Soc. Sports Nutr. 17, 24.
- Naderpoor N, Mousa A, Gomez-Arango L F, Barrett H L, Nitert M D, Courten B.De. Faecal microbiota are related to insulin sensitivity and secretion in overweight or obese adults. J. Clin. Med. 8, 452.
- Neyrinck A M, De Backer F, Cani P D, Bindels L B, Stroobants A, Portetelle D. Immunomodulatory properties of two wheat bran fractions - aleurone-enriched and crude fractions - in obese mice fed a high fat diet. Int. Immunopharmacol. 8, 1423–1432.
- Nout Y S, Hinchcliff K W, Jose-Cunilleras E, Dearth L R, Sivko G S, DeWille J W. Effect of moderate exercise immediately followed by induced hyperglycemia on gene expression and content of the glucose transporter-4 protein in skeletal muscles of horses. Am. J. Vet. Res. 64, 1401–1408.
- Pacini G, Bergman R N. MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test. Comput. Methods Programs Biomed. 23, 113–122.
- Parks D H, Tyson G W, Hugenholtz P, Beiko R G. STAMP: statistical analysis of taxonomic and functional profiles. Bioinformatics 30, 3123–3124.
- Petersen L M, Bautista E J, Nguyen H, Hanson B M, Chen L, Lek S H. Community characteristics of the gut microbiomes of competitive cyclists. Microbiome 5, 98.
- Piccione G, Giannetto C, Faggio C, Alberghina D, Panzera M. Three-time feeding does not influence insulin daily rhythm in horses. Biol. Rhythm Res. 44, 421–426.
- Pratt S E, Geor R J, Spriet L L, McCutcheon L J. Time course of insulin sensitivity and skeletal muscle glycogen synthase activity after a single bout of exercise in horses. J. Appl. Physiol. 103, 1063–1069.
- Pratt-Phillips S. Effect of exercise conditioning on countering the effects of obesity and insulin resistance in horses—a review. Animals 14, 727.
- Pratt-Phillips S E, Geor R J, McCutcheon L J. Comparison among the euglycemic-hyperinsulinemic clamp, insulin-modified frequently sampled intravenous glucose tolerance test, and oral glucose tolerance test for assessment of insulin sensitivity in healthy Standardbreds. Am. J. Vet. Res. 76, 84–91.
- Pritchard A, Nielsen B, McLean A, Robison C, Yokoyama M, Hengemuehle S. Insulin resistance as a result of body condition categorized as thin, moderate, and obese in domesticated U.S. donkeys (Equus asinus). J. Equine Vet. Sci. 77, 31–35.
- Quigley E M M, Gajula P. Recent advances in modulating the microbiome. Res 9, F1000.
- Ridaura V K, Faith J J, Rey F E, Cheng J, Duncan A E, Kau A L. Gut microbiota from twins discordant for obesity modulate metabolism in mice. Sci. 1979, 341.
- Rosa N N, Pekkinen J, Zavala K, Fouret G, Korkmaz A, Feillet-Coudray C. Impact of wheat aleurone structure on metabolic disorders caused by a high-fat diet in mice. J. Agric. Food Chem. 62, 10101–10109.
- Schoster A, Mosing M, Jalali M, Staempfli H R, Weese J S. Effects of transport, fasting and anaesthesia on the faecal microbiota of healthy adult horses. Equine Vet. J. 48, 595–602.
- Slentz C A, Tanner C J, Bateman L A, Durheim M T, Huffman K M, Houmard J A. Effects of exercise training intensity on pancreatic β-cell function. Diabetes Care 32, 1807–1811.
- Smith S, Harris P A, Menzies-Gow N J. Comparison of the in-feed glucose test and the oral sugar test. Equine Vet. J. 48, 224–227.
- Snow D H, Persson S G B, Rose R J. Equine exercise physiology. Proceedings of the first international conference, Oxford, September 22nd-24th, 1982. Cambridge. Granta Editions, 47 Norfolk Street.
- Stewart-Hunt L, Geor R J, Mccutcheon L J. Effects of short-term training on insulin sensitivity and skeletal muscle glucose metabolism in Standardbred horses. Equine Vet. J. 38, 226–232.
- Szemplinski K L, Thompson A, Cherry N, Guay K, Smith W B, Brady J. Transporting and exercising unconditioned Horses: effects on microflora populations. J. Equine Vet. Sci. 90, 102988.
- Valberg S J, Velez-Irizarry D, Williams Z J, Pagan J D, Mesquita V, Waldridge B. Novel expression of GLUT3, GLUT6 and GLUT10 in equine gluteal muscle following glycogen-depleting exercise: impact of dietary starch and fat. Metabolites 13, 718.
- Valentini M, Gonzalez D, Mavridou D A, Filloux A. Lifestyle transitions and adaptive pathogenesis of Pseudomonas aeruginosa. Curr. Opin. Microbiol. 41, 15–20.
- Vidal Moreno de Vega C, Lemmens D, de Meeûs d’Argenteuil C, Boshuizen B, de Maré L, Leybaert L. Dynamics of training and acute exercise-induced shifts in muscular glucose transporter (GLUT) 4, 8, and 12 expression in locomotion versus posture muscles in healthy horses. Front. Physiol. 14, 1256217.
- Walsh D M, McGowan C M, McGowan T, Lamb S V, Schanbacher B J, Place N J. Correlation of plasma insulin concentration with laminitis score in a field study of equine cushing’s disease and equine metabolic syndrome. J. Equine Vet. Sci. 29, 87–94.
- Wang H, Lu Y, Yan Y, Tian S, Zheng D, Leng D. Promising treatment for type 2 diabetes: fecal microbiota transplantation reverses insulin resistance and impaired islets. Front. Cell Infect. Microbiol. 9, 455.
- Zannoni A, Pietra M, Gaspardo A, Accorsi P A, Barone M, Turroni S. Non-invasive assessment of fecal stress biomarkers in hunting dogs during exercise and at rest. Front. Vet. Sci. 7, 126.
- Zhang H, Chen X, Braithwaite D, He Z. Phylogenetic and metagenomic analyses of substrate-dependent bacterial temporal dynamics in microbial fuel cells. PLoS One 9, e107460.
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