Alteration in intestinal morphologic features associated with extensive large-colon resection in horses.
Abstract: Light microscopy, morphometry, and scanning electron microscopy were used to examine the mucosal morphologic features of 7 intestinal specimens (3 from the small intestine; 4 from the large intestine) from each of 8 horses 1 year after sham operation (group 1; n = 3) or extensive large-colon resection (group 2; n = 5). Qualitative light microscopic examination did not reveal differences between groups, but morphometry revealed significantly (P less than 0.05) greater intercrypt area and distance in horses with colon resection and this was most pronounced in the cecum and remaining right ventral and dorsal colon. Crypt area and depth were similar for horses with colon resection and sham operation (P greater than 0.05). Qualitative evaluation of the scanning electron micrographs revealed more prominent crypt orifices in the large intestine of horses with colon resection. The larger intercrypt distance in the colon of horses with resection was not an obvious feature of the qualitative evaluation of the surface with scanning electron microscopy. Small intestinal morphologic features were variable and significant differences were not detected between horses with sham operation and colon resection. Horses adapted to extensive large-colon resection within 1 year by increasing the absorptive (intercrypt) surface area of the remaining large intestine.
Publication Date: 1990-09-01 PubMed ID: 2396796
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- Journal Article
- Research Support
- U.S. Gov't
- Non-P.H.S.
- Anatomy
- Clinical Findings
- Clinical Pathology
- Clinical Study
- Colic
- Digestive Tract
- Equine Health
- Gastrointestinal Diseases
- Gastrointestinal Health
- Horses
- Intestinal Pathology
- Intestinal Surgery
- Microscopy
- Morphology
- Morphometry
- Post-Operative Period
- Scanning Electron Microscopy
- Surgery
- Veterinary Care
- Veterinary Medicine
Summary
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This research explores the morphological changes in the intestines of horses following extensive large-colon resection, concluding that horses adapt within a year by increasing the absorptive surface area of the remaining large intestine.
Study Methodology
- The researchers used light microscopy, morphometry, and scanning electron microscopy to study the intestinal morphologic features of horses.
- They examined seven intestinal specimens (both from the small and large intestines) from each of eight horses.
- These horses were divided into two groups: group 1 consisted of three horses that underwent a sham operation, whereas group 2 comprised five horses that underwent an extensive large-colon resection.
Microscopic Examination and Findings
- Qualitative light microscopic examination showed no differences between the two groups.
- However, morphometry demonstrated a significantly greater intercrypt area and distance among horses that had a colon resection, especially visible in the cecum and the remaining right ventral and dorsal colon.
- The crypt area and depth were almost the same for horses with a colon resection and those who underwent a sham operation.
- Scanning electron micrographs revealed more prominent crypt orifices in the large intestine of horses with a colon resection.
Adaptation to Large-Colon Resection
- Interestingly, the larger intercrypt distance in the colon of horses with resection was not apparent when evaluated qualitatively using scanning electron microscopy.
- The small intestinal morphologic features were variable, and the researchers did not find significant differences between the horses that underwent a sham operation and those with a colon resection.
- Based on the findings, the study concluded that horses are capable of adapting to extensive large-colon resection within a year.
- This adaptation is achieved through an increase in the absorptive (intercrypt) surface area of the remaining large intestine.
Cite This Article
APA
Bertone AL, Cockerell GL, Lee RE, Stashak TS.
(1990).
Alteration in intestinal morphologic features associated with extensive large-colon resection in horses.
Am J Vet Res, 51(9), 1471-1475.
Publication
Researcher Affiliations
- Department of Clinical Sciences, College of Veterinary Medicine and Biological Sciences, Colorado State University, Fort Collins 80523.
MeSH Terms
- Animals
- Cecum / surgery
- Cecum / ultrastructure
- Colon / surgery
- Colon / ultrastructure
- Horses / anatomy & histology
- Horses / surgery
- Intestinal Mucosa / ultrastructure
- Intestine, Large / ultrastructure
- Intestine, Small / ultrastructure
- Microscopy, Electron, Scanning
- Time Factors
Citations
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