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Journal of functional biomaterials2020; 11(4); 79; doi: 10.3390/jfb11040079

An Overview of the Use of Equine Collagen as Emerging Material for Biomedical Applications.

Abstract: Type I collagen has always aroused great interest in the field of life-science and bioengineering, thanks to its favorable structural properties and bioactivity. For this reason, in the last five decades it has been widely studied and employed as biomaterial for the manufacture of implantable medical devices. Commonly used sources of collagen are represented by bovine and swine but their applications are limited because of the zoonosis transmission risks, the immune response and the religious constrains. Thus, type-I collagen isolated from horse tendon has recently gained increasing interest as an attractive alternative, so that, although bovine and porcine derived collagens still remain the most common ones, more and more companies started to bring to market a various range of equine collagen-based products. In this context, this work aims to overview the properties of equine collagen making it particularly appealing in medicine, cosmetics and pharmaceuticals, as well as its main biomedical applications and the currently approved equine collagen-based medical devices, focusing on experimental studies and clinical trials of the last 15 years. To the best of our knowledge, this is the first review focusing on the use of equine collagen, as well as on equine collagen-based marketed products for healthcare.
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Publication Date: 2020-11-01 PubMed ID: 33139660PubMed Central: PMC7712325DOI: 10.3390/jfb11040079Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the increasing interest and application of equine (horse) collagen in the biomedical field due to its advantages over traditionally utilized sources like bovine and swine collagen. The paper mainly delves into the properties possessed by equine collagen that make it a preferred choice in medicine, cosmetics, and pharmaceuticals, and outlines its current applications and approved medical devices based on clinical trials and studies conducted over the last 15 years.

Equine Collagen’s Rising Popularity

  • The study outlines how in recent times, the interest in equine collagen has been on the rise. Researchers attribute this to the limitations associated with other commonly used sources of collagen, such as bovine (cattle) and swine (pig). There are several risks with these sources, including the transmission of zoonosis — diseases that can be transmitted to humans from animals — possible immune responses, and religious restrictions that prohibit the use of products derived from these sources.

Benefits and Properties of Equine Collagen

  • According to the study, the appeal of equine collagen extends to several fields including medicine, cosmetics, and pharmaceuticals due to its structural properties and bioactivity similar to that of Type I collagen, one of the main types of collagen found in humans.
  • This collagen variant has demonstrated promising results as a biomaterial for the manufacture of implantable medical devices in bioengineering applications.

Applications and Current Approvals

  • The study also provides a detailed review of the existing biomedical applications of equine collagen and the medical devices that have been approved for use that are based on it.
  • The research emphasizes the findings of experimental studies and clinical trials conducted over the last 15 years, thus providing an updated overview of the current uses of equine collagen in the healthcare field.

Significance of the Study

  • The research is significant for the fact that it presents a focused review on the use of equine collagen and its market application, a topic that hadn’t previously been singled out for study.

Cite This Article

APA
Gallo N, Natali ML, Sannino A, Salvatore L. (2020). An Overview of the Use of Equine Collagen as Emerging Material for Biomedical Applications. J Funct Biomater, 11(4), 79. https://doi.org/10.3390/jfb11040079

Publication

Journal of functional biomaterials
ISSN: 2079-4983
NlmUniqueID: 101570734
Country: Switzerland
Language: English
Volume: 11
Issue: 4
PII: 79

Researcher Affiliations

Gallo, Nunzia
  • Department of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy.
Natali, Maria Lucia
  • Department of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy.
Sannino, Alessandro
  • Department of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy.
Salvatore, Luca
  • Department of Engineering for Innovation, University of Salento, Via Monteroni, 73100 Lecce, Italy.

Conflict of Interest Statement

The authors declare no conflict of interest.

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