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Home / Equine Research Bank / Asian-Australas J Anim Sci / Analysis of cross-population differentiation between Thoroug...
Asian-Australasian journal of animal sciences2017; 31(8); 1110-1118; doi: 10.5713/ajas.17.0460

Analysis of cross-population differentiation between Thoroughbred and Jeju horses.

Abstract: This study was intended to identify genes positively selected in Thoroughbred horses (THBs) that potentially contribute to their running performances. Methods: The genomes of THB and Jeju horses (JH, Korean native horse) were compared to identify genes positively selected in THB. We performed cross-population extended haplotype homozygosity (XP-EHH) and cross-population composite likelihood ratio test (XP-CLR) statistical methods for our analysis using whole genome resequencing data of 14 THB and 6 JH. Results: We identified 98 (XP-EHH) and 200 (XP-CLR) genes that are under positive selection in THB. Gene enrichment analysis identified 72 gene ontology biological process (GO BP) terms. The genes and GO BP terms explained some of THB's characteristics such as immunity, energy metabolism and eye size and function related to running performances. GO BP terms that play key roles in several cell signaling mechanisms, which affected ocular size and visual functions were identified. GO BP term Eye photoreceptor cell differentiation is among the terms annotated presumed to affect eye size. Conclusions: Our analysis revealed some positively selected candidate genes in THB related to their racing performances. The genes detected are related to the immunity, ocular size and function, and energy metabolism.
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Publication Date: 2017-12-19 PubMed ID: 29268585PubMed Central: PMC6043458DOI: 10.5713/ajas.17.0460Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The abstract is about a research that compared the genomes of Thoroughbred and Jeju horses in an effort to identify genes that contribute to Thoroughbred horses’ superior running performance. Using two statistical methods, the study found a number of genes positively selected in Thoroughbred horses that correlate with characteristics such as immunity, energy metabolism, and eye size and function.

Research Methodology

  • The researchers examined and compared the genomes of Thoroughbred and Jeju horses. Thoroughbred horses are well-known for their running capabilities, whilst Jeju horses are a native breed from Korea.
  • The genetic comparison was conducted using two statistical methods: cross-population extended haplotype homozygosity (XP-EHH) and cross-population composite likelihood ratio test (XP-CLR). Both of these methods utilise whole genome resequencing data.
  • The sample for this study comprised of 14 Thoroughbred horses and 6 Jeju horses.

Results of the Study

  • The XP-EHH method identified 98 genes, while the XP-CLR method found 200 genes that are under positive selection in Thoroughbred horses. The term ‘positive selection’ refers to genetic variations that offer some sort of advantage, hence are more likely to be passed down to future generations.
  • Using gene enrichment analysis, the researchers identified 72 gene ontology biological process (GO BP) terms. These are terms used to annotate genes and gene products according to their associated biological processes.
  • The identified genes and the associated GO BP terms shed light on some of the Thoroughbred’s unique characteristics related to running performance. These include immunity, energy metabolism, and eye size and function.
  • The genes related to eye size and function were found to play a key role in cell signalling mechanisms affecting ocular size and visual functions. The GO BP term “Eye photoreceptor cell differentiation” was also identified and is thought to affect eye size.

Research Conclusions

  • The study concluded by revealing several positively selected candidate genes in Thoroughbred horses that potentially contribute to their racing performances.
  • The detected genes are most notably related to immunity, energy metabolism, and ocular size and function.

Cite This Article

APA
Lee W, Park KD, Taye M, Lee C, Kim H, Lee HK, Shin D. (2017). Analysis of cross-population differentiation between Thoroughbred and Jeju horses. Asian-Australas J Anim Sci, 31(8), 1110-1118. https://doi.org/10.5713/ajas.17.0460

Publication

Asian-Australasian journal of animal sciences
ISSN: 1011-2367
NlmUniqueID: 9884245
Country: Korea (South)
Language: English
Volume: 31
Issue: 8
Pages: 1110-1118

Researcher Affiliations

Lee, Wonseok
  • Department of Agricultural Biotechnology, Animal Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.
Park, Kyung-Do
  • Department of Animal Biotechnology, College of Agricultural and Life Sciences, Chonbuk National University, Jeonju 54896, Korea.
Taye, Mengistie
  • Department of Agricultural Biotechnology, Animal Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.
  • College of Agriculture and Environmental Sciences, Bahir Dar University, PO Box 79, Bahir Dar, Ethiopia.
Lee, Chul
  • Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, Korea.
Kim, Heebal
  • Department of Agricultural Biotechnology, Animal Biotechnology, and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Korea.
  • Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, Korea.
  • Institute for Biomedical Sciences, Shinshu University, Nagano 8304, Japan.
Lee, Hak-Kyo
  • Department of Animal Biotechnology, College of Agricultural and Life Sciences, Chonbuk National University, Jeonju 54896, Korea.
Shin, Donghyun
  • Department of Animal Biotechnology, College of Agricultural and Life Sciences, Chonbuk National University, Jeonju 54896, Korea.

Conflict of Interest Statement

. We certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript.

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