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Home / Equine Research Bank / J Orthop Translat / Animal model for tendinopathy.
Journal of orthopaedic translation2023; 42; 43-56; doi: 10.1016/j.jot.2023.06.005

Animal model for tendinopathy.

Abstract: Tendinopathy is a common motor system disease that leads to pain and reduced function. Despite its prevalence, our mechanistic understanding is incomplete, leading to limited efficacy of treatment options. Animal models contribute significantly to our understanding of tendinopathy and some therapeutic options. However, the inadequacies of animal models are also evident, largely due to differences in anatomical structure and the complexity of human tendinopathy. Different animal models reproduce different aspects of human tendinopathy and are therefore suitable for different scenarios. This review aims to summarize the existing animal models of tendinopathy and to determine the situations in which each model is appropriate for use, including exploring disease mechanisms and evaluating therapeutic effects. Unassigned: We reviewed relevant literature in the PubMed database from January 2000 to December 2022 using the specific terms ((tendinopathy) OR (tendinitis)) AND (model) AND ((mice) OR (rat) OR (rabbit) OR (lapin) OR (dog) OR (canine) OR (sheep) OR (goat) OR (horse) OR (equine) OR (pig) OR (swine) OR (primate)). This review summarized different methods for establishing animal models of tendinopathy and classified them according to the pathogenesis they simulate. We then discussed the advantages and disadvantages of each model, and based on this, identified the situations in which each model was suitable for application. Unassigned: For studies that aim to study the pathophysiology of tendinopathy, naturally occurring models, treadmill models, subacromial impingement models and metabolic models are ideal. They are closest to the natural process of tendinopathy in humans. For studies that aim to evaluate the efficacy of possible treatments, the selection should be made according to the pathogenesis simulated by the modeling method. Existing tendinopathy models can be classified into six types according to the pathogenesis they simulate: extracellular matrix synthesis-decomposition imbalance, inflammation, oxidative stress, metabolic disorder, traumatism and mechanical load. Unassigned: The critical factor affecting the translational value of research results is whether the selected model is matched with the research purpose. There is no single optimal model for inducing tendinopathy, and researchers must select the model that is most appropriate for the study they are conducting. Unassigned: The critical factor affecting the translational value of research results is whether the animal model used is compatible with the research purpose. This paper provides a rationale and practical guide for the establishment and selection of animal models of tendinopathy, which is helpful to improve the clinical transformation ability of existing models and develop new models.
© 2023 The Authors.
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Publication Date: 2023-08-14 PubMed ID: 37637777PubMed Central: PMC10450357DOI: 10.1016/j.jot.2023.06.005Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about reviewing and evaluating the use of various animal models in understanding and treating tendinopathy, a common motor system disease.

Objective of the Research

The researchers aim to review the efficacy and suitability of different animal models for tendinopathy research. They sought to identify situations in which each model is best applicable, such as exploring disease mechanisms or evaluating potential treatments.

Methodology Used

  • The researchers conducted a literature review of publications from January 2000 to December 2022 on PubMed, focusing on terms related to tendinopathy and animal models such as mice, rats, rabbits, dogs, sheep, goats, horses, pigs, and primates.
  • They summarized the varying methods used to establish animal models of tendinopathy and categorized them based on the pathology they mimic.
  • Each model was evaluated in terms of its advantages and disadvantages and was matched with suitable application scenarios.

Findings of the Study

  • For the study of tendinopathy’s pathophysiology, the researchers recommend naturally occurring models, treadmill models, subacromial impingement models, and metabolic models due to their closeness to the natural development of human tendinopathy.
  • When evaluating the efficacy of potential treatments, researchers should select the model based on the pathology being simulated.
  • The authors proposed a classification of existing tendinopathy models into six types: extracellular matrix synthesis-decomposition imbalance, inflammation, oxidative stress, metabolic disorder, traumatism, and mechanical load.

Implications of the Research

  • The researchers noted that the key to maximizing the translational value of research results lies in matching the chosen model with the research purpose.
  • There is no one-size-fits-all model for tendinopathy research, and model selection should be tailored to each specific study’s objectives.
  • The paper provides practical guidance on choosing and establishing animal models for tendinopathy, aiming to enhance the existing models’ clinical transformability and guide the development of new ones.

Cite This Article

APA
Luo J, Wang Z, Tang C, Yin Z, Huang J, Ruan D, Fei Y, Wang C, Mo X, Li J, Zhang J, Fang C, Li J, Chen X, Shen W. (2023). Animal model for tendinopathy. J Orthop Translat, 42, 43-56. https://doi.org/10.1016/j.jot.2023.06.005

Publication

Journal of orthopaedic translation
ISSN: 2214-031X
NlmUniqueID: 101625127
Country: Singapore
Language: English
Volume: 42
Pages: 43-56

Researcher Affiliations

Luo, Junchao
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Wang, Zetao
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Tang, Chenqi
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Binjiang Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Yin, Zi
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Huang, Jiayun
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Ruan, Dengfeng
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Fei, Yang
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Wang, Canlong
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Mo, Xianan
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Li, Jiajin
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
Zhang, Jun
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Department of Orthopedics, Longquan People's Hospital, Zhejiang, 323799, China.
Fang, Cailian
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
Li, Jianyou
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Department of Orthopedics, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Zhejiang University Huzhou Hospital, 313000, Huzhou, Zhejiang, China.
Chen, Xiao
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Shen, Weiliang
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.

Conflict of Interest Statement

A conflict of interest occurs when an individuals objectivity is potentially compromised by a desire for financial gain, prominence, professional advancement or a successful outcome. The Editors of the Journal of Orthopaedic Translation strive to ensure that what is published in the Journal is as balanced, objective and evidence-based as possible. Since it can be difficult to distinguish between an actual conflict of interest and a perceived conflict of interest, the Journal requires authors to disclose all and any potential conflicts of interest.

References

This article includes 200 references
  1. Millar NL, Silbernagel KG, Thorborg K, Kirwan PD, Galatz LM, Abrams GD, Murrell GAC, McInnes IB, Rodeo SA. Tendinopathy.. Nat Rev Dis Primers 2021 Jan 7;7(1):1.
    pubmed: 33414454doi: 10.1038/s41572-020-00234-1google scholar: lookup
  2. Dekkers JS, Schoones JW, Huizinga TW, Toes RE, van der Helm-van Mil AH. Possibilities for preventive treatment in rheumatoid arthritis? Lessons from experimental animal models of arthritis: a systematic literature review and meta-analysis.. Ann Rheum Dis 2017 Feb;76(2):458-467.
    pubmed: 27481831doi: 10.1136/annrheumdis-2016-209830google scholar: lookup
  3. Hooijmans CR, Rovers MM, de Vries RB, Leenaars M, Ritskes-Hoitinga M, Langendam MW. SYRCLE's risk of bias tool for animal studies.. BMC Med Res Methodol 2014 Mar 26;14:43.
    pmc: PMC4230647pubmed: 24667063doi: 10.1186/1471-2288-14-43google scholar: lookup
  4. Murao A, Aziz M, Wang H, Brenner M, Wang P. Release mechanisms of major DAMPs.. Apoptosis 2021 Apr;26(3-4):152-162.
    pmc: PMC8016797pubmed: 33713214doi: 10.1007/s10495-021-01663-3google scholar: lookup
  5. Crowe LAN, McLean M, Kitson SM, Melchor EG, Patommel K, Cao HM, Reilly JH, Leach WJ, Rooney BP, Spencer SJ, Mullen M, Chambers M, Murrell GAC, McInnes IB, Akbar M, Millar NL. S100A8 & S100A9: Alarmin mediated inflammation in tendinopathy.. Sci Rep 2019 Feb 6;9(1):1463.
    pmc: PMC6365574pubmed: 30728384doi: 10.1038/s41598-018-37684-3google scholar: lookup
  6. Iba T, Levy JH. Inflammation and thrombosis: roles of neutrophils, platelets and endothelial cells and their interactions in thrombus formation during sepsis.. J Thromb Haemost 2018 Feb;16(2):231-241.
    pubmed: 29193703doi: 10.1111/jth.13911google scholar: lookup
  7. Alim MA, Peterson M, Pejler G. Do Mast Cells Have a Role in Tendon Healing and Inflammation?. Cells 2020 May 4;9(5).
    pmc: PMC7290807pubmed: 32375419doi: 10.3390/cells9051134google scholar: lookup
  8. Benage LG, Sweeney JD, Giers MB, Balasubramanian R. Dynamic Load Model Systems of Tendon Inflammation and Mechanobiology.. Front Bioeng Biotechnol 2022;10:896336.
    pmc: PMC9335371pubmed: 35910030doi: 10.3389/fbioe.2022.896336google scholar: lookup
  9. Maruyama K, Nemoto E, Yamada S. Mechanical regulation of macrophage function - cyclic tensile force inhibits NLRP3 inflammasome-dependent IL-1β secretion in murine macrophages.. Inflamm Regen 2019;39:3.
    pmc: PMC6367847pubmed: 30774738doi: 10.1186/s41232-019-0092-2google scholar: lookup
  10. Shan S, Fang B, Zhang Y, Wang C, Zhou J, Niu C, Gao Y, Zhao D, He J, Wang J, Zhang X, Li Q. Mechanical stretch promotes tumoricidal M1 polarization via the FAK/NF-κB signaling pathway.. FASEB J 2019 Dec;33(12):13254-13266.
    pubmed: 31539281doi: 10.1096/fj.201900799RRgoogle scholar: lookup
  11. Mousavizadeh R, Hojabrpour P, Eltit F, McDonald PC, Dedhar S, McCormack RG, Duronio V, Jafarnejad SM, Scott A. β1 integrin, ILK and mTOR regulate collagen synthesis in mechanically loaded tendon cells.. Sci Rep 2020 Jul 28;10(1):12644.
    pmc: PMC7387456pubmed: 32724089doi: 10.1038/s41598-020-69267-6google scholar: lookup
  12. Alves C, Mendes D, Marques FB. Fluoroquinolones and the risk of tendon injury: a systematic review and meta-analysis.. Eur J Clin Pharmacol 2019 Oct;75(10):1431-1443.
    pubmed: 31270563doi: 10.1007/s00228-019-02713-1google scholar: lookup
  13. Teichtahl AJ, Brady SR, Urquhart DM, Wluka AE, Wang Y, Shaw JE, Cicuttini FM. Statins and tendinopathy: a systematic review.. Med J Aust 2016 Feb 15;204(3):115-21.e1.
    pubmed: 26866552doi: 10.5694/mja15.00806google scholar: lookup
  14. Lui PPY, Wong CM. Biology of Tendon Stem Cells and Tendon in Aging.. Front Genet 2019;10:1338.
    pmc: PMC6976534pubmed: 32010194doi: 10.3389/fgene.2019.01338google scholar: lookup
  15. Cannata F, Vadalà G, Ambrosio L, Napoli N, Papalia R, Denaro V, Pozzilli P. The impact of type 2 diabetes on the development of tendinopathy.. Diabetes Metab Res Rev 2021 Sep;37(6):e3417.
    pubmed: 33156563doi: 10.1002/dmrr.3417google scholar: lookup
  16. Li K, Deng Y, Deng G, Chen P, Wang Y, Wu H, Ji Z, Yao Z, Zhang X, Yu B, Zhang K. High cholesterol induces apoptosis and autophagy through the ROS-activated AKT/FOXO1 pathway in tendon-derived stem cells.. Stem Cell Res Ther 2020 Mar 20;11(1):131.
    pmc: PMC7082977pubmed: 32197645doi: 10.1186/s13287-020-01643-5google scholar: lookup
  17. Cook JL, Purdam CR. Is tendon pathology a continuum? A pathology model to explain the clinical presentation of load-induced tendinopathy.. Br J Sports Med 2009 Jun;43(6):409-16.
    pubmed: 18812414doi: 10.1136/bjsm.2008.051193google scholar: lookup
  18. Cook JL, Rio E, Purdam CR, Docking SI. Revisiting the continuum model of tendon pathology: what is its merit in clinical practice and research?. Br J Sports Med 2016 Oct;50(19):1187-91.
    pmc: PMC5118437pubmed: 27127294doi: 10.1136/bjsports-2015-095422google scholar: lookup
  19. Yang G, Crawford RC, Wang JH. Proliferation and collagen production of human patellar tendon fibroblasts in response to cyclic uniaxial stretching in serum-free conditions.. J Biomech 2004 Oct;37(10):1543-50.
    pubmed: 15336929doi: 10.1016/j.jbiomech.2004.01.005google scholar: lookup
  20. Samiric T, Parkinson J, Ilic MZ, Cook J, Feller JA, Handley CJ. Changes in the composition of the extracellular matrix in patellar tendinopathy.. Matrix Biol 2009 May;28(4):230-6.
    pubmed: 19371780doi: 10.1016/j.matbio.2009.04.001google scholar: lookup
  21. Pringels L, Cook JL, Witvrouw E, Burssens A, Vanden Bossche L, Wezenbeek E. Exploring the role of intratendinous pressure in the pathogenesis of tendon pathology: a narrative review and conceptual framework.. Br J Sports Med 2023 Aug;57(16):1042-1048.
    pmc: PMC10423488pubmed: 36323498doi: 10.1136/bjsports-2022-106066google scholar: lookup
  22. Millar NL, Murrell GA, McInnes IB. Inflammatory mechanisms in tendinopathy - towards translation.. Nat Rev Rheumatol 2017 Jan 25;13(2):110-122.
    pubmed: 28119539doi: 10.1038/nrrheum.2016.213google scholar: lookup
  23. Vesterinen HM, Sena ES, Egan KJ, Hirst TC, Churolov L, Currie GL, Antonic A, Howells DW, Macleod MR. Meta-analysis of data from animal studies: a practical guide.. J Neurosci Methods 2014 Jan 15;221:92-102.
    pubmed: 24099992doi: 10.1016/j.jneumeth.2013.09.010google scholar: lookup
  24. Yin NH, McCarthy I, Birch HL. An equine tendon model for studying intra-tendinous shear in tendons that have more than one muscle contribution.. Acta Biomater 2021 Jun;127:205-212.
    pubmed: 33836223doi: 10.1016/j.actbio.2021.03.072google scholar: lookup
  25. Martinello T, Bronzini I, Perazzi A, Testoni S, De Benedictis GM, Negro A, Caporale G, Mascarello F, Iacopetti I, Patruno M. Effects of in vivo applications of peripheral blood-derived mesenchymal stromal cells (PB-MSCs) and platlet-rich plasma (PRP) on experimentally injured deep digital flexor tendons of sheep.. J Orthop Res 2013 Feb;31(2):306-14.
    pubmed: 22893604doi: 10.1002/jor.22205google scholar: lookup
  26. Serrani D, Volta A, Cingolani F, Pennasilico L, Di Bella C, Bonazzi M, Salvaggio A, Palumbo Piccionello A. Serial Ultrasonographic and Real-Time Elastosonographic Assessment of the Ovine Common Calcaneal Tendon, after an Experimentally Induced Tendinopathy.. Vet Sci 2021 Mar 25;8(4).
    pmc: PMC8064454pubmed: 33806121doi: 10.3390/vetsci8040054google scholar: lookup
  27. Gerber C, Schneeberger AG, Beck M, Schlegel U. Mechanical strength of repairs of the rotator cuff.. J Bone Joint Surg Br 1994 May;76(3):371-80.
    pubmed: 8175836
  28. Pluim M, Martens A, Vanderperren K, Sarrazin S, Koene M, Luciani A, van Weeren PR, Delesalle C. Short- and long term follow-up of 150 sports horses diagnosed with tendinopathy or desmopathy by ultrasonographic examination and treated with high-power laser therapy.. Res Vet Sci 2018 Aug;119:232-238.
    pubmed: 30005398doi: 10.1016/j.rvsc.2018.06.003google scholar: lookup
  29. Grumet RC, Hadley S, Diltz MV, Lee TQ, Gupta R. Development of a new model for rotator cuff pathology: the rabbit subscapularis muscle.. Acta Orthop 2009 Feb;80(1):97-103.
    pmc: PMC2823248pubmed: 19234889doi: 10.1080/17453670902807425google scholar: lookup
  30. Hsu RW, Hsu WH, Tai CL, Lee KF. Effect of shock-wave therapy on patellar tendinopathy in a rabbit model.. J Orthop Res 2004 Jan;22(1):221-7.
    pubmed: 14656684doi: 10.1016/S0736-0266(03)00138-4google scholar: lookup
  31. Jiang G, Wu Y, Meng J, Wu F, Li S, Lin M, Gao X, Hong J, Chen W, Yan S, Yan R, Feng G, Cheng Z. Comparison of Leukocyte-Rich Platelet-Rich Plasma and Leukocyte-Poor Platelet-Rich Plasma on Achilles Tendinopathy at an Early Stage in a Rabbit Model.. Am J Sports Med 2020 Apr;48(5):1189-1199.
    pubmed: 32134682doi: 10.1177/0363546520906142google scholar: lookup
  32. Ko PY, Hsu CC, Chen SY, Kuo LC, Su WR, Jou IM, Su FC, Wu PT. Cross-Linked Hyaluronate and Corticosteroid Combination Ameliorate the Rat Experimental Tendinopathy through Anti-Senescent and -Apoptotic Effects.. Int J Mol Sci 2022 Aug 28;23(17).
    pmc: PMC9456262pubmed: 36077161doi: 10.3390/ijms23179760google scholar: lookup
  33. Kokubu S, Inaki R, Hoshi K, Hikita A. Adipose-derived stem cells improve tendon repair and prevent ectopic ossification in tendinopathy by inhibiting inflammation and inducing neovascularization in the early stage of tendon healing.. Regen Ther 2020 Jun;14:103-110.
    pmc: PMC6970144pubmed: 31989000doi: 10.1016/j.reth.2019.12.003google scholar: lookup
  34. Sugiyama Y, Naito K, Goto K, Kojima Y, Furuhata A, Igarashi M, Nagaoka I, Kaneko K. Effect of aging on the tendon structure and tendon-associated gene expression in mouse foot flexor tendon.. Biomed Rep 2019 Apr;10(4):238-244.
    pmc: PMC6439433pubmed: 30972219doi: 10.3892/br.2019.1200google scholar: lookup
  35. Derwin KA, Baker AR, Iannotti JP, McCarron JA. Preclinical models for translating regenerative medicine therapies for rotator cuff repair.. Tissue Eng Part B Rev 2010 Feb;16(1):21-30.
    pmc: PMC2817667pubmed: 19663651doi: 10.1089/ten.TEB.2009.0209google scholar: lookup
  36. Chen Z, Chen P, Zheng M, Gao J, Liu D, Wang A, Zheng Q, Leys T, Tai A, Zheng M. Challenges and perspectives of tendon-derived cell therapy for tendinopathy: from bench to bedside.. Stem Cell Res Ther 2022 Sep 2;13(1):444.
    pmc: PMC9438319pubmed: 36056395doi: 10.1186/s13287-022-03113-6google scholar: lookup
  37. Silawal S, Kohl B, Girke G, Schneider T, Schulze-Tanzil G. Complement regulation in tenocytes under the influence of leukocytes in an indirect co-culture model.. Inflamm Res 2021 Apr;70(4):495-507.
    pubmed: 33772629doi: 10.1007/s00011-021-01451-4google scholar: lookup
  38. Schoenenberger AD, Tempfer H, Lehner C, Egloff J, Mauracher M, Bird A, Widmer J, Maniura-Weber K, Fucentese SF, Traweger A, Silvan U, Snedeker JG. Macromechanics and polycaprolactone fiber organization drive macrophage polarization and regulate inflammatory activation of tendon in vitro and in vivo.. Biomaterials 2020 Aug;249:120034.
    pubmed: 32315865doi: 10.1016/j.biomaterials.2020.120034google scholar: lookup
  39. Jiang H, Lin X, Liang W, Li Y, Yu X. Friedelin Alleviates the Pathogenesis of Collagenase-Induced Tendinopathy in Mice by Promoting the Selective Autophagic Degradation of p65.. Nutrients 2022 Apr 18;14(8).
    pmc: PMC9031956pubmed: 35458235doi: 10.3390/nᐈ1673google scholar: lookup
  40. Fedato RA, Francisco JC, Sliva G, de Noronha L, Olandoski M, Faria Neto JR, Ferreira PE, Simeoni RB, Abdelwahid E, de Carvalho KAT, Guarita-Souza LC. Stem Cells and Platelet-Rich Plasma Enhance the Healing Process of Tendinitis in Mice.. Stem Cells Int 2019;2019:1497898.
    pmc: PMC6778922pubmed: 31662764doi: 10.1155/2019/1497898google scholar: lookup
  41. Kang KK, Lee EJ, Kim YD, Chung MJ, Kim JY, Kim SY, Hwang SK, Jeong KS. Vitamin C Improves Therapeutic Effects of Adipose-derived Stem Cell Transplantation in Mouse Tendonitis Model.. In Vivo 2017 May-Jun;31(3):343-348.
    pmc: PMC5461443pubmed: 28438861doi: 10.21873/invivo.11065google scholar: lookup
  42. Chen Y, Xie Y, Liu M, Hu J, Tang C, Huang J, Qin T, Chen X, Chen W, Shen W, Yin Z. Controlled-release curcumin attenuates progression of tendon ectopic calcification by regulating the differentiation of tendon stem/progenitor cells.. Mater Sci Eng C Mater Biol Appl 2019 Oct;103:109711.
    pubmed: 31349489doi: 10.1016/j.msec.2019.04.090google scholar: lookup
  43. Lee JM, Hwang JW, Kim MJ, Jung SY, Kim KS, Ahn EH, Min K, Choi YS. Mitochondrial Transplantation Modulates Inflammation and Apoptosis, Alleviating Tendinopathy Both In Vivo and In Vitro.. Antioxidants (Basel) 2021 Apr 28;10(5).
    pmc: PMC8146308pubmed: 33925007doi: 10.3390/antiox10050696google scholar: lookup
  44. Lui PP, Chan LS, Lee YW, Fu SC, Chan KM. Sustained expression of proteoglycans and collagen type III/type I ratio in a calcified tendinopathy model.. Rheumatology (Oxford) 2010 Feb;49(2):231-9.
    pubmed: 19955224doi: 10.1093/rheumatology/kep384google scholar: lookup
  45. Allen AD, Bassil AM, Berkoff DJ, Al Maliki M, Draeger RW, Weinhold PS. Minocycline microspheres did not significantly improve outcomes after collagenase injection of tendon.. J Orthop 2019 Nov-Dec;16(6):580-584.
    pmc: PMC6806656pubmed: 31660026doi: 10.1016/j.jor.2019.06.007google scholar: lookup
  46. Kitagawa T, Nakase J, Takata Y, Shimozaki K, Asai K, Tsuchiya H. Histopathological study of the infrapatellar fat pad in the rat model of patellar tendinopathy: A basic study.. Knee 2019 Jan;26(1):14-19.
    pubmed: 30150068doi: 10.1016/j.knee.2018.07.016google scholar: lookup
  47. Marques AC, Albertini R, Serra AJ, da Silva EA, de Oliveira VL, Silva LM, Leal-Junior EC, de Carvalho PT. Photobiomodulation therapy on collagen type I and III, vascular endothelial growth factor, and metalloproteinase in experimentally induced tendinopathy in aged rats.. Lasers Med Sci 2016 Dec;31(9):1915-1923.
    pubmed: 27624782doi: 10.1007/s10103-016-2070-0google scholar: lookup
  48. Gong F, Cui L, Zhang X, Zhan X, Gong X, Wen Y. Piperine ameliorates collagenase-induced Achilles tendon injury in the rat.. Connect Tissue Res 2018 Jan;59(1):21-29.
    pubmed: 28165813doi: 10.1080/03008207.2017.1289188google scholar: lookup
  49. Pires D, Xavier M, Araújo T, Silva JA Jr, Aimbire F, Albertini R. Low-level laser therapy (LLLT; 780 nm) acts differently on mRNA expression of anti- and pro-inflammatory mediators in an experimental model of collagenase-induced tendinitis in rat.. Lasers Med Sci 2011 Jan;26(1):85-94.
    pubmed: 20737183doi: 10.1007/s10103-010-0811-zgoogle scholar: lookup
  50. Vieira CP, De Oliveira LP, Da Ré Guerra F, Dos Santos De Almeida M, Marcondes MC, Pimentel ER. Glycine improves biochemical and biomechanical properties following inflammation of the achilles tendon.. Anat Rec (Hoboken) 2015 Mar;298(3):538-45.
    pubmed: 25156668doi: 10.1002/ar.23041google scholar: lookup
  51. Perucca Orfei C, Lovati AB, Lugano G, Viganò M, Bottagisio M, D'Arrigo D, Sansone V, Setti S, de Girolamo L. Pulsed electromagnetic fields improve the healing process of Achilles tendinopathy: a pilot study in a rat model.. Bone Joint Res 2020 Sep;9(9):613-622.
    pmc: PMC7533373pubmed: 33072305doi: 10.1302/2046-3758.99.BJR-2020-0113.R1google scholar: lookup
  52. Shah V, Bendele A, Dines JS, Kestler HK, Hollinger JO, Chahine NO, Hee CK. Dose-response effect of an intra-tendon application of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in a rat Achilles tendinopathy model.. J Orthop Res 2013 Mar;31(3):413-20.
    pubmed: 22933269doi: 10.1002/jor.22222google scholar: lookup
  53. Kamineni S, Butterfield T, Sinai A. Percutaneous ultrasonic debridement of tendinopathy-a pilot Achilles rabbit model.. J Orthop Surg Res 2015 May 20;10:70.
    pmc: PMC4490679pubmed: 25986341doi: 10.1186/s13018-015-0207-7google scholar: lookup
  54. Hsieh YL, Lin MT, Hong CZ, Chen HS. Percutaneous soft tissue release performed using a blunt cannula in rabbits with chronic collagenase-induced Achilles tendinopathy.. Foot Ankle Surg 2019 Apr;25(2):186-192.
    pubmed: 29409286doi: 10.1016/j.fas.2017.10.007google scholar: lookup
  55. de Cesar Netto C, Godoy-Santos AL, Augusto Pontin P, Natalino RJM, Pereira CAM, Lima FDO, da Fonseca LF, Staggers JR, Cavinatto LM, Schon LC, de Camargo OP, Fernandes TD. Novel animal model for Achilles tendinopathy: Controlled experimental study of serial injections of collagenase in rabbits.. PLoS One 2018;13(2):e0192769.
    pmc: PMC5811024pubmed: 29438431doi: 10.1371/journal.pone.0192769google scholar: lookup
  56. Lacitignola L, Staffieri F, Rossi G, Francioso E, Crovace A. Survival of bone marrow mesenchymal stem cells labelled with red fluorescent protein in an ovine model of collagenase-induced tendinitis.. Vet Comp Orthop Traumatol 2014;27(3):204-9.
    pubmed: 24764044doi: 10.3415/VCOT-13-09-0113google scholar: lookup
  57. Crovace A, Lacitignola L, Francioso E, Rossi G. Histology and immunohistochemistry study of ovine tendon grafted with cBMSCs and BMMNCs after collagenase-induced tendinitis.. Vet Comp Orthop Traumatol 2008;21(4):329-36.
    pubmed: 18704239doi: 10.3415/vcot-07-05-0050google scholar: lookup
  58. Palumbo Piccionello A, Riccio V, Senesi L, Volta A, Pennasilico L, Botto R, Rossi G, Tambella AM, Galosi L, Marini C, Vullo C, Gigante A, Zavan B, De Francesco F, Riccio M. Adipose micro-grafts enhance tendinopathy healing in ovine model: An in vivo experimental perspective study.. Stem Cells Transl Med 2021 Nov;10(11):1544-1560.
    pmc: PMC8550708pubmed: 34398527doi: 10.1002/sctm.20-0496google scholar: lookup
  59. Wu YT, Wu PT, Jou IM. Peritendinous elastase treatment induces tendon degeneration in rats: A potential model of tendinopathy in vivo.. J Orthop Res 2016 Mar;34(3):471-7.
    pubmed: 26291184doi: 10.1002/jor.23030google scholar: lookup
  60. Rezvani SN, Chen J, Li J, Midura R, Cali V, Sandy JD, Plaas A, Wang VM. In-Vivo Efficacy of Recombinant Human Hyaluronidase (rHuPH20) Injection for Accelerated Healing of Murine Retrocalcaneal Bursitis and Tendinopathy.. J Orthop Res 2020 Jan;38(1):59-69.
    pmc: PMC6917826pubmed: 31478241doi: 10.1002/jor.24459google scholar: lookup
  61. Sikes KJ, Li J, Gao SG, Shen Q, Sandy JD, Plaas A, Wang VM. TGF-b1 or hypoxia enhance glucose metabolism and lactate production via HIF1A signaling in tendon cells.. Connect Tissue Res 2018 Sep;59(5):458-471.
    pmc: PMC6175639pubmed: 29447016doi: 10.1080/03008207.2018.1439483google scholar: lookup
  62. Bell R, Li J, Gorski DJ, Bartels AK, Shewman EF, Wysocki RW, Cole BJ, Bach BR Jr, Mikecz K, Sandy JD, Plaas AH, Wang VM. Controlled treadmill exercise eliminates chondroid deposits and restores tensile properties in a new murine tendinopathy model.. J Biomech 2013 Feb 1;46(3):498-505.
    pubmed: 23159096doi: 10.1016/j.jbiomech.2012.10.020google scholar: lookup
  63. Sullo A, Maffulli N, Capasso G, Testa V. The effects of prolonged peritendinous administration of PGE1 to the rat Achilles tendon: a possible animal model of chronic Achilles tendinopathy.. J Orthop Sci 2001;6(4):349-57.
    pubmed: 11479765doi: 10.1007/s007760100031google scholar: lookup
  64. Khan MH, Li Z, Wang JH. Repeated exposure of tendon to prostaglandin-E2 leads to localized tendon degeneration.. Clin J Sport Med 2005 Jan;15(1):27-33.
    pubmed: 15654188doi: 10.1097/00042752-200501000-00006google scholar: lookup
  65. Li H, Tang K, Deng Y, Xie M, Chang D, Tao X, Xu J. [Effects of exogenous prostaglandin E2 on collagen content of Achilles tendon of rabbits in vivo].. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2012 Mar;26(3):352-8.
    pubmed: 22506477
  66. Zhou Y, Zhou B, Tang K. The effects of substance p on tendinopathy are dose-dependent: an in vitro and in vivo model study.. J Nutr Health Aging 2015 May;19(5):555-61.
    pubmed: 25923486doi: 10.1007/s12603-014-0576-3google scholar: lookup
  67. Berkoff DJ, Kallianos SA, Eskildsen SM, Weinhold PS. Use of an IL1-receptor antagonist to prevent the progression of tendinopathy in a rat model.. J Orthop Res 2016 Apr;34(4):616-22.
    pubmed: 26418607doi: 10.1002/jor.23057google scholar: lookup
  68. Liu YC, Wang HL, Huang YZ, Weng YH, Chen RS, Tsai WC, Yeh TH, Lu CS, Chen YL, Lin YW, Chen YJ, Hsu CC, Chiu CH, Chiu CC. Alda-1, an activator of ALDH2, ameliorates Achilles tendinopathy in cellular and mouse models.. Biochem Pharmacol 2020 May;175:113919.
    pubmed: 32194057doi: 10.1016/j.bcp.2020.113919google scholar: lookup
  69. Chen HS, Su YT, Chan TM, Su YJ, Syu WS, Harn HJ, Lin SZ, Chiu SC. Human adipose-derived stem cells accelerate the restoration of tensile strength of tendon and alleviate the progression of rotator cuff injury in a rat model.. Cell Transplant 2015;24(3):509-20.
    pubmed: 25654771doi: 10.3727/096368915X686968google scholar: lookup
  70. Naterstad IF, Rossi RP, Marcos RL, Parizzoto NA, Frigo L, Joensen J, Lopes Martins PSL, Bjordal JM, Lopes-Martins RAB. Comparison of Photobiomodulation and Anti-Inflammatory Drugs on Tissue Repair on Collagenase-Induced Achilles Tendon Inflammation in Rats.. Photomed Laser Surg 2018 Mar;36(3):137-145.
    pubmed: 29265910doi: 10.1089/pho.2017.4364google scholar: lookup
  71. Perucca Orfei C, Lovati AB, Viganò M, Stanco D, Bottagisio M, Di Giancamillo A, Setti S, de Girolamo L. Dose-Related and Time-Dependent Development of Collagenase-Induced Tendinopathy in Rats.. PLoS One 2016;11(8):e0161590.
    pmc: PMC4993508pubmed: 27548063doi: 10.1371/journal.pone.0161590google scholar: lookup
  72. Chen L, Liu JP, Tang KL, Wang Q, Wang GD, Cai XH, Liu XM. Tendon derived stem cells promote platelet-rich plasma healing in collagenase-induced rat achilles tendinopathy.. Cell Physiol Biochem 2014;34(6):2153-68.
    pubmed: 25562162doi: 10.1159/000369659google scholar: lookup
  73. Sharma P, Maffulli N. Tendon injury and tendinopathy: healing and repair.. J Bone Joint Surg Am 2005 Jan;87(1):187-202.
    pubmed: 15634833doi: 10.2106/JBJS.D.01850google scholar: lookup
  74. Nichols AEC, Best KT, Loiselle AE. The cellular basis of fibrotic tendon healing: challenges and opportunities.. Transl Res 2019 Jul;209:156-168.
    pmc: PMC6545261pubmed: 30776336doi: 10.1016/j.trsl.2019.02.002google scholar: lookup
  75. Meng XM, Nikolic-Paterson DJ, Lan HY. TGF-β: the master regulator of fibrosis.. Nat Rev Nephrol 2016 Jun;12(6):325-38.
    pubmed: 27108839doi: 10.1038/nrneph.2016.48google scholar: lookup
  76. Hu B, Phan SH. Myofibroblasts.. Curr Opin Rheumatol 2013 Jan;25(1):71-7.
    pmc: PMC4007118pubmed: 23114586doi: 10.1097/BOR.0b013e32835b1352google scholar: lookup
  77. Bell R, Li J, Shewman EF, Galante JO, Cole BJ, Bach BR Jr, Troy KL, Mikecz K, Sandy JD, Plaas AH, Wang VM. ADAMTS5 is required for biomechanically-stimulated healing of murine tendinopathy.. J Orthop Res 2013 Oct;31(10):1540-8.
    pubmed: 23754494doi: 10.1002/jor.22398google scholar: lookup
  78. Du G, Cheng X, Zhang Z, Han L, Wu K, Li Y, Lin X. TGF-Beta Induced Key Genes of Osteogenic and Adipogenic Differentiation in Human Mesenchymal Stem Cells and MiRNA-mRNA Regulatory Networks.. Front Genet 2021;12:759596.
    pmc: PMC8656281pubmed: 34899844doi: 10.3389/fgene.2021.759596google scholar: lookup
  79. Thorpe CT, Screen HR. Tendon Structure and Composition.. Adv Exp Med Biol 2016;920:3-10.
    pubmed: 27535244doi: 10.1007/978-3-319-33943-6_1google scholar: lookup
  80. Bouchery T, Harris N. Neutrophil-macrophage cooperation and its impact on tissue repair.. Immunol Cell Biol 2019 Mar;97(3):289-298.
    pubmed: 30710448doi: 10.1111/imcb.12241google scholar: lookup
  81. Tang C, Chen Y, Huang J, Zhao K, Chen X, Yin Z, Heng BC, Chen W, Shen W. The roles of inflammatory mediators and immunocytes in tendinopathy.. J Orthop Translat 2018 Jul;14:23-33.
    pmc: PMC6034108pubmed: 30035030doi: 10.1016/j.jot.2018.03.003google scholar: lookup
  82. Smith WL, Urade Y, Jakobsson PJ. Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis.. Chem Rev 2011 Oct 12;111(10):5821-65.
    pmc: PMC3285496pubmed: 21942677doi: 10.1021/cr2002992google scholar: lookup
  83. MacKenzie KF, Clark K, Naqvi S, McGuire VA, Nöehren G, Kristariyanto Y, van den Bosch M, Mudaliar M, McCarthy PC, Pattison MJ, Pedrioli PG, Barton GJ, Toth R, Prescott A, Arthur JS. PGE(2) induces macrophage IL-10 production and a regulatory-like phenotype via a protein kinase A-SIK-CRTC3 pathway.. J Immunol 2013 Jan 15;190(2):565-77.
    pmc: PMC3620524pubmed: 23241891doi: 10.4049/jimmunol.1202462google scholar: lookup
  84. Wang J, Liu Y, Ding H, Shi X, Ren H. Mesenchymal stem cell-secreted prostaglandin E(2) ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization.. Stem Cell Res Ther 2021 Jan 7;12(1):15.
    pmc: PMC7792134pubmed: 33413632doi: 10.1186/s13287-020-02070-2google scholar: lookup
  85. Levin G, Duffin KL, Obukowicz MG, Hummert SL, Fujiwara H, Needleman P, Raz A. Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2.. Biochem J 2002 Jul 15;365(Pt 2):489-96.
    pmc: PMC1222686pubmed: 11939906doi: 10.1042/BJ20011798google scholar: lookup
  86. Cattell V, Smith J, Cook HT. Prostaglandin E1 suppresses macrophage infiltration and ameliorates injury in an experimental model of macrophage-dependent glomerulonephritis.. Clin Exp Immunol 1990 Feb;79(2):260-5.
    pmc: PMC1534770pubmed: 2311303doi: 10.1111/j.1365-2249.1990.tb05188.xgoogle scholar: lookup
  87. Gunes T, Bilgic E, Erdem M, Bostan B, Koseoglu RD, Sahin SA, Sen C. Effect of radiofrequency microtenotomy on degeneration of tendons: an experimental study on rabbits.. Foot Ankle Surg 2014 Mar;20(1):61-6.
    pubmed: 24480503doi: 10.1016/j.fas.2013.11.003google scholar: lookup
  88. Ackermann PW, Ahmed M, Kreicbergs A. Early nerve regeneration after achilles tendon rupture--a prerequisite for healing? A study in the rat.. J Orthop Res 2002 Jul;20(4):849-56.
    pubmed: 12168677doi: 10.1016/S0736-0266(01)00159-0google scholar: lookup
  89. Ljung BO, Alfredson H, Forsgren S. Neurokinin 1-receptors and sensory neuropeptides in tendon insertions at the medial and lateral epicondyles of the humerus. Studies on tennis elbow and medial epicondylalgia.. J Orthop Res 2004 Mar;22(2):321-7.
    pubmed: 15013091doi: 10.1016/S0736-0266(03)00183-9google scholar: lookup
  90. Spang C, Harandi VM, Alfredson H, Forsgren S. Marked innervation but also signs of nerve degeneration in between the Achilles and plantaris tendons and presence of innervation within the plantaris tendon in midportion Achilles tendinopathy.. J Musculoskelet Neuronal Interact 2015 Jun;15(2):197-206.
    pmc: PMC5133724pubmed: 26032213
  91. Assas BM, Pennock JI, Miyan JA. Calcitonin gene-related peptide is a key neurotransmitter in the neuro-immune axis.. Front Neurosci 2014;8:23.
    pmc: PMC3924554pubmed: 24592205doi: 10.3389/fnins.2014.00023google scholar: lookup
  92. Raddant AC, Russo AF. Calcitonin gene-related peptide in migraine: intersection of peripheral inflammation and central modulation.. Expert Rev Mol Med 2011 Nov 29;13:e36.
    pmc: PMC3383830pubmed: 22123247doi: 10.1017/S1462399411002067google scholar: lookup
  93. Kulka M, Sheen CH, Tancowny BP, Grammer LC, Schleimer RP. Neuropeptides activate human mast cell degranulation and chemokine production.. Immunology 2008 Mar;123(3):398-410.
    pmc: PMC2433325pubmed: 17922833doi: 10.1111/j.1365-2567.2007.02705.xgoogle scholar: lookup
  94. Kashiba H, Senba E. [Primary sensory neurons expressing histamine H1-receptor mRNA].. Nihon Yakurigaku Zasshi 2001 Jul;118(1):43-9.
    pubmed: 11496826doi: 10.1254/fpj.118.43google scholar: lookup
  95. Carlsson O, Schizas N, Li J, Ackermann PW. Substance P injections enhance tissue proliferation and regulate sensory nerve ingrowth in rat tendon repair.. Scand J Med Sci Sports 2011 Aug;21(4):562-9.
    pubmed: 20459473doi: 10.1111/j.1600-0838.2009.01080.xgoogle scholar: lookup
  96. Barbe MF, Hilliard BA, Fisher PW, White AR, Delany SP, Iannarone VJ, Harris MY, Amin M, Cruz GE, Popoff SN. Blocking substance P signaling reduces musculotendinous and dermal fibrosis and sensorimotor declines in a rat model of overuse injury.. Connect Tissue Res 2020 Nov;61(6):604-619.
    pmc: PMC7036028pubmed: 31443618doi: 10.1080/03008207.2019.1653289google scholar: lookup
  97. Oh SY, Kim DK, Han SH, Lee HH, Jeong Y, Baek M, Kim H, Ahn W, Lee S. Sustained Exposure of Substance P Causes Tendinopathy.. Int J Mol Sci 2020 Nov 16;21(22).
    pmc: PMC7709031pubmed: 33207770doi: 10.3390/ijms21228633google scholar: lookup
  98. Kawasaki T, Kawai T. Toll-like receptor signaling pathways.. Front Immunol 2014;5:461.
    pmc: PMC4174766pubmed: 25309543doi: 10.3389/fimmu.2014.00461google scholar: lookup
  99. Landström M. The TAK1-TRAF6 signalling pathway.. Int J Biochem Cell Biol 2010 May;42(5):585-9.
    pubmed: 20060931doi: 10.1016/j.biocel.2009.12.023google scholar: lookup
  100. Akbar M, Gilchrist DS, Kitson SM, Nelis B, Crowe LAN, Garcia-Melchor E, Reilly JH, Kerr SC, Murrell GAC, McInnes IB, Millar NL. Targeting danger molecules in tendinopathy: the HMGB1/TLR4 axis.. RMD Open 2017;3(2):e000456.
    pmc: PMC5574425pubmed: 28879051doi: 10.1136/rmdopen-2017-000456google scholar: lookup
  101. Balan S, Saxena M, Bhardwaj N. Dendritic cell subsets and locations.. Int Rev Cell Mol Biol 2019;348:1-68.
    pubmed: 31810551doi: 10.1016/bs.ircmb.2019.07.004google scholar: lookup
  102. Khotimchenko M, Tiasto V, Kalitnik A, Begun M, Khotimchenko R, Leonteva E, Bryukhovetskiy I, Khotimchenko Y. Antitumor potential of carrageenans from marine red algae.. Carbohydr Polym 2020 Oct 15;246:116568.
    pubmed: 32747241doi: 10.1016/j.carbpol.2020.116568google scholar: lookup
  103. Bhattacharyya S, Gill R, Chen ML, Zhang F, Linhardt RJ, Dudeja PK, Tobacman JK. Toll-like receptor 4 mediates induction of the Bcl10-NFkappaB-interleukin-8 inflammatory pathway by carrageenan in human intestinal epithelial cells.. J Biol Chem 2008 Apr 18;283(16):10550-8.
    pmc: PMC2447641pubmed: 18252714doi: 10.1074/jbc.M708833200google scholar: lookup
  104. Tillander B, Franzén LE, Nilsson E, Norlin R. Carrageenan-induced subacromial bursitis caused changes in the rat's rotator cuff.. J Orthop Res 2001 May;19(3):441-7.
    pubmed: 11398858doi: 10.1016/S0736-0266(00)90022-6google scholar: lookup
  105. Li P, Zhou H, Tu T, Lu H. Dynamic exacerbation in inflammation and oxidative stress during the formation of peritendinous adhesion resulted from acute tendon injury.. J Orthop Surg Res 2021 May 5;16(1):293.
    pmc: PMC8097959pubmed: 33952274doi: 10.1186/s13018-021-02445-ygoogle scholar: lookup
  106. Yuan T, Qian H, Yu X, Meng J, Lai CT, Jiang H, Zhao JN, Bao NR. Proteomic analysis reveals rotator cuff injury caused by oxidative stress.. Ther Adv Chronic Dis 2021;12:2040622320987057.
    pmc: PMC7975570pubmed: 33796243doi: 10.1177/2040622320987057google scholar: lookup
  107. Forman HJ, Zhang H. Targeting oxidative stress in disease: promise and limitations of antioxidant therapy.. Nat Rev Drug Discov 2021 Sep;20(9):689-709.
    pmc: PMC8243062pubmed: 34194012doi: 10.1038/s41573-021-00233-1google scholar: lookup
  108. Simonin MA, Gegout-Pottie P, Minn A, Gillet P, Netter P, Terlain B. Pefloxacin-induced achilles tendon toxicity in rodents: biochemical changes in proteoglycan synthesis and oxidative damage to collagen.. Antimicrob Agents Chemother 2000 Apr;44(4):867-72.
    pmc: PMC89784pubmed: 10722483doi: 10.1128/AAC.44.4.867-872.2000google scholar: lookup
  109. Schmidt AM. Highlighting Diabetes Mellitus: The Epidemic Continues.. Arterioscler Thromb Vasc Biol 2018 Jan;38(1):e1-e8.
    pmc: PMC5776687pubmed: 29282247doi: 10.1161/ATVBAHA.117.310221google scholar: lookup
  110. Ueda Y, Inui A, Mifune Y, Sakata R, Muto T, Harada Y, Takase F, Kataoka T, Kokubu T, Kuroda R. The effects of high glucose condition on rat tenocytes in vitro and rat Achilles tendon in vivo.. Bone Joint Res 2018 May;7(5):362-372.
    pmc: PMC5987694pubmed: 29922457doi: 10.1302/2046-3758.75.BJR-2017-0126.R2google scholar: lookup
  111. Wu YF, Wang HK, Chang HW, Sun J, Sun JS, Chao YH. High glucose alters tendon homeostasis through downregulation of the AMPK/Egr1 pathway.. Sci Rep 2017 Mar 7;7:44199.
    pmc: PMC5339827pubmed: 28266660doi: 10.1038/srep44199google scholar: lookup
  112. Korntner S, Kunkel N, Lehner C, Gehwolf R, Wagner A, Augat P, Stephan D, Heu V, Bauer HC, Traweger A, Tempfer H. A high-glucose diet affects Achilles tendon healing in rats.. Sci Rep 2017 Apr 10;7(1):780.
    pmc: PMC5429625pubmed: 28396584doi: 10.1038/s41598-017-00700-zgoogle scholar: lookup
  113. Studentsova V, Mora KM, Glasner MF, Buckley MR, Loiselle AE. Obesity/Type II Diabetes Promotes Function-limiting Changes in Murine Tendons that are not reversed by Restoring Normal Metabolic Function.. Sci Rep 2018 Jun 15;8(1):9218.
    pmc: PMC6003963pubmed: 29907811doi: 10.1038/s41598-018-27634-4google scholar: lookup
  114. Wu YF, Huang YT, Wang HK, Yao CJ, Sun JS, Chao YH. Hyperglycemia Augments the Adipogenic Transdifferentiation Potential of Tenocytes and Is Alleviated by Cyclic Mechanical Stretch.. Int J Mol Sci 2017 Dec 28;19(1).
    pmc: PMC5796040pubmed: 29283422doi: 10.3390/ijms19010090google scholar: lookup
  115. Lui PPY. Tendinopathy in diabetes mellitus patients-Epidemiology, pathogenesis, and management.. Scand J Med Sci Sports 2017 Aug;27(8):776-787.
    pubmed: 28106286doi: 10.1111/sms.12824google scholar: lookup
  116. Al-Awar A, Kupai K, Veszelka M, Szűcs G, Attieh Z, Murlasits Z, Török S, Pósa A, Varga C. Experimental Diabetes Mellitus in Different Animal Models.. J Diabetes Res 2016;2016:9051426.
    pmc: PMC4993915pubmed: 27595114doi: 10.1155/2016/9051426google scholar: lookup
  117. Furman BL. Streptozotocin-Induced Diabetic Models in Mice and Rats.. Curr Protoc Pharmacol 2015 Sep 1;70:5.47.1-5.47.20.
    pubmed: 26331889doi: 10.1002/0471141755.ph0547s70google scholar: lookup
  118. Heydemann A. An Overview of Murine High Fat Diet as a Model for Type 2 Diabetes Mellitus.. J Diabetes Res 2016;2016:2902351.
    pmc: PMC4983380pubmed: 27547764doi: 10.1155/2016/2902351google scholar: lookup
  119. Ji J, wang Z, Shi D, Gao X, Jiang Q. Pathologic changes of Achilles tendon in leptin-deficient mice.. Rheumatol Int 2010 Feb;30(4):489-93.
    pubmed: 19547982doi: 10.1007/s00296-009-1001-9google scholar: lookup
  120. Mukohara S, Mifune Y, Inui A, Nishimoto H, Kurosawa T, Yamaura K, Yoshikawa T, Kuroda R. In vitro and in vivo tenocyte-protective effectiveness of dehydroepiandrosterone against high glucose-induced oxidative stress.. BMC Musculoskelet Disord 2021 Jun 5;22(1):519.
    pmc: PMC8180149pubmed: 34090401doi: 10.1186/s12891-021-04398-zgoogle scholar: lookup
  121. Oliveira RR, Medina de Mattos R, Magalhães Rebelo L, Guimarães Meireles Ferreira F, Tovar-Moll F, Eurico Nasciutti L, de Castro Brito GA. Experimental Diabetes Alters the Morphology and Nano-Structure of the Achilles Tendon.. PLoS One 2017;12(1):e0169513.
    pmc: PMC5240962pubmed: 28095484doi: 10.1371/journal.pone.0169513google scholar: lookup
  122. Volper BD, Huynh RT, Arthur KA, Noone J, Gordon BD, Zacherle EW, Munoz E, Sørensen MA, Svensson RB, Broderick TL, Magnusson SP, Howden R, Hale TM, Carroll CC. Influence of acute and chronic streptozotocin-induced diabetes on the rat tendon extracellular matrix and mechanical properties.. Am J Physiol Regul Integr Comp Physiol 2015 Nov 1;309(9):R1135-43.
    pubmed: 26310937doi: 10.1152/ajpregu.00189.2015google scholar: lookup
  123. de Oliveira RR, Martins CS, Rocha YR, Braga AB, Mattos RM, Hecht F, Brito GA, Nasciutti LE. Experimental diabetes induces structural, inflammatory and vascular changes of Achilles tendons.. PLoS One 2013;8(10):e74942.
    pmc: PMC3794027pubmed: 24130676doi: 10.1371/journal.pone.0074942google scholar: lookup
  124. Soslowsky LJ, Fryhofer GW. Tendon Homeostasis in Hypercholesterolemia.. Adv Exp Med Biol 2016;920:151-65.
    pubmed: 27535257doi: 10.1007/978-3-319-33943-6_14google scholar: lookup
  125. Tabas I, Bornfeldt KE. Macrophage Phenotype and Function in Different Stages of Atherosclerosis.. Circ Res 2016 Feb 19;118(4):653-67.
    pmc: PMC4762068pubmed: 26892964doi: 10.1161/CIRCRESAHA.115.306256google scholar: lookup
  126. Li K, Deng G, Deng Y, Chen S, Wu H, Cheng C, Zhang X, Yu B, Zhang K. High cholesterol inhibits tendon-related gene expressions in tendon-derived stem cells through reactive oxygen species-activated nuclear factor-κB signaling.. J Cell Physiol 2019 Aug;234(10):18017-18028.
    pubmed: 30825206doi: 10.1002/jcp.28433google scholar: lookup
  127. Chandra A, Sharma K, Pratap K, Singh V, Saini N. Inhibition of microRNA-128-3p attenuates hypercholesterolemia in mouse model.. Life Sci 2021 Jan 1;264:118633.
    pubmed: 33190783doi: 10.1016/j.lfs.2020.118633google scholar: lookup
  128. Yu H, Rimbert A, Palmer AE, Toyohara T, Xia Y, Xia F, Ferreira LMR, Chen Z, Chen T, Loaiza N, Horwitz NB, Kacergis MC, Zhao L, Soukas AA, Kuivenhoven JA, Kathiresan S, Cowan CA. GPR146 Deficiency Protects against Hypercholesterolemia and Atherosclerosis.. Cell 2019 Nov 27;179(6):1276-1288.e14.
    pmc: PMC6889877pubmed: 31778654doi: 10.1016/j.cell.2019.10.034google scholar: lookup
  129. Zhao Y, Qu H, Wang Y, Xiao W, Zhang Y, Shi D. Small rodent models of atherosclerosis.. Biomed Pharmacother 2020 Sep;129:110426.
    pubmed: 32574973doi: 10.1016/j.biopha.2020.110426google scholar: lookup
  130. Grewal N, Thornton GM, Behzad H, Sharma A, Lu A, Zhang P, Reid WD, Granville Alex Scott DJ. Accumulation of oxidized LDL in the tendon tissues of C57BL/6 or apolipoprotein E knock-out mice that consume a high fat diet: potential impact on tendon health.. PLoS One 2014;9(12):e114214.
    pmc: PMC4264764pubmed: 25502628doi: 10.1371/journal.pone.0114214google scholar: lookup
  131. Croen BJ, Carballo CB, Wada S, Zhang X, Patel S, Deng XH, Rodeo SA. Chronic subacromial impingement leads to supraspinatus muscle functional and morphological changes: Evaluation in a murine model.. J Orthop Res 2021 Oct;39(10):2243-2251.
    pubmed: 33336819doi: 10.1002/jor.24964google scholar: lookup
  132. Liu Y, Deng XH, Zhang X, Cong T, Chen D, Hall AJ, Ying L, Rodeo SA. The Role of Indian Hedgehog Signaling in Tendon Response to Subacromial Impingement: Evaluation Using a Mouse Model.. Am J Sports Med 2022 Feb;50(2):362-370.
    pubmed: 34904906doi: 10.1177/03635465211062244google scholar: lookup
  133. Ding Shuchen, Tian Z, Ma C, Fang X, Yu R, Qiu Y, Wang L, Yin Z. [Establishment of microinvasive modle of chronic rotator cuff injury in rats].. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi 2014 Oct;28(10):1225-30.
    pubmed: 25591297
  134. Liu Y, Deng XH, Carballo CB, Cong T, Piacentini A, Jordan Hall A, Ying L, Rodeo SA. Evaluating the role of subacromial impingement in rotator cuff tendinopathy: development and analysis of a novel rat model.. J Shoulder Elbow Surg 2022 Sep;31(9):1898-1908.
    pubmed: 35430367doi: 10.1016/j.jse.2022.02.041google scholar: lookup
  135. Schneeberger AG, Nyffeler RW, Gerber C. Structural changes of the rotator cuff caused by experimental subacromial impingement in the rat.. J Shoulder Elbow Surg 1998 Jul-Aug;7(4):375-80.
    pubmed: 9752647doi: 10.1016/s1058-2746(98)90026-xgoogle scholar: lookup
  136. Soslowsky LJ, Thomopoulos S, Esmail A, Flanagan CL, Iannotti JP, Williamson JD 3rd, Carpenter JE. Rotator cuff tendinosis in an animal model: role of extrinsic and overuse factors.. Ann Biomed Eng 2002 Sep;30(8):1057-63.
    pubmed: 12449766doi: 10.1114/1.1509765google scholar: lookup
  137. Zhang Y, Deng XH, Lebaschi AH, Wada S, Carballo CB, Croen B, Ying L, Rodeo SA. Expression of alarmins in a murine rotator cuff tendinopathy model.. J Orthop Res 2020 Nov;38(11):2513-2520.
    pubmed: 32285963doi: 10.1002/jor.24690google scholar: lookup
  138. Cong GT, Lebaschi AH, Camp CL, Carballo CB, Nakagawa Y, Wada S, Deng XH, Rodeo SA. Evaluating the role of subacromial impingement in rotator cuff tendinopathy: Development and analysis of a novel murine model.. J Orthop Res 2018 Oct;36(10):2780-2788.
    pmc: PMC6371402pubmed: 29683224doi: 10.1002/jor.24026google scholar: lookup
  139. Zhang X, Bowen E, Zhang M, Szeto HH, Deng XH, Rodeo SA. SS-31 as a Mitochondrial Protectant in the Treatment of Tendinopathy: Evaluation in a Murine Supraspinatus Tendinopathy Model.. J Bone Joint Surg Am 2022 Nov 2;104(21):1886-1894.
    pubmed: 35984013doi: 10.2106/JBJS.21.01449google scholar: lookup
  140. Zhang X, Wada S, Zhang Y, Chen D, Deng XH, Rodeo SA. Assessment of Mitochondrial Dysfunction in a Murine Model of Supraspinatus Tendinopathy.. J Bone Joint Surg Am 2021 Jan 20;103(2):174-183.
    pubmed: 32941310doi: 10.2106/JBJS.20.00385google scholar: lookup
  141. Eliasberg CD, Wada S, Carballo CB, Nakagawa Y, Nemirov DA, Bhandari R, Otero M, Deng XH, Rodeo SA. Identification of Inflammatory Mediators in Tendinopathy Using a Murine Subacromial Impingement Model.. J Orthop Res 2019 Dec;37(12):2575-2582.
    pubmed: 31378986doi: 10.1002/jor.24434google scholar: lookup
  142. Kim BS, Joo YC, Choi BH, Kim KH, Kang JS, Park SR. The effect of dry needling and treadmill running on inducing pathological changes in rat Achilles tendon.. Connect Tissue Res 2015 Nov;56(6):452-60.
    pubmed: 26076317doi: 10.3109/03008207.2015.1052876google scholar: lookup
  143. Krey D, Borchers J, McCamey K. Tendon needling for treatment of tendinopathy: A systematic review.. Phys Sportsmed 2015 Feb;43(1):80-6.
    pubmed: 25613418doi: 10.1080/00913847.2015.1004296google scholar: lookup
  144. McDevitt AW, Snodgrass SJ, Cleland JA, Leibold MBR, Krause LA, Mintken PE. Treatment of individuals with chronic bicipital tendinopathy using dry needling, eccentric-concentric exercise and stretching; a case series.. Physiother Theory Pract 2020 Mar;36(3):397-407.
    pubmed: 29932797doi: 10.1080/09593985.2018.1488023google scholar: lookup
  145. Almeida Mdos S, Guerra Fda R, de Oliveira LP, Vieira CP, Pimentel ER. A hypothesis for the anti-inflammatory and mechanotransduction molecular mechanisms underlying acupuncture tendon healing.. Acupunct Med 2014 Apr;32(2):178-82.
    pubmed: 24334277doi: 10.1136/acupmed-2013-010455google scholar: lookup
  146. Neal BS, Longbottom J. Is there a role for acupuncture in the treatment of tendinopathy?. Acupunct Med 2012 Dec;30(4):346-9.
    pubmed: 22918022doi: 10.1136/acupmed-2012-010208google scholar: lookup
  147. Ho TC, Tsai SH, Yeh SI, Chen SL, Tung KY, Chien HY, Lu YC, Huang CH, Tsao YP. PEDF-derived peptide promotes tendon regeneration through its mitogenic effect on tendon stem/progenitor cells.. Stem Cell Res Ther 2019 Jan 3;10(1):2.
    pmc: PMC6318926pubmed: 30606221doi: 10.1186/s13287-018-1110-zgoogle scholar: lookup
  148. Nakama LH, King KB, Abrahamsson S, Rempel DM. Evidence of tendon microtears due to cyclical loading in an in vivo tendinopathy model.. J Orthop Res 2005 Sep;23(5):1199-205.
    pubmed: 16140201doi: 10.1016/j.orthres.2005.03.006google scholar: lookup
  149. Uygur E, Aktaş B, Özkut A, Erinç S, Yilmazoglu EG. Dry needling in lateral epicondylitis: a prospective controlled study.. Int Orthop 2017 Nov;41(11):2321-2325.
    pubmed: 28828509doi: 10.1007/s00264-017-3604-1google scholar: lookup
  150. Zhang J, Pan T, Wang JH. Cryotherapy suppresses tendon inflammation in an animal model.. J Orthop Translat 2014 Apr;2(2):75-81.
    pmc: PMC4654415pubmed: 26594634doi: 10.1016/j.jot.2014.01.001google scholar: lookup
  151. Riggin CN, Chen M, Gordon JA, Schultz SM, Soslowsky LJ, Khoury V. Ultrasound-Guided Dry Needling of the Healthy Rat Supraspinatus Tendon Elicits Early Healing Without Causing Permanent Damage.. J Orthop Res 2019 Sep;37(9):2035-2042.
    pmc: PMC6688919pubmed: 31042318doi: 10.1002/jor.24329google scholar: lookup
  152. Calderón-Díez L, Sánchez-Sánchez JL, Herrero-Turrión J, Cleland J, Arias-Buría JL, Fernández-de-Las-Peñas C. Dry Needling of a Healthy Rat Achilles Tendon Increases Its Gene Expressions: A Pilot Study.. Pain Med 2021 Feb 4;22(1):112-117.
    pubmed: 33155027doi: 10.1093/pm/pnaa352google scholar: lookup
  153. O'Brien EJ, Shrive NG, Rosvold JM, Thornton GM, Frank CB, Hart DA. Tendon mineralization is accelerated bilaterally and creep of contralateral tendons is increased after unilateral needle injury of murine achilles tendons.. J Orthop Res 2013 Oct;31(10):1520-8.
    pubmed: 23754538doi: 10.1002/jor.22404google scholar: lookup
  154. Friedrich T, Schmidt W, Jungmichel D, Horn LC, Josten C. Histopathology in rabbit Achilles tendon after operative tenolysis (longitudinal fiber incisions).. Scand J Med Sci Sports 2001 Feb;11(1):4-8.
    pubmed: 11169228doi: 10.1034/j.1600-0838.2001.011001004.xgoogle scholar: lookup
  155. Kavaguchi De Grandis A, Boulocher C, Viguier E, Roger T, Sawaya S. Ultrasonograph and clinical quantitative characterization of tendinopathy by modified splitting in a goat model.. ScientificWorldJournal 2012;2012:472023.
    pmc: PMC3444857pubmed: 22997496doi: 10.1100/2012/472023google scholar: lookup
  156. Johnson J, von Stade D, Regan D, Easley J, Chow L, Dow S, Romeo T, Schlegel T, McGilvray K. Tendon midsubstance trauma as a means for the development of translatable chronic rotator cuff degeneration in an ovine model.. Ann Transl Med 2021 Nov;9(21):1616.
    pmc: PMC8640899pubmed: 34926660doi: 10.21037/atm-21-2749google scholar: lookup
  157. Melrose J, Smith MM, Smith SM, Ravi V, Young AA, Dart AJ, Sonnabend DH, Little CB. Altered stress induced by partial transection of the infraspinatus tendon leads to perlecan (HSPG2) accumulation in an ovine model of tendinopathy.. Tissue Cell 2013 Feb;45(1):77-82.
    pubmed: 23245384doi: 10.1016/j.tice.2012.10.001google scholar: lookup
  158. Moqbel SAA, Xu K, Chen Z, Xu L, He Y, Wu Z, Ma C, Ran J, Wu L, Xiong Y. Tectorigenin Alleviates Inflammation, Apoptosis, and Ossification in Rat Tendon-Derived Stem Cells via Modulating NF-Kappa B and MAPK Pathways.. Front Cell Dev Biol 2020;8:568894.
    pmc: PMC7642480pubmed: 33195199doi: 10.3389/fcell.2020.568894google scholar: lookup
  159. Xu K, Lin C, Ma D, Chen M, Zhou X, He Y, Moqbel SAA, Ma C, Wu L. Spironolactone Ameliorates Senescence and Calcification by Modulating Autophagy in Rat Tendon-Derived Stem Cells via the NF-κB/MAPK Pathway.. Oxid Med Cell Longev 2021;2021:5519587.
    pmc: PMC8263237pubmed: 34306308doi: 10.1155/2021/5519587google scholar: lookup
  160. Johnson J, von Stade D, Regan D, Easley J, Chow L, Dow S, Romeo T, Schlegel T, McGilvray K. Enthesis trauma as a means for the development of translatable chronic rotator cuff degeneration in an ovine model.. Ann Transl Med 2021 May;9(9):741.
    pmc: PMC8246224pubmed: 34268354doi: 10.21037/atm-21-354google scholar: lookup
  161. Zhu M, Musson D, Oliver M, Firth E, Cornish J, Munro J. Modelling gluteus medius tendon degeneration and repair in a large animal model.. Arch Orthop Trauma Surg 2022 Jan;142(1):1-12.
    pubmed: 32813126doi: 10.1007/s00402-020-03573-6google scholar: lookup
  162. Nie D, Zhou Y, Wang W, Zhang J, Wang JH. Mechanical Overloading Induced-Activation of mTOR Signaling in Tendon Stem/Progenitor Cells Contributes to Tendinopathy Development.. Front Cell Dev Biol 2021;9:687856.
    pmc: PMC8311934pubmed: 34322484doi: 10.3389/fcell.2021.687856google scholar: lookup
  163. Chen G, Jiang H, Tian X, Tang J, Bai X, Zhang Z, Wang L. Mechanical loading modulates heterotopic ossification in calcific tendinopathy through the mTORC1 signaling pathway.. Mol Med Rep 2017 Nov;16(5):5901-5907.
    pmc: PMC5865767pubmed: 28901376doi: 10.3892/mmr.2017.7380google scholar: lookup
  164. Zhang J, Wang JH. Mechanobiological response of tendon stem cells: implications of tendon homeostasis and pathogenesis of tendinopathy.. J Orthop Res 2010 May;28(5):639-43.
    pubmed: 19918904doi: 10.1002/jor.21046google scholar: lookup
  165. Jafari L, Savard M, Gobeil F, Langelier E. Characterization of moderate tendinopathy in ex vivo stress-deprived rat tail tendons.. Biomed Eng Online 2019 May 8;18(1):54.
    pmc: PMC6507059pubmed: 31068196doi: 10.1186/s12938-019-0673-ygoogle scholar: lookup
  166. Thornton GM, Shao X, Chung M, Sciore P, Boorman RS, Hart DA, Lo IK. Changes in mechanical loading lead to tendonspecific alterations in MMP and TIMP expression: influence of stress deprivation and intermittent cyclic hydrostatic compression on rat supraspinatus and Achilles tendons.. Br J Sports Med 2010 Aug;44(10):698-703.
    pubmed: 18801769doi: 10.1136/bjsm.2008.050575google scholar: lookup
  167. Wang T, Chen P, Chen L, Zhou Y, Wang A, Zheng Q, Mitchell CA, Leys T, Tuan RS, Zheng MH. Reduction of mechanical loading in tendons induces heterotopic ossification and activation of the β-catenin signaling pathway.. J Orthop Translat 2021 Jul;29:42-50.
    pmc: PMC8142054pubmed: 34094857doi: 10.1016/j.jot.2021.03.004google scholar: lookup
  168. Wang C, Zhang Y, Zhang G, Yu W, He Y. Adipose Stem Cell-Derived Exosomes Ameliorate Chronic Rotator Cuff Tendinopathy by Regulating Macrophage Polarization: From a Mouse Model to a Study in Human Tissue.. Am J Sports Med 2021 Jul;49(9):2321-2331.
    pubmed: 34259608doi: 10.1177/03635465211020010google scholar: lookup
  169. Zhang J, Wang JH. The effects of mechanical loading on tendons--an in vivo and in vitro model study.. PLoS One 2013;8(8):e71740.
    pmc: PMC3747237pubmed: 23977130doi: 10.1371/journal.pone.0071740google scholar: lookup
  170. Seto SP, Parks AN, Qiu Y, Soslowsky LJ, Karas S, Platt MO, Temenoff JS. Cathepsins in Rotator Cuff Tendinopathy: Identification in Human Chronic Tears and Temporal Induction in a Rat Model.. Ann Biomed Eng 2015 Sep;43(9):2036-46.
    pmc: PMC4492897pubmed: 25558848doi: 10.1007/s10439-014-1245-8google scholar: lookup
  171. Xu SY, Li SF, Ni GX. Strenuous Treadmill Running Induces a Chondrocyte Phenotype in Rat Achilles Tendons.. Med Sci Monit 2016 Oct 15;22:3705-3712.
    pmc: PMC5070615pubmed: 27742920doi: 10.12659/MSM.897726google scholar: lookup
  172. Zhao G, Zhang J, Nie D, Zhou Y, Li F, Onishi K, Billiar T, Wang JH. HMGB1 mediates the development of tendinopathy due to mechanical overloading.. PLoS One 2019;14(9):e0222369.
    pmc: PMC6764662pubmed: 31560698doi: 10.1371/journal.pone.0222369google scholar: lookup
  173. Yoshida M, Funasaki H, Kubota M, Marumo K. Therapeutic effects of high molecular weight hyaluronan injections for tendinopathy in a rat model.. J Orthop Sci 2015 Jan;20(1):186-95.
    pubmed: 25253243doi: 10.1007/s00776-014-0650-zgoogle scholar: lookup
  174. Zhang J, Li F, Nie D, Onishi K, Hogan MV, Wang JH. Effect of Metformin on Development of Tendinopathy Due to Mechanical Overloading in an Animal Model.. Foot Ankle Int 2020 Dec;41(12):1455-1465.
    pmc: PMC7736509pubmed: 33180557doi: 10.1177/1071100720966318google scholar: lookup
  175. Sun HB, Li Y, Fung DT, Majeska RJ, Schaffler MB, Flatow EL. Coordinate regulation of IL-1beta and MMP-13 in rat tendons following subrupture fatigue damage.. Clin Orthop Relat Res 2008 Jul;466(7):1555-61.
    pmc: PMC2505236pubmed: 18470577doi: 10.1007/s11999-008-0278-4google scholar: lookup
  176. Tucker JJ, Riggin CN, Connizzo BK, Mauck RL, Steinberg DR, Kuntz AF, Soslowsky LJ, Bernstein J. Effect of overuse-induced tendinopathy on tendon healing in a rat supraspinatus repair model.. J Orthop Res 2016 Jan;34(1):161-6.
    pmc: PMC4710550pubmed: 26218457doi: 10.1002/jor.22993google scholar: lookup
  177. Kocadal O, Pepe M, Akyurek N, Gunes Z, Surer H, Aksahin E, Ogut B, Aktekin CN. The Evaluation of Exogenous Melatonin Administration in Supraspinatus Overuse Tendinopathy in an Experimental Rat Model.. Clin Shoulder Elb 2019 Jun;22(2):79-86.
    pmc: PMC7714296pubmed: 33330199doi: 10.5397/cise.2019.22.2.79google scholar: lookup
  178. Heinemeier KM, Skovgaard D, Bayer ML, Qvortrup K, Kjaer A, Kjaer M, Magnusson SP, Kongsgaard M. Uphill running improves rat Achilles tendon tissue mechanical properties and alters gene expression without inducing pathological changes.. J Appl Physiol (1985) 2012 Sep 1;113(5):827-36.
    pubmed: 22797314doi: 10.1152/japplphysiol.00401.2012google scholar: lookup
  179. Xu SY, Liu SY, Xu L, Deng SY, He YB, Li SF, Ni GX. Response of decorin to different intensity treadmill running.. Mol Med Rep 2018 Jun;17(6):7911-7917.
    pubmed: 29620182doi: 10.3892/mmr.2018.8802google scholar: lookup
  180. Zhang J, Nie D, Williamson K, McDowell A, Hogan MV, Wang JH. Moderate and intensive mechanical loading differentially modulate the phenotype of tendon stem/progenitor cells in vivo.. PLoS One 2020;15(12):e0242640.
    pmc: PMC7771689pubmed: 33373386doi: 10.1371/journal.pone.0242640google scholar: lookup
  181. Zhang J, Wang JH. Production of PGE(2) increases in tendons subjected to repetitive mechanical loading and induces differentiation of tendon stem cells into non-tenocytes.. J Orthop Res 2010 Feb;28(2):198-203.
    pubmed: 19688869doi: 10.1002/jor.20962google scholar: lookup
  182. Giantsis IA, Diakakis NE, Avdi M. High Frequencies of TNC and COL5A1 Genotypes Associated With Low Risk for Superficial Digital Flexor Tendinopathy in Greek Indigenous Horse Breeds Compared With Warmblood Horses.. J Equine Vet Sci 2020 Sep;92:103173.
    pubmed: 32797795doi: 10.1016/j.jevs.2020.103173google scholar: lookup
  183. Mistieri ML, Wigger A, Canola JC, Filho JG, Kramer M. Ultrasonographic evaluation of canine supraspinatus calcifying tendinosis.. J Am Anim Hosp Assoc 2012 Nov-Dec;48(6):405-10.
    pubmed: 23033462doi: 10.5326/JAAHA-MS-5818google scholar: lookup
  184. Gates S, Hinnigan G, Rich A, Ricci E, Owen K. A Case Series of Five Horses with Superficial Digital Flexor Tendon Lesions in the Carpal Canal.. J Equine Vet Sci 2021 Aug;103:103656.
    pubmed: 34281638doi: 10.1016/j.jevs.2021.103656google scholar: lookup
  185. Biewener AA. Muscle-tendon stresses and elastic energy storage during locomotion in the horse.. Comp Biochem Physiol B Biochem Mol Biol 1998 May;120(1):73-87.
    pubmed: 9787779doi: 10.1016/s0305-0491(98)00024-8google scholar: lookup
  186. Thorpe CT, Clegg PD, Birch HL. A review of tendon injury: why is the equine superficial digital flexor tendon most at risk?. Equine Vet J 2010 Mar;42(2):174-80.
    pubmed: 20156256doi: 10.2746/042516409X480395google scholar: lookup
  187. Longo UG, Forriol F, Campi S, Maffulli N, Denaro V. Animal models for translational research on shoulder pathologies: from bench to bedside.. Sports Med Arthrosc Rev 2011 Sep;19(3):184-93.
    pubmed: 21822100doi: 10.1097/JSA.0b013e318205470egoogle scholar: lookup
  188. Grassato L, Drudi D, Pinna S, Valentini S, Diana A, Spinella G. Shoulder Lameness in Dogs: Preliminary Investigation on Ultrasonography, Signalment and Hemato-Biochemical Findings Correlation.. Front Vet Sci 2019;6:229.
    pmc: PMC6629763pubmed: 31338372doi: 10.3389/fvets.2019.00229google scholar: lookup
  189. Kaiser SM, Harms O, Konar M, Staudacher A, Langer A, Thiel C, Kramer M, Schaub S, von Pückler KH. Clinical, radiographic, and magnetic resonance imaging findings of gastrocnemius musculotendinopathy in various dog breeds.. Vet Comp Orthop Traumatol 2016 Nov 23;29(6):515-521.
    pubmed: 27739554doi: 10.3415/VCOT-16-01-0015google scholar: lookup
  190. Abbey R, Pettitt R. Prevalence of mineralisation of the tendon of the supraspinatus muscle in non-lame dogs.. J Small Anim Pract 2021 Jun;62(6):450-454.
    pubmed: 33492687doi: 10.1111/jsap.13298google scholar: lookup
  191. Fleischhacker V, Klatte-Schulz F, Minkwitz S, Schmock A, Rummler M, Seliger A, Willie BM, Wildemann B. In Vivo and In Vitro Mechanical Loading of Mouse Achilles Tendons and Tenocytes-A Pilot Study.. Int J Mol Sci 2020 Feb 15;21(4).
    pmc: PMC7072865pubmed: 32075290doi: 10.3390/ijms21041313google scholar: lookup
  192. Asundi KR, King KB, Rempel DM. Evaluation of gene expression through qRT-PCR in cyclically loaded tendons: an in vivo model.. Eur J Appl Physiol 2008 Feb;102(3):265-70.
    pubmed: 17922137doi: 10.1007/s00421-007-0582-9google scholar: lookup
  193. Nakama LH, King KB, Abrahamsson S, Rempel DM. VEGF, VEGFR-1, and CTGF cell densities in tendon are increased with cyclical loading: An in vivo tendinopathy model.. J Orthop Res 2006 Mar;24(3):393-400.
    pubmed: 16479573doi: 10.1002/jor.20053google scholar: lookup
  194. Chen P, Chen Z, Mitchell C, Gao J, Chen L, Wang A, Leys T, Landao-Bassonga E, Zheng Q, Wang T, Zheng M. Intramuscular injection of Botox causes tendon atrophy by induction of senescence of tendon-derived stem cells.. Stem Cell Res Ther 2021 Jan 7;12(1):38.
    pmc: PMC7791643pubmed: 33413592doi: 10.1186/s13287-020-02084-wgoogle scholar: lookup
  195. Abraham AC, Fang F, Golman M, Oikonomou P, Thomopoulos S. The role of loading in murine models of rotator cuff disease.. J Orthop Res 2022 Apr;40(4):977-986.
    pmc: PMC8639823pubmed: 34081350doi: 10.1002/jor.25113google scholar: lookup
  196. Tsang AS, Dart AJ, Biasutti SA, Jeffcott LB, Smith MM, Little CB. Effects of tendon injury on uninjured regional tendons in the distal limb: An in-vivo study using an ovine tendinopathy model.. PLoS One 2019;14(4):e0215830.
    pmc: PMC6478347pubmed: 31013317doi: 10.1371/journal.pone.0215830google scholar: lookup
  197. Moraska A, Deak T, Spencer RL, Roth D, Fleshner M. Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats.. Am J Physiol Regul Integr Comp Physiol 2000 Oct;279(4):R1321-9.
    pubmed: 11004000doi: 10.1152/ajpregu.2000.279.4.R1321google scholar: lookup
  198. Warden SJ. Animal models for the study of tendinopathy.. Br J Sports Med 2007 Apr;41(4):232-40.
    pmc: PMC2658951pubmed: 17127722doi: 10.1136/bjsm.2006.032342google scholar: lookup
  199. Zhang G, Zhou X, Hu S, Jin Y, Qiu Z. Large animal models for the study of tendinopathy.. Front Cell Dev Biol 2022;10:1031638.
    pmc: PMC9640604pubmed: 36393858doi: 10.3389/fcell.2022.1031638google scholar: lookup
  200. Zhao W, Yang J, Kang Y, Hu K, Jiao M, Zhao B, Jiang Y, Liu C, Ding F, Yuan B, Ma B, Zhang K, Mikos AG, Zhang X. Animal Models of Rotator Cuff Injury and Repair: A Systematic Review.. Tissue Eng Part B Rev 2022 Dec;28(6):1258-1273.
    pubmed: 35972750doi: 10.1089/ten.TEB.2022.0034google scholar: lookup

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