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Journal of orthopaedic translation2023; 42; 43-56; doi: 10.1016/j.jot.2023.06.005

Animal model for tendinopathy.

Abstract: Tendinopathy is a common motor system disease that leads to pain and reduced function. Despite its prevalence, our mechanistic understanding is incomplete, leading to limited efficacy of treatment options. Animal models contribute significantly to our understanding of tendinopathy and some therapeutic options. However, the inadequacies of animal models are also evident, largely due to differences in anatomical structure and the complexity of human tendinopathy. Different animal models reproduce different aspects of human tendinopathy and are therefore suitable for different scenarios. This review aims to summarize the existing animal models of tendinopathy and to determine the situations in which each model is appropriate for use, including exploring disease mechanisms and evaluating therapeutic effects. Unassigned: We reviewed relevant literature in the PubMed database from January 2000 to December 2022 using the specific terms ((tendinopathy) OR (tendinitis)) AND (model) AND ((mice) OR (rat) OR (rabbit) OR (lapin) OR (dog) OR (canine) OR (sheep) OR (goat) OR (horse) OR (equine) OR (pig) OR (swine) OR (primate)). This review summarized different methods for establishing animal models of tendinopathy and classified them according to the pathogenesis they simulate. We then discussed the advantages and disadvantages of each model, and based on this, identified the situations in which each model was suitable for application. Unassigned: For studies that aim to study the pathophysiology of tendinopathy, naturally occurring models, treadmill models, subacromial impingement models and metabolic models are ideal. They are closest to the natural process of tendinopathy in humans. For studies that aim to evaluate the efficacy of possible treatments, the selection should be made according to the pathogenesis simulated by the modeling method. Existing tendinopathy models can be classified into six types according to the pathogenesis they simulate: extracellular matrix synthesis-decomposition imbalance, inflammation, oxidative stress, metabolic disorder, traumatism and mechanical load. Unassigned: The critical factor affecting the translational value of research results is whether the selected model is matched with the research purpose. There is no single optimal model for inducing tendinopathy, and researchers must select the model that is most appropriate for the study they are conducting. Unassigned: The critical factor affecting the translational value of research results is whether the animal model used is compatible with the research purpose. This paper provides a rationale and practical guide for the establishment and selection of animal models of tendinopathy, which is helpful to improve the clinical transformation ability of existing models and develop new models.
© 2023 The Authors.
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Publication Date: 2023-08-14 PubMed ID: 37637777PubMed Central: PMC10450357DOI: 10.1016/j.jot.2023.06.005Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article is about reviewing and evaluating the use of various animal models in understanding and treating tendinopathy, a common motor system disease.

Objective of the Research

The researchers aim to review the efficacy and suitability of different animal models for tendinopathy research. They sought to identify situations in which each model is best applicable, such as exploring disease mechanisms or evaluating potential treatments.

Methodology Used

  • The researchers conducted a literature review of publications from January 2000 to December 2022 on PubMed, focusing on terms related to tendinopathy and animal models such as mice, rats, rabbits, dogs, sheep, goats, horses, pigs, and primates.
  • They summarized the varying methods used to establish animal models of tendinopathy and categorized them based on the pathology they mimic.
  • Each model was evaluated in terms of its advantages and disadvantages and was matched with suitable application scenarios.

Findings of the Study

  • For the study of tendinopathy’s pathophysiology, the researchers recommend naturally occurring models, treadmill models, subacromial impingement models, and metabolic models due to their closeness to the natural development of human tendinopathy.
  • When evaluating the efficacy of potential treatments, researchers should select the model based on the pathology being simulated.
  • The authors proposed a classification of existing tendinopathy models into six types: extracellular matrix synthesis-decomposition imbalance, inflammation, oxidative stress, metabolic disorder, traumatism, and mechanical load.

Implications of the Research

  • The researchers noted that the key to maximizing the translational value of research results lies in matching the chosen model with the research purpose.
  • There is no one-size-fits-all model for tendinopathy research, and model selection should be tailored to each specific study’s objectives.
  • The paper provides practical guidance on choosing and establishing animal models for tendinopathy, aiming to enhance the existing models’ clinical transformability and guide the development of new ones.

Cite This Article

APA
Luo J, Wang Z, Tang C, Yin Z, Huang J, Ruan D, Fei Y, Wang C, Mo X, Li J, Zhang J, Fang C, Li J, Chen X, Shen W. (2023). Animal model for tendinopathy. J Orthop Translat, 42, 43-56. https://doi.org/10.1016/j.jot.2023.06.005

Publication

Journal of orthopaedic translation
ISSN: 2214-031X
NlmUniqueID: 101625127
Country: Singapore
Language: English
Volume: 42
Pages: 43-56

Researcher Affiliations

Luo, Junchao
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Wang, Zetao
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Tang, Chenqi
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Binjiang Institute of Zhejiang University, Hangzhou, Zhejiang, China.
Yin, Zi
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Huang, Jiayun
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Ruan, Dengfeng
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Fei, Yang
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Wang, Canlong
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Mo, Xianan
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Li, Jiajin
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
Zhang, Jun
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Department of Orthopedics, Longquan People's Hospital, Zhejiang, 323799, China.
Fang, Cailian
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
Li, Jianyou
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Department of Orthopedics, Huzhou Central Hospital, Affiliated Central Hospital of Huzhou University, Zhejiang University Huzhou Hospital, 313000, Huzhou, Zhejiang, China.
Chen, Xiao
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.
Shen, Weiliang
  • Department of Orthopedic Surgery, The Second Affiliated Hospital of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Orthopedics Research Institute of Zhejiang University, 310058, Hangzhou City, Zhejiang Province, China.
  • Sports Medicine Institute of Zhejiang University, 310058, Hangzhou, Zhejiang, China.
  • Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Clinical Research Center of Motor System Disease of Zhejiang Province, 315825, Hangzhou, Zhejiang, China.
  • Dr. Li Dak Sum and Yip Yio Chin Center for Stem Cell and Regenerative Medicine, Zhejiang University, 310058, Hangzhou, Zhejiang, China.

Conflict of Interest Statement

A conflict of interest occurs when an individuals objectivity is potentially compromised by a desire for financial gain, prominence, professional advancement or a successful outcome. The Editors of the Journal of Orthopaedic Translation strive to ensure that what is published in the Journal is as balanced, objective and evidence-based as possible. Since it can be difficult to distinguish between an actual conflict of interest and a perceived conflict of interest, the Journal requires authors to disclose all and any potential conflicts of interest.

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Citations

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