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Interdisciplinary perspectives on infectious diseases2010; 2010; 709791; doi: 10.1155/2010/709791

Animal models of CNS viral disease: examples from borna disease virus models.

Abstract: Borna disease (BD), caused by the neurotropic RNA virus, Borna Disease virus, is an affliction ranging from asymptomatic to fatal meningoencephalitis across naturally and experimentally infected warmblooded (mammalian and bird) species. More than 100 years after the first clinical descriptions of Borna disease in horses and studies beginning in the 1980's linking Borna disease virus to human neuropsychiatric diseases, experimentally infected rodents have been used as models for examining behavioral, neuropharmacological, and neurochemical responses to viral challenge at different stages of life. These studies have contributed to understanding the role of CNS viral injury in vulnerability to behavioral, developmental, epileptic, and neurodegenerative diseases and aided evaluation of the proposed and still controversial links to human disease.
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Publication Date: 2010-02-24 PubMed ID: 20204069PubMed Central: PMC2829629DOI: 10.1155/2010/709791Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research discusses how rodent models infected with Borna Disease virus have been used to understand behavioural, neurochemical, and neuropharmacological responses at different life stages, therefore, aiding in the understanding of viral injury’s role in behavioural, developmental, epileptic, and neurodegenerative diseases.

Overview of Borna Disease Virus

  • Borna disease (BD), an affliction caused by Borna Disease virus, a neurotropic RNA virus, can range from asymptomatic to fatal meningoencephalitis.
  • This disease affects both mammalian and bird species that are naturally and experimentally infected.
  • The disease was first clinically described in horses over a century ago and has been linked to human neuropsychiatric diseases since the 1980s.

Use of Animal Models

  • Rodents have been experimentally infected as models to examine behavioral, neuropharmacological, and neurochemical responses at different stages of life.
  • The results from these animal model studies contribute to the understanding of the role of CNS viral injury in various diseases.

Contribution to Behavioral, Epileptic, and Neurodegenerative Diseases Comprehension

  • The research on rodent models infected by Borna Disease virus has improved understanding of the role of CNS viral injuries in vulnerability to behavioral, developmental, epileptic, and neurodegenerative disorders.
  • Such research is vital in developing effective treatments and preventative measures.

Controversial Links to Human Disease

  • The study also examines controversial proposals linking Borna Disease virus to human disease.
  • The outcomes from such explorations can help shape future research and inform strategies to address these diseases.

Cite This Article

APA
Solbrig MV. (2010). Animal models of CNS viral disease: examples from borna disease virus models. Interdiscip Perspect Infect Dis, 2010, 709791. https://doi.org/10.1155/2010/709791

Publication

Interdisciplinary perspectives on infectious diseases
ISSN: 1687-7098
NlmUniqueID: 101496545
Country: Egypt
Language: English
Volume: 2010
Pages: 709791
PII: 709791

Researcher Affiliations

Solbrig, Marylou V
  • Department of Internal Medicine (Neurology) and Medical Microbiology, University of Manitoba, Winnipeg, MB, Canada R3A 1R9.

Grant Funding

  • R01 NS042307 / NINDS NIH HHS

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Citations

This article has been cited 8 times.
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