Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species.
Abstract: In this blinded randomized and controlled study, the anthelmintic efficacy of a tablet formula of ivermectin-praziquantel was evaluated in horses experimentally infected with three species of Strongylus larvae. Eighteen previously dewormed horses were inoculated on study day 0 with third-stage larvae of Strongylus vulgaris, Strongylus equinus, and Strongylus edentatus. The horses were randomly allocated to three groups (n = 6): test-drug (tablet formula), positive-control (reference gel), and negative-control (placebo tablet). On day 56, the horses were treated once with the respective drugs. On day 95, the horses were sacrificed, and necropsy examinations were performed to assess the status of the parasite burden (L4 and immature L5) and pathological lesions on selected organs and tissues. By the criteria of worm counts, the test-drug and positive-control showed, respectively, 100% and 97.3% anthelmintic efficacies on S. vulgaris, 100% and 81.4% on S. equinus, and equally 100% on S. edentatus. However, the efficacies on S. equinus and S. edentatus should be taken only as face values considering their respective low worm counts in the placebo group. The S. vulgaris-induced arterial lesions were also reduced in the test-drug and positive-control groups with efficacies of 73.9% and 62.9%, respectively. No adverse reactions were observed with either of the drugs. Our data demonstrate that the Equimax tablet formula was as safe and efficacious as the gel formula anthelmintic on large strongyles in horses.
Publication Date: 2009-06-02 PubMed ID: 19488785DOI: 10.1007/s00436-009-1460-7Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research study examines the effectiveness of a tablet containing ivermectin-praziquantel in treating horses infected with three different species of Strongylus parasites. The tablet showed good results in reducing both the parasites and the damage they cause without any observed adverse reactions.
Research Methodology
- This was a controlled and blinded study, which means the researchers and subjects did not know which treatment was being administered. This helps avoid bias.
- Eighteen horses, which had previously been dewormed, were artificially infected with third-stage larvae of three different types of Strongylus parasites.
- The horses were separated into three different groups: one group received the test drug (tablet formula), the second group got a reference gel as a positive control, and the third group was given a placebo as a negative control.
- 56 days after being treated, the horses were sacrificed and dissected to evaluate the effect of the treatments on the number of parasites and the extent of tissue damage.
Results of the Study
- All three groups of horses showed varying degrees of reduction in the parasite count and related damages.
- The group administered the test-drug achieved 100% elimination of all three types of parasites. The positive control group achieved 97.3% elimination for S. vulgaris, 81.4% for S. equinus, and 100% for S. edentatus.
- Regarding the tissue damage caused by S. vulgaris, the test drug and positive control reduced arterial lesions by 73.9% and 62.9%, respectively.
- No negative side effects were observed for any of the treatments.
Conclusion of the Research
- The study thus demonstrated that the tablet formula was as safe and effective in treating Strongylus parasite infections on horses as the gel formula, reducing both the parasite burden and associated vascular damage.
Cite This Article
APA
Bonneau S, Maynard L, Tomczuk K, Kok D, Eun HM.
(2009).
Anthelmintic efficacies of a tablet formula of ivermectin-praziquantel on horses experimentally infected with three Strongylus species.
Parasitol Res, 105(3), 817-823.
https://doi.org/10.1007/s00436-009-1460-7 Publication
Researcher Affiliations
- R&D Department, Virbac S.A., B.P. 27, 06511, Carros Cedex, France.
MeSH Terms
- Animals
- Anthelmintics / administration & dosage
- Anthelmintics / adverse effects
- Anthelmintics / therapeutic use
- Arteries / pathology
- Body Weight
- Double-Blind Method
- Female
- Horse Diseases / drug therapy
- Horse Diseases / parasitology
- Horses
- Ivermectin / administration & dosage
- Ivermectin / adverse effects
- Ivermectin / therapeutic use
- Male
- Placebos / administration & dosage
- Praziquantel / administration & dosage
- Praziquantel / adverse effects
- Praziquantel / therapeutic use
- Severity of Illness Index
- Strongylida Infections / drug therapy
- Strongylida Infections / veterinary
- Strongylus / drug effects
- Tablets / administration & dosage
- Treatment Outcome
References
This article includes 19 references
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Citations
This article has been cited 2 times.- de Almeida GL, Santurio JM, Filho JO, Zanette RA, Camillo G, Flores AG, da Silva JH, de la Rue ML. Predatory activity of the fungus Duddingtonia flagrans in equine strongyle infective larvae on natural pasture in the Southern Region of Brazil. Parasitol Res 2012 Feb;110(2):657-62.
- Kuzmina TA, Königová A, Burcáková L, Babjak M, Syrota Y. Strongylids of Domestic Horses in Eastern Slovakia: Species Diversity and Evaluation of Particular Factors Affecting Strongylid Communities. Acta Parasitol 2024 Jun;69(2):1284-1294.
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