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Home / Equine Research Bank / Vet Med Int / Anthelmintic Efficacy of Strongyle Nematodes to Ivermectin a...
Veterinary medicine international2020; 2020; 4868797; doi: 10.1155/2020/4868797

Anthelmintic Efficacy of Strongyle Nematodes to Ivermectin and Fenbendazole on Working Donkeys (Equus asinus) in and around Hosaena Town, Southern Ethiopia.

Abstract: Gastrointestinal helminth parasite infection is a major influencing factor against profitability of working equines all over the world. Objective: A study was conducted from October 2016 to May 2017 in and around Hosaena to determine the efficacy of benzimidazole (BZ) and avermectin (AVM) chemical groups against strongyle nematodes in working donkeys. Methods: A total of 230 donkeys from Hosaena, Soro, Anlemo, and Gombora were randomly allocated into 5 groups of 46 donkeys in each group. All groups, except group 1 (control), were treated with ivermectin 1%, ivertong 10%, fenbendazole, and Fenacure 750 mg, respectively. Fecal samples were collected perrectally before treatment (day 0) and after treatment (day 14), and an egg per gram (EPG) value of >200 was used as a cutoff for inclusion to assess the efficacy of anthelmintics. Results: Accordingly, the study revealed that AVM was effective against strongyle nematodes of donkeys with the mean fecal egg count reduction (FECR) of 100% in three study areas and 97.2% in one study area, respectively, whereas BZ resistance was suspected in the areas where the drug was tested, with the mean FECR of less than 94% in the three study areas. The study also revealed that 73% of the donkeys were affected with a severe degree of strongyle infection as determined by EPG, while 10.4% of donkeys were affected with a mild degree of Parascaris equorum infection. Conclusions: The findings of the present study are expected to serve as baseline data for future investigations and control actions to design realistic control programs to minimize factors that favor emergence of anthelmintic resistance and improve the overall health of the donkeys. Thus, further detailed studies are needed to determine the factors that reduce anthelmintic efficacy and increase anthelmintic resistance in donkeys.
Copyright © 2020 Haben Fesseha et al.
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Publication Date: 2020-09-24 PubMed ID: 33029340PubMed Central: PMC7532375DOI: 10.1155/2020/4868797Google Scholar: Lookup
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Summary

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The research article detailed a study that sought to understand the effectiveness of different drugs, namely benzimidazole (BZ) and avermectin (AVM) against infections caused by strongyle nematodes in working donkeys in Southern Ethiopia, exploring the levels of drug resistance.

Objectives and Methods of Research

  • The research was carried out in and around the town of Hosaena, in Southern Ethiopia, over an eight-month period from October 2016 to May 2017.
  • The key aim of the research was to identify the efficacy of two specific drugs, benzimidazole (BZ) and avermectin (AVM), against strongyle nematodes in working donkeys. These worms are a common problem in working donkeys and can significantly impact their health and productivity.
  • The study involved a total of 230 donkeys from four locations: Hosaena, Soro, Anlemo, and Gombora. These donkeys were split into five groups of 46, with each group subject to a different treatment or control.
  • The control group (Group 1) did not receive any treatment. The other four groups were treated, respectively, with ivermectin 1%, ivertong 10%, fenbendazole, and Fenacure 750 mg.
  • Fecal samples were collected both before treatment and after two weeks of treatment. These were used to assess the load of eggs of the strongyle nematodes as a marker of the intensity of the infection and the efficacy of the drug treatments.

Findings of the Study

  • The major finding of this study was that avermectin (AVM) was very effective against strongyle nematodes, resulting in a complete reduction in egg counts in three out of four study areas and a decrease of 97.2% in the fourth area.
  • However, the efficacy of benzimidazole (BZ) was less certain, with a mean fecal egg count reduction (FECR) of less than 94% in the three study areas. This suggests that there may be resistance developing to BZ in the strongyle nematodes in these areas.
  • The study also highlighted that 73% of the donkeys had a severe degree of infection as determined by the egg count, whereas 10.4% had a mild degree of infection, indicating a significant burden of infestation in the working donkey population.

Suggested Future Research and Implications

  • The authors recommend using the outcome of their research study as base data for future investigations and in creating control programs to combat the factors that are aiding the emergence of anthelmintic resistance in strongyle nematodes.
  • More thorough studies are also suggested to identify the factors that are reducing anthelmintic efficacy and increasing anthelmintic resistance in donkeys.
  • Upholding the overall health and productivity of the working donkeys is essential, given their role in transportation and farming in many regions of Ethiopia.

Cite This Article

APA
Fesseha H, Mathewos M, Kidanemariam F. (2020). Anthelmintic Efficacy of Strongyle Nematodes to Ivermectin and Fenbendazole on Working Donkeys (Equus asinus) in and around Hosaena Town, Southern Ethiopia. Vet Med Int, 2020, 4868797. https://doi.org/10.1155/2020/4868797

Publication

Veterinary medicine international
ISSN: 2090-8113
NlmUniqueID: 101524203
Country: United States
Language: English
Volume: 2020
Pages: 4868797

Researcher Affiliations

Fesseha, Haben
  • Wolaita Sodo University, School of Veterinary Medicine, Department of Veterinary Surgery and Diagnostic Imaging, P.O. Box 138, Wolaita Sodo, Ethiopia.
Mathewos, Mesfin
  • Wolaita Sodo University, School of Veterinary Medicine, Department of Veterinary Pathology, P.O. Box 138, Wolaita Sodo, Ethiopia.
Kidanemariam, Friat
  • Mekelle University College of Veterinary Science, Department of Tropical Veterinary Medicine, P.O. Box 2084, Mekelle, Ethiopia.

Conflict of Interest Statement

The authors declare that they have no conflicts of interest.

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