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The Veterinary clinics of North America. Equine practice1994; 10(3); 535-547; doi: 10.1016/s0749-0739(17)30345-0

Anti-inflammatory and immune support in endotoxemia and septicemia.

Abstract: Endotoxemia and septicemia are encountered frequently in equine veterinary practice. The deleterious effects of endotoxin are related to the severity of the response of the host's inflammatory system. Consequently, it is imperative that appropriate steps be taken to identify animals at risk of developing endotoxemia or septicemia, and to initiate treatments that will reduce the inflammatory response. This article discusses the anti-inflammatory and immune support of horses and foals with endotoxemia and septicemia.
Publication Date: 1994-12-01 PubMed ID: 7704817DOI: 10.1016/s0749-0739(17)30345-0Google Scholar: Lookup
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Summary

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This research article explores the importance of identifying horses at risk of developing endotoxemia or septicemia and administering treatments that minimize the inflammatory response. The authors delve into methods of providing anti-inflammatory and immune support for affected horses and foals.

Understanding Endotoxemia and Septicemia

  • The terms endotoxemia and septicemia refer to medical conditions commonly seen in horses. Endotoxemia involves toxins entering the bloodstream, causing a severe inflammatory response. Septicemia, on the other hand, is a systemic, often life-threatening infection that results from bacteria entering the bloodstream. Both conditions can be detrimental to the horse’s health and require immediate medical intervention.

The Role of the Inflammatory Response

  • The research highlights the significant role of the host’s inflammatory system in these diseases. When the body encounters toxins or bacteria in the bloodstream, the inflammatory system’s response determines the severity of the condition. A more severe inflammatory response can elevate the harmful effects of endotoxins, leading to more serious health concerns for the horse.

Identifying and Treating At-Risk Horses

  • An essential part of managing these conditions is identifying horses at high risk of developing endotoxemia or septicemia. Early identification and intervention can significantly improve the prognosis for these animals.
  • The authors stress the importance of using treatments that can effectively minimize the inflammatory response, thereby reducing the damage caused by the toxins or bacteria. This involves providing adequate anti-inflammatory and immune support to affected horses and foals, helping to bolster their defenses against these harmful agents and mitigate the effects of the diseases.

Conclusion

  • This research provides insight into understanding endotoxemia and septicemia in horses and underscores the need for preventative measures and effective treatment strategies. The paper emphasizes the role of inflammation in these conditions and the importance of reducing the inflammatory response through appropriate treatments. The suggested approach offers a potential avenue for improving the health and survival rates of horses afflicted with these serious conditions.

Cite This Article

APA
Holbrook TC, Moore JN. (1994). Anti-inflammatory and immune support in endotoxemia and septicemia. Vet Clin North Am Equine Pract, 10(3), 535-547. https://doi.org/10.1016/s0749-0739(17)30345-0

Publication

ISSN: 0749-0739
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 10
Issue: 3
Pages: 535-547

Researcher Affiliations

Holbrook, T C
  • Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens.
Moore, J N

    MeSH Terms

    • Animals
    • Anti-Inflammatory Agents / therapeutic use
    • Antioxidants / therapeutic use
    • Endotoxins / blood
    • Horse Diseases / immunology
    • Horse Diseases / microbiology
    • Horse Diseases / physiopathology
    • Horse Diseases / therapy
    • Horses
    • Immunotherapy / veterinary
    • Inflammation Mediators / metabolism
    • Sepsis / physiopathology
    • Sepsis / therapy
    • Sepsis / veterinary
    • Toxemia / therapy
    • Toxemia / veterinary

    Citations

    This article has been cited 2 times.
    1. Balagholi S, Dabbaghi R, Mohammadi S, Abbasi Malati Z, Javan MR, Eshghi P. Investigation of the potential of leukoreduction filters in the creation of anti-inflammatory compound. Transfus Apher Sci 2023 Feb;62(1):103520.
      doi: 10.1016/j.transci.2022.103520pubmed: 36115766google scholar: lookup
    2. Hedges JF, Demaula CD, Moore BD, McLaughlin BE, Simon SI, MacLachlan NJ. Characterization of equine E-selectin. Immunology 2001 Aug;103(4):498-504.