Antibody response to Influenza booster vaccination in Franches-Montagnes stallions supplemented with Equi-Strath® : a randomized trial.
Abstract: Bio-Strath is a plasmolyzed yeast product enriched with herbs, malt, honey and orange juice. In this study, the effect of Equi-Strath , the adapted product for horses, on the equine immune system was evaluated. A routine influenza booster vaccination was used as a model to study the effects of Equi-Strath supplementation on the immune response. Twenty healthy Franches-Montagnes stallions with pre-existing antibody levels were randomly divided into a study group (SG, n = 10) receiving 0.06 mL/kg bodyweight of Equi-Strath , and a control group (CG, n = 10), receiving the same amount of placebo, daily. The supplement and placebo were given from week 1 until week 14 of the trial. After 10 weeks, the horses were vaccinated with a commercial vaccine containing equine influenza strains of the H3N8 subtype. Antibody titres in blood were measured at day 0 before vaccination, and 14 and 32 days after vaccination. In addition, a complete blood count (CBC) was performed on day 0 and day 32. A linear increase of haemagglutination inhibition titres in both groups was observed after vaccination, but with no difference between treatment groups. CBC components remained unaffected by treatment. In conclusion, daily Equi-Strath supplementation did not affect the adaptive immune response in stallions after a routine commercial H3N8 influenza booster vaccination.
© 2018 The Authors. Veterinary Medicine and Science Published by John Wiley & Sons Ltd.
Publication Date: 2018-02-27 PubMed ID: 29851307PubMed Central: PMC5980167DOI: 10.1002/vms3.95Google Scholar: Lookup
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- Journal Article
- Randomized Controlled Trial
- Research Support
- Non-U.S. Gov't
Summary
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This study evaluated the impact of Equi-Strath, a supplement developed for horses, on the equine immune system using a equine influenza booster vaccination as a model, concluding that daily supplementation had no effect on the horses’ immune response.
Objective of the Research
- The main objective of this study was to analyze the effects of Equi-Strath, a variation of Bio-Strath formulated for horses, on the equine immune system. The researchers employed the administration of a routine influenza booster vaccination as a yardstick to measure these effects.
Research Methodology
- Twenty healthy Franches-Montagnes stallions, all with pre-existing antibody levels, were used in this study. The stallions were divided randomly into two groups, the Study Group (SG) and the Control Group (CG), with each group containing 10 horses.
- The SG was given 0.06 mL/kg bodyweight of Equi-Strath on a daily basis, while the CG received an equal quantity of a placebo. This daily supplementation regime occurred from the first week to the fourteenth week of the trial.
- At the end of ten weeks, all the horses were vaccinated using a commercial vaccine containing equine influenza strains of the H3N8 subtype.
- Antibody titres in the blood were evaluated at three different points: day 0 before vaccination, and 14 and 32 days post-vaccination. Additionally, a Complete Blood Count (CBC) was carried out on day 0 and day 32.
Research Findings
- The researchers observed a linear increase in haemagglutination inhibition titres in both groups following vaccination, but they found no significant difference between the SG and CG.
- The counts of different types of cells in the blood, as per the CBC, remained unchanged due to the treatment.
- In conclusion, the study showed that daily supplementation of Equi-Strath did not have any impact on the adaptive immune response of the stallions after they were given a standard H3N8 influenza booster vaccination.
Cite This Article
APA
van Dorland HA, Zanoni R, Gerber V, Jeannerat E, Wiederkehr D, Burger D.
(2018).
Antibody response to Influenza booster vaccination in Franches-Montagnes stallions supplemented with Equi-Strath® : a randomized trial.
Vet Med Sci, 4(2), 133-139.
https://doi.org/10.1002/vms3.95 Publication
Researcher Affiliations
- School of Agricultural, Forest and Food Sciences, Bern University of Applied Sciences, Zollikofen, Switzerland.
- Institute of Virology and Immunology, Vetsuisse Faculty University of Bern, Bern, Switzerland.
- Swiss Institute of Equine Medicine, University of Bern, and Agroscope, Avenches, Switzerland.
- Swiss Institute of Equine Medicine, University of Bern, and Agroscope, Avenches, Switzerland.
- School of Agricultural, Forest and Food Sciences, Bern University of Applied Sciences, Zollikofen, Switzerland.
- Swiss Institute of Equine Medicine, University of Bern, and Agroscope, Avenches, Switzerland.
MeSH Terms
- Animals
- Antibodies, Viral / blood
- Antibodies, Viral / immunology
- Hemagglutination Inhibition Tests / veterinary
- Horse Diseases / immunology
- Horses / immunology
- Immunization, Secondary / veterinary
- Influenza A Virus, H3N8 Subtype / immunology
- Influenza Vaccines / administration & dosage
- Influenza Vaccines / immunology
- Male
- Orthomyxoviridae Infections / immunology
- Vaccination / veterinary
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Citations
This article has been cited 1 times.- Ganda E, Chakrabarti A, Sardi MI, Tench M, Kozlowicz BK, Norton SA, Warren LK, Khafipour E. Saccharomyces cerevisiae fermentation product improves robustness of equine gut microbiome upon stress. Front Vet Sci 2023;10:1134092.
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