Antibody responses induced by Japanese whole inactivated vaccines against equine influenza virus (H3N8) belonging to Florida sublineage clade2.
Abstract: In 2010, the World Organisation for Animal Health recommended the inclusion of a Florida sublineage clade2 strain of equine influenza virus (H3N8), which is represented by A/equine/Richmond/1/07 (Richmond07), in equine influenza vaccines. Here, we evaluate the antigenic differences between Japanese vaccine strains and Richmond07 by performing hemagglutination inhibition (HI) assays. Ferret antiserum raised to A/equine/La Plata/93 (La Plata93), which is a Japanese vaccine strain, reacted with Richmond07 at a similar titer to La Plata93. Moreover, two hundred racehorses exhibited similar geometric mean HI antibody titers against La Plata93 and Richmond07 (73.1 and 80.8, respectively). Therefore, we can expect the antibody induced by the current Japanese vaccines to provide some protection against Richmond07-like viruses.
Publication Date: 2010-11-19 PubMed ID: 21099188DOI: 10.1292/jvms.10-0408Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research examines the effectiveness of Japanese vaccines against a particular strain of equine influenza virus (H3N8). The results suggest that the protection offered by these vaccines against the studied strain is moderate, based on antibody response.
Objectives and Background
- The study focused on the Florida sublineage clade2 strain of equine influenza virus (H3N8), specifically A/equine/Richmond/1/07 (Richmond07).
- This strain was advised to be included in equine influenza vaccines by the World Organisation for Animal Health in 2010.
- The researchers aimed to assess the antigenic differences between Japanese vaccine strains and Richmond07.
Methodology – Hemagglutination Inhibition (HI) Assays
- The team performed hemagglutination inhibition (HI) assays, a laboratory procedure that measures the presence and level of antibodies against viruses in a blood sample.
- Ferret antiserum raised against A/equine/La Plata/93 (La Plata93), a Japanese vaccine strain, was tested against Richmond07.
Results – Antibody Responses
- The La Plata93 antiserum reacted with Richmond07 at a similar level to how it reacted with La Plata93, suggesting the vaccines could have comparable effectiveness.
- Antibody titers from 200 racehorses were analyzed, showing similar geometric mean HI antibody titers against La Plata93 and Richmond07 (73.1 and 80.8, respectively).
Conclusion
- Given the similarity in reactions, researchers infer that the antibodies induced by Japanese vaccines may provide some level of protection against Richmond07-like viruses.
- However, further research is essential to validate these findings and ascertain the effectiveness of the current vaccine formulas against evolving influenza strains.
Cite This Article
APA
Yamanaka T, Bannai H, Nemoto M, Tsujimura K, Kondo T, Matsumura T.
(2010).
Antibody responses induced by Japanese whole inactivated vaccines against equine influenza virus (H3N8) belonging to Florida sublineage clade2.
J Vet Med Sci, 73(4), 483-485.
https://doi.org/10.1292/jvms.10-0408 Publication
Researcher Affiliations
- Epizootic Research Center, Equine Research Institute, Japan Racing Association, 1400–4 Shiba, Shimotsuke, Tochigi 329–0412, Japan. yamanaka@epizoo.equinst.go.jp
MeSH Terms
- Animals
- Antibodies, Viral / blood
- Antibodies, Viral / immunology
- Antibody Affinity
- Antigens, Viral
- Ferrets
- Hemagglutination Tests / veterinary
- Horse Diseases / blood
- Horse Diseases / epidemiology
- Horse Diseases / prevention & control
- Horses
- Influenza A Virus, H3N8 Subtype / classification
- Influenza A Virus, H3N8 Subtype / immunology
- Japan / epidemiology
- Orthomyxoviridae Infections / blood
- Orthomyxoviridae Infections / epidemiology
- Orthomyxoviridae Infections / prevention & control
- Orthomyxoviridae Infections / veterinary
Citations
This article has been cited 5 times.- Yamanaka T, Nemoto M, Bannai H, Tsujimura K, Matsumura T, Kokado H, Gildea S, Cullinane A. Neutralization antibody response to booster/priming immunization with new equine influenza vaccine in Japan.. J Vet Med Sci 2018 Mar 2;80(2):382-386.
- Gamoh K, Nakamura S. Update of inactivated equine influenza vaccine strain in Japan.. J Vet Med Sci 2017 Mar 23;79(3):649-653.
- Yamanaka T, Nemoto M, Bannai H, Tsujimura K, Kondo T, Matsumura T, Gildea S, Cullinane A. Assessment of antigenic difference of equine influenza virus strains by challenge study in horses.. Influenza Other Respir Viruses 2016 Nov;10(6):536-539.
- Paillot R. A Systematic Review of Recent Advances in Equine Influenza Vaccination.. Vaccines (Basel) 2014 Nov 14;2(4):797-831.
- Yamanaka T, Nemoto M, Bannai H, Tsujimura K, Kondo T, Matsumura T, Muranaka M, Ueno T, Kinoshita Y, Niwa H, Hidari KI, Suzuki T. No evidence of horizontal infection in horses kept in close contact with dogs experimentally infected with canine influenza A virus (H3N8).. Acta Vet Scand 2012 Apr 16;54(1):25.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
