Antifungal sensitivity testing for equine keratomycosis.
Abstract: We evaluated 31 fungal specimens obtained from equine corneas over a 10-year period, 1973 to 1983. More than half were received in late summer and early autumn, and the number tended to increase in frequency during the 1980s. These isolates included 13 different genera and 20 different species. The prevalent genus was Aspergillus (35%). On the basis of examinations for tube-dilution minimal inhibitory concentrations and minimal fungicidal concentrations of 16 fungal isolates, the imidazole antibiotics such as miconazole and ketoconazole consistently showed the lowest geometric mean titers for filamentous fungi. Because fungal sensitivities varied considerably among different species in vitro sensitivity testing is suggested as an aid in the determination of optimal therapy.
Publication Date: 1985-03-01 PubMed ID: 3994133
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- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research article studied the effectiveness of various antifungal treatments for horse eye infections caused by different fungal species, suggesting that conducting sensitivity tests may help with selecting the optimal therapy.
Background of the Study
- The study involved analysis of 31 fungal specimens collected from horse eyes over a decade, from 1973 to 1983.
- The investigation noticed that most specimens were collected during late summer and early autumn, and the frequency of these infections was found rising throughout the 80s.
The Fungal Specimens
- The fungal isolates collected comprised 13 different genera and 20 different species.
- Aspergillus was identified as the most prevalent genus, making up about 35% of the samples.
Antifungal Sensitivity Testing
- The research conducted tube-dilution minimal inhibitory concentration (MIC) and minimal fungicidal concentration (MFC) tests on 16 fungal isolates.
- This process was aimed to evaluate and ascertain the most efficient antifungal treatment options.
Efficacy of Antifungal Treatments
- Relatively, imidazole antibiotics (such as miconazole and ketoconazole) were found to consistently show the lowest geometric mean titers for filamentous fungi, implying these treatments might be highly effective.
Recommendations and Conclusion
- Given that the fungal sensitivities were observed to vary significantly among different species, the research recommended in vitro sensitivity testing as a method to help determine the best treatment approach for each infection.
- In other words, each therapy plan would ideally be custom-tailored to be most effective against the particular species causing infection.
Cite This Article
APA
Coad CT, Robinson NM, Wilhelmus KR.
(1985).
Antifungal sensitivity testing for equine keratomycosis.
Am J Vet Res, 46(3), 676-678.
Publication
Researcher Affiliations
MeSH Terms
- Animals
- Antifungal Agents / pharmacology
- Aspergillus / drug effects
- Cornea / microbiology
- Corneal Diseases / microbiology
- Corneal Diseases / veterinary
- Drug Resistance, Microbial
- Fungi / drug effects
- Horse Diseases / microbiology
- Horses
- Microbial Sensitivity Tests
- Mycoses / microbiology
- Mycoses / veterinary
- Seasons
- Species Specificity
Citations
This article has been cited 3 times.- Tamura N, Okano A, Kuroda T, Niwa H, Kusano K, Matsuda Y, Fukuda K, Mita H, Nagata S. Utility of systemic voriconazole in equine keratomycosis based on pharmacokinetic-pharmacodynamic analysis of tear fluid following oral administration.. Vet Ophthalmol 2020 Jul;23(4):640-647.
- Reed Z, Thomasy SM, Good KL, Maggs DJ, Magdesian KG, Pusterla N, Hollingsworth SR. Equine keratomycoses in California from 1987 to 2010 (47 cases).. Equine Vet J 2013 May;45(3):361-6.
- Aho R, Tala M, Kivalo M. Mycotic keratitis in a horse caused by Aspergillus fumigatus. The first reported case in Finland.. Acta Vet Scand 1991;32(3):373-6.
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