FREE SHIPPING over $40
OVER 9000 FIVE-STAR REVIEWS
5% OFF ALL SUBSCRIPTIONS
100% HAPPINESS GUARANTEE
Analyze Diet
0
Home / Equine Research Bank / Virus Genes / Antigenic and molecular analyses reveal that the equine rota...
Virus genes2001; 22(1); 5-20; doi: 10.1023/a:1008175716816

Antigenic and molecular analyses reveal that the equine rotavirus strain H-1 is closely related to porcine, but not equine, rotaviruses: interspecies transmission from pigs to horses?

Abstract: We have sequenced the genes encoding the inner capsid protein VP6 and the outer capsid glycoprotein VP7 of the subgroup (SG) I equine rotavirus strain H-1 (P9[7], G5). The VP6 and VP7 proteins of the equine rotavirus strain H-1 shared a high degree of sequence and deduced amino acid identity with SG I porcine strains and serotype G5 porcine strains, respectively. Previous sequence analyses of the genes encoding the outer capsid spike protein VP4 and the nonstructural proteins NSP1 and NSP4 of equine H-1 strain also revealed a high degree of sequence and deduced amino acid homology with the prototype porcine rotavirus strain OSU (P9[7], G5). We have also confirmed and extended the VP4 and VP7 antigenic relatedness of equine rotavirus strain H-1 to porcine strains of P9[7] and G5 serotype specificities isolated in the United States, Venezuela, Argentina, and Australia based on cross-neutralization studies. In addition, the pathogenicity of tissue culture-adapted equine H-1, H-2, FI-14, FI-23, and L338, and porcine OSU rotavirus strains was compared in the neonatal mouse model. The 50% diarrhea dose (DD50) of equine H-1 was similar to that of porcine OSU and equine H-2 and L338 strains, while the DD50 of equine H-2 was > or = 50 or 315-fold lower than those of equine FI-14 or FI-23, respectively. Our sequence comparison of NSP4 of the rotavirus strains tested potentially identified amino acid residue 136, within the variable region spanning amino acids 130 to 141, as playing a role in virulence. Taken together, there is strong support to suggest that the equine rotavirus strain H-1 may represent an example of interspecies transmission from pigs to horses.
Get Full Text
Publication Date: 2001-02-24 PubMed ID: 11210939DOI: 10.1023/a:1008175716816Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
LinkedInCopy
  • Journal Article
  • Research Support
  • Non-U.S. Gov't
  • Research Support
  • U.S. Gov't
  • P.H.S.

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the genetic comparison of equine rotavirus strain H-1 with porcine and other equine strains, aiming to determine the likelihood of interspecies transmission from pigs to horses.

Rotavirus Strain Sequences

  • The researchers sequenced the genes encoding the inner capsid protein (VP6) and the outer capsid glycoprotein (VP7) of a specific equine rotavirus strain, H-1.
  • The sequences showed a high degree of identity to the corresponding proteins in certain porcine strains, indicating a close relationship between these equine and porcine rotavirus strains.

Previous Research Comparisons

  • Prior analysis of other proteins (VP4, NSP1 and NSP4) in equine H-1 strain has also revealed a notable similarity to the prototype of porcine rotavirus strain OSU.

Cross-Neutralization Studies

  • Based on cross-neutralization studies, the researchers confirmed and extended the VP4 and VP7 antigenic relatedness of the equine H-1 strain to porcine strains isolated in different parts of the world, such as the United States, Venezuela, Argentina, and Australia.

Pathogenicity Comparison

  • The pathogenicity of different tissue culture-adapted equine and porcine strains was compared in a neonatal mouse model.
  • The disease severity thresholds of the equine H-1 strain were similar to those of porcine OSU and other equine strains.
  • However, the pathogenicity of equine H-2 was significantly lower than those of certain equine strains.

Potential Virulence Factors

  • By comparing the NSP4 sequence of the tested strains, the researchers inferred that a certain amino acid (residue 136) could play a role in virulence.

Conclusions

  • The findings of this study provide a robust basis for the hypothesis that the equine rotavirus strain H-1 may have resulted from interspecies transmission from pigs to horses.

Cite This Article

APA
Ciarlet M, I a P, Conner ME, Liprandi F. (2001). Antigenic and molecular analyses reveal that the equine rotavirus strain H-1 is closely related to porcine, but not equine, rotaviruses: interspecies transmission from pigs to horses? Virus Genes, 22(1), 5-20. https://doi.org/10.1023/a:1008175716816

Publication

Virus genes
ISSN: 0920-8569
NlmUniqueID: 8803967
Country: United States
Language: English
Volume: 22
Issue: 1
Pages: 5-20

Researcher Affiliations

Ciarlet, M
  • Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA. mciarlet@bcm.tmc.edu
I a, P
    Conner, M E
      Liprandi, F

        MeSH Terms

        • Amino Acid Sequence
        • Animals
        • Antigens, Viral / immunology
        • Capsid / chemistry
        • Capsid / genetics
        • Capsid / immunology
        • Capsid Proteins
        • Horse Diseases / transmission
        • Horse Diseases / virology
        • Horses
        • Mice
        • Molecular Sequence Data
        • Rotavirus / genetics
        • Rotavirus / immunology
        • Rotavirus / pathogenicity
        • Rotavirus Infections / transmission
        • Rotavirus Infections / veterinary
        • Rotavirus Infections / virology
        • Swine
        • Swine Diseases / transmission
        • Swine Diseases / virology

        Grant Funding

        • AI24998 / NIAID NIH HHS

        References

        This article includes 57 references
        1. Ito H, Minamoto N, Hiraga S, Sugiyama M. Sequence analysis of the VP6 gene in group A turkey and chicken rotaviruses.. Virus Res 1997 Jan;47(1):79-83.
          pubmed: 9037739doi: 10.1016/s0168-1702(96)01401-3google scholar: lookup
        2. Taniguchi K, Urasawa T, Urasawa S. Species specificity and interspecies relatedness in VP4 genotypes demonstrated by VP4 sequence analysis of equine, feline, and canine rotavirus strains.. Virology 1994 May 1;200(2):390-400.
          pubmed: 8178429doi: 10.1006/viro.1994.1203google scholar: lookup
        3. Cunliffe NA, Woods PA, Leite JP, Das BK, Ramachandran M, Bhan MK, Hart CA, Glass RI, Gentsch JR. Sequence analysis of NSP4 gene of human rotavirus allows classification into two main genetic groups.. J Med Virol 1997 Sep;53(1):41-50.
          pubmed: 9298731
        4. Horie Y, Nakagomi O, Koshimura Y, Nakagomi T, Suzuki Y, Oka T, Sasaki S, Matsuda Y, Watanabe S. Diarrhea induction by rotavirus NSP4 in the homologous mouse model system.. Virology 1999 Sep 30;262(2):398-407.
          pubmed: 10502518doi: 10.1006/viro.1999.9912google scholar: lookup
        5. Browning GF, Chalmers RM, Fitzgerald TA, Snodgrass DR. Serological and genomic characterization of L338, a novel equine group A rotavirus G serotype.. J Gen Virol 1991 May;72 ( Pt 5):1059-64.
          pubmed: 1851806doi: 10.1099/0022-1317-72-5-1059google scholar: lookup
        6. Green KY, Hoshino Y, Ikegami N. Sequence analysis of the gene encoding the serotype-specific glycoprotein (VP7) of two new human rotavirus serotypes.. Virology 1989 Feb;168(2):429-33.
          pubmed: 2536991doi: 10.1016/0042-6822(89)90289-4google scholar: lookup
        7. Pongsuwanna Y, Taniguchi K, Chiwakul M, Urasawa T, Wakasugi F, Jayavasu C, Urasawa S. Serological and genomic characterization of porcine rotaviruses in Thailand: detection of a G10 porcine rotavirus.. J Clin Microbiol 1996 May;34(5):1050-7.
          pubmed: 8727874doi: 10.1128/jcm.34.5.1050-1057.1996google scholar: lookup
        8. Huang JA, Nagesha HS, Holmes IH. Comparative sequence analysis of VP4s from five Australian porcine rotaviruses: implication of an apparent new P type.. Virology 1993 Sep;196(1):319-27.
          pubmed: 8395121doi: 10.1006/viro.1993.1482google scholar: lookup
        9. González SA, Tomasini L, Tortorici MA, Affranchino JL. VP6 from porcine rotavirus strain CN86: amino acid sequence divergence with conservation of subgroup II specificity.. J Gen Virol 1995 Jan;76 ( Pt 1):221-4.
          pubmed: 7844537doi: 10.1099/0022-1317-76-1-221google scholar: lookup
        10. Kirkwood CD, Palombo EA. Genetic characterization of the rotavirus nonstructural protein, NSP4.. Virology 1997 Sep 29;236(2):258-65.
          pubmed: 9325233doi: 10.1006/viro.1997.8727google scholar: lookup
        11. Wu H, Taniguchi K, Urasawa T, Urasawa S. Genomic relatedness of five equine rotavirus strains with different G serotype and P type specificities.. Res Virol 1993 Nov-Dec;144(6):455-64.
          pubmed: 8140288doi: 10.1016/s0923-2516(06)80060-9google scholar: lookup
        12. Tarlow O, McCrae MA. Nucleotide sequence of group antigen (VP6) of the UK tissue culture adapted strain of bovine rotavirus.. Nucleic Acids Res 1990 Aug 25;18(16):4921.
          pubmed: 2168543doi: 10.1093/nar/18.16.4921google scholar: lookup
        13. Browning GF, Fitzgerald TA, Chalmers RM, Snodgrass DR. A novel group A rotavirus G serotype: serological and genomic characterization of equine isolate FI23.. J Clin Microbiol 1991 Sep;29(9):2043-6.
          pubmed: 1663521doi: 10.1128/jcm.29.9.2043-2046.1991google scholar: lookup
        14. Zhang M, Zeng CQ, Dong Y, Ball JM, Saif LJ, Morris AP, Estes MK. Mutations in rotavirus nonstructural glycoprotein NSP4 are associated with altered virus virulence.. J Virol 1998 May;72(5):3666-72.
          pubmed: 9557647doi: 10.1128/JVI.72.5.3666-3672.1998google scholar: lookup
        15. Isa P, Wood AR, Netherwood T, Ciarlet M, Imagawa H, Snodgrass DR. Survey of equine rotaviruses shows conservation of one P genotype in background of two G genotypes.. Arch Virol 1996;141(9):1601-12.
          pubmed: 8893784doi: 10.1007/BF01718285google scholar: lookup
        16. Cohen J, Lefevre F, Estes MK, Bremont M. Cloning of bovine rotavirus (RF strain): nucleotide sequence of the gene coding for the major capsid protein.. Virology 1984 Oct 15;138(1):178-82.
          pubmed: 6093360doi: 10.1016/0042-6822(84)90159-4google scholar: lookup
        17. Feng N, Burns JW, Bracy L, Greenberg HB. Comparison of mucosal and systemic humoral immune responses and subsequent protection in mice orally inoculated with a homologous or a heterologous rotavirus.. J Virol 1994 Dec;68(12):7766-73.
          pubmed: 7966566doi: 10.1128/JVI.68.12.7766-7773.1994google scholar: lookup
        18. Huang J, Nagesha HS, Dyall-Smith ML, Holmes IH. Comparative sequence analysis of VP7 genes from five Australian porcine rotaviruses.. Arch Virol 1989;109(3-4):173-83.
          pubmed: 2558633doi: 10.1007/BF01311079google scholar: lookup
        19. Hoshino Y, Wyatt RG, Greenberg HB, Kalica AR, Flores J, Kapikian AZ. Isolation and characterization of an equine rotavirus.. J Clin Microbiol 1983 Sep;18(3):585-91.
          pubmed: 6313746doi: 10.1128/jcm.18.3.585-591.1983google scholar: lookup
        20. Santos N, Lima RC, Nozawa CM, Linhares RE, Gouvea V. Detection of porcine rotavirus type G9 and of a mixture of types G1 and G5 associated with Wa-like VP4 specificity: evidence for natural human-porcine genetic reassortment.. J Clin Microbiol 1999 Aug;37(8):2734-6.
          pubmed: 10405435doi: 10.1128/JCM.37.8.2734-2736.1999google scholar: lookup
        21. Isa P, Snodgrass DR. Serological and genomic characterization of equine rotavirus VP4 proteins identifies three different P serotypes.. Virology 1994 Jun;201(2):364-72.
          pubmed: 7514321doi: 10.1006/viro.1994.1302google scholar: lookup
        22. Ciarlet M, Ludert JE, Liprandi F. Comparative amino acid sequence analysis of the major outer capsid protein (VP7) of porcine rotaviruses with G3 and G5 serotype specificities isolated in Venezuela and Argentina.. Arch Virol 1995;140(3):437-51.
          pubmed: 7733818doi: 10.1007/BF01718422google scholar: lookup
        23. Gentsch JR, Woods PA, Ramachandran M, Das BK, Leite JP, Alfieri A, Kumar R, Bhan MK, Glass RI. Review of G and P typing results from a global collection of rotavirus strains: implications for vaccine development.. J Infect Dis 1996 Sep;174 Suppl 1:S30-6.
          pubmed: 8752288doi: 10.1093/infdis/174.supplement_1.s30google scholar: lookup
        24. Hardy ME, Woode GN, Xu ZC, Williams JD, Conner ME, Dwyer RM, Powell DG. Analysis of serotypes and electropherotypes of equine rotaviruses isolated in the United States.. J Clin Microbiol 1991 May;29(5):889-93.
          pubmed: 1647407doi: 10.1128/jcm.29.5.889-893.1991google scholar: lookup
        25. Nishikawa K, Hoshino Y, Gorziglia M. Sequence of the VP7 gene of chicken rotavirus Ch2 strain of serotype 7 rotavirus.. Virology 1991 Dec;185(2):853-6.
          pubmed: 1660203doi: 10.1016/0042-6822(91)90558-sgoogle scholar: lookup
        26. Both GW, Siegman LJ, Bellamy AR, Ikegami N, Shatkin AJ, Furuichi Y. Comparative sequence analysis of rotavirus genomic segment 6--the gene specifying viral subgroups 1 and 2.. J Virol 1984 Jul;51(1):97-101.
          pubmed: 6328048doi: 10.1128/JVI.51.1.97-101.1984google scholar: lookup
        27. López S, Arias CF. Sequence analysis of rotavirus YM VP6 and NS28 proteins.. J Gen Virol 1993 Jun;74 ( Pt 6):1223-6.
          pubmed: 8389808doi: 10.1099/0022-1317-74-6-1223google scholar: lookup
        28. Ciarlet M, Hidalgo M, Liprandi F. Cross-reactive, serotype- and monotype-specific neutralization epitopes on VP7 of serotype G3 and G5 porcine rotavirus strains.. Arch Virol 1996;141(3-4):601-14.
          pubmed: 8645098doi: 10.1007/BF01718320google scholar: lookup
        29. Palombo EA, Bishop RF. Sequences of VP6 genes of human rotavirus strain RV3 and its vaccine derivative.. J Gen Virol 1994 Sep;75 ( Pt 9):2415-9.
          pubmed: 8077942doi: 10.1099/0022-1317-75-9-2415google scholar: lookup
        30. Hofer JM, Sato F, Street JE, Bellamy AR. Nucleotide sequence for gene 6 of rotavirus strain S2.. Nucleic Acids Res 1987 Sep 11;15(17):7175.
          pubmed: 2821494doi: 10.1093/nar/15.17.7175google scholar: lookup
        31. Horie Y, Masamune O, Nakagomi O. Three major alleles of rotavirus NSP4 proteins identified by sequence analysis.. J Gen Virol 1997 Sep;78 ( Pt 9):2341-6.
          pubmed: 9292024doi: 10.1099/0022-1317-78-9-2341google scholar: lookup
        32. Gorziglia M, Aguirre Y, Hoshino Y, Esparza J, Blumentals I, Askaa J, Thompson M, Glass RI, Kapikian AZ, Chanock RM. VP7 serotype-specific glycoprotein of OSU porcine rotavirus: coding assignment and gene sequence.. J Gen Virol 1986 Nov;67 ( Pt 11):2445-54.
          pubmed: 3023532doi: 10.1099/0022-1317-67-11-2445google scholar: lookup
        33. Smith RE, Kister SE, Carozzi NB. Cloning and expression of the major inner capsid protein of SA-11 simian rotavirus in Escherichia coli.. Gene 1989 Jul 15;79(2):239-48.
          pubmed: 2551775doi: 10.1016/0378-1119(89)90206-0google scholar: lookup
        34. Burke B, McCrae MA, Desselberger U. Sequence analysis of two porcine rotaviruses differing in growth in vitro and in pathogenicity: distinct VP4 sequences and conservation of NS53, VP6 and VP7 genes.. J Gen Virol 1994 Sep;75 ( Pt 9):2205-12.
          pubmed: 8077920doi: 10.1099/0022-1317-75-9-2205google scholar: lookup
        35. Nishikawa K, Hoshino Y, Taniguchi K, Green KY, Greenberg HB, Kapikian AZ, Chanock RM, Gorziglia M. Rotavirus VP7 neutralization epitopes of serotype 3 strains.. Virology 1989 Aug;171(2):503-15.
          pubmed: 2474892doi: 10.1016/0042-6822(89)90620-xgoogle scholar: lookup
        36. Browning GF, Chalmers RM, Fitzgerald TA, Snodgrass DR. Evidence for two serotype G3 subtypes among equine rotaviruses.. J Clin Microbiol 1992 Feb;30(2):485-91.
          pubmed: 1371520doi: 10.1128/jcm.30.2.485-491.1992google scholar: lookup
        37. Both GW, Mattick JS, Bellamy AR. Serotype-specific glycoprotein of simian 11 rotavirus: coding assignment and gene sequence.. Proc Natl Acad Sci U S A 1983 May;80(10):3091-5.
          pubmed: 6304692doi: 10.1073/pnas.80.10.3091google scholar: lookup
        38. Ciarlet M, Hidalgo M, Gorziglia M, Liprandi F. Characterization of neutralization epitopes on the VP7 surface protein of serotype G11 porcine rotaviruses.. J Gen Virol 1994 Aug;75 ( Pt 8):1867-73.
          pubmed: 7519247doi: 10.1099/0022-1317-75-8-1867google scholar: lookup
        39. Taniguchi K, Urasawa T, Pongsuwanna Y, Choonthanom M, Jayavasu C, Urasawa S. Molecular and antigenic analyses of serotypes 8 and 10 of bovine rotaviruses in Thailand.. J Gen Virol 1991 Dec;72 ( Pt 12):2929-37.
          pubmed: 1662688doi: 10.1099/0022-1317-72-12-2929google scholar: lookup
        40. Richardson MA, Iwamoto A, Ikegami N, Nomoto A, Furuichi Y. Nucleotide sequence of the gene encoding the serotype-specific antigen of human (Wa) rotavirus: comparison with the homologous genes from simian SA11 and UK bovine rotaviruses.. J Virol 1984 Sep;51(3):860-2.
          pubmed: 6088808doi: 10.1128/JVI.51.3.860-862.1984google scholar: lookup
        41. Liprandi F, Rodriguez I, Piña C, Larralde G, Gorziglia M. VP4 monotype specificities among porcine rotavirus strains of the same VP4 serotype.. J Virol 1991 Mar;65(3):1658-61.
          pubmed: 1847483doi: 10.1128/JVI.65.3.1658-1661.1991google scholar: lookup
        42. Rohwedder A, Irmak H, Werchau H, Brüssow H. Nucleotide sequence of gene 6 of avian-like group A rotavirus 993/83.. Virology 1993 Aug;195(2):820-5.
          pubmed: 8393250doi: 10.1006/viro.1993.1437google scholar: lookup
        43. Greenberg H, McAuliffe V, Valdesuso J, Wyatt R, Flores J, Kalica A, Hoshino Y, Singh N. Serological analysis of the subgroup protein of rotavirus, using monoclonal antibodies.. Infect Immun 1983 Jan;39(1):91-9.
          pubmed: 6185436doi: 10.1128/iai.39.1.91-99.1983google scholar: lookup
        44. Imagawa H, Tanaka T, Sekiguchi K, Fukunaga Y, Anzai T, Minamoto N, Kamada M. Electropherotypes, serotypes, and subgroups of equine rotaviruses isolated in Japan.. Arch Virol 1993;131(1-2):169-76.
          pubmed: 8392320doi: 10.1007/BF01379088google scholar: lookup
        45. Gorziglia M, Nishikawa K, Green K, Taniguchi K. Gene sequence of the VP7 serotype specific glycoprotein of Gottfried porcine rotavirus.. Nucleic Acids Res 1988 Jan 25;16(2):775.
          pubmed: 2829137doi: 10.1093/nar/16.2.775google scholar: lookup
        46. Fukuhara N, Nishikawa K, Gorziglia M, Kapikian AZ. Nucleotide sequence of gene segment 1 of a porcine rotavirus strain.. Virology 1989 Dec;173(2):743-9.
          pubmed: 2556853doi: 10.1016/0042-6822(89)90590-4google scholar: lookup
        47. Ciarlet M, Liprandi F, Conner ME, Estes MK. Species specificity and interspecies relatedness of NSP4 genetic groups by comparative NSP4 sequence analyses of animal rotaviruses.. Arch Virol 2000;145(2):371-83.
          pubmed: 10752559doi: 10.1007/s007050050029google scholar: lookup
        48. Tang B, Gilbert JM, Matsui SM, Greenberg HB. Comparison of the rotavirus gene 6 from different species by sequence analysis and localization of subgroup-specific epitopes using site-directed mutagenesis.. Virology 1997 Oct 13;237(1):89-96.
          pubmed: 9344910doi: 10.1006/viro.1997.8762google scholar: lookup
        49. Kojima K, Taniguchi K, Kobayashi N. Species-specific and interspecies relatedness of NSP1 sequences in human, porcine, bovine, feline, and equine rotavirus strains.. Arch Virol 1996;141(1):1-12.
          pubmed: 8629937doi: 10.1007/BF01718584google scholar: lookup
        50. Browning GF, Begg AP. Prevalence of G and P serotypes among equine rotaviruses in the faeces of diarrhoeic foals.. Arch Virol 1996;141(6):1077-89.
          pubmed: 8712925doi: 10.1007/BF01718611google scholar: lookup
        51. Gorziglia M, Hoshino Y, Nishikawa K, Maloy WL, Jones RW, Kapikian AZ, Chanock RM. Comparative sequence analysis of the genomic segment 6 of four rotaviruses each with a different subgroup specificity.. J Gen Virol 1988 Jul;69 ( Pt 7):1659-69.
          pubmed: 2455770doi: 10.1099/0022-1317-69-7-1659google scholar: lookup
        52. Ciarlet M, Liprandi F. Serological and genomic characterization of two porcine rotaviruses with serotype G1 specificity.. J Clin Microbiol 1994 Jan;32(1):269-72.
          pubmed: 8126197doi: 10.1128/jcm.32.1.269-272.1994google scholar: lookup
        53. Ball JM, Tian P, Zeng CQ, Morris AP, Estes MK. Age-dependent diarrhea induced by a rotaviral nonstructural glycoprotein.. Science 1996 Apr 5;272(5258):101-4.
          pubmed: 8600515doi: 10.1126/science.272.5258.101google scholar: lookup
        54. Browning GF, Chalmers RM, Fitzgerald TA, Corley KT, Campbell I, Snodgrass DR. Rotavirus serotype G3 predominates in horses.. J Clin Microbiol 1992 Jan;30(1):59-62.
          pubmed: 1310333doi: 10.1128/jcm.30.1.59-62.1992google scholar: lookup
        55. Taniguchi K, Urasawa T, Kobayashi N, Gorziglia M, Urasawa S. Nucleotide sequence of VP4 and VP7 genes of human rotaviruses with subgroup I specificity and long RNA pattern: implication for new G serotype specificity.. J Virol 1990 Nov;64(11):5640-4.
          pubmed: 2170690doi: 10.1128/JVI.64.11.5640-5644.1990google scholar: lookup
        56. Ciarlet M, Reggeti F, Piña CI, Liprandi F. Equine rotaviruses with G14 serotype specificity circulate among venezuelan horses.. J Clin Microbiol 1994 Oct;32(10):2609-12.
          pubmed: 7814511doi: 10.1128/jcm.32.10.2609-2612.1994google scholar: lookup
        57. Elleman TC, Hoyne PA, Dyall-Smith ML, Holmes IH, Azad AA. Nucleotide sequence of the gene encoding the serotype-specific glycoprotein of UK bovine rotavirus.. Nucleic Acids Res 1983 Jul 25;11(14):4689-701.
          pubmed: 6308556doi: 10.1093/nar/11.14.4689google scholar: lookup

        Citations

        This article has been cited 14 times.
        1. Nemoto M, Matsumura T. Equine rotavirus infection. J Equine Sci 2021 Mar;32(1):1-9.
          doi: 10.1294/jes.32.1pubmed: 33776534google scholar: lookup
        2. Luchs A, Timenetsky Mdo C. Group A rotavirus gastroenteritis: post-vaccine era, genotypes and zoonotic transmission. Einstein (Sao Paulo) 2016 Apr-Jun;14(2):278-87.
          doi: 10.1590/S1679-45082016RB3582pubmed: 27462899google scholar: lookup
        3. Ghosh S, Kobayashi N. Exotic rotaviruses in animals and rotaviruses in exotic animals. Virusdisease 2014;25(2):158-72.
          doi: 10.1007/s13337-014-0194-zpubmed: 25674582google scholar: lookup
        4. Bailey KE, Gilkerson JR, Browning GF. Equine rotaviruses--current understanding and continuing challenges. Vet Microbiol 2013 Nov 29;167(1-2):135-44.
          doi: 10.1016/j.vetmic.2013.07.010pubmed: 23932076google scholar: lookup
        5. Pane JA, Webster NL, Graham KL, Holloway G, Zufferey C, Coulson BS. Rotavirus acceleration of murine type 1 diabetes is associated with a T helper 1-dependent specific serum antibody response and virus effects in regional lymph nodes. Diabetologia 2013 Mar;56(3):573-82.
          doi: 10.1007/s00125-012-2798-4pubmed: 23238791google scholar: lookup
        6. Collins PJ, Cullinane A, Martella V, O'Shea H. Molecular characterization of equine rotavirus in Ireland. J Clin Microbiol 2008 Oct;46(10):3346-54.
          doi: 10.1128/JCM.00995-08pubmed: 18716232google scholar: lookup
        7. Dhama K, Chauhan RS, Mahendran M, Malik SV. Rotavirus diarrhea in bovines and other domestic animals. Vet Res Commun 2009 Jan;33(1):1-23.
          doi: 10.1007/s11259-008-9070-xpubmed: 18622713google scholar: lookup
        8. Matthijnssens J, Ciarlet M, Heiman E, Arijs I, Delbeke T, McDonald SM, Palombo EA, Iturriza-Gómara M, Maes P, Patton JT, Rahman M, Van Ranst M. Full genome-based classification of rotaviruses reveals a common origin between human Wa-Like and porcine rotavirus strains and human DS-1-like and bovine rotavirus strains. J Virol 2008 Apr;82(7):3204-19.
          doi: 10.1128/JVI.02257-07pubmed: 18216098google scholar: lookup
        9. Gulati BR, Deepa R, Singh BK, Rao CD. Diversity in Indian equine rotaviruses: identification of genotype G10,P6[1] and G1 strains and a new VP7 genotype (G16) strain in specimens from diarrheic foals in India. J Clin Microbiol 2007 Mar;45(3):972-8.
          doi: 10.1128/JCM.01696-06pubmed: 17135436google scholar: lookup
        10. Bomsel M, Alfsen A. Entry of viruses through the epithelial barrier: pathogenic trickery. Nat Rev Mol Cell Biol 2003 Jan;4(1):57-68.
          doi: 10.1038/nrm1005pubmed: 12511869google scholar: lookup
        11. Ciarlet M, Hyser JM, Estes MK. Sequence analysis of the VP4, VP6, VP7, and NSP4 gene products of the bovine rotavirus WC3. Virus Genes 2002 Mar;24(2):107-18.
          doi: 10.1023/a:1014512314545pubmed: 12018701google scholar: lookup
        12. Palombo EA. Genetic analysis of Group A rotaviruses: evidence for interspecies transmission of rotavirus genes. Virus Genes 2002;24(1):11-20.
          doi: 10.1023/a:1014073618253pubmed: 11928984google scholar: lookup
        13. Ghonaim AH, Rouby SR, Nageeb WM, Elgendy AA, Xu R, Jiang C, Ghonaim NH, He Q, Li W. Insights into recent advancements in human and animal rotavirus vaccines: Exploring new frontiers. Virol Sin 2025 Feb;40(1):1-14.
          doi: 10.1016/j.virs.2024.12.001pubmed: 39672271google scholar: lookup
        14. Carossino M, Vissani MA, Barrandeguy ME, Balasuriya UBR, Parreño V. Equine Rotavirus A under the One Health Lens: Potential Impacts on Public Health. Viruses 2024 Jan 16;16(1).
          doi: 10.3390/v16010130pubmed: 38257830google scholar: lookup
        Subscribe to our newsletter
        Join 99,344 horse owners like you who receive our email updates on horse health and nutrition.