Antigenic relationship between the surface antigens of avian and equine influenze viruses.
Abstract: Influenza virus Equine 1 (A/equine/Prague/56) has a hemagglutinin which is antigenically related to the hemagglutinin of fowl plague virus strain Rostock (FPV) and a neuraminidase which cross-reacts with the enzyme of virus N (A/chick/Germany/49). After a single injection of chickens with Equine 1 virus no hemagglutination inhibiting (HI) and neutralizing antibodies against FPV can be demonstrated, although the birds are fully protected against a lethal dose of FPV. HI and neutralizing antibodies against FPV appear after a second injection of Equine 1 virus several weeks after the first one. Liberation of newly sunthesized FPV from the host cell is ingibited by antibodies cross-reacting with any antigen of virus surface.
Publication Date: 1975-09-19 PubMed ID: 53781DOI: 10.1007/BF02122713Google Scholar: Lookup
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- Journal Article
Summary
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This study explores the antigenic connection between the surface antigens of avian and equine influenza viruses and reveals significant cross-reactivity and immunological protection against lethal doses of avian influenza following equine influenza vaccinations.
Research Objective and Methods
- The study aimed to understand the antigenic relationship between the surface antigens, specifically the hemagglutinin and neuraminidase, of avian (fowl plague virus – FPV) and equine influenza viruses (Equine 1).
- This was achieved through the injection of chickens with the Equine 1 virus and subsequent examination of the immunological response and antibody production in the birds.
Key Findings
- It was found that the hemagglutinin of the Equine 1 virus was antigenically akin to the hemagglutinin of the FPV.
- Similarly, the neuraminidase of Equine 1 cross-reacted with the enzyme of virus N, another avian strain.
- Interestingly, after a single dose of Equine 1, no hemagglutination inhibiting (HI) or neutralizing antibodies against FPV were evident, despite the birds being fully protected against a lethal dose of FPV.
- Upon a second dose of Equine 1, several weeks after the first dose, HI and neutralizing antibodies against FPV began to appear.
Implications of the Study
- This study pointed towards the possibility that immunization with differing strains of the influenza virus may result in cross-protection against otherwise lethal strains.
- The research also suggests that the liberation of newly synthesized FPV from the host cell can be inhibited by antibodies cross-reacting with any antigen of the virus surface.
- Overall, these findings provide valuable insight into potential strategies for combatting various strains of influenza through multi-dose vaccinations and targeted antibody responses.
Cite This Article
APA
Rott R, Becht H, Orlich .
(1975).
Antigenic relationship between the surface antigens of avian and equine influenze viruses.
Med Microbiol Immunol, 161(4), 253-261.
https://doi.org/10.1007/BF02122713 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Antigens, Viral / administration & dosage
- Binding Sites, Antibody
- Epitopes
- Equartevirus / immunology
- Fluorescent Antibody Technique
- Hemadsorption
- Hemagglutination Inhibition Tests
- Hemagglutination Tests
- Hemagglutinins, Viral / isolation & purification
- Influenza A virus / immunology
- Injections, Intravenous
- Neuraminidase / analysis
- Neutralization Tests
- RNA Viruses / immunology
- Viral Plaque Assay
References
This article includes 10 references
- Bachmayer H, Schmidt G. Selective removal of neuraminidase from influenza A 2 viruses.. Med Microbiol Immunol 1972;158(2):91-4.
- Rott R, Becht H, Orlich M. The significance of influenza virus neuraminidase in immunity.. J Gen Virol 1974 Jan;22(1):35-41.
- Brecht H, Hämmerling U, Rott R. Undisturbed release of influenza virus in the presence of univalent antineuraminidase antibodies.. Virology 1971 Nov;46(2):337-43.
- DAVENPORT FM, ROTT R, SCHAEFER W. Physical and biological properties of influenza virus components obtained after ether treatment.. J Exp Med 1960 Nov 1;112(5):765-82.
- Tumová B, Schild GC. Antigenic relationships between type a influenza viruses of human, porcine, equine, and avian origin.. Bull World Health Organ 1972;47(4):453-60.
- Fazekas de Saint Groth, Webster RG, Davenport FM. The antigenic subunits of influenza viruses. I. The homologous antibody response.. J Immunol 1969 Nov;103(5):1099-106.
- Becht H. [Studies on biosynthesis and serological demonstration of ribonucleoprotein antigen of influenza viruses. I. Studies on biosynthesis of RNP antigen and the role of cell nucleus in its synthesis].. Z Med Mikrobiol Immunol 1971;156(4):309-30.
- Seto JT, Rott R. Functional significance of sialidose during influenza virus multiplication.. Virology 1966 Dec;30(4):731-7.
- Becht H, Rott R. Purification of influenza virus hemagglutinin by affinity chromatography.. Med Microbiol Immunol 1972;158(2):67-70.
- . A revised system of nomenclature for influenza viruses.. Bull World Health Organ 1971;45(1):119-24.
Citations
This article has been cited 7 times.- Alexander DJ, Parsons G. Protection of chickens against challenge with virulent influenza A viruses of Hav5 subtype conferred by prior infection with influenza A viruses of Hsw1 subtype. Arch Virol 1980;66(3):265-9.
- Maywald F, Bosch FX, Orlich M, Rott R. Evidence for the contribution of the host species to the extent of antigenic variation of N1 influenza virus neuraminidase. Med Microbiol Immunol 1983;172(1):1-11.
- Lang G, Gagnon A, Geraci JR. Isolation of an influenza A virus from seals. Arch Virol 1981;68(3-4):189-95.
- Rott R, Orlich M, Scholtissek C. Attenuation of pathogenicity of fowl plague virus by recombination with other influenza A viruses nonpathogenic for fowl: nonexculsive dependence of pathogenicity on hemagglutinin and neuraminidase of the virus. J Virol 1976 Jul;19(1):54-60.
- Becht H, Malole B. Comparative evaluation of different fixation procedures and different coupling reagents for the demonstration of influenza virus-specific antibodies by the indirect hemagglutination test. Med Microbiol Immunol 1975 Dec 30;162(1):43-53.
- Werner J, Thraenhart O, Kuwert E. Detection of antigenic variation in influenza virus neuraminidase by the ESSEN-NIT and the WHO standard procedure. Med Microbiol Immunol 1978 Nov 17;166(1-4):165-71.
- Stephenson JR, ter Meulen V. Antigenic relationships between measles and canine distemper viruses: comparison of immune response in animals and humans to individual virus-specific polypeptides. Proc Natl Acad Sci U S A 1979 Dec;76(12):6601-5.
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