Antimicrobial resistance and virulence profiles of Enterococcus spp. isolated from horses in korea.
Abstract: Antimicrobial-resistant (AR) enterococci have emerged as leading nosocomial pathogens. Transmission of AR Enterococci from animals to humans has been demonstrated. However, there is limited information on the transmission of enterococci from horses to humans. To address this issue, we characterized 260 enterococci isolated from horse-associated samples in Korea in 2013 based on their AR profiles and virulence traits. AR profiling revealed an average ratio of AR enterococci of 23.8%. Seven isolates (2.7%) were multidrug-resistant Enterococcus faecalis. Most tetracycline-resistant enterococci harbored either tetM or tetL or both genes; genes conferring resistance to other antimicrobials were detected at low rates. Biofilm formation and gelatinase activity were observed in 51.1% and 47.7% of isolates, respectively; most were E. faecalis harboring the gelE gene. Evidence of transmission of AR enterococci between horses and their environments was provided by pulsed-field gel electrophoresis, and highlights the risk of AR enterococcus transmission to horse riders and handlers through close contact.
Copyright © 2016 Elsevier Ltd. All rights reserved.
Publication Date: 2016-07-12 PubMed ID: 27638114DOI: 10.1016/j.cimid.2016.07.001Google Scholar: Lookup
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- Journal Article
Summary
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This study is about analyzing Enterococcus bacteria isolated from horses in Korea with particular focus on their antimicrobial resistance and virulence traits, as this bacteria could potentially spread from horses to humans.
Study Purpose and Methodology
- The purpose of this study was to gather information about the transmission of a type of bacterial species known as Enterococcus from horses to humans. This bacteria can be resistant to antibiotics (AR), making it a leading cause of hospital-acquired infections.
- The researchers analyzed 260 samples of Enterococcus collected from horses in Korea in 2013 to determine their antimicrobial-resistant profiles and virulence traits.
Antimicrobial Resistance Profiles
- The AR profiling revealed that an average of 23.8% of the Enterococci samples demonstrated resistance to antibiotics. Furthermore, seven samples (2.7%) were identified as multidrug-resistant Enterococcus faecalis.
- The majority of the tetracycline-resistant enterococci carried one or both of the resistance genes tetM or tetL. Resistance genes for other antibiotics occurred at much lower rates.
Virulence Traits
- Regarding virulence traits, over half of the samples (51.1%) were observed with biofilm formation and 47.7% displayed gelatinase activity, most of which were E. faecalis containing the gelE gene.
Transmission Evidence
- The study also provided evidence of transmission of AR enterococci between horses and their environment through a technique called pulsed-field gel electrophoresis.
- This result suggests there is a potential risk of AR Enterococcus transmission to individuals who have close contact with horses, such as horse riders and handlers, which highlights the greater public health concern.
Cite This Article
APA
Kim DH, Chung YS, Park YK, Yang SJ, Lim SK, Park YH, Park KT.
(2016).
Antimicrobial resistance and virulence profiles of Enterococcus spp. isolated from horses in korea.
Comp Immunol Microbiol Infect Dis, 48, 6-13.
https://doi.org/10.1016/j.cimid.2016.07.001 Publication
Researcher Affiliations
- Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.
- Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.
- Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.
- Department of Animal Science and Technology, College of Biotechnology and Natural Resource, Chung-Ang University, 2nd Campus, Anseong 456-756, Republic of Korea.
- Animal and Plant Quarantine and Inspection Agency (QIA), Anyang 430-757, Republic of Korea.
- Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea.
- Department of Veterinary Microbiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Republic of Korea. Electronic address: magic007@snu.ac.kr.
MeSH Terms
- Animals
- Bacterial Proteins / genetics
- Biofilms
- Cross Infection / microbiology
- Cross Infection / transmission
- Drug Resistance, Microbial / genetics
- Drug Resistance, Multiple, Bacterial / genetics
- Electrophoresis, Gel, Pulsed-Field
- Enterococcus / drug effects
- Enterococcus / enzymology
- Enterococcus / genetics
- Enterococcus / pathogenicity
- Enterococcus faecalis / genetics
- Feces / microbiology
- Gelatinases / biosynthesis
- Gram-Positive Bacterial Infections / transmission
- Horses / microbiology
- Humans
- Microbial Sensitivity Tests
- Republic of Korea
- Virulence / genetics
Citations
This article has been cited 7 times.- Jia T, Chang WS, Marcelino VR, Zhao S, Liu X, You Y, Holmes EC, Shi M, Zhang C. Characterization of the Gut Microbiome and Resistomes of Wild and Zoo-Captive Macaques. Front Vet Sci 2021;8:778556.
- Shnaiderman-Torban A, Navon-Venezia S, Paitan Y, Archer H, Abu Ahmad W, Bonder D, Hanael E, Nissan I, Zizelski Valenci G, Weese SJ, Steinman A. Extended spectrum β lactamase-producing Enterobacteriaceae shedding by race horses in Ontario, Canada. BMC Vet Res 2020 Dec 9;16(1):479.
- Cui P, Feng L, Zhang L, He J, An T, Fu X, Li C, Zhao X, Zhai Y, Li H, Yan W, Li H, Luo X, Lei C, Wang H, Yang X. Antimicrobial Resistance, Virulence Genes, and Biofilm Formation Capacity Among Enterococcus species From Yaks in Aba Tibetan Autonomous Prefecture, China. Front Microbiol 2020;11:1250.
- Gawryszewska I, Malinowska K, Kuch A, Chrobak-Chmiel D, Trokenheim LL, Hryniewicz W, Sadowy E. Distribution of antimicrobial resistance determinants, virulence-associated factors and clustered regularly interspaced palindromic repeats loci in isolates of Enterococcus faecalis from various settings and genetic lineages. Pathog Dis 2017 Mar 1;75(2).
- Ngbede EO, Raji MA, Kwanashie CN, Kwaga JKP. Antimicrobial resistance and virulence profile of enterococci isolated from poultry and cattle sources in Nigeria. Trop Anim Health Prod 2017 Mar;49(3):451-458.
- Sfaciotte RAP, Parussolo L, Melo FD, Schneider MF, da Costa UM, Schwarz DGG, Salbego FZ, Ferraz SM. Vancomycin-resistant Enterococcus (VRE) isolates from dogs and cats in veterinary hospitals in Brazil. BMC Vet Res 2025 Feb 25;21(1):99.
- Yang J, Chen Y, Dong Z, Zhang W, Liu L, Meng W, Li Q, Fu K, Zhou Z, Liu H, Zhong Z, Xiao X, Zhu J, Peng G. Distribution and association of antimicrobial resistance and virulence characteristics in Enterococcus spp. isolates from captive Asian elephants in China. Front Microbiol 2023;14:1277221.
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