Application of polymeric N-acetyl-D-glucosamine (chitin) to veterinary practice.
Abstract: The sponge-, cotton-, and flake-type remedies made of chitin (chitin-sponge, chitin-cotton, and chitin-flake, respectively), and non-woven fabric of polyester (NWF) composited with chitin (chitin-NWF) were applied to various types of trauma, abscess, surgical tissue defect and herniorrhaphy in 147 clinical cases including 72 dogs, 38 cows, 33 cats, 2 rabbits, one monkey and one horse. Chitin-sponge was applied in 30 cases as filling agent of surgical tissue defect, and in 25 cases of trauma, 31 cases of abscess as wound dressing or tissue defect filling agent. In 77 out of 86 cases (89.5%), good healing developed. When chitin-sponge was buried in surgical tissue defects due to oncotomy in 20 cases, recurrence of the tumor developed in one case on one month post-operatively, but was not recognized for 3-24 months in 19 cases. Chitin-NWF was applied in 2 cases of trauma and 12 cases of abscess as wound dressing or tissue defect filling agent, 6 cases as filling agent of surgical tissue defect, and 12 cases of umbilical hernia as prosthesis of suture site of hernia ring. In 28 out of 32 cases (87.5%), good healing developed. Chitin-cotton was applied in 8 cases of trauma and 12 cases of abscess as wound dressing or tissue defect filling agent. In 18 out of 20 cases (90.0%), good healing developed. Chitin-flake was applied in 9 cases of trauma as wound dressing or tissue defect filling agent. In 8 out of 9 cases (88.9%), good healing developed. In all cases, no side effects were observed.
Publication Date: 1993-10-01 PubMed ID: 8286525DOI: 10.1292/jvms.55.743Google Scholar: Lookup
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The study is focused on the use of polymeric N-acetyl-D-glucosamine, also known as chitin, in a variety of forms for veterinary practices including trauma, abscess treatment, surgical tissue repair, and herniorrhaphy. The study, involving multiple test animals, has shown a high percentage of successful healing and no observed side effects.
Introduction and Materials
- The primary focus of the study is on the application of chitin substances in veterinary practices.
- Different types of chitin were used, including chitin-sponge, chitin-cotton, chitin-flake, and chitin composited with a non-woven fabric of polyester (chitin-NWF).
- These chitin substances were applied in treating various conditions such as trauma, abscess, surgical tissue defects and herniorrhaphy in a total of 147 cases with different types of animals.
Application of Chitin Sponge
- Chitin-sponge was used as a filling agent for surgical tissue defects and for trauma and abscess cases, either as wound dressing or tissue defect filling agent.
- The sponge saw favorable results in 89.5% of cases.
- In instances where it was used in surgical tissue defects due to tumor removal, there was only one case of tumor recurrence out of the total 20 instances.
Application of Chitin-NWF
- Chitin-NWF was applied to trauma and abscess cases as a wound dressing or tissue filling agent, and for filling surgical tissue defects and hernia suture sites.
- Satisfactory healing developed in 87.5% of these instances.
Application of Chitin-Cotton and Chitin-Flake
- Chitin-cotton was used as a wound dressing or tissue defect filling agent in trauma and abscess cases.
- It resulted in successful healing in 90.0% of cases.
- Chitin-flake was used in trauma cases as a wound dressing or tissue defect filling agent.
- In these applications, it resulted in effective healing in 88.9% of trauma cases.
- Across all cases, no side effects were observed, indicating the safety of using chitin substances in veterinary medical applications.
The effectiveness and safety of these treatments indicate promising potential for the wider application of chitin substances in veterinary medicine.
Cite This Article
APA
Okamoto Y, Minami S, Matsuhashi A, Sashiwa H, Saimoto H, Shigemasa Y, Tanigawa T, Tanaka Y, Tokura S.
(1993).
Application of polymeric N-acetyl-D-glucosamine (chitin) to veterinary practice.
J Vet Med Sci, 55(5), 743-747.
https://doi.org/10.1292/jvms.55.743 Publication
Researcher Affiliations
- Department of Veterinary Surgery, Faculty of Agriculture, Tottori University, Japan.
MeSH Terms
- Abscess / pathology
- Abscess / therapy
- Abscess / veterinary
- Animals
- Bandages
- Cats
- Cattle
- Chitin
- Dog Diseases
- Dogs
- Gossypium
- Haplorhini
- Horses
- Polyesters
- Rabbits
- Skin Diseases / pathology
- Skin Diseases / therapy
- Skin Diseases / veterinary
- Surgical Sponges
- Wounds and Injuries / pathology
- Wounds and Injuries / therapy
- Wounds and Injuries / veterinary
Citations
This article has been cited 4 times.- Zhao WY, Zhang LY, Wang ZC, Fang QQ, Wang XF, Du YZ, Shi BH, Lou D, Xuan GD, Tan WQ. The compound losartan cream inhibits scar formation via TGF-β/Smad pathway. Sci Rep 2022 Aug 22;12(1):14327.
- Divakar P, Moodie KL, Demidenko E, Jack Hoopes P, Wegst UGK. Quantitative evaluation of the in vivo biocompatibility and performance of freeze-cast tissue scaffolds. Biomed Mater 2020 Jul 23;15(5):055003.
- Seenuvasan M, Vinodhini G, Malar CG, Balaji N, Kumar KS. Magnetic nanoparticles: a versatile carrier for enzymes in bio-processing sectors. IET Nanobiotechnol 2018 Aug;12(5):535-548.
- Azuma K, Izumi R, Osaki T, Ifuku S, Morimoto M, Saimoto H, Minami S, Okamoto Y. Chitin, chitosan, and its derivatives for wound healing: old and new materials. J Funct Biomater 2015 Mar 13;6(1):104-42.
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