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Home / Equine Research Bank / Animals (Basel) / Assessment of P Wave Indices in Healthy Standardbred Horses.
Animals : an open access journal from MDPI2023; 13(6); doi: 10.3390/ani13061070

Assessment of P Wave Indices in Healthy Standardbred Horses.

Abstract: P wave indices are used as non-invasive electrocardiographic markers of atrial remodelling in humans. Few studies have investigated their use in animals. The aim of this study was to measure P wave duration and P wave dispersion (Pd) in healthy standardbred horses and investigate variables that might influence these measurements. A 12-lead electrocardiogram was recorded at rest and P wave indices were calculated in 53 horses. A general linear model was used to investigate the main effects: age, bodyweight, sex, resting heart rate, presence of a murmur, exercise status and the number of years raced. There were significant associations with exercise status for both the maximum P wave duration and Pd, with both values being increased in strenuously exercising versus non-active horses. Furthermore, a significant moderate positive correlation was identified between the duration of exercise (number of years raced) and both Pmax and Pd. No other significant associations were identified. These findings are similar to those reported in elite human athletes versus sedentary individuals. The increases in these P wave indices most likely occur due to prolongation and heterogeneity in atrial conduction time, which are associated with structural and electrical remodelling, and may explain the increased risk of atrial fibrillation in athletic horses.
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Publication Date: 2023-03-16 PubMed ID: 36978611PubMed Central: PMC10044338DOI: 10.3390/ani13061070Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This study is related to the use of P wave indices, a type of electrocardiographic marker, in standardbred horses to detect changes in their cardiovascular system due to factors such as age, weight, sex, heart rate at rest, presence of murmurs, exercise status, and the number of years raced.

Overview of the Study

  • This research was conducted to measure P wave duration and P wave dispersion (Pd) in healthy standardbred horses, and to investigate the factors that may affect these measurements.
  • The study took into consideration variables such as the age of the horse, its bodyweight, sex, resting heart rate, presence of a murmur, its exercise status, and the number of years it has raced.
  • The P wave indices were calculated using a 12-lead electrocardiogram recorded at rest for 53 standardbred horses. A general linear model was used to analyze the correlations.

Results of the Study

  • The study found significant associations between the P wave indices and the exercise status of the horses, revealing higher values for strenuously active horses compared to inactive ones.
  • A moderate positive correlation was also noted between the duration of exercise (number of years raced) and both Pmax (maximum P wave duration) and Pd (P wave dispersion).
  • However, no significant associations were identified between P wave indices and other variables like age, weight, sex, heart rate at rest, or the presence of murmurs.

Comparison with Human Studies

  • The findings paralleled already-known information in human studies, where P wave indices are increased in elite athletes versus sedentary individuals.

Implications of the Study

  • The increase in P wave indices is possibly linked to a prolongation and heterogeneity in atrial conduction time, which in turn may be associated with structural and electrical remodeling of the heart.
  • This could potentially explain the increased risk of atrial fibrillation in athletic horses.
  • The findings could potentially contribute to veterinary medicine by allowing for the use of non-invasive P wave indices as potential markers of atrial remodeling in animals, specifically horses.

Cite This Article

APA
White R, Nath L, Hebart M, Franklin S. (2023). Assessment of P Wave Indices in Healthy Standardbred Horses. Animals (Basel), 13(6). https://doi.org/10.3390/ani13061070

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 13
Issue: 6

Researcher Affiliations

White, Rebecca
  • School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Roseworthy, SA 5371, Australia.
Nath, Laura
  • School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Roseworthy, SA 5371, Australia.
Hebart, Michelle
  • School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Roseworthy, SA 5371, Australia.
Franklin, Samantha
  • School of Animal and Veterinary Sciences, The University of Adelaide, Roseworthy Campus, Roseworthy, SA 5371, Australia.

Grant Funding

  • N/A / University of Adelaide
  • N/A / Racing Victoria

Conflict of Interest Statement

The authors declare no conflict of interest.

References

This article includes 76 references
  1. Platonov P.G.. P-wave morphology: Underlying mechanisms and clinical implications.. Ann. Noninvasive Electrocardiol. 2012;17:161–169.
    doi: 10.1111/j.1542-474X.2012.00534.xpmc: PMC6932587pubmed: 22816534google scholar: lookup
  2. Pérez-Riera A.R., de Abreu L.C., Barbosa-Barros R., Grindler J., Fernandes-Cardoso A., Baranchuk A.. P-wave dispersion: An update.. Indian Pacing Electrophysiol. J. 2016;16:126–133.
    doi: 10.1016/j.ipej.2016.10.002pmc: PMC5197451pubmed: 27924760google scholar: lookup
  3. Okutucu S., Aytemir K., Oto A.. P-wave dispersion: What we know till now?. JRSM Cardiovasc. Dis. 2016;5:2048004016639443.
    doi: 10.1177/2048004016639443pmc: PMC4814939pubmed: 27081484google scholar: lookup
  4. Centurión O.A., García L.B., Marecos A., Torales J., Scavenius K., Miño L., Sequeira O.. P-wave morphology, amplitude, duration and dispersion in atrial arrhythmias.. J. Cardiol. Ther. 2018;6:1–6.
    doi: 10.12970/2311-052X.2018.06.01google scholar: lookup
  5. Hari K.J., Nguyen T.P., Soliman E.Z.. Relationship between P-wave duration and the risk of atrial fibrillation.. Expert Rev. Cardiovasc. Ther. 2018;16:837–843.
    doi: 10.1080/14779072.2018.1533814pubmed: 30295096google scholar: lookup
  6. Dilaveris P.E., Stefanadis C.I.. P wave dispersion: A valuable non-invasive marker of vulnerability to atrial arrhythmias.. Hosp. Chron. 2006;1:130–137.
  7. Gialafos J.E., Dilaveris P.E., Gialafos E.J., Andrikopoulos G.K., Richter D.J., Triposkiadis F., Kyriakidis M.K.. P wave dispersion: A valuable electrocardiographic marker for the prediction of paroxysmal lone atrial fibrillation.. Ann. Noninvasive Electrocardiol. 1999;4:39–45.
    doi: 10.1111/j.1542-474X.1999.tb00363.xgoogle scholar: lookup
  8. Aytemir K., Özer N., Atalar E., Sade E., Aksöyek S., Övünç K., Oto A., Özmen F., Kes S.. P wave dispersion on 12-lead electrocardiography in patients with paroxysmal atrial fibrillation.. Pacing Clin. Electrophysiol. 2000;23:1109–1112.
    doi: 10.1111/j.1540-8159.2000.tb00910.xpubmed: 10914366google scholar: lookup
  9. Dilaveris P.E., Gialafos J.E.. P-wave dispersion: A novel predictor of paroxysmal atrial fibrillation.. Ann. Noninvasive Electrocardiol. 2001;6:159–165.
    doi: 10.1111/j.1542-474X.2001.tb00101.xpmc: PMC7027606pubmed: 11333174google scholar: lookup
  10. Perzanowski C., Ho A.T., Jacobson A.K.. Increased P-wave dispersion predicts recurrent atrial fibrillation after cardioversion.. J. Electrocardiol. 2005;38:43–46.
    doi: 10.1016/j.jelectrocard.2004.09.008pubmed: 15660346google scholar: lookup
  11. Yıldız B.Ş., Şahin A., Yıldız M.. P wave dispersion detected from the surface electrocardiography and atrial fibrillation.. Koşuyolu Heart J. 2014;17:128–130.
    doi: 10.4274/khj.5244google scholar: lookup
  12. Nielsen J.B., Kühl J.T., Pietersen A., Graff C., Lind B., Struijk J.J., Olesen M.S., Sinner M.F., Bachmann T.N., Haunsø S.. P-wave duration and the risk of atrial fibrillation: Results from the Copenhagen ECG Study.. Heart Rhythm. 2015;12:1887–1895.
    doi: 10.1016/j.hrthm.2015.04.026pubmed: 25916567google scholar: lookup
  13. Metin G., Yildiz M., Bayraktar B., Yucesir I., Kasap H., Cakar L.. Assessment of the p wave dispersion and duration in elite women basketball players.. Indian Pacing Electrophysiol. J. 2010;10:10.
    pmc: PMC2803602pubmed: 20084192
  14. Puerta R.C., Aliz E.L., Lopez-Calleja M.A.R., Ramirez R.R., Pena G.P.. Increased P wave dispersion in elite athletes.. Indian Pacing Electrophysiol. J. 2011;11:73.
    pmc: PMC3083449pubmed: 21556156
  15. Puerta R.C., Martín R.R., López-Calleja M.A.R., León J.M., González L.P., Torres Y.C., González E.C.. Increased P wave dispersion in high performance soccer players and its relationship with sport practice time.. CorSalud (Rev. Enferm. Cardiovasc.) 2014;5:155–160.
  16. Wilhelm M., Roten L., Tanner H., Wilhelm I., Schmid J.-P., Saner H.. Atrial remodeling, autonomic tone, and lifetime training hours in nonelite athletes.. Am. J. Cardiol. 2011;108:580–585.
    doi: 10.1016/j.amjcard.2011.03.086pubmed: 21658663google scholar: lookup
  17. Abdulla J., Nielsen J.R.. Is the risk of atrial fibrillation higher in athletes than in the general population? A systematic review and meta-analysis.. Europace. 2009;11:1156–1159.
    doi: 10.1093/europace/eup197pubmed: 19633305google scholar: lookup
  18. Elliott A.D., Mahajan R., Lau D.H., Sanders P.. Atrial fibrillation in endurance athletes: From mechanism to management.. Cardiol. Clin. 2016;34:567–578.
    doi: 10.1016/j.ccl.2016.06.006pubmed: 27692225google scholar: lookup
  19. Flannery M.D., Kalman J.M., Sanders P., La Gerche A.. State of the art review: Atrial fibrillation in athletes.. Heart Lung Circ. 2017;26:983–989.
    doi: 10.1016/j.hlc.2017.05.132pubmed: 28606607google scholar: lookup
  20. Sanchis-Gomar F., Perez-Quilis C., Lippi G., Cervellin G., Leischik R., Löllgen H., Serrano-Ostáriz E., Lucia A.. Atrial fibrillation in highly trained endurance athletes—Description of a syndrome.. Int. J. Cardiol. 2017;226:11–20.
    doi: 10.1016/j.ijcard.2016.10.047pubmed: 27776250google scholar: lookup
  21. Elliott A.D., Mahajan R., Linz D., Stokes M., Verdicchio C.V., Middeldorp M.E., La Gerche A., Lau D.H., Sanders P.. Atrial remodeling and ectopic burden in recreational athletes: Implications for risk of atrial fibrillation.. Clin. Cardiol. 2018;41:843–848.
    doi: 10.1002/clc.22967pmc: PMC6490079pubmed: 29671875google scholar: lookup
  22. Trivedi S.J., Claessen G., Stefani L., Flannery M.D., Brown P., Janssens K., Elliott A., Sanders P., Kalman J., Heidbuchel H.. Differing mechanisms of atrial fibrillation in athletes and non-athletes: Alterations in atrial structure and function.. Eur. Heart J. Cardiovasc. Imaging. 2020;21:1374–1383.
    doi: 10.1093/ehjci/jeaa183pubmed: 32757003google scholar: lookup
  23. Peritz D.C., Catino A.B., Csecs I., Kaur G., Kheirkhahan M., Loveless B., Wasmund S., Kholmovski E., Morris A., Marrouche N.F.. High-intensity endurance training is associated with left atrial fibrosis.. Am. Heart J. 2020;226:206–213.
    doi: 10.1016/j.ahj.2020.05.015pubmed: 32615358google scholar: lookup
  24. La Gerche A.. The potential cardiotoxic effects of exercise.. Can. J. Cardiol. 2016;32:421–428.
    doi: 10.1016/j.cjca.2015.11.010pubmed: 26922291google scholar: lookup
  25. YOUNG L.E.. Cardiac responses to training in 2-year-old Thoroughbreds: An echocardiographic study.. Equine Vet. J. 1999;31:195–198.
    doi: 10.1111/j.2042-3306.1999.tb05217.xpubmed: 10659251google scholar: lookup
  26. Buhl R., Ersbøll A.K., Eriksen L., Koch J.. Changes over time in echocardiographic measurements in young Standardbred racehorses undergoing training and racing and association with racing performance.. J. Am. Vet. Med. Assoc. 2005;226:1881–1887.
    doi: 10.2460/javma.2005.226.1881pubmed: 15934256google scholar: lookup
  27. Buhl R., Ersbøll A.K.. Echocardiographic evaluation of changes in left ventricular size and valvular regurgitation associated with physical training during and after maturity in Standardbred trotters.. J. Am. Vet. Med. Assoc. 2012;240:205–212.
    doi: 10.2460/javma.240.2.205pubmed: 22217030google scholar: lookup
  28. Shave R., Howatson G., Dickson D., Young L.. Exercise-induced cardiac remodeling: Lessons from humans, horses, and dogs.. Vet. Sci. 2017;4:9.
    doi: 10.3390/vetsci4010009pmc: PMC5606617pubmed: 29056668google scholar: lookup
  29. Holmes J.. Cardiac arrhythmias on the racecourse.. Equine Exerc. Physiol. 1987;2:781–785.
  30. Ohmura H., Hiraga A., Takahashi T., Kai M., Jones J.H.. Risk factors for atrial fibrillation during racing in slow-finishing horses.. J. Am. Vet. Med. Assoc. 2003;223:84–88.
    doi: 10.2460/javma.2003.223.84pubmed: 12839069google scholar: lookup
  31. Slack J., Boston R., Soma L., Reef V.. Occurrence of cardiac arrhythmias in Standardbred racehorses.. Equine Vet. J. 2015;47:398–404.
    doi: 10.1111/evj.12299pubmed: 24819401google scholar: lookup
  32. Nath L.C., Elliott A.D., Weir J., Curl P., Rosanowski S.M., Franklin S.. Incidence, recurrence, and outcome of postrace atrial fibrillation in Thoroughbred horses.. J. Vet. Intern. Med. 2021;35:1111–1120.
    doi: 10.1111/jvim.16063pmc: PMC7995445pubmed: 33604980google scholar: lookup
  33. Hoogsteen J., Schep G., Van Hemel N.M., Van Der Wall E.E.. Paroxysmal atrial fibrillation in male endurance athletes. A 9-year follow up.. EP Eur. 2004;6:222–228.
    doi: 10.1016/j.eupc.2004.01.004pubmed: 15121075google scholar: lookup
  34. Simantirakis E.N., Papakonstantinou P.E., Kanoupakis E., Chlouverakis G.I., Tzeis S., Vardas P.E.. Recurrence rate of atrial fibrillation after the first clinical episode: A prospective evaluation using continuous cardiac rhythm monitoring.. Clin. Cardiol. 2018;41:594–600.
    doi: 10.1002/clc.22904pmc: PMC6489953pubmed: 29761516google scholar: lookup
  35. Decloedt A., Van Steenkiste G., Vera L., Buhl R., van Loon G.. Atrial fibrillation in horses part 1: Pathophysiology.. Vet. J. 2020;263:105521.
    doi: 10.1016/j.tvjl.2020.105521pubmed: 32928494google scholar: lookup
  36. Decloedt A., Schwarzwald C.C., De Clercq D., Van Der Vekens N., Pardon B., Reef V.B., van Loon G.. Risk factors for recurrence of atrial fibrillation in horses after cardioversion to sinus rhythm.. J. Vet. Intern. Med. 2015;29:946–953.
    doi: 10.1111/jvim.12606pmc: PMC4895430pubmed: 25917409google scholar: lookup
  37. Noszczyk-Nowak A., Pasławska U., Szałas A., Nicpoń J.. P-wave dispersion in healthy dogs. A preliminary study.. Bull. Vet. Inst. Pulawy. 2008;52:683–688.
  38. Noszczyk-Nowak A., Szałas A., Pasławska U., Nicpoń J.. Comparison of P-wave dispersion in healthy dogs, dogs with chronic valvular disease and dogs with disturbances of supraventricular conduction.. Acta Vet. Scand. 2011;53:18.
    doi: 10.1186/1751-0147-53-18pmc: PMC3061947pubmed: 21396110google scholar: lookup
  39. Noszczyk-Nowak A.. P-wave dispersion in prediction of maintenance of sinus rhythm after an electrical cardioversion of atrial fibrillation in dogs.. J. Vet. Res. 2012;56:99–102.
    doi: 10.2478/v10213-012-0018-0google scholar: lookup
  40. Michlik K., Noszczyk-Nowak A., Pasławska U., Janus I., Nicpoń J.. Physiological values of P-wave dispersion in Silesian breed horses and Polish Primitive horses.. J. Vet. Res. 2013;57:85–89.
    doi: 10.2478/bvip-2013-0016google scholar: lookup
  41. Savarino P., Borgarelli M., Tarducci A., Crosara S., Bello N.M., Margiocco M.. Diagnostic performance of P wave duration in the identification of left atrial enlargement in dogs.. J. Small Anim. Pract. 2012;53:267–272.
    doi: 10.1111/j.1748-5827.2012.01200.xpubmed: 22512699google scholar: lookup
  42. Dittrich G., Campos G.M.V.d.B., Sousa M.G., Oliveira S.T.. P wave dispersion in obese dogs with and without mitral valve disease.. Ciência Rural. 2018;48.
    doi: 10.1590/0103-8478cr20180047google scholar: lookup
  43. Carroll C., Huntington P.. Body condition scoring and weight estimation of horses.. Equine Vet. J. 1988;20:41–45.
    doi: 10.1111/j.2042-3306.1988.tb01451.xpubmed: 3366105google scholar: lookup
  44. Hesselkilde E.M., Isaksen J.L., Petersen B.V., Carstensen H., Jespersen T., Pehrson S., Kanters J.K., Buhl R.. A novel approach for obtaining 12-lead electrocardiograms in horses.. J. Vet. Intern. Med. 2021;35:521–531.
    doi: 10.1111/jvim.15980pmc: PMC7848388pubmed: 33274799google scholar: lookup
  45. Dilaveris P., Batchvarov V., Gialafos J., Malik M.. Comparison of different methods for manual P wave duration measurement in 12-lead electrocardiograms.. Pacing Clin. Electrophysiol. 1999;22:1532–1538.
    doi: 10.1111/j.1540-8159.1999.tb00358.xpubmed: 10588156google scholar: lookup
  46. Magnani J.W., Williamson M.A., Ellinor P.T., Monahan K.M., Benjamin E.J.. P wave indices: Current status and future directions in epidemiology, clinical, and research applications.. Circ. Arrhythmia Electrophysiol. 2009;2:72–79.
    doi: 10.1161/CIRCEP.108.806828pmc: PMC2760837pubmed: 19808445google scholar: lookup
  47. Nissen S.D., Weis R., Krag-Andersen E.K., Hesselkilde E.M., Isaksen J.L., Carstensen H., Kanters J.K., Linz D., Sanders P., Hopster-Iversen C.. Electrocardiographic characteristics of trained and untrained standardbred racehorses.. J. Vet. Intern. Med. 2022;36:1119–1130.
    doi: 10.1111/jvim.16427pmc: PMC9151491pubmed: 35488721google scholar: lookup
  48. Karakaya O., Saglam M., Barutcu I., Esen A.M., Ocak Y., Melek M., Kaya D., Turkmen M., Onrat E., Ozdemir N.. Comparison of the predictors for atrial rhythm disturbances between trained athletes and control subjects.. Tohoku J. Exp. Med. 2005;207:165–170.
    doi: 10.1620/tjem.207.165pubmed: 16141686google scholar: lookup
  49. Kriz N.G., Hodgson D.R., Rose R.J.. Changes in cardiac dimensions and indices of cardiac function during deconditioning in horses.. Am. J. Vet. Res. 2000;61:1553–1560.
    doi: 10.2460/ajvr.2000.61.1553pubmed: 11131598google scholar: lookup
  50. Elliott A.D., Linz D., Verdicchio C.V., Sanders P.. Exercise and atrial fibrillation: Prevention or causation?. Heart Lung Circ. 2018;27:1078–1085.
    doi: 10.1016/j.hlc.2018.04.296pubmed: 29891251google scholar: lookup
  51. Guasch E., Benito B., Qi X., Cifelli C., Naud P., Shi Y., Mighiu A., Tardif J.-C., Tadevosyan A., Chen Y.. Atrial fibrillation promotion by endurance exercise: Demonstration and mechanistic exploration in an animal model.. J. Am. Coll. Cardiol. 2013;62:68–77.
    doi: 10.1016/j.jacc.2013.01.091pubmed: 23583240google scholar: lookup
  52. Benito B., Gay-Jordi G., Serrano-Mollar A., Guasch E., Shi Y., Tardif J.-C., Brugada J., Nattel S., Mont L.. Cardiac arrhythmogenic remodeling in a rat model of long-term intensive exercise training.. Circulation. 2011;123:13–22.
    doi: 10.1161/CIRCULATIONAHA.110.938282pubmed: 21173356google scholar: lookup
  53. Newman W., Parry-Williams G., Wiles J., Edwards J., Hulbert S., Kipourou K., Papadakis M., Sharma R., O’Driscoll J.. Risk of atrial fibrillation in athletes: A systematic review and meta-analysis.. Br. J. Sport. Med. 2021;55:1233–1238.
    doi: 10.1136/bjsports-2021-103994pubmed: 34253538google scholar: lookup
  54. Mascia G., Perrotta L., Galanti G., Padeletti L.. Atrial fibrillation in athletes.. Int. J. Sport. Med. 2013;34:379–384.
    doi: 10.1055/s-0032-1321896pubmed: 23041967google scholar: lookup
  55. La Gerche A., Heidbuchel H.. Can intensive exercise harm the heart? You can get too much of a good thing.. Circulation. 2014;130:992–1002.
    doi: 10.1161/CIRCULATIONAHA.114.008141pubmed: 25223770google scholar: lookup
  56. Lombard C.W., Spencer C.P.. Correlation of radiographic, echocardiographic, and electrocardiographic signs of left heart enlargement in dogs with mitral regurgitation.. Vet. Radiol. 1985;26:89–97.
    doi: 10.1111/j.1740-8261.1985.tb01389.xgoogle scholar: lookup
  57. Mont L., Tamborero D., Elosua R., Molina I., Coll-Vinent B., Sitges M., Vidal B., Scalise A., Tejeira A., Berruezo A.. Physical activity, height, and left atrial size are independent risk factors for lone atrial fibrillation in middle-aged healthy individuals.. Europace. 2008;10:15–20.
    doi: 10.1093/europace/eum263pubmed: 18178694google scholar: lookup
  58. Centurión O., Aquino N., Torales J., Scavenius K., Miño L., Sequeira O.. P Wave Duration and Dispersion as a Useful Conventional Electrocardiographic Marker for Atrial Fibrillation Prediction.. J. Cardiol. Curr. Res. 2017;8:00285.
  59. Ariyarajah V., Mercado K., Apiyasawat S., Puri P., Spodick D.H.. Correlation of left atrial size with p-wave duration in interatrial block.. Chest. 2005;128:2615–2618.
    doi: 10.1378/chest.128.4.2615pubmed: 16236933google scholar: lookup
  60. Puerta R.C., Martínez E.L., López-Calleja M.A.R., Peña G.P., Torres Y.C., Elizundia J.M.C., González F.R., Vázquez L.Á.G., González E.C.. New Parameter of the Second Half of the P-Wave, P-Wave Duration, and Atrial Conduction Times Predict Atrial Fibrillation during Electrophysiological Studies.. Med. Princ. Pract. 2021;30:462–469.
    doi: 10.1159/000518262pmc: PMC8562052pubmed: 34348309google scholar: lookup
  61. Herrera C., Bruña V., Comella A., de la Rosa A., Díaz-González L., Ruiz-Ortiz M., Lacalzada-Almeida J., Lucía A., Boraita A., Bayés-de-Luna A.. Left atrial enlargement in competitive athletes and atrial electrophysiology.. Rev. Española Cardiol. (Engl. Ed.) 2022;75:421–428.
    doi: 10.1016/j.recesp.2021.05.016pubmed: 34373222google scholar: lookup
  62. Ciuffo L., Bruña V., Martínez-Sellés M., de Vasconcellos H.D., Tao S., Zghaib T., Nazarian S., Spragg D.D., Marine J., Berger R.D.. Association between interatrial block, left atrial fibrosis, and mechanical dyssynchrony: Electrocardiography-magnetic resonance imaging correlation.. J. Cardiovasc. Electrophysiol. 2020;31:1719–1725.
    doi: 10.1111/jce.14608pmc: PMC7703864pubmed: 32510679google scholar: lookup
  63. Aizawa Y., Watanabe H., Okumura K.. Electrocardiogram (ECG) for the prediction of incident atrial fibrillation: An overview.. J. Atr. Fibrillation. 2017;10:1724.
    doi: 10.4022/jafib.1724pmc: PMC5821635pubmed: 29487684google scholar: lookup
  64. Tüukek T., Akkaya V., Atilgan D., Demirel Ş., ÖZCAN M., Güuven Ö., Korkut F.. Effect of left atrial size and function on P-wave dispersion: A study in patients with paroxysmal atrial fibrillation.. Clin. Cardiol. 2001;24:676–680.
    doi: 10.1002/clc.4960241008pmc: PMC6655144pubmed: 11596617google scholar: lookup
  65. Ozyigit T., Kocas O., Karadag B., Ozben B.. Three dimensional left atrial volume index is correlated with P wave dispersion in elderly patients with sinus rhythm.. Wien. Klin. Wochenschr. 2016;128:182–186.
    doi: 10.1007/s00508-016-0973-1pubmed: 26932799google scholar: lookup
  66. De Clercq D., Van Loon G., Tavernier R., Duchateau L., Deprez P.. Atrial and ventricular electrical and contractile remodeling and reverse remodeling owing to short-term pacing-induced atrial fibrillation in horses.. J. Vet. Intern. Med. 2008;22:1353–1359.
    doi: 10.1111/j.1939-1676.2008.0202.xpubmed: 19000247google scholar: lookup
  67. Decloedt A., Verheyen T., Van Der Vekens N., Sys S., De Clercq D., van Loon G.. Long-term follow-up of atrial function after cardioversion of atrial fibrillation in horses.. Vet. J. 2013;197:583–588.
    doi: 10.1016/j.tvjl.2013.05.032pubmed: 23823082google scholar: lookup
  68. Hesselkilde E.Z., Carstensen H., Flethøj M., Fenner M., Kruse D.D., Sattler S.M., Tfelt-Hansen J., Pehrson S., Braunstein T.H., Carlson J.. Longitudinal study of electrical, functional and structural remodelling in an equine model of atrial fibrillation.. BMC Cardiovasc. Disord. 2019;19:228.
    doi: 10.1186/s12872-019-1210-4pmc: PMC6805623pubmed: 31638896google scholar: lookup
  69. Cheema A.N., Ahmed M.W., Kadish A.H., Goldberger J.J.. Effects of autonomic stimulation and blockade on signal-averaged P wave duration.. J. Am. Coll. Cardiol. 1995;26:497–502.
    doi: 10.1016/0735-1097(95)80028-Fpubmed: 7608455google scholar: lookup
  70. Kose S., Kiliç A., İyisoy A., Kursaklioglu H., Lenk M.K.. P wave duration and P dispersion in healthy children.. Turk. J. Pediatr. 2003;45:133–135.
    pubmed: 12921300
  71. Yildiz M., Aygin D., Pazarli P., Sayan A., Semiz O., Kahyaoglu O., Yildiz B.S., Hasdemir H., Akin I., Keser N.. Assessment of resting electrocardiogram, P wave dispersion and duration in different genders applying for registration to the School of Physical Education and Sports–results of a single centre Turkish Trial with 2093 healthy subjects.. Cardiol. Young. 2011;21:545–550.
    doi: 10.1017/S1047951111000382pubmed: 21554825google scholar: lookup
  72. Pritchett A.M., Jacobsen S.J., Mahoney D.W., Rodeheffer R.J., Bailey K.R., Redfield M.M.. Left atrial volume as an index ofleft atrial size: A population-based study.. J. Am. Coll. Cardiol. 2003;41:1036–1043.
    doi: 10.1016/S0735-1097(02)02981-9pubmed: 12651054google scholar: lookup
  73. Zucca E., Ferrucci F., Croci C., Di Fabio V., Zaninelli M., Ferro E.. Echocardiographic measurements of cardiac dimensions in normal Standardbred racehorses.. J. Vet. Cardiol. 2008;10:45–51.
    doi: 10.1016/j.jvc.2008.04.002pubmed: 18511359google scholar: lookup
  74. Young L., Rogers K., Wood J.. Left ventricular size and systolic function in Thoroughbred racehorses and their relationships to race performance.. J. Appl. Physiol. 2005;99:1278–1285.
    doi: 10.1152/japplphysiol.01319.2004pubmed: 15920096google scholar: lookup
  75. LONG K.J., Bonagura J., Darke P.. Standardised imaging technique for guided M-mode and Doppler echocardiography in the horse.. Equine Vet. J. 1992;24:226–235.
    doi: 10.1111/j.2042-3306.1992.tb02820.xpubmed: 1606937google scholar: lookup
  76. Bakos Z., Vörös K., Järvinen T.. Two-dimensional and M-mode echocardiographic measurements of cardiac dimensions in healthy standardbred trotters.. Acta Vet. Hung. 2002;50:273–282.
    doi: 10.1556/avet.50.2002.3.3pubmed: 12237968google scholar: lookup

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