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Genetics, selection, evolution : GSE2003; 35 Suppl 1(Suppl 1); S177-S190; doi: 10.1186/1297-9686-35-S1-S177

Association between the MHC gene region and variation of serum IgE levels against specific mould allergens in the horse.

Abstract: To investigate whether the equine major histocompatibility complex (MHC) gene region influences the production of mould-specific immunoglobulin E antibodies (IgE), alleles of the equine leukocyte antigen (ELA-A) locus and three microsatellite markers (UM-011, HTG-05 and HMS-42) located on the same chromosome as the equine MHC were determined in 448 Lipizzan horses. Statistical analyses based on composite models, showed significant associations of the ELA-A and UM-011 loci with IgE titres against the recombinant Aspergillus fumigatus 7 antigen (rAsp f 7). UM-011 was also significantly associated with IgE titres against the recombinant Aspergillus fumigatus 8 antigen (rAsp f 8). In addition to the loci mentioned above, the MHC class II DQA and DRA loci were determined in 76 Lipizzans from one stud. For IgE levels against rAsp f 7, the composite model showed the strongest association for DQA ([Formula: see text]P) while for rAsp f 8 specific IgE levels, similarly to the results found with all 448 horses, the strongest association was found with UM-011 (P=0.01), which is closely linked with the MHC class II DRB locus. These results suggest that the equine MHC gene region and possibly MHC class II loci, influence the specific IgE response in the horse. However, although the strongest associations were found with DQA and UM-011, this study did not distinguish if the observed effects were due to the MHC itself or to other tightly linked genes.
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Publication Date: 2003-08-21 PubMed ID: 12927090PubMed Central: PMC3231759DOI: 10.1186/1297-9686-35-S1-S177Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research aims to discern if there’s a correlation between the horse’s major histocompatibility complex (MHC) gene region and the production of mould-specific antibodies (IgE). The study found significant associations between specific loci and IgE levels but could not conclusively attribute the effects to the MHC or other closely linked genes.

MHC Gene Region and IgE Production

  • The researchers examined the MHC region of the horse genome, specifically focusing on the equine leukocyte antigen (ELA-A) and some microsatellite markers.
  • The association between these markers and the production of specific immunoglobulin E antibodies (IgE) in response to mould allergens was studied in a sample population of 448 Lipizzan horses.
  • IgE antibodies are part of the body’s immune response and can be triggered by allergens like moulds.

Statistical Analysis and Results

  • Statistical findings reported associations of the ELA-A and UM-011 loci with IgE titres against the recombinant Aspergillus fumigatus 7 antigen (rAsp f 7).
  • The UM-011 locus was also significantly associated with IgE titres against another antigen, the recombinant Aspergillus fumigatus 8 antigen (rAsp f 8).
  • A subset of the sample, 76 Lipizzans from one stud, were assessed for variations in MHC class II DQA and DRA loci.
  • These latter results revealed a strong association of the DQA with IgE levels against rAsp f 7, while a similar strong association was found between UM-011 and rAsp f 8 specific IgE levels, which aligns with the results from the larger sample of 448 horses.

Implications of Research

  • The findings of the study suggest that the equine MHC gene region, and possibly MHC class II loci, may influence the specific IgE response in horses.
  • The strongest associations were found with DQA and UM-011 loci.
  • Nevertheless, it is important to note that the research could not definitively discern whether the observed effects were due to the MHC itself or other genes closely linked to it.
  • This uncertainty indicates the need for further investigation to confirm the cause of these observed effects.

Cite This Article

APA
Curik I, Fraser D, Eder C, Achmann R, Swinburne J, Crameri R, Brem G, Sölkner J, Marti E. (2003). Association between the MHC gene region and variation of serum IgE levels against specific mould allergens in the horse. Genet Sel Evol, 35 Suppl 1(Suppl 1), S177-S190. https://doi.org/10.1186/1297-9686-35-S1-S177

Publication

Genetics, selection, evolution : GSE
ISSN: 0999-193X
NlmUniqueID: 9114088
Country: France
Language: English
Volume: 35 Suppl 1
Issue: Suppl 1
Pages: S177-S190

Researcher Affiliations

Curik, Ino
  • Animal Science Department, Faculty of Agriculture, University of Zagreb, Svetosimunska 25, 10000-Zagreb, Croatia.
Fraser, Darrilyn
    Eder, Claudia
      Achmann, Roland
        Swinburne, June
          Crameri, Reto
            Brem, Gottfried
              Sölkner, Johann
                Marti, Eliane

                  MeSH Terms

                  • Allergens / immunology
                  • Animals
                  • Europe
                  • Gene Frequency
                  • Genetics, Population
                  • HLA Antigens / genetics
                  • Horses / genetics
                  • Horses / immunology
                  • Immunoglobulin E / blood
                  • Linear Models
                  • Major Histocompatibility Complex / genetics
                  • Microsatellite Repeats / genetics
                  • Models, Genetic

                  Citations

                  This article has been cited 5 times.
                  1. Vasoya D, Tzelos T, Benedictus L, Karagianni AE, Pirie S, Marr C, Oddsdóttir C, Fintl C, Connelley T. High-Resolution Genotyping of Expressed Equine MHC Reveals a Highly Complex MHC Structure. Genes (Basel) 2023 Jul 10;14(7).
                    doi: 10.3390/genes14071422pubmed: 37510326google scholar: lookup
                  2. Sarmiento J, Perez B, Morales N, Henriquez C, Vidal L, Folch H, Galecio JS, Morán G. Apoptotic effects of tamoxifen on leukocytes from horse peripheral blood and bronchoalveolar lavage fluid. Vet Res Commun 2013 Dec;37(4):333-8.
                    doi: 10.1007/s11259-013-9571-0pubmed: 23846832google scholar: lookup
                  3. Moran G, Folch H, Henriquez C, Ortloff A, Barria M. Reaginic antibodies from horses with recurrent airway obstruction produce mast cell stimulation. Vet Res Commun 2012 Dec;36(4):251-8.
                    doi: 10.1007/s11259-012-9534-xpubmed: 23011757google scholar: lookup
                  4. Moran G, Buechner-Maxwell VA, Folch H, Henriquez C, Galecio JS, Perez B, Carrasco C, Barria M. Increased apoptosis of CD4 and CD8 T lymphocytes in the airways of horses with recurrent airway obstruction. Vet Res Commun 2011 Oct;35(7):447-56.
                    doi: 10.1007/s11259-011-9482-xpubmed: 21594641google scholar: lookup
                  5. Morán G, Folch H, Araya O, Burgos R, Barria M. Detection of reaginic antibodies against Faenia rectivirgula from the serum of horses affected with Recurrent Airway Obstruction by an in vitro bioassay. Vet Res Commun 2010 Dec;34(8):719-26.
                    doi: 10.1007/s11259-010-9440-zpubmed: 20814741google scholar: lookup
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