Association of arytenoid chondritis with equine lymphocyte antigens but no association with laryngeal hemiplegia, umbilical hernias and cryptorchidism.
Abstract: Associations were sought between ELA A1-A10 and W11 antigens and the presence of laryngeal hemiplegia, arytenoid chondritis, umbilical hernias and cryptorchidism in Thoroughbreds and/or Quarter Horses. No significant associations were detected between laryngeal hemiplegia and any ELA antigen in Thoroughbreds. The association between arytenoid chondritis and A9 was significant with a relative risk (RR) of 15.6 and aetiologic fraction (EF) of 0.80 in Thoroughbreds. There were apparent associations based on RR between A4 and A5 in Quarter Horses with umbilical hernias (RR = 7.5 and 6.1 respectively); however, these were not statistically significant. No significant associations were detected with cryptorchidism in Quarter Horses when the control population included both sexes. When only unaffected males were used as the control group, there was an apparent increase in relative risk with A6 (from RR = 1.7 to 4.3); however this was not statistically significant. Cryptorchidism in Thoroughbreds showed an increased relative risk with A5 regardless of whether the control population included males and females (RR = 4.1) or only males (RR = 4.7) but the increases were not statistically significant.
Publication Date: 1988-01-01 PubMed ID: 2906791DOI: 10.1111/j.1365-2052.1988.tb00834.xGoogle Scholar: Lookup
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- Journal Article
- Research Support
- Non-U.S. Gov't
- Research Support
- U.S. Gov't
- Non-P.H.S.
Summary
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This research investigated potential connections between certain equine lymphocyte antigens (ELA) and conditions such as laryngeal hemiplegia, arytenoid chondritis, umbilical hernias, and cryptorchidism in Thoroughbreds and Quarter Horses. It was found that arytenoid chondritis had a significant association with antigen A9 in Thoroughbreds, but no other substantial links were identified.
Research Methodology and Findings
- The performed research aimed to investigate possible associations between ELA A1-A10 and W11 antigens and certain conditions in Thoroughbreds and Quarter Horses, including laryngeal hemiplegia, arytenoid chondritis, umbilical hernias, and cryptorchidism.
- No significant connections were found between laryngeal hemiplegia and any ELA antigen in Thoroughbreds.
- A notable finding was a significant association between arytenoid chondritis and A9 antigen in Thoroughbreds, with a relative risk (RR) of 15.6 and an aetiological fraction (EF) of 0.80.
- Despite high relative risks between A4 and A5 in Quarter Horses with umbilical hernias (RR = 7.5 and 6.1 respectively), these links were not statistically significant.
- No significant associations were identified with cryptorchidism in Quarter Horses when both sexes were used as a control group. However, there was an apparent increase in relative risk with A6 (from RR = 1.7 to 4.3) when males only were used as controls, but this was not statistically significant.
- Though Thoroughbreds with cryptorchidism showed an elevated relative risk with A5, regardless of the control population’s composition (RR=4.1 with mixed sex controls and RR=4.7 with male only controls), these increases were not statistically significant.
Conclusion
- The study concludes that, while some weak associations were observed, only one significant correlation was found, that being between arytenoid chondritis and antigen A9 in Thoroughbreds.
- Further research would be needed to definitively rule out the other potential associations established, due to them not reaching statistical significance in this study.
Cite This Article
APA
McClure JJ, Koch C, Powell M, McClure JR.
(1988).
Association of arytenoid chondritis with equine lymphocyte antigens but no association with laryngeal hemiplegia, umbilical hernias and cryptorchidism.
Anim Genet, 19(4), 427-433.
https://doi.org/10.1111/j.1365-2052.1988.tb00834.x Publication
Researcher Affiliations
- Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge 70803.
MeSH Terms
- Animals
- Antigens, Differentiation / analysis
- Arytenoid Cartilage / immunology
- Cartilage Diseases / immunology
- Cartilage Diseases / veterinary
- Cryptorchidism / immunology
- Cryptorchidism / veterinary
- Female
- Gene Frequency
- Hernia, Umbilical / immunology
- Hernia, Umbilical / veterinary
- Histocompatibility Antigens / analysis
- Histocompatibility Antigens / genetics
- Horse Diseases / immunology
- Horses
- Lymphocytes / immunology
- Male
- Species Specificity
- Vocal Cord Paralysis / immunology
- Vocal Cord Paralysis / veterinary
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