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Home / Equine Research Bank / J Vet Intern Med / Association of Presence of Band Cells and Toxic Neutrophils ...
Journal of veterinary internal medicine2016; 30(4); 1284-1292; doi: 10.1111/jvim.13968

Association of Presence of Band Cells and Toxic Neutrophils with Systemic Inflammatory Response Syndrome and Outcome in Horses with Acute Disease.

Abstract: Band cells and toxic neutrophils are thought to indicate acute and severe systemic illness but no studies have investigated their importance in adult equine emergency admissions. Objective: The objective of this study was to evaluate the association of band cells and toxic neutrophils with systemic inflammatory response syndrome (SIRS) and outcome in horses. Methods: One hundred and five adult horses admitted on emergency basis to a private primary referral practice. Methods: Prospective observational study with sample collection. All horses admitted on emergency basis over the study period were included in the study if they had a CBC and a blood smear collected on admission. Results: The detection of band neutrophils on admission was associated with the SIRS status of the horse (RR = 2.80; 95% CI = 1.57-4.99; P < .001) and with poor outcome (RR = 1.88; 95% CI: 1.05-3.37; P = .038). Similarly, the presence of a neutrophil toxic grade higher than 3 was associated with SIRS (RR = 1.71; 95% CI: 1.03-2.82; P = .034) and death (RR = 2.34; 95% CI: 1.22-4.50, P = .007). The information gained from the blood smear review could not be captured by looking at only the WBC or neutrophil count. Conclusions: The microscopic review of blood smears from critically ill horses to detect band cells or neutrophil toxic change is valuable and could help in assessing disease severity and prognosis in adult equine emergency admissions.
Copyright © 2016 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
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Publication Date: 2016-05-23 PubMed ID: 27214343PubMed Central: PMC5089578DOI: 10.1111/jvim.13968Google Scholar: Lookup
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  • Journal Article
  • Observational Study

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the correlation between the presence of band cells and toxic neutrophils with systemic inflammatory response syndrome (SIRS) and the prognosis of horses with an acute illness. The study proposes that by reviewing blood smear of ill horses, one can gain valuable information about disease severity that could aid in more precise diagnosis and prognosis.

Objective of Research

  • The primary goal of this study was to assess the relationship between band cells and toxic neutrophils with systemic inflammatory response syndrome (SIRS) and disease outcome in horses.

Research Methodology

  • The study included 105 adult horses admitted on an emergency basis to a primary referral practice.
  • The methodology involved a prospective observational method with sample collection.
  • The criteria for the horses to be included in the study was they should have a complete blood count (CBC) and a blood smear collected on admission.

Research Findings

  • The research findings suggest a strong link between the presence of band neutrophils and the SIRS status of the horse. This link was also extended to the overall prognosis of the horse’s health.
  • Similarly, the presence of a neutrophil toxic grade higher than 3 was associated with SIRS and, more significantly, with death.
  • The results of the blood smear review could not be replicated by only reviewing the white blood cell (WBC) or neutrophil count, indicating the importance of a thorough blood smear review.

Conclusion

  • The microscopic review of blood smears from critically ill horses for the detection of band cells or neutrophil toxic changes was found to be valuable. This information could help in assessing disease severity and prognosis in adult equine emergency admissions.

Cite This Article

APA
Lambert JL, Fernandez NJ, Roy MF. (2016). Association of Presence of Band Cells and Toxic Neutrophils with Systemic Inflammatory Response Syndrome and Outcome in Horses with Acute Disease. J Vet Intern Med, 30(4), 1284-1292. https://doi.org/10.1111/jvim.13968

Publication

Journal of veterinary internal medicine
ISSN: 1939-1676
NlmUniqueID: 8708660
Country: United States
Language: English
Volume: 30
Issue: 4
Pages: 1284-1292

Researcher Affiliations

Lambert, J L
  • Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB.
Fernandez, N J
  • Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB.
Roy, M-F
  • Department of Veterinary Clinical and Diagnostic Sciences, Faculty of Veterinary Medicine, University of Calgary, Calgary, AB.

MeSH Terms

  • Animals
  • Female
  • Horse Diseases / pathology
  • Horses
  • Male
  • Neutrophils
  • Systemic Inflammatory Response Syndrome / blood
  • Systemic Inflammatory Response Syndrome / pathology
  • Systemic Inflammatory Response Syndrome / veterinary
  • Treatment Outcome

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Citations

This article has been cited 13 times.
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