Basic physiology of wound healing in the horse.
Abstract: Wound healing is part of the normal general repair process of the body. Its efficient completion depends on many factors, some physical, eg, pH, oxygen tension and tissue tension, and some biological, eg, cell-cell interaction and feedback of extracellular matrix on to the cells which produce it. The factors which affect healing are discussed and failures and anomalies in the process described. New techniques which may improve the quality of healing in specialised tissues are explained. Recent research on wound healing has concentrated on the role of the different cell types in the process and also on the effects of micro-environment on the enhancement or inhibition of cellular activity. The wound is a situation in which cells are apparently operating at the limits of their powers of survival and very slight modification of the micro-environment can render the tissue either unduly hostile to the cell or can enhance cellular activity. While it is not possible to increase the rate of healing of a clean surgical wound to any useful degree, an understanding of the mechanics of wound healing is essential to a rational treatment of simple or indolent wounds. It is especially important that surgical or medical treatment should complement, rather than compete with, the natural process. Tight bandages, which compress circulation, or excessive washing, which may remove macrophages and dilute bacteriostatic or chemotaxic agents, should be avoided.
Publication Date: 1982-01-01 PubMed ID: 6177529DOI: 10.1111/j.2042-3306.1982.tb02326.xGoogle Scholar: Lookup
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- Journal Article
Summary
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The study delves into the fundamental physiology of wound healing in horses, discussing the various physical and biological factors influencing the process, the potential problems encountered, and potential techniques to enhance healing quality, particularly in specialized tissues.
Understanding Wound Healing
- The research begins by portraying wound healing as a standard repair mechanism of the body. Various physical factors, such as pH, oxygen tension, and tissue tension, play crucial roles in effective healing.
- Biological aspects, including cell-cell interaction and the feedback of the extracellular matrix on the cells that produce it, also influence the healing process.
Challenges in Wound Healing
- The paper discusses anomalies and instances of failure in the wound healing process. This could refer to situations where, due to certain impediments or sub-optimal conditions, wounds do not heal as they should.
Advancements in Wound Healing Techniques
- Special mention is given to new techniques developed to improve the quality of wound healing in specialized tissues. While the research abstract doesn’t specify these techniques, it underscores their significance in the wound healing process.
Recent Research Focus
- Current research on wound healing, as highlighted by the authors, has focused on the role of distinct cell types in the process and the impacts of microenvironments on promoting or inhibiting cellular activity.
Microenvironment and Cellular Activity
- The study describes a wound as a situation where cells operate at the limits of their survival potential. Minor alterations in the microenvironment can either make the tissue more hostile to the cell or augment cellular activity.
Surgical and Medical Treatment Guidelines
- The paper states that comprehending the dynamics of wound healing is vital for effective treatment of simple or indolent wounds. The authors emphasise that interventions, whether surgical or medical, should augment the natural healing process rather than interfering with it.
- They caution against practices like applying tight bandages, which can constrain circulation, or excessive washing, which may remove vital macrophages and dilute bacteriostatic or chemotaxic agents, both of which are necessary for the wound healing process.
Cite This Article
APA
Silver IA.
(1982).
Basic physiology of wound healing in the horse.
Equine Vet J, 14(1), 7-15.
https://doi.org/10.1111/j.2042-3306.1982.tb02326.x Publication
Researcher Affiliations
MeSH Terms
- Animals
- Collagen / metabolism
- Connective Tissue / pathology
- Epithelium / pathology
- Foreign Bodies / physiopathology
- Foreign Bodies / veterinary
- Horse Diseases / physiopathology
- Horses / physiology
- Neovascularization, Pathologic
- Wound Healing
- Wound Infection / veterinary
- Wounds and Injuries / physiopathology
- Wounds and Injuries / veterinary
Citations
This article has been cited 3 times.- Xie F, Teng L, Lu J, Xu J, Zhang C, Yang L, Ma X, Zhao M. Interleukin-10-Modified Adipose-Derived Mesenchymal Stem Cells Prevent Hypertrophic Scar Formation via Regulating the Biological Characteristics of Fibroblasts and Inflammation. Mediators Inflamm 2022;2022:6368311.
- Ayele T, Zuki AB, Noorjahan BM, Noordin MM. Tissue engineering approach to repair abdominal wall defects using cell-seeded bovine tunica vaginalis in a rabbit model. J Mater Sci Mater Med 2010 May;21(5):1721-30.
- Fretz PB, Li Z. Low energy laser irradiation treatment for second intention wound healing in horses. Can Vet J 1992 Oct;33(10):650-3.
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