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Benzimidazole resistance in equine cyathostomes in Slovakia.
Abstract: The present study included 19 stud farms, including 243 horses, that were investigated for the occurrence of anthelmintic resistant cyathostomes. The number of horses on the farms varied from nine to more than 100, and horses of all ages were included. A minimum of seven horses were used for faecal egg count reduction (FECR) tests. The anthelmintics included were: fenbendazole (paste formulation), ivermectin (paste formulation) and pyrantel (powder). Resistance to benzimidazoles was detected on 14 farms, with FECR values ranging from 65.1 to 86.3%. Larval cultures after fenbendazole treatment revealed exclusively cyathostome larvae. Ivermectin was tested on eight farms and proved to be effective on all. Pyrantel was tested on two farms and FECR test indicated high efficacy (92-97%). Egg hatch assay (EHA) results showed that mean concentrations of thiabendazole that inhibited hatching in 50% of the eggs (ED(50)) in resistant populations were over 0.1 microg ml(-1). The results of our study suggest widespread resistance to fenbendazole in equine cyathostomes in Slovakia, and possible strategies to delay anthelmintic resistance are discussed briefly.
Publication Date: 2000-11-18 PubMed ID: 11078945DOI: 10.1016/s0304-4017(00)00366-6Google Scholar: Lookup The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
This research studied the prevalence of resistance to certain deworming drugs in a type of parasitic worm found in horses in Slovakia. The study found widespread resistance to the drug fenbendazole, with other tested drugs showing higher levels of effectiveness.
Study Setup
- The study was conducted in Slovakia across 19 stud farms with a total of 243 horses of various ages.
- Each farm had a population of nine to more than 100 horses.
- The research employed a minimum of seven horses per farm for faecal egg count reduction (FECR) tests to measure the effectiveness of the anthelmintic drugs – substances that destroy parasitic worms.
Drugs Tested
- The anthelmintics used in this study included fenbendazole (in a paste formulation), ivermectin (also in a paste formulation), and pyrantel (in a powder form).
FECR Test Results
- FECR tests revealed that resistance to the drug fenbendazole was found on 14 of the 19 stud farms.
- The FECR values, a measure of the effectiveness of the drug, ranged between 65.1% and 86.3%.
- Larval cultures established after fenbendazole treatment showed only cyathostome larvae – a type of parasitic worm found commonly in horses.
Findings For Other Drugs
- Ivermectin was tested on eight of the farms and was found to be effective on all.
- Pyrantel was tested on two farms and the associated FECR tests indicated high efficacy, with values between 92% and 97%.
Egg Hatch Assay Results
- Egg Hatch Assay (EHA) results showed that the average concentrations of thiabendazole (a type of benzimidazole) that inhibited hatching in 50% of the eggs (ED(50)) in resistant populations were over 0.1 micrograms per milliliter.
Conclusions
- From the study, it is evident that resistance to the anthelmintic fenbendazole is widespread in equine cyathostomes in Slovakia.
- The researchers discuss possible strategies briefly to delay the development of further anthelmintic resistance.
Cite This Article
APA
Várady M, Königová A, Corba J.
(2000).
Benzimidazole resistance in equine cyathostomes in Slovakia.
Vet Parasitol, 94(1-2), 67-74.
https://doi.org/10.1016/s0304-4017(00)00366-6 Publication
Researcher Affiliations
- Parasitological Institute, Slovak Academy of Sciences, Hlinkova 3, 040 01, Kosice, Slovak Republic. varady@saske.sk
MeSH Terms
- Animals
- Anthelmintics / administration & dosage
- Anthelmintics / pharmacology
- Anthelmintics / therapeutic use
- Benzimidazoles / administration & dosage
- Benzimidazoles / pharmacology
- Benzimidazoles / therapeutic use
- Drug Resistance
- Feces / parasitology
- Fenbendazole / administration & dosage
- Fenbendazole / pharmacology
- Fenbendazole / therapeutic use
- Horse Diseases / drug therapy
- Horse Diseases / parasitology
- Horses
- Ivermectin / administration & dosage
- Ivermectin / pharmacology
- Ivermectin / therapeutic use
- Logistic Models
- Parasite Egg Count / veterinary
- Pyrantel / administration & dosage
- Pyrantel / pharmacology
- Pyrantel / therapeutic use
- Slovakia
- Strongylida Infections / drug therapy
- Strongylida Infections / parasitology
- Strongylida Infections / veterinary
- Strongyloidea / drug effects
Citations
This article has been cited 9 times.- Jamshidpour R, Nabavi R, Moadab H, Rezaie F, Chale AC, Sargison N. Evaluation of Benzimidazole Resistance in Equine Cyathostomins in the Kermanshah Province of Iran Using Coprological Analysis and Allele-Specific PCR. Iran J Parasitol 2025 Jul-Sep;20(3):389-399.
- Kuzmina TA, Königová A, Burcáková L, Babjak M, Syrota Y. Strongylids of Domestic Horses in Eastern Slovakia: Species Diversity and Evaluation of Particular Factors Affecting Strongylid Communities. Acta Parasitol 2024 Jun;69(2):1284-1294.
- Nielsen MK. Anthelmintic resistance in equine nematodes: Current status and emerging trends. Int J Parasitol Drugs Drug Resist 2022 Dec;20:76-88.
- Dauparaitė E, Kupčinskas T, Varady M, Petkevičius S. Anthelmintic resistance of horse strongyle nematodes to fenbendazole in Lithuania. Acta Vet Scand 2022 Sep 15;64(1):26.
- Nápravníková J, Várady M, Vadlejch J. Total Failure of Fenbendazole to Control Strongylid Infections in Czech Horse Operations. Front Vet Sci 2022;9:833204.
- Babják M, Königová A, Urda Dolinská M, Kupčinskas T, Vadlejch J, von Samson-Himmelstjerna G, Petkevičius S, Várady M. Does the in vitro egg hatch test predict the failure of benzimidazole treatment in Haemonchus contortus?. Parasite 2021;28:62.
- von Samson-Himmelstjerna G, Coles GC, Jackson F, Bauer C, Borgsteede F, Cirak VY, Demeler J, Donnan A, Dorny P, Epe C, Harder A, Höglund J, Kaminsky R, Kerboeuf D, Küttler U, Papadopoulos E, Posedi J, Small J, Várady M, Vercruysse J, Wirtherle N. Standardization of the egg hatch test for the detection of benzimidazole resistance in parasitic nematodes. Parasitol Res 2009 Sep;105(3):825-34.
- Lind EO, Kuzmina T, Uggla A, Waller PJ, Höglund J. A field study on the effect of some anthelmintics on cyathostomins of horses in sweden. Vet Res Commun 2007 Jan;31(1):53-65.
- Königová A, Várady M, Corba J. Comparison of in vitro methods and faecal egg count reduction test for the detection of benzimidazole resistance in small strongyles of horses. Vet Res Commun 2003 May;27(4):281-8.
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