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Home / Equine Research Bank / Equine Vet J / BEVA primary care clinical guidelines: Analgesia.
Equine veterinary journal2019; 52(1); 13-27; doi: 10.1111/evj.13198

BEVA primary care clinical guidelines: Analgesia.

Abstract: Primary care guidelines provide a reference point to guide clinicians based on a systematic review of the literature, contextualised by expert clinical opinion. These guidelines develop a modification of the GRADE framework for assessment of research evidence (vetGRADE) and applied this to a range of clinical scenarios regarding use of analgesic agents. Key guidelines produced by the panel included recommendations that horses undergoing routine castration should receive intratesticular local anaesthesia irrespective of methods adopted and that horses should receive NSAIDs prior to surgery (overall certainty levels high). Butorphanol and buprenorphine should not be considered appropriate as sole analgesic for such procedures (high certainty). The panel recommend the continuation of analgesia for 3 days following castration (moderate certainty) and conclude that phenylbutazone provided superior analgesia to meloxicam and firocoxib for hoof pain/laminitis (moderate certainty), but that enhanced efficacy has not been demonstrated for joint pain. In horses with colic, flunixin and firocoxib are considered to provide more effective analgesia than meloxicam or phenylbutazone (moderate certainty). Given the risk of adverse events of all classes of analgesic, these agents should be used only under the control of a veterinary surgeon who has fully evaluated a horse and developed a therapeutic, analgesic plan that includes ongoing monitoring for such adverse events such as the development of right dorsal colitis with all classes of NSAID and spontaneous locomotor activity and potentially ileus with opiates. Finally, the panel call for the development of a single properly validated composite pain score for horses to allow accurate comparisons between medications in a robust manner.
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Publication Date: 2019-10-28 PubMed ID: 31657050DOI: 10.1111/evj.13198Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research presents new clinical guidelines for pain relief in horses. The guidance was developed by assessing existing research and combining it with expert opinions. Recommendations include changes to pain management during and after horse castration, and differences in effective medications for various types of pain.

Development of Guidelines

  • The guidelines were created by modifying the GRADE framework, a widely used system for assessing the quality of research.
  • This modified version, known as vetGRADE, was then applied to various scenarios involving the usage of pain-relieving drugs in horses.

Analgesia for Castration

  • The guidelines recommend that horses should always receive local pain relief during castration, regardless of the method used (certainty level high).
  • Non-steroidal anti-inflammatory drugs (NSAIDs) should be administered to horses prior to surgery.
  • The use of butorphanol and buprenorphine, common opiate painkillers, is not recommended as the only form of pain relief for castration (high certainty).
  • After castration, horses should continue to receive pain relief for at least three days (moderate certainty).

Pain Management for Hoof Pain and Colic

  • The panel found that phenylbutazone provided superior pain relief for hoof pain and laminitis compared to meloxicam and firocoxib, other common NASIDs (moderate certainty).
  • However, the increased efficacy of phenylbutazone was not demonstrated for joint pain.
  • In horses with colic, flunixin and firocoxib were found to be more effective than meloxicam or phenylbutazone (moderate certainty).

Controlled Usage and Monitoring

  • The guidelines stress the need for careful use of analgesic agents due to the risk of adverse events, including inflammation of the colon and potential ileus with opiate usage.
  • These drugs should only be used under the supervision of a veterinary surgeon who can develop a tailored plan and monitor for adverse effects.

Future Recommendations

  • The panel calls for the development of a single, validated score for measuring pain in horses. This would enable more accurate comparisons between different medications.

Cite This Article

APA
Bowen IM, Redpath A, Dugdale A, Burford JH, Lloyd D, Watson T, Hallowell GD. (2019). BEVA primary care clinical guidelines: Analgesia. Equine Vet J, 52(1), 13-27. https://doi.org/10.1111/evj.13198

Publication

Equine veterinary journal
ISSN: 2042-3306
NlmUniqueID: 0173320
Country: United States
Language: English
Volume: 52
Issue: 1
Pages: 13-27

Researcher Affiliations

Bowen, I M
  • Oakham Veterinary Hospital/University of Nottingham, Sutton Bonington, Loughborough, UK.
Redpath, A
  • Oakham Veterinary Hospital/University of Nottingham, Sutton Bonington, Loughborough, UK.
Dugdale, A
  • School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Loughborough, UK.
Burford, J H
  • School of Veterinary Medicine and Science, University of Nottingham, Sutton Bonington, Loughborough, UK.
Lloyd, D
  • ChesterGates Veterinary Specialists, Chester, UK.
Watson, T
  • Waterlane Equine Vets, Stroud, UK.
Hallowell, G D
  • Liphook Equine Hospital, Liphook, UK.

MeSH Terms

  • Analgesia / veterinary
  • Animals
  • Horse Diseases / drug therapy
  • Horses
  • Pain / drug therapy
  • Pain / veterinary
  • Practice Guidelines as Topic
  • Societies, Scientific / standards
  • United Kingdom
  • Veterinary Medicine / standards

References

This article includes 158 references
  1. Wald R, Tentori F, Tighiouart H, Zager PG, Miskulin DC. Impact of the Kidney Disease Outcomes Quality Initiative (KDOQI) Clinical Practice Guidelines for Bone Metabolism and Disease in a large dialysis network. Am. J. Kidney Dis. 49, 257-266.
  2. Faul M, Wald MM, Rutland-Brown W, Sullivent EE, Sattin RW. Using a cost-benefit analysis to estimate outcomes of a clinical treatment guideline: testing the Brain Trauma Foundation guidelines for the treatment of severe traumatic brain injury. J. Trauma 63, 1271-1278.
  3. Didomenico RJ, Perez A, Schumann HM, Fontana DR, Kondos GT, Schumock GT. Impact of treatment guidelines on clinical and economic outcomes of acute decompensated heart failure. Ann. Pharmacother. 42, 327-333.
  4. Ihle BU. Clinical practice guidelines for improving outcomes in sepsis. Heart Lung Circ. 17, Suppl. 4, S26-S31.
  5. Patel GW, Roderman N, Gehring H, Saad J, Bartek W. Assessing the effect of the Surviving Sepsis Campaign treatment guidelines on clinical outcomes in a community hospital. Ann. Pharmacother. 44, 1733-1738.
  6. Hubbard IJ, Harris D, Kilkenny MF, Faux SG, Pollack MR, Cadilhac DA. Adherence to clinical guidelines improves patient outcomes in Australian audit of stroke rehabilitation practice. Arch. Phys. Med. Rehabil. 93, 965-971.
  7. Woolf S, Schunemann HJ, Eccles MP, Grimshaw JM, Shekelle P. Developing clinical practice guidelines: types of evidence and outcomes; values and economics, synthesis, grading, and presentation and deriving recommendations. Implement Sci. 7, 61.
  8. Balshem H, Helfand M, Schunemann HJ, Oxman AD, Kunz R, Brozek J, Vist GE, Falck-Ytter Y, Meerpohl J, Norris S, Guyatt GH. GRADE guidelines: 3. Rating the quality of evidence. J. Clin. Epidemiol. 64, 401-406.
  9. Kavanagh BP. The GRADE system for rating clinical guidelines. PLoS Med. 6, e1000094.
  10. Guyatt G, Oxman AD, Akl EA, Kunz R, Vist G, Brozek J, Norris S, Falck-Ytter Y, Glasziou P, DeBeer H, Jaeschke R, Rind D, Meerpohl J, Dahm P, Schunemann HJ. GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables. J. Clin. Epidemiol. 64, 383-394.
  11. Alonso-Coello P, Oxman AD, Moberg J, Brignardello-Petersen R, Akl EA, Davoli M, Treweek S, Mustafa RA, Vandvik PO, Meerpohl J, Guyatt GH, Schunemann HJ. GRADE evidence to decision (EtD) frameworks: a systematic and transparent approach to making well informed healthcare choices. 2: clinical practice guidelines. BMJ 353, i2089.
  12. Taylor PM, Rest RJ, Duckham TN, Wood EJ. Possible potentiated sulphonamide and detomidine interactions. Vet. Rec. 122, 143.
  13. Trachsel DS, Tejada MA, Groesfjeld Christensen V, Pedersen PJ, Kanters JK, Buhl R, Calloe K, Klaerke DA. Effects of trimethoprim-sulfadiazine and detomidine on the function of equine Kv 11.1 channels in a two-electrode voltage-clamp (TEVC) oocyte model. J. Vet. Pharmacol. Ther. 41, 536-545.
  14. Dick IG, White SK. Possible potentiated sulphonamide-associated fatality in an anaesthetised horse. Vet. Rec. 121, 288.
  15. Van Duijkeren E, Vulto AG, Van Miert AS. Trimethoprim/sulfonamide combinations in the horse: a review. J. Vet. Pharmacol. Ther. 17, 64-73.
  16. Kumar A, Miladinovic B, Guyatt GH, Schunemann HJ, Djulbegovic B. GRADE guidelines system is reproducible when instructions are clearly operationalized even among the guidelines panel members with limited experience with GRADE. J. Clin. Epidemiol. 75, 115-118.
  17. Price J, Eager RA, Welsh EM, Waran NK. Current practice relating to equine castration in the UK. Res. Vet. Sci. 78, 277-280.
  18. BVA, BCVA. Analgesia in calves. British Veterinary Association .
  19. Dalla Costa E, Minero M, Lebelt D, Stucke D, Canali E, Leach MC. Development of the Horse Grimace Scale (HGS) as a pain assessment tool in horses undergoing routine castration. PLoS One 9, e92281.
  20. Haga HA, Lykkjen S, Revold T, Ranheim B. Effect of intratesticular injection of lidocaine on cardiovascular responses to castration in isoflurane-anesthetized stallions. Am. J. Vet. Res. 67, 403-408.
  21. Joyce J, Hendrickson DA. Comparison of intraoperative pain responses following intratesticular or mesorchial injection of lidocaine in standing horses undergoing laparoscopic cryptorchidectomy. J. Am. Vet. Med. Ass. 229, 1779-1783.
  22. Love EJ, Taylor PM, Clark C, Whay HR, Murrell J. Analgesic effect of butorphanol in ponies following castration. Equine Vet. J. 41, 552-556.
  23. Merl S, Scherzer S, Palme R, Möstl E. Pain causes increased concentrations of glucocorticoid metabolites in horse feces. J. Equine Vet. Sci. 20, 586-590.
  24. Olson ME, Fierheller E, Burwash L, Ralston B, Schatz C, Matheson-Bird H. The efficacy of meloxicam oral suspension for controlling pain and inflammation after castration in horses. J. Equine Vet. Sci. 35, 724-730.
  25. Portier KG, Jaillardon L, Leece EA, Walsh CM. Castration of horses under total intravenous anaesthesia: analgesic effects of lidocaine. Vet. Anaesth. Analg. 36, 173-179.
  26. Prügner W, Huber R, Lühmann R. Eltenac, a new anti-inflammatory and analgesic drug for horses: clinical aspects. J. Vet. Pharmacol. Ther. 14, 193-199.
  27. Sanz MG, Sellon DC, Cary JA, Hines MT, Farnsworth KD. Analgesic effects of butorphanol tartrate and phenylbutazone administered alone and in combination in young horses undergoing routine castration. J. Am. Vet. Med. Ass. 235, 1194-1203.
  28. Suriano R, Varasano V, Robbe D, Carluccio A, Straticò P, Contri A, Petrizzi L. Intraoperative analgesic effect of intrafunicular lidocaine injection during orchiectomy in isoflurane-anesthetized martina franca donkeys. J. Equine Vet. Sci. 34, 793-798.
  29. Taffarel MO, Luna SPL, Cardoso GS, de Oliveira FA, de Moura Alonso J, Gozalo-Marcilla M. Preemptive analgesia, including morphine, does not affect recovery quality and times in either pain-free horses or horses undergoing orchiectomy. J. Equine Vet. Sci. 48, 82-85.
  30. Abass M, Picek S, Garzón JFG, Kühnle C, Zaghlou A, Bettschart-Wolfensberger R. Local mepivacaine before castration of horses under medetomidine isoflurane balanced anaesthesia is effective to reduce perioperative nociception and cytokine release. Equine Vet. J. 50, 733-738.
  31. Love EJ, Taylor PM, Whay HR, Murrell J. Postcastration analgesia in ponies using buprenorphine hydrochloride. Vet. Rec. 172, 635.
  32. Hubbell JAE, Saville WJA, Bednarski RM. The use of sedatives, analgesic and anaesthetic drugs in the horse: an electronic survey of members of the American Association of Equine Practitioners (AAEP). Equine Vet. J. 42, 487-493.
  33. Lees P, Toutain PL. Pharmacokinetics, pharmacodynamics, metabolism, toxicology and residues of phenylbutazone in humans and horses. Vet. J. 196, 294-303.
  34. Raekallio M, Taylor PM, Bennett RC. Preliminary investigations of pain and analgesia assessment in horses administered phenylbutazone or placebo after arthroscopic surgery. Vet. Surg. 26, 150-155.
  35. Foreman JH, Barange A, Lawrence LM, Hungerford LL. Effects of single-dose intravenous phenylbutazone on experimentally induced, reversible lameness in the horse. J. Vet. Pharmacol. Ther. 31, 39-44.
  36. Sabate D, Homedes J, Salichs M, Sust M, Monreal L. Multicentre, controlled, randomised and blinded field study comparing efficacy of suxibuzone and phenylbutazone in lame horses. Equine Vet. J. 41, 700-705.
  37. King JN, Gerring EL. Antagonism of endotoxin-induced disruption of equine bowel motility by flunixin and phenylbutazone. Equine Vet. J. 21. Suppl. 7, 38-42.
  38. Semrad SD, Hardee GE, Hardee MM, Moore JN. Low dose flunixin meglumine: effects on eicosanoid production and clinical signs induced by experimental endotoxaemia in horses. Equine Vet. J. 19, 201-206.
  39. Foreman JH, Bergstrom BE, Golden KS, Roark JJ, Coren DS, Foreman CR, Schumacher SA. Dose titration of the clinical efficacy of intravenously administered flunixin meglumine in a reversible model of equine foot lameness. Equine Vet. J. 44, Suppl. 43, 17-20.
  40. Erkert RS, MacAllister CG, Payton ME, Clarke CR. Use of force plate analysis to compare the analgesic effects of intravenous administration of phenylbutazone and flunixin meglumine in horses with navicular syndrome. Am. J. Vet. Res. 66, 284-288.
  41. Foreman JH, Grubb TL, Inoue OJ, Banner SE, Ball KT. Efficacy of single-dose intravenous phenylbutazone and flunixin meglumine before, during and after exercise in an experimental reversible model of foot lameness in horses. Equine Vet. J. 42, Suppl. 38, 601-605.
  42. Cristina R, Gurban-Marcu A, Dumitrescu E, Janos D. Activity of flunixin meglumine and metamizole in a field study on 23 horses with colic. Lucrări Ştiinţifice Medicină Veterinară. XLV, 166-171.
  43. Jochle W, Moore JN, Brown J, Baker GJ, Lowe JE, Fubini S, Reeves MJ, Watkins JP, White NA. Comparison of detomidine, butorphanol, flunixin meglumine and xylazine in clinical cases of equine colic. Equine Vet. J. 21, Suppl. 7, 111-116.
  44. McKellar QA, Bogan JA, von Fellenberg RL, Ludwig B, Cawley GD. Pharmacokinetic, biochemical and tolerance studies on carprofen in the horse. Equine Vet. J. 23, 280-284.
  45. Lees P, McKellar Q, May SA, Ludwig B. Pharmacodynamics and pharmacokinetics of carprofen in the horse. Equine Vet. J. 26, 203-208.
  46. Lees P, Landoni MF. Pharmacodynamics and enantioselective pharmacokinetics of racemic carprofen in the horse. J. Vet. Pharmacol. Ther. 25, 433-448.
  47. Johnson CB, Taylor PM, Young SS, Brearley JC. Postoperative analgesia using phenylbutazone, flunixin or carprofen in horses. Vet. Rec. 133, 336-338.
  48. Schatzmann U, Gugelmann M, Von Cranach J, Ludwig BM, Rehm WF. Pharmacodynamic evaluation of the peripheral pain inhibition by carprofen and flunixin in the horse. Schweiz Arch. Tierheilkd. 132, 497-504.
  49. Gilmour MA, Payton ME. Comparison of the effects of IV administration of meloxicam, carprofen, and flunixin meglumine on prostaglandin E(2) concentration in aqueous humor of dogs with aqueocentesis-induced anterior uveitis. Am. J. Vet. Res. 73, 698-703.
  50. Pinard CL, Gauvin D, Moreau M, Martel-Pelletier J, Pelletier JP, Troncy E. Measurements of canine aqueous humor inflammatory mediators and the effect of carprofen following anterior chamber paracentesis. Vet. Ophthalmol. 14, 296-303.
  51. Owens JG, Kamerling SG, Stanton SR, Keowen ML. Effects of ketoprofen and phenylbutazone on chronic hoof pain and lameness in the horse. Equine Vet. J. 27, 296-300.
  52. Owens JG, Kamerling SG, Stanton SR, Keowen ML, Prescott-Mathews JS. Effects of pretreatment with ketoprofen and phenylbutazone on experimentally induced synovitis in horses. Am. J. Vet. Res. 57, 866-874.
  53. Longo E, Autefage A, Bayle R, Keister M, Van Gool E. Efficacy of a non-stroidal anti-inflammatory, ketofen 10%® (ketoprofen)in the treatment of colic in horses. J. Equine Vet. Sci. 12, 311-315.
  54. Beretta C, Garavaglia G, Cavalli M. COX-1 and COX-2 inhibition in horse blood by phenylbutazone, flunixin, carprofen and meloxicam: an in vitro analysis. Pharmacol. Res. 52, 302-306.
  55. Little D, Brown SA, Campbell NB, Moeser AJ, Davis JL, Blikslager AT. Effects of the cyclooxygenase inhibitor meloxicam on recovery of ischemia-injured equine jejunum. Am. J. Vet. Res. 68, 614-624.
  56. Naylor RJ, Taylor AH, Knowles EJ, Wilford S, Linnenkohl W, Mair TS, Johns IC. Comparison of flunixin meglumine and meloxicam for post operative management of horses with strangulating small intestinal lesions. Equine Vet. J. 46, 427-434.
  57. Di Salvo A, Giorgi M, Nannarone S, Lee HK, Corsalini J, Della Rocca G. Postoperative pharmacokinetics of meloxicam in horses after surgery for colic syndrome. J. Vet. Pharmacol. Ther. 41, 369-373.
  58. Toutain PL, Cester CC. Pharmacokinetic-pharmacodynamic relationships and dose response to meloxicam in horses with induced arthritis in the right carpal joint. Am. J. Vet. Res. 65, 1533-1541.
  59. UCVM Class of 2016, Banse H, Cribb AE. Comparative efficacy of oral meloxicam and phenylbutazone in 2 experimental pain models in the horse. Can. Vet. J. 58, 157-167.
  60. Olson ME, Nagel D, Custead S, Wise W, Penttila K, Burwash L, Ralston B, Schatz C, Matheson-Bird H. The palatability and comparative efficacy of meloxicam oral suspension for the treatment of chronic musculoskeletal disease in horses. J. Equine Vet. Sci. 44, 26-31.
  61. Walliser U, Fenner A, Mohren N, Keefe T, deVries F, Rundfeldt C. Evaluation of the efficacy of meloxicam for post-operative management of pain and inflammation in horses after orthopaedic surgery in a placebo controlled clinical field trial. BMC Vet. Res. 11, 113.
  62. Barton MH, Paske E, Norton N, King D, Giguère S, Budsberg S. Efficacy of cyclo-oxygenase inhibition by two commercially available firocoxib products in horses. Equine Vet. J. 46, 72-75.
  63. Koene M, Goupil X, Kampmann C, Hanson PD, Denton D, Pollmeier MG. Field trial validation of the efficacy and acceptability of firocoxib, a highly selective Cox-2 inhibitor, in a group of 96 lame horses. J. Equine Vet. Sci. 30, 237-243.
  64. Back W, MacAllister CG, van Heel MC, Pollmeier M, Hanson PD. The use of force plate measurements to titrate the dosage of a new COX-2 inhibitor in lame horses. Equine Vet. J. 41, 309-312.
  65. Orsini JA, Ryan WG, Carithers DS, Boston RC. Evaluation of oral administration of firocoxib for the management of musculoskeletal pain and lameness associated with osteoarthritis in horses. Am. J. Vet. Res. 73, 664-671.
  66. Foreman J, Foreman C, Bergstrom B. Efficacy of phenylbutazone versus firocoxib in experimental lameness in horses. Equine Vet. J. 46, Suppl. 46, 3.
  67. Doucet MY, Bertone AL, Hendrickson D, Hughes F, Macallister C, McClure S, Reinemeyer C, Rossier Y, Sifferman R, Vrins AA, White G, Kunkle B, Alva R, Romano D, Hanson PD. Comparison of efficacy and safety of paste formulations of firocoxib and phenylbutazone in horses with naturally occurring osteoarthritis. J. Am. Vet. Med. Ass. 232, 91-97.
  68. Cook VL, Meyer CT, Campbell NB, Blikslager AT. Effect of firocoxib or flunixin meglumine on recovery of ischemic-injured equine jejunum. Am. J. Vet. Res. 70, 992-1000.
  69. Ziegler AL, Freeman CK, Fogle CA, Burke MJ, Davis JL, Cook VL, Southwood LL, Blikslager AT. Multicentre, blinded, randomised clinical trial comparing the use of flunixin meglumine with firocoxib in horses with small intestinal strangulating obstruction. Equine Vet. J. 51, 329-335.
  70. Hilton HG, Magdesian KG, Groth AD, Knych H, Stanley SD, Hollingsworth SR. Distribution of flunixin meglumine and firocoxib into aqueous humor of horses. J. Vet. Intern. Med. 25, 1127-1133.
  71. Keegan KG, Messer NT, Reed SK, Wilson DA, Kramer J. Effectiveness of administration of phenylbutazone alone or concurrent administration of phenylbutazone and flunixin meglumine to alleviate lameness in horses. Am. J. Vet. Res. 69, 167-173.
  72. Foreman JH, Ruemmler R. Phenylbutazone and flunixin meglumine used singly or in combination in experimental lameness in horses. Equine Vet. J. 43, Suppl. 40, 12-17.
  73. Reed SK, Messer NT, Tessman RK, Keegan KG. Effects of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses. Am. J. Vet. Res. 67, 398-402.
  74. Kivett L, Taintor J, Wright J. Evaluation of the safety of a combination of oral administration of phenylbutazone and firocoxib in horses. J. Vet. Pharmacol. Ther. 37, 413-416.
  75. Frisbie DD, McIlwraith CW, Kawcak CE, Werpy NM, Pearce GL. Evaluation of topically administered diclofenac liposomal cream for treatment of horses with experimentally induced osteoarthritis. Am. J. Vet. Res. 70, 210-215.
  76. Schleining JA, McClure SR, Evans RB, Hyde WG, Wulf LW, Kind AJ. Liposome-based diclofenac for the treatment of inflammation in an acute synovitis model in horses. J. Vet. Pharmacol. Ther. 31, 554-561.
  77. Davis JL. Nonsteroidal anti-inflammatory drug associated right dorsal colitis in the horse. Equine Vet. Educ. 29, 104-113.
  78. Monreal L, Sabate D, Segura D, Mayós I, Homedes J. Lower gastric ulcerogenic effect of suxibuzone compared to phenylbutazone when administered orally to horses. Res. Vet. Sci. 76, 145-149.
  79. Andrews FM, Reinemeyer CR, Longhofer SL. Effects of top-dress formulations of suxibuzone and phenylbutazone on development of gastric ulcers in horses. Vet. Ther. 10, 113-120.
  80. Monreal L, Sabate D, Segura D, Mayos I, Homedes J. Lower gastric ulcerogenic effect of suxibuzone compared to phenylbutazone when administered orally to horses. Res. Vet. Sci. 76, 145-149.
  81. MacAllister CG, Morgan SJ, Borne AT, Pollet RA. Comparison of adverse effects of phenylbutazone, flunixin meglumine, and ketoprofen in horses. J. Am. Vet. Med. Ass. 202, 71-77.
  82. Adam MI, Köller G, Arnold C, Schusser G. Effects of using flunixin meglumine, metamizole, and phenylbutazone on equine kidney functions, urinary mucus, and secretory Immunoglobulin A (IgA) concentrations. Pferdeheilkunde 33, 263-270.
  83. Traub-Dargatz JL, Bertone JJ, Gould DH, Wrigley RH, Weiser MG, Forney SD. Chronic flunixin meglumine therapy in foals. Am. J. Vet. Res. 49, 7-12.
  84. Noble G, Edwards S, Lievaart J, Pippia J, Boston R, Raidal SL. Pharmacokinetics and safety of single and multiple oral doses of meloxicam in adult horses. J. Vet. Intern. Med. 26, 1192-1201.
  85. Hewetson M, Sykes BW, Hallowell GD, Tulamo R-M. Diagnostic accuracy of blood sucrose as a screening test for equine gastric ulcer syndrome (EGUS) in adult horses. Acta Vet. Scand. 59, 15.
  86. Raidal SL, Edwards S, Pippia J, Boston R, Noble GK. Pharmacokinetics and safety of oral administration of meloxicam to foals. J. Vet. Intern. Med. 27, 300-307.
  87. Richardson LM, Whitfield-Cargile CM, Cohen ND, Chamoun-Emanuelli AM, Dockery HJ. Effect of selective versus nonselective cyclooxygenase inhibitors on gastric ulceration scores and intestinal inflammation in horses. Vet. Surg. 47, 784-791.
  88. Hovanessian N, Davis JL, McKenzie HC 3rd, Hodgson JL, Hodgson DR, Crisman MV. Pharmacokinetics and safety of firocoxib after oral administration of repeated consecutive doses to neonatal foals. J. Vet. Pharmacol. Ther. 37, 243-251.
  89. Clarke KW, Paton BS. Combined use of detomidine with opiates in the horse. Equine Vet. J. 20, 331-334.
  90. Love EJ, Taylor PM, Murrell J, Whay HR, Waterman-Pearson AE. Assessment of the sedative effects of buprenorphine administered with 10 µg/kg detomidine in horses. Vet. Rec. 168, 379.
  91. Taylor PM, Browning AP, Harris CP. Detomidine-butorphanol sedation in equine clinical practice. Vet. Rec. 123, 388-390.
  92. Doherty TJ, Geiser DR, Rohrbach BW. Effect of high volume epidural morphine, ketamine and butorphanol on halothane minimum alveolar concentration in ponies. Equine Vet. J. 29, 370-373.
  93. Gozalo-Marcilla M, Hopster K, Gasthuys F, Krajewski AE, Schwarz A, Schauvliege S. Minimum end-tidal sevoflurane concentration necessary to prevent movement during a constant rate infusion of morphine, or morphine plus dexmedetomidine in ponies. Vet. Anaesth. Analg. 41, 212-219.
  94. Knych HKD, Steffey EP, Mama KR, Stanley SD. Effects of high plasma fentanyl concentrations on minimum alveolar concentration of isoflurane in horses. Am. J. Vet. Res. 70, 1193-1200.
  95. Matthews NS, Lindsay SL. Effect of low-dose butorphanol on halothane minimum alveolar concentration in ponies. Equine Vet. J. 22, 325-327.
  96. Bettschart-Wolfensberger R, Dicht S, Vullo C, Frotzler A, Kuemmerle JM, Ringer SK. A clinical study on the effect in horses during medetomidine-isoflurane anaesthesia, of butorphanol constant rate infusion on isoflurane requirements, on cardiopulmonary function and on recovery characteristics. Vet. Anaesth. Analg. 38, 186-194.
  97. Rigotti C, De Vries A, Taylor PM. Buprenorphine provides better anaesthetic conditions than butorphanol for field castration in ponies: results of a randomised clinical trial. Vet. Rec. 175, 623.
  98. Taylor PM, Hoare HR, De Vries A, Love EJ, Coumbe KM, White KL, Murrell JC. A multicentre, prospective, randomised, blinded clinical trial to compare some perioperative effects of buprenorphine or butorphanol premedication before equine elective general anaesthesia and surgery. Equine Vet. J. 48, 442-450.
  99. Boatwright CE, Fubini SLF, Grohn YT, Goossens L. A comparison of N-butylscopolammonium bromide and butorphanol tartrate for analgesia using a balloon model of abdominal pain in ponies. Can. J. Vet. Res. 60, 65-68.
  100. Kalpravidh M, Lumb WV, Wright M, Heath RB. Effects of butorphanol, flunixin, levorphanol, morphine, and xylazine in ponies. Am. J. Vet. Res. 45, 217-223.
  101. Kalpravidh M, Lumb WV, Wright M, Heath RB. Analgesic effects of butorphanol in horses: dose-response studies. Am. J. Vet. Res. 45, 211-216.
  102. Muir WW, Robertson JT. Visceral analgesia: effects of xylazine, butorphanol, meperidine, and pentazocine in horses. Am. J. Vet. Res. 46, 2081-2084.
  103. Sanchez LC, Elfenbein JR, Robertson SA. Effect of acepromazine, butorphanol, or N-butylscopolammonium bromide on visceral and somatic nociception and duodenal motility in conscious horses. Am. J. Vet. Res. 69, 579-585.
  104. Carregaro AB, Freitas GC, Ribeiro MH, Xavier NV, Doria RG. Physiological and analgesic effects of continuous-rate infusion of morphine, butorphanol, tramadol or methadone in horses with lipopolysaccharide (LPS)-induced carpal synovitis. BMC Vet. Res. 10, 966.
  105. Beck AA, De La Côrte FD, Brass KE, Dau SL, Silva GB, de Aguiar Camillo M. Effect of xylazine and butorphanol on experimental hind limb lameness in horses. J. Equine Vet. Sci. 73, 56-62.
  106. Queiroz Neto A, Zamur G, Mataqueiro MI, D'Angelis FHF, Araujo RA, Silva MHM, Basile RC, Ferraz GC. Behavioral and antinociceptive effects of alfentanil, butorphanol, and flunixin in horses. J. Equine Vet. Sci. 33, 1095-1100.
  107. Spadavecchia C, Arendt-Nielsen L, Spadavecchia L, Mosing M, Auer U, van den Hoven R. Effects of butorphanol on the withdrawal reflex using threshold, suprathreshold and repeated subthreshold electrical stimuli in conscious horses. Vet. Anaesth. Analg. 34, 48-58.
  108. Walker AF. Sublingual administration of buprenorphine for long-term analgesia in the horse. Vet. Rec. 160, 808-809.
  109. Messenger KM, Davis JL, LaFevers DH, Barlow BM, Posner LP. Intravenous and sublingual buprenorphine in horses: pharmacokinetics and influence of sampling site. Vet. Anaesth. Analg. 38, 374-384.
  110. Grubb TL, Kurkowski D, Sellon DC, Seino KK, Coffey T, Davis JL. Pharmacokinetics and physiologic/behavioral effects of buprenorphine administered sublingually and intravenously to neonatal foals. J. Vet. Pharmacol. Ther. 42, 26-36.
  111. Carregaro AB, Luna SPL, Mataqueiro MI, de Queiroz Neto A. Effects of buprenorphine on nociception and spontaneous locomotor activity in horses. Am. J. Vet. Res. 68, 246-250.
  112. Love EJ, Pelligand L, Taylor PM, Murrell JC, Sear JW. Pharmacokinetic-pharmacodynamic modelling of intravenous buprenorphine in conscious horses. Vet. Anaesth. Analg. 42, 17-29.
  113. Love EJ, Taylor PM, Whay HR, Murrell J. Postcastration analgesia in ponies using buprenorphine hydrochloride. Vet. Rec. 172, 635.
  114. Foreman JH, Ruemmler R. Efficacy of intramuscular meperidine hydrochloride versus placebo in experimental foot lameness in horses. Equine Vet. J. 45, 48-53.
  115. Hunt JR, Attenburrow PM, Slingsby LS, Murrell JC. Comparison of premedication with buprenorphine or methadone with meloxicam for postoperative analgesia in dogs undergoing orthopaedic surgery. J. Small Anim. Pract. 54, 418-424.
  116. Figueiredo JP, Muir WW, Sams R. Cardiorespiratory, gastrointestinal, and analgesic effects of morphine sulfate in conscious healthy horses. Am. J. Vet. Res. 73, 799-808.
  117. Lopes C, Luna SPL, Rosa AC, Quarterone C, Crosignani N, Taylor PM, Pantoja JC, Puoli JNP. Antinociceptive effects of methadone combined with detomidine or acepromazine in horses. Equine Vet. J. 48, 613-618.
  118. de Oliveira FA, Pignaton W, Teixeira-Neto FJ, de Queiroz-Neto A, Puoli-Filho JNP, Scognamillo MVR, Viveiros BM, Luna SPL. Antinociceptive and behavioral effects of methadone alone or in combination with detomidine in conscious horses. J. Equine Vet. Sci. 34, 380-386.
  119. Ruiz CC, Benedetti ICC, Guillebert I, Portier KG. Effect of pre- and postoperative phenylbutazone and morphine administration on the breathing response to skin incision, recovery quality, behavior, and cardiorespiratory variables in horses undergoing fetlock arthroscopy: a pilot study. Front. Vet. Sci. 2, 58.
  120. Davies JV, Gerring EL. Effect of spasmolytic analgesic drugs on the motility patterns of the equine small intestine. Res. Vet. Sci. 34, 334-339.
  121. Sojka JE, Adams SB, Lamar CH, Eller LL. Effect of butorphanol, pentazocine, meperidine, or metoclopramide on intestinal motility in female ponies. Am. J. Vet. Res. 49, 527-529.
  122. Merritt AM, Campbell-Thompson ML, Lowrey S. Effect of butorphanol on equine antroduodenal motility. Equine Vet. J. 21, Suppl. 7, 21-23.
  123. Merritt AM, Burrow JA, Hartless CS. Effect of xylazine, detomidine, and a combination of xylazine and butorphanol on equine duodenal motility. Am. J. Vet. Res. 59, 619-623.
  124. Sutton DGM, Preston T, Christley RM, Cohen ND, Love S, Roussel AJ. The effects of xylazine, detomidine, acepromazine and butorphanol on equine solid phase gastric emptying rate. Equine Vet. J. 34, 486-492.
  125. Boscan P, van Hoogmoed LM, Farver TB, Snyder JR. Evaluation of the effects of the opioid agonist morphine on gastrointestinal tract function in horses. Am. J. Vet. Res. 67, 992-997.
  126. Levionnois OL, Graubner C, Spadavecchia C. Colon constipation in horses after sustained-release buprenorphine administration. Vet. Anaesth. Analg. 45, 876-880.
  127. Bailey PA, Hague BA, Davis M, Major MD, Zubrod CJ, Brakenhoff JE. Incidence of post-anesthetic colic in non-fasted adult equine patients. Can. Vet. J. 57, 1263-1266.
  128. Senior JM, Pinchbeck GL, Dugdale AHA, Clegg PD. Retrospective study of the risk factors and prevalence of colic in horses after orthopaedic surgery. Vet. Rec. 155, 321-325.
  129. Andersen MS, Clark L, Dyson SJ, Newton JR. Risk factors for colic in horses after general anaesthesia for MRI or nonabdominal surgery: absence of evidence of effect from perianaesthetic morphine. Equine Vet. J. 38, 368-374.
  130. Jago RC, Corletto F, Wright IM. Peri-anaesthetic complications in an equine referral hospital: risk factors for post anaesthetic colic. Equine Vet. J. 47, 635-640.
  131. Mircica E, Clutton RE, Kyles KW, Blissitt KJ. Problems associated with perioperative morphine in horses: a retrospective case analysis. Vet. Anaesth. Analg. 30, 147-155.
  132. Senior JM, Pinchbeck GL, Allister R, Dugdale AH, Clark L, Clutton RE, Coumbe K, Dyson S, Clegg PD. Reported morbidities following 861 anaesthetics given at four equine hospitals. Vet. Rec. 160, 407-408.
  133. Combie J, Dougherty J, Nugent E, Tobin T. The pharmacology of narcotic analgesics in the horse. IV. Dose and time response relationships for behavioral responses to morphine, meperidine, pentazocine, anileridine, methadone, and hydromorphone. J. Equine Med. Surg. 3, 377-385.
  134. Nolan AM, Besley W, Reid J, Gray G. The effects of butorphanol on locomotor activity in ponies: a preliminary study. J. Vet. Pharmacol. Ther. 17, 323-326.
  135. de Oliveira FA, Pignaton W, Teixeira Neto FJ, de Queiroz-Neto A, Puoli-Filho JNP, Scognamillo MVR, Viveiros BM, Luna SPL. Antinociceptive and behavioral effects of methadone alone or in combination with detomidine in conscious horses. J. Equine Vet. Sci. 34, 380-386.
  136. Sellon DC, Monroe VL, Roberts MC, Papich MG. Pharmacokinetics and adverse effects of butorphanol administered by single intravenous injection or continuous intravenous infusion in horses. Am. J. Vet. Res. 62, 183-189.
  137. Szoke MO, Blais D, Cuvelliez SG, Lavoie JP. Effects of buprenorphine on cardiovascular and pulmonary function in clinically normal horses and horses with chronic obstructive pulmonary disease. Am. J. Vet. Res. 59, 1287-1291.
  138. Ramsey R, Golde DW. Aplastic anemia from veterinary phenylbutazone. J. Am. Med. Ass. 236, 1049.
  139. Neirinckx E, Vervaet C, De Boever S, Remon JP, Gommeren K, Daminet S, De Backer P, Croubels S. Species comparison of oral bioavailability, first-pass metabolism and pharmacokinetics of acetaminophen. Res. Vet. Sci. 89, 113-119.
  140. West E, Bardell D, Morgan R, Senior M. Use of acetaminophen (paracetamol) as a short-term adjunctive analgesic in a laminitic pony. Vet. Anaesth. Analg. 38, 521-522.
  141. Lascelles BD, Gaynor JS, Smith ES, Roe SC, Marcellin-Little DJ, Davidson G, Boland E, Carr J. Amantadine in a multimodal analgesic regimen for alleviation of refractory osteoarthritis pain in dogs. J. Vet. Intern. Med. 22, 53-59.
  142. Rees WA, Harkins JD, Woods WE, Blouin RA, Lu M, Fenger C, Holland RE, Chambers TM, Tobin T. Amantadine and equine influenza: pharmacology, pharmacokinetics and neurological effects in the horse. Equine Vet. J. 29, 104-110.
  143. Dirikolu L, Dafalla A, Ely KJ, Connerly AL, Jones CN, ElkHoly H, Lehner AF, Thompson K, Tobin T. Pharmacokinetics of gabapentin in horses. J. Vet. Pharmacol. Ther. 31, 175-177.
  144. Terry RL, McDonnell SM, Van Eps AW, Soma LR, Liu Y, Uboh CE, Moate PJ, Driessen B. Pharmacokinetic profile and behavioral effects of gabapentin in the horse. J. Vet. Pharmacol. Ther. 33, 485-494.
  145. Cox S, Villarino N, Doherty T. Determination of oral tramadol pharmacokinetics in horses. Res. Vet. Sci. 89, 236-241.
  146. Dhanjal JK, Wilson DV, Robinson E, Tobin TT, Dirikolu L. Intravenous tramadol: effects, nociceptive properties, and pharmacokinetics in horses. Vet. Anaesth. Analg. 36, 581-590.
  147. Guedes A, Knych H, Hood D. Plasma concentrations, analgesic and physiological assessments in horses with chronic laminitis treated with two doses of oral tramadol. Equine Vet. J. 48, 528-531.
  148. Knych HK, Corado CR, McKemie DS, Scholtz E, Sams R. Pharmacokinetics and pharmacodynamics of tramadol in horses following oral administration. J. Vet. Pharmacol. Ther. 36, 389-398.
  149. Shilo Y, Britzi M, Eytan B, Lifschitz T, Soback S, Steinman A. Pharmacokinetics of tramadol in horses after intravenous, intramuscular and oral administration. J. Vet. Pharmacol. Ther. 31, 60-65.
  150. Stewart AJ, Boothe DM, Cruz-Espindola C, Mitchum EJ, Springfield J. Pharmacokinetics of tramadol and metabolites O-desmethyltramadol and N-desmethyltramadol in adult horses. Am. J. Vet. Res. 72, 967-974.
  151. Franco LG, Moreno JCD, Teixeira Neto AR, Souza MC, Silva LAF. Tramadol effects on clinical variables and the mechanical nociceptive threshold in horses. Ciência Rural 44, 517-523.
  152. Giorgi M. Tramadol vs tapentadol: a new horizon in pain treatment. Am. J. Anim. Vet. Sci. 7, 7-11.
  153. Guedes AGP, Aristizabal F, Sole A, Adedeji A, Brosnan R, Knych H, Yang J, Hwang SH, Morisseau C, Hammock BD. Pharmacokinetics and antinociceptive effects of the soluble epoxide hydrolase inhibitor t-TUCB in horses with experimentally induced radiocarpal synovitis. J. Vet. Pharmacol. Ther. 41, 230-238.
  154. Guedes AGP, Morisseau C, Sole A, Soares JHN, Ulu A, Dong H, Hammock BD. Use of a soluble epoxide hydrolase inhibitor as an adjunctive analgesic in a horse with laminitis. Vet. Anaesth. Analg. 40, 440-448.
  155. Sanchez LC, Robertson SA, Maxwell LK, Zientek K, Cole C. Effect of fentanyl on visceral and somatic nociception in conscious horses. J. Vet. Intern. Med. 21, 1067-1075.
  156. Eberspacher E, Stanley SD, Rezende M, Steffey EP. Pharmacokinetics and tolerance of transdermal fentanyl administration in foals. Vet. Anaesth. Analg. 35, 249-255.
  157. Maxwell LK, Thomasy SM, Slovis N, Kollias-Baker C. Pharmacokinetics of fentanyl following intravenous and transdermal administration in horses. Equine Vet. J. 35, 484-490.
  158. Orsini JA, Moate PJ, Kuersten K, Soma LR, Boston RC. Pharmacokinetics of fentanyl delivered transdermally in healthy adult horses-variability among horses and its clinical implications. J. Vet. Pharmacol. Ther. 29, 539-546.
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