Bioavailability of two ibuprofen oral paste formulations in fed or nonfed ponies.

This research study investigates the bioavailability and pharmacokinetics of two oral paste formulations of ibuprofen in ponies, under both fed and non-fed conditions. The study found that both formulations had an absolute bioavailability of about 80%, regardless of whether the ponies were fed or not.

Objective of Research

• This research was oriented towards understanding the bioavailability and pharmacokinetics of ibuprofen when administered as oral paste formulations to Shetland ponies.
• The study also aimed to determine if feeding influenced the bioavailability of the drug in any way.

Methodology

• The researchers employed healthy Shetland ponies for their study.
• Ibuprofen was administered in two formats: as a suspension and as a solid solution oral paste.
• These formulations were given to ponies that were fasted and those that were fed (allowed water and hay).
• The drug was also administered intravenously to establish a comparison standard for drug bioavailability.

Findings

• The findings from the study indicated an absolute bioavailability of approximately 80% for both ibuprofen formulations.
• This suggests that the majority of the ingested ibuprofen was successfully absorbed into the systemic circulation of the ponies and was available to exert its therapeutic effect.
• The bioavailability of the two formulations was not influenced by the feeding status of the ponies. Whether the ponies were fed or not, the bioavailability of ibuprofen remained at around 80%.

Implications

• The study provides useful insights on the administration of ibuprofen to ponies, offering a practical guide for dosing whether they are fed or fasted.
• This can help in better management of pain and inflammation in ponies by offering effective dosing strategies.
• The fact that feeding does not impact bioavailability can simplify medication regimes for ponies, making treatment schedules more flexible and easier to implement.