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Home / Equine Research Bank / Animals (Basel) / Biomarkers of Intestinal Injury in Colic.
Animals : an open access journal from MDPI2023; 13(2); doi: 10.3390/ani13020227

Biomarkers of Intestinal Injury in Colic.

Abstract: Biomarkers are typically proteins, enzymes, or other molecular changes that are elevated or decreased in body fluids during the course of inflammation or disease. Biomarkers pose an extremely attractive tool for establishing diagnoses and prognoses of equine gastrointestinal colic, one of the most prevalent causes of morbidity and mortality in horses. This topic has received increasing attention because early diagnosis of some forms of severe colic, such as intestinal ischemia, would create opportunities for rapid interventions that would likely improve case outcomes. This review explores biomarkers currently used in equine medicine for colic, including acute phase proteins, proinflammatory cytokines, markers of endotoxemia, and tissue injury metabolites. To date, no single biomarker has been identified that is perfectly sensitive and specific for intestinal ischemia; however, L-lactate has been proven to be a very functional and highly utilized diagnostic tool. However, further exploration of other biomarkers discussed in this review may provide the key to accelerated identification, intervention, and better outcomes for horses suffering from severe colic.
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Publication Date: 2023-01-07 PubMed ID: 36670767PubMed Central: PMC9854801DOI: 10.3390/ani13020227Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research article discusses the potential of biomarkers in diagnosing and determining the prognosis of equine gastrointestinal colic – a common cause of illness and death in horses. It focuses on various biomarkers presently used in equine medicine for colic, reviews their effectiveness, and emphasizes the need for further exploration to improve the early diagnosis and treatment of severe colic in horses.

Understanding Biomarkers

  • Biomarkers are usually proteins, enzymes, or other molecular changes that increase or decrease in body fluids during inflammation or disease.
  • These biomarkers are helpful in establishing diagnoses and prognoses of certain diseases including equine gastrointestinal colic – a common disease that affects the well-being and survival of horses.

Role of Biomarkers in Equine Medicine

  • In equine medicine, various biomarkers such as acute phase proteins, proinflammatory cytokines, markers of endotoxemia, and tissue injury metabolites are used for detecting and treating colic.
  • Early diagnosis of some severe forms of colic, like intestinal ischemia, can lead to timely interventions, likely leading to improved case outcomes.

Evaluating the Effectiveness of Biomarkers

  • Despite the utilisation of various biomarkers, no single biomarker has been identified that is completely sensitive and specific for intestinal ischemia – a severe form of colic.
  • However, L-lactate has proven to be a highly functional and frequently used diagnostic tool in equine colic cases.

Need for Further Exploration

  • While current biomarkers are helping in diagnosing and treating colic in horses, the review reaffirms the need for further exploration of other biomarkers.
  • New research may provide the key to quicker identification, intervention, and better outcomes for horses suffering from severe colic.

Cite This Article

APA
Ludwig EK, Hobbs KJ, McKinney-Aguirre CA, Gonzalez LM. (2023). Biomarkers of Intestinal Injury in Colic. Animals (Basel), 13(2). https://doi.org/10.3390/ani13020227

Publication

Animals : an open access journal from MDPI
ISSN: 2076-2615
NlmUniqueID: 101635614
Country: Switzerland
Language: English
Volume: 13
Issue: 2

Researcher Affiliations

Ludwig, Elsa K
  • Department of Clinical Sciences, North Carolina State University, Raleigh, NC 27606, USA.
Hobbs, Kallie J
  • Department of Clinical Sciences, North Carolina State University, Raleigh, NC 27606, USA.
McKinney-Aguirre, Caroline A
  • Department of Clinical Sciences, North Carolina State University, Raleigh, NC 27606, USA.
Gonzalez, Liara M
  • Department of Clinical Sciences, North Carolina State University, Raleigh, NC 27606, USA.

Grant Funding

  • T32 OD011130 / NIH HHS
  • U01 TR002953 / NCATS NIH HHS
  • U01TR002953-04 / NIH HHS
  • 2 T32 OD011130-16 / NIH HHS

Conflict of Interest Statement

The authors declare no conflict of interest.

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