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Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)2024; doi: 10.1111/vec.13418

Bioreactance noninvasive cardiac output monitoring in euvolemic adult horses subjected with 7.2% saline and 6% hydroxyethyl starch (130/0.4) solution infusions.

Abstract: To compare the ability of bioreactance noninvasive cardiac output (BR-NICO) with thermodilution cardiac output (TDCO) for the measurement of cardiac output (CO) in healthy adult horses receiving 2 different IV volume replacement solutions. Methods: Prospective randomized crossover study from September to November 2021. Methods: University teaching hospital. Methods: Six university-owned adult horses. Methods: Horses were randomly assigned to receive 7.2% hypertonic saline solution (HSS) or 6% hydroxyethyl starch (130/0.4) solution (HETA). BR-NICO and TDCO were measured simultaneously at baseline, 10, 20, 30, 40, 50, 60, 90, and 120 minutes before fluid administration and again at the same times after starting a bolus infusion of IV volume replacers. All solutions were administered within 10 minutes. Results: BR-NICO and TDCO were strongly correlated (Pearson r = 0.93; P < 0.01). Regression analysis showed the relationship between TDCO and BR-NICO was BR-NICO = 0.48 × TDCO + 0.6. For the corrected BR-NICO values, the Bland-Altman agreement mean bias and lower/upper limits of agreement were -0.62 and -5.3 to 3.9 L/min, respectively. Lin's concordance (95% confidence interval) between methods was 0.894 (0.825-1.097). Compared with baseline, HSS increased the CO at 10 and 20 minutes (TDCO and BR-NICO). Compared with baseline, HETA decreased the CO at 10 and 20 minutes (TDCO and BR-NICO) and increased the CO at 90 (TDCO only) and 120 minutes (TDCO and BR-NICO). Conclusions: BR-NICO strongly agreed with TDCO in the measurement of CO in healthy unsedated adult horses. HSS administration significantly increased CO in the first 30 minutes, while HETA initially decreased CO at 10 minutes but increased CO to above baseline values by 90 minutes.
© Veterinary Emergency and Critical Care Society 2024.
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Publication Date: 2024-09-10 PubMed ID: 39256943DOI: 10.1111/vec.13418Google Scholar: Lookup
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Summary

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The research involved assessing the performance of noninvasive bioreactance cardiac output (BR-NICO) monitoring in adult horses as compared to thermodilution cardiac output (TDCO) measurement. The comparison was done on horses administered with two distinct intravenous replacements, namely hypertonic saline solution (HSS) and hydroxyethyl starch (HETA). Findings revealed a strong correlation between BR-NICO and TDCO, and their responsiveness to the administered solutions differed in time.

Study Design and Participants

  • The study was prospective, randomized and of a crossover design carried out at a university teaching hospital between September and November 2021.
  • Six adult horses owned by the university served as subjects for the experiment. The selection criteria or overall health of the horses was not specified.

Experimental Procedure

  • The horses were randomly assigned to receive either 7.2% hypertonic saline solution (HSS) or 6% hydroxyethyl starch (130/0.4) solution (HETA).
  • BR-NICO and TDCO measurements were taken simultaneously at various time intervals before and after starting a bolus infusion of the volume replacement solutions. The time intervals included baseline, 10, 20, 30, 40, 50, 60, 90, and 120 minutes. The solutions were administered within 10 minutes.

Results

  • The results demonstrated a strong correlation between BR-NICO and TDCO measurements (Pearson r = 0.93; P < 0.01).
  • Regression analysis revealed the relationship between TDCO and BR-NICO was defined by the equation: BR-NICO = 0.48 × TDCO + 0.6.
  • Further assessment using the Bland-Altman agreement showed a mean bias and lower/upper limits of agreement between the two methods were -0.62 and -5.3 to 3.9 L/min, respectively.
  • Lin’s concordance coefficient between the two methods was 0.894 (95% confidence interval: 0.825-1.097), implying strong agreement.
  • The impact of HSS on cardiac output (CO) was an increase at 10 and 20 minutes from baseline as recorded by both TDCO and BR-NICO.
  • On the other hand, HETA infusion led to a decrease in CO at 10 and 20 minutes but increased CO at 90 (TDCO only) and 120 minutes as recorded by TDCO and BR-NICO.

Conclusions

  • The study concluded that BR-NICO has strong agreement with TDCO in measuring CO in healthy, unsedated adult horses.
  • The administration of HSS markedly increased CO in the first 30 minutes post-administration; meanwhile, HETA initially decreased CO at 10 minutes but increased CO above baseline values by 90 minutes.

Cite This Article

APA
Long AE, Hurcombe S, Hopster K. (2024). Bioreactance noninvasive cardiac output monitoring in euvolemic adult horses subjected with 7.2% saline and 6% hydroxyethyl starch (130/0.4) solution infusions. J Vet Emerg Crit Care (San Antonio). https://doi.org/10.1111/vec.13418

Publication

Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001)
ISSN: 1476-4431
NlmUniqueID: 101152804
Country: United States
Language: English

Researcher Affiliations

Long, Alicia E
  • New Bolton Center, Department of Clinical Sciences, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Hurcombe, Samuel
  • New Bolton Center, Department of Clinical Sciences, University of Pennsylvania, Kennett Square, Pennsylvania, USA.
Hopster, Klaus
  • New Bolton Center, Department of Clinical Sciences, University of Pennsylvania, Kennett Square, Pennsylvania, USA.

Grant Funding

  • 015801 / Intramural funding of the Department of Clinical Studies at New Bolton Center, School of Veterinary Medicine, University of Pennsylvania

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