Blood Glucose and Insulin Concentrations after Octreotide Administration in Horses With Insulin Dysregulation.
Abstract: Octreotide is a somatostatin analog that suppresses insulin secretion. Objective: We hypothesized that octreotide would suppress insulin concentrations in horses and that normal (N) horses and those with insulin dysregulation (ID) would differ significantly in their plasma glucose and insulin responses to administration of octreotide. Methods: Twelve horses, N = 5, ID = 7. Methods: Prospective study. An oral sugar test was performed to assign horses to N and ID groups. Octreotide (1.0 μg/kg IV) was then administered, and blood was collected at 0, 5, 10, 15, 20, 25, 30, 45, 60, 75, and 90 minute, and 2, 3, 4, 6, 8, 12, and 24 hour for measurement of glucose and insulin concentrations. Area under the curve (AUC) values were calculated. Results: Mean AUC values for glucose and insulin did not differ between normal (n = 5) and ID (n = 7) groups after octreotide injection. Significant time (P < .001) effects were detected for glucose and insulin concentrations. A group × time interaction (P = .091) was detected for insulin concentrations after administration of octreotide, but the group (P = .33) effect was not significant. Conclusions: Octreotide suppresses insulin secretion, resulting in hyperglycemia, and then concentrations increase above baseline as glycemic control is restored. Our hypothesis that octreotide causes insulin concentrations to decrease in horses was supported, but differences between N and ID groups did not reach statistical significance when blood glucose and insulin responses were compared. The utility of an octreotide response test remains to be determined.
Copyright © 2017 The Authors. Journal of Veterinary Internal Medicine published by Wiley Periodicals, Inc. on behalf of the American College of Veterinary Internal Medicine.
Publication Date: 2017-05-15 PubMed ID: 28503791PubMed Central: PMC5508354DOI: 10.1111/jvim.14718Google Scholar: Lookup
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Summary
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The research article investigates the impact of the drug Octreotide, a suppressor of insulin secretion, on blood glucose and insulin concentrations in horses, particularly those that have insulin dysregulation. Both normal horses and those with insulin dysregulation were studied, with results indicating notable reductions in insulin levels, though the distinctions between the two groups did not reach statistical significance.
Methodology
- The study was prospective in nature and involved a total of twelve horses out of which, five were normal and seven had insulin dysregulation.
- An oral sugar test was conducted initially in order to categorize the horses into two groups: normal (N) and insulin dysregulated (ID).
- After that, Octreotide of dosage 1.0 μg/kg IV was administered to the horses with blood samples being collected at specific intervals ranging from immediately post administration up to 24 hours later for the measurement of glucose and insulin concentrations in the blood.
- To quantify the results, the researchers computed the area under the curve (AUC) values for each sample.
Key Findings
- The mean Area Under Curve (AUC) values for both glucose and insulin did not exhibit any significant variation between the normal (n = 5) and insulin dysregulated (n = 7) groups post-Octreotide injection.
- The data revealed significant time effects on both glucose and insulin concentrations.
- While a group x time interaction was identified for insulin concentrations post-Octreotide administration, the group effect itself was found insignificant. The interaction was not significant enough to show a meaningful difference in results between the normal horses and those with insulin dysregulation.
- Ultimately, the data supported the hypothesis that Octreotide reduces insulin concentrations in horses, causing a temporary hike in blood glucose (hyperglycemia) before rebounding above baseline as glycemic control is reinstated.
Conclusions
- The study concluded that Octreotide does indeed suppress insulin secretion, leading to a temporary phase of high blood glucose levels (hyperglycemia), before it increases above the baseline as control over glycemic level is regained.
- However, the differences between horses that were normal (N) and those with insulin dysregulation (ID) did not reach statistical significance when it came to their blood glucose and insulin responses after Octreotide treatment. It implies that the Octreotide impacts the horses in a similar way irrespective of their insulin regulation.
- The use of an Octreotide response test to determine insulin dysregulation in horses still requires further examination and validation.
Cite This Article
APA
Frank N, Hermida P, Sanchez-Londoño A, Singh R, Gradil CM, Uricchio CK.
(2017).
Blood Glucose and Insulin Concentrations after Octreotide Administration in Horses With Insulin Dysregulation.
J Vet Intern Med, 31(4), 1188-1192.
https://doi.org/10.1111/jvim.14718 Publication
Researcher Affiliations
- Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA.
- Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA.
- Department of Environmental and Population Health, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA.
- Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA.
- Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA.
- Stockbridge School of Agriculture, University of Massachusetts, Amherst, MA.
MeSH Terms
- Animals
- Blood Glucose / analysis
- Female
- Glucose Tolerance Test / veterinary
- Horse Diseases / blood
- Horse Diseases / drug therapy
- Horses / blood
- Hyperinsulinism / blood
- Hyperinsulinism / drug therapy
- Hyperinsulinism / veterinary
- Insulin / blood
- Insulin / metabolism
- Insulin Secretion
- Male
- Octreotide / therapeutic use
- Somatostatin / analogs & derivatives
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