Blood proteins and inflammation in the horse.
Abstract: Activation of the host response to infection, the "acute-phase response," is a highly organized physiologic reaction that includes changes in concentrations of plasma acute-phase proteins (APPs). The APPs are increasingly being used as markers for prognosis and monitoring response to therapy along with general determinants of equine health. Use of APPs in veterinary medicine is becoming more widespread as more commercial diagnostic kits are being validated. This article reviews the salient features of APPs and examines their current application and potential utility in equine inflammatory disorders.
Publication Date: 2008-07-26 PubMed ID: 18652956DOI: 10.1016/j.cveq.2008.03.004Google Scholar: Lookup
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Summary
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The research article discusses the use of acute-phase proteins (APPs) as indicators of infection and inflammation in horses, and the increasing prevalence of APPs in veterinary medicine.
What is the Acute-Phase Response?
- The acute-phase response is a bodily reaction to infection, involving various physiological changes including alterations in the concentration of plasma acute-phase proteins (APPs).
- It’s a highly organized physiological reaction that serves as the body’s defensive mechanism against infection or injury.
Significance of Acute-Phase Proteins (APPs)
- The main focus of the paper is on APPs which are a group of proteins that show significant changes in their plasma concentrations in response to inflammation or infection.
- The production of APPs is typically triggered by the release of certain chemicals during inflammation or when the body is under stress.
- These proteins play a pivotal role in the body’s response to inflammation, helping to restore homeostasis and stimulate recovery.
APPs in Veterinary Medicine
- The utilization of APPs in veterinary medicine is expanding as more diagnostic kits are being validated and commercialized.
- In horses, APPs are used to monitor the response to therapy, as well as the overall health of the animal.
- They can serve as reliable markers of disease or injury, aiding diagnosis, prognosis and management.
Usefulness of APPs in Equine Inflammatory Disorders
- The research explores the current application of APPs in equine disorders and suggests potential future uses.
- Monitoring APP levels in horses can indicate the presence or progress of inflammatory disorders, enabling timely and effective treatment strategies.
- Research into APPs may offer insights into their potential role as therapeutic targets, improving treatment and management of inflammatory disorders in horses.
Cite This Article
APA
Crisman MV, Scarratt WK, Zimmerman KL.
(2008).
Blood proteins and inflammation in the horse.
Vet Clin North Am Equine Pract, 24(2), 285-vi.
https://doi.org/10.1016/j.cveq.2008.03.004 Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, Virginia Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg, VA 24061, USA. farmuse@vt.edu
MeSH Terms
- Acute-Phase Proteins / analysis
- Acute-Phase Reaction / blood
- Acute-Phase Reaction / veterinary
- Animals
- Biomarkers / blood
- Blood Proteins / analysis
- Horse Diseases / blood
- Horses
- Inflammation / blood
- Inflammation / veterinary
- Prognosis
Citations
This article has been cited 26 times.- Bollinger L, Bartel A, Weber C, Gehlen H. Pre-Ride Biomarkers and Endurance Horse Welfare: Analyzing the Impact of the Elimination of Superoxide Dismutase, δ-Aminolevulinic-Dehydratase, Thiobarbituric Acid Reactive Substances, Iron, and Serum Amyloid A Levels in Elite 160 km Endurance Rides.. Animals (Basel) 2023 May 17;13(10).
- Grzędzicka J, Dąbrowska I, Malin K, Witkowska-Piłaszewicz O. Exercise-related changes in the anabolic index (testosterone to cortisol ratio) and serum amyloid A concentration in endurance and racehorses at different fitness levels.. Front Vet Sci 2023;10:1148990.
- Blangy-Letheule A, Vergnaud A, Dupas T, Rozec B, Lauzier B, Leroux AA. Spontaneous Sepsis in Adult Horses: From Veterinary to Human Medicine Perspectives.. Cells 2023 Mar 30;12(7).
- Ludwig EK, Hobbs KJ, McKinney-Aguirre CA, Gonzalez LM. Biomarkers of Intestinal Injury in Colic.. Animals (Basel) 2023 Jan 7;13(2).
- Mihelić K, Vrbanac Z, Bojanić K, Kostanjšak T, Ljubić BB, Gotić J, Vnuk D, Bottegaro NB. Changes in Acute Phase Response Biomarkers in Racing Endurance Horses.. Animals (Basel) 2022 Oct 31;12(21).
- Thurston CC, Stefanovski D, MacKinnon MC, Chapman HS, Richardson DW, Levine DG. Serum amyloid A and fibrinogen as markers for early detection of surgical site infection associated with internal fixation in the horse.. Front Vet Sci 2022;9:960865.
- Przewoźny M, Senderska-Płonowska M, Rząsa A, Wierzbicki H, Borkowski J, Swagemakers JH, Żak-Bochenek A, Stefaniak T. Usefulness of Selected Acute-Phase Proteins in the Postsurgical Monitoring of Arthroscopy and Splint Bone Removal in Horses.. Animals (Basel) 2021 Oct 13;11(10).
- Valigura HC, Leatherwood JL, Martinez RE, Norton SA, White-Springer SH. Dietary supplementation of a Saccharomyces cerevisiae fermentation product attenuates exercise-induced stress markers in young horses.. J Anim Sci 2021 Aug 1;99(8).
- Serra Aguado CI, Ramos-Plá JJ, Soler C, Segarra S, Moratalla V, Redondo JI. Effects of Oral Hyaluronic Acid Administration in Dogs Following Tibial Tuberosity Advancement Surgery for Cranial Cruciate Ligament Injury.. Animals (Basel) 2021 Apr 27;11(5).
- Perez-Ecija A, Buzon-Cuevas A, Aguilera-Aguilera R, Gonzalez-De Cara C, Mendoza Garcia FJ. Reference intervals of acute phase proteins in healthy Andalusian donkeys and response to experimentally induced endotoxemia.. J Vet Intern Med 2021 Jan;35(1):580-589.
- Aslam MW, Lau SF, Chin CSL, Ahmad NI, Rahman NA, Kuppusamy K, Omar S, Radzi R. Clinicopathological and radiographic features in 40 cats diagnosed with pulmonary and cutaneous Rhodococcus equi infection (2012-2018).. J Feline Med Surg 2020 Aug;22(8):774-790.
- Long A, Nolen-Walston R. Equine Inflammatory Markers in the Twenty-First Century: A Focus on Serum Amyloid A.. Vet Clin North Am Equine Pract 2020 Apr;36(1):147-160.
- Starzonek J, Roscher K, Blüher M, Blaue D, Schedlbauer C, Hirz M, Raila J, Vervuert I. Effects of a blend of green tea and curcuma extract supplementation on lipopolysaccharide-induced inflammation in horses and ponies.. PeerJ 2019;7:e8053.
- Assunção P, Barbosa T, Yonezawa L, Barbosa L, Watanabe M, Kohayagawa A, Schmidt E. Acute-phase protein profile in horses subjected to different exercise protocols.. Can J Vet Res 2019 Oct;83(4):272-278.
- Battaglia B, Angelone M, Vera E, Basini G, Bussolati S, Paci M, Bue MD, Aldigeri R, Grolli S, Quintavalla F, Ramoni R. Clinical Effects of the Extract of the Seeds of the Indian Celery-Apium Graveolens-In Horses Affected by Chronic Osteoarthritis.. Animals (Basel) 2019 Aug 20;9(8).
- Fernandez NJ, Roy MF. Do plasma protein:fibrinogen ratios in horses provide additional information compared with fibrinogen concentration alone?. Can Vet J 2019 Jun;60(6):625-629.
- Hooijberg EH, Miller M, Cray C, Buss P, Steenkamp G, Goddard A. Serum protein electrophoresis in healthy and injured southern white rhinoceros (Ceratotherium simum simum).. PLoS One 2018;13(7):e0200347.
- Junkkari R, Simojoki H, Heiskanen ML, Pelkonen S, Sankari S, Tulamo RM, Mykkänen A. A comparison of unheated loose housing with stables on the respiratory health of weaned-foals in cold winter conditions: an observational field-study.. Acta Vet Scand 2017 Oct 26;59(1):73.
- Sikora M, Król J, Nowak M, Stefaniak T, Aubertsson G, Kozdrowski R. The usefulness of uterine lavage and acute phase protein levels as a diagnostic tool for subclinical endometritis in Icelandic mares.. Acta Vet Scand 2016 Sep 7;58(1):50.
- Giguère S, Berghaus LJ, Miller CD. Clinical Assessment of a Point-of-Care Serum Amyloid A Assay in Foals with Bronchopneumonia.. J Vet Intern Med 2016 Jul;30(4):1338-43.
- Bauquier JR, Forbes G, Nath L, Tudor E, Bailey SR. Plasma HMGB-1 and Nucleosome Concentrations in Horses with Colic and Healthy Horses.. J Vet Intern Med 2016 Jan-Feb;30(1):260-8.
- Woodman J, Wagg CR, Boysen SR, Leguillette R, Mizen K, Roy MF. Evaluation of coagulation via thromboelastography in healthy horses administered dexamethasone.. Can Vet J 2015 Dec;56(12):1271-4.
- Leclere M, Lavoie-Lamoureux A, Lavoie JP. Acute phase proteins in racehorses with inflammatory airway disease.. J Vet Intern Med 2015 May-Jun;29(3):940-5.
- Hooijberg EH, van den Hoven R, Tichy A, Schwendenwein I. Diagnostic and predictive capability of routine laboratory tests for the diagnosis and staging of equine inflammatory disease.. J Vet Intern Med 2014 Sep-Oct;28(5):1587-93.
- Cywinska A, Witkowski L, Szarska E, Schollenberger A, Winnicka A. Serum amyloid A (SAA) concentration after training sessions in Arabian race and endurance horses.. BMC Vet Res 2013 May 1;9:91.
- Heegaard PM, Stockmarr A, Piñeiro M, Carpintero R, Lampreave F, Campbell FM, Eckersall PD, Toussaint MJ, Gruys E, Sorensen NS. Optimal combinations of acute phase proteins for detecting infectious disease in pigs.. Vet Res 2011 Mar 17;42(1):50.
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