Analyze Diet
Medical hypotheses2012; 80(1); 103; doi: 10.1016/j.mehy.2012.10.010

Blue-green algae or cyanobacteria in the intestinal micro-flora may produce neurotoxins such as Beta-N-Methylamino-L-Alanine (BMAA) which may be related to development of amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson-Dementia-Complex in humans and Equine Motor Neuron Disease in horses.

Abstract: No abstract available
Publication Date: 2012-11-10 PubMed ID: 23146671DOI: 10.1016/j.mehy.2012.10.010Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
  • Letter

Cite This Article

APA
Brenner SR. (2012). Blue-green algae or cyanobacteria in the intestinal micro-flora may produce neurotoxins such as Beta-N-Methylamino-L-Alanine (BMAA) which may be related to development of amyotrophic lateral sclerosis, Alzheimer’s disease and Parkinson-Dementia-Complex in humans and Equine Motor Neuron Disease in horses. Med Hypotheses, 80(1), 103. https://doi.org/10.1016/j.mehy.2012.10.010

Publication

ISSN: 1532-2777
NlmUniqueID: 7505668
Country: United States
Language: English
Volume: 80
Issue: 1
Pages: 103
PII: S0306-9877(12)00461-6

Researcher Affiliations

Brenner, Steven R

    MeSH Terms

    • Alzheimer Disease / chemically induced
    • Amino Acids, Diamino / analysis
    • Amino Acids, Diamino / toxicity
    • Amyotrophic Lateral Sclerosis / chemically induced
    • Animals
    • Cyanobacteria / chemistry
    • Cyanobacteria Toxins
    • Horse Diseases / chemically induced
    • Horses
    • Humans
    • Metagenome
    • Models, Biological
    • Motor Neuron Disease / chemically induced
    • Motor Neuron Disease / veterinary
    • Neurotoxins / analysis
    • Neurotoxins / toxicity
    • Parkinson Disease
    • Supranuclear Palsy, Progressive / chemically induced

    Citations

    This article has been cited 37 times.
    1. Arumugam R, Ravichandran P, Yeap SK, Sharma RSK, Zulkifly SB, Yawah D, Annavi G. Application of High-Throughput Sequencing (HTS) to Enhance the Well-Being of an Endangered Species (Malayan Tapir): Characterization of Gut Microbiome Using MG-RAST.. Methods Mol Biol 2023;2649:175-194.
      doi: 10.1007/978-1-0716-3072-3_8pubmed: 37258862google scholar: lookup
    2. Riederer P, Nagatsu T, Youdim MBH, Wulf M, Dijkstra JM, Sian-Huelsmann J. Lewy bodies, iron, inflammation and neuromelanin: pathological aspects underlying Parkinson's disease.. J Neural Transm (Vienna) 2023 May;130(5):627-646.
      doi: 10.1007/s00702-023-02630-9pubmed: 37062012google scholar: lookup
    3. Ma X, Li J, Yang L, Liu H, Zhu Y, Ren H, Yu F, Liu B. Short Term Effect of Ivermectin on the Bacterial Microbiota from Fecal Samples in Chinchillas (Chinchilla lanigera).. Vet Sci 2023 Feb 20;10(2).
      doi: 10.3390/vetsci10020169pubmed: 36851473google scholar: lookup
    4. Silva DF, Empadinhas N, Cardoso SM, Esteves AR. Neurodegenerative Microbially-Shaped Diseases: Oxidative Stress Meets Neuroinflammation.. Antioxidants (Basel) 2022 Oct 28;11(11).
      doi: 10.3390/antiox11112141pubmed: 36358513google scholar: lookup
    5. Clark A, Zelmanovich R, Hosseini Siyanaki MR, Michel M, Hanna C, Davidson C, Lucke-Wold B. Microbiome and Neurotrauma: Emerging Innovations.. Neurol Neurother Open Access J 2022;7(2).
      pubmed: 36035066
    6. Koksharova OA, Safronova NA. Non-Proteinogenic Amino Acid β-N-Methylamino-L-Alanine (BMAA): Bioactivity and Ecological Significance.. Toxins (Basel) 2022 Aug 7;14(8).
      doi: 10.3390/toxins14080539pubmed: 36006201google scholar: lookup
    7. Winiarska-Mieczan A, Tomaszewska E, Donaldson J, Jachimowicz K. The Role of Nutritional Factors in the Modulation of the Composition of the Gut Microbiota in People with Autoimmune Diabetes.. Nutrients 2022 Jun 16;14(12).
      doi: 10.3390/nᐒ2498pubmed: 35745227google scholar: lookup
    8. Hu C, Rzymski P. Non-Photosynthetic Melainabacteria (Cyanobacteria) in Human Gut: Characteristics and Association with Health.. Life (Basel) 2022 Mar 25;12(4).
      doi: 10.3390/life12040476pubmed: 35454968google scholar: lookup
    9. Khatri DK, Kadbhane A, Patel M, Nene S, Atmakuri S, Srivastava S, Singh SB. Gauging the role and impact of drug interactions and repurposing in neurodegenerative disorders.. Curr Res Pharmacol Drug Discov 2021;2:100022.
      doi: 10.1016/j.crphar.2021.100022pubmed: 34909657google scholar: lookup
    10. Stopińska K, Radziwoń-Zaleska M, Domitrz I. The Microbiota-Gut-Brain Axis as a Key to Neuropsychiatric Disorders: A Mini Review.. J Clin Med 2021 Oct 10;10(20).
      doi: 10.3390/jcm10204640pubmed: 34682763google scholar: lookup
    11. Sini P, Dang TBC, Fais M, Galioto M, Padedda BM, Lugliè A, Iaccarino C, Crosio C. Cyanobacteria, Cyanotoxins, and Neurodegenerative Diseases: Dangerous Liaisons.. Int J Mol Sci 2021 Aug 13;22(16).
      doi: 10.3390/ijms22168726pubmed: 34445429google scholar: lookup
    12. Sharma C, Kim SR. Linking Oxidative Stress and Proteinopathy in Alzheimer's Disease.. Antioxidants (Basel) 2021 Jul 30;10(8).
      doi: 10.3390/antiox10081231pubmed: 34439479google scholar: lookup
    13. Angiolillo A, Gandaglia A, Arcaro A, Carpi A, Gentile F, Naso F, Di Costanzo A. Altered Blood Levels of Anti-Gal Antibodies in Alzheimer's Disease: A New Clue to Pathogenesis?. Life (Basel) 2021 Jun 9;11(6).
      doi: 10.3390/life11060538pubmed: 34207559google scholar: lookup
    14. Hou M, Xu G, Ran M, Luo W, Wang H. APOE-ε4 Carrier Status and Gut Microbiota Dysbiosis in Patients With Alzheimer Disease.. Front Neurosci 2021;15:619051.
      doi: 10.3389/fnins.2021.619051pubmed: 33732104google scholar: lookup
    15. Zhang W, Sun Z, Zhang Q, Sun Z, Su Y, Song J, Wang B, Gao R. Preliminary evidence for an influence of exposure to polycyclic aromatic hydrocarbons on the composition of the gut microbiota and neurodevelopment in three-year-old healthy children.. BMC Pediatr 2021 Feb 17;21(1):86.
      doi: 10.1186/s12887-021-02539-wpubmed: 33596845google scholar: lookup
    16. Wang YN, Sun MS, Ni XX, Tian T, Liu L, Li X, Xu T, Zhou SY, Chen J, Liang FR, Liu JX, Zhao L. Comparison of Effects and Brain-Gut Regulatory Mechanisms of Acupuncture and Flunarizine for Migraine: Study Protocol for a Randomized Controlled Trial.. Evid Based Complement Alternat Med 2021;2021:5676718.
      doi: 10.1155/2021/5676718pubmed: 33505495google scholar: lookup
    17. Kosolapova AO, Antonets KS, Belousov MV, Nizhnikov AA. Biological Functions of Prokaryotic Amyloids in Interspecies Interactions: Facts and Assumptions.. Int J Mol Sci 2020 Sep 30;21(19).
      doi: 10.3390/ijms21197240pubmed: 33008049google scholar: lookup
    18. Vascellari S, Palmas V, Melis M, Pisanu S, Cusano R, Uva P, Perra D, Madau V, Sarchioto M, Oppo V, Simola N, Morelli M, Santoru ML, Atzori L, Melis M, Cossu G, Manzin A. Gut Microbiota and Metabolome Alterations Associated with Parkinson's Disease.. mSystems 2020 Sep 15;5(5).
      doi: 10.1128/mSystems.00561-20pubmed: 32934117google scholar: lookup
    19. Téglás T, Ábrahám D, Jókai M, Kondo S, Mohammadi R, Fehér J, Szabó D, Wilhelm M, Radák Z. Exercise combined with a probiotics treatment alters the microbiome, but moderately affects signalling pathways in the liver of male APP/PS1 transgenic mice.. Biogerontology 2020 Dec;21(6):807-815.
      doi: 10.1007/s10522-020-09895-7pubmed: 32812166google scholar: lookup
    20. Ceppa FA, Izzo L, Sardelli L, Raimondi I, Tunesi M, Albani D, Giordano C. Human Gut-Microbiota Interaction in Neurodegenerative Disorders and Current Engineered Tools for Its Modeling.. Front Cell Infect Microbiol 2020;10:297.
      doi: 10.3389/fcimb.2020.00297pubmed: 32733812google scholar: lookup
    21. Guo T, Zhang D, Zeng Y, Huang TY, Xu H, Zhao Y. Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer's disease.. Mol Neurodegener 2020 Jul 16;15(1):40.
      doi: 10.1186/s13024-020-00391-7pubmed: 32677986google scholar: lookup
    22. Nunes-Costa D, Magalhães JD, G-Fernandes M, Cardoso SM, Empadinhas N. Microbial BMAA and the Pathway for Parkinson's Disease Neurodegeneration.. Front Aging Neurosci 2020;12:26.
      doi: 10.3389/fnagi.2020.00026pubmed: 32317956google scholar: lookup
    23. Raimondi I, Izzo L, Tunesi M, Comar M, Albani D, Giordano C. Organ-On-A-Chip in vitro Models of the Brain and the Blood-Brain Barrier and Their Value to Study the Microbiota-Gut-Brain Axis in Neurodegeneration.. Front Bioeng Biotechnol 2019;7:435.
      doi: 10.3389/fbioe.2019.00435pubmed: 31998702google scholar: lookup
    24. Fox M, Knorr DA, Haptonstall KM. Alzheimer's disease and symbiotic microbiota: an evolutionary medicine perspective.. Ann N Y Acad Sci 2019 Aug;1449(1):3-24.
      doi: 10.1111/nyas.14129pubmed: 31180143google scholar: lookup
    25. Lin SY, Lin CL, Wang IK, Lin CC, Lin CH, Hsu WH, Kao CH. Dementia and vagotomy in Taiwan: a population-based cohort study.. BMJ Open 2018 Mar 30;8(3):e019582.
      doi: 10.1136/bmjopen-2017-019582pubmed: 29602843google scholar: lookup
    26. Nair AT, Ramachandran V, Joghee NM, Antony S, Ramalingam G. Gut Microbiota Dysfunction as Reliable Non-invasive Early Diagnostic Biomarkers in the Pathophysiology of Parkinson's Disease: A Critical Review.. J Neurogastroenterol Motil 2018 Jan 30;24(1):30-42.
      doi: 10.5056/jnm17105pubmed: 29291606google scholar: lookup
    27. Clouston SAP, Shapira O, Kotov R, Lei L, Waszczuk M, Bromet EJ, Luft BJ. Proton pump inhibitors and the risk of severe cognitive impairment: The role of posttraumatic stress disorder.. Alzheimers Dement (N Y) 2017 Nov;3(4):579-583.
      doi: 10.1016/j.trci.2017.08.007pubmed: 29124117google scholar: lookup
    28. Parashar A, Udayabanu M. Gut microbiota: Implications in Parkinson's disease.. Parkinsonism Relat Disord 2017 May;38:1-7.
    29. Li CQ, Zheng Q, Wang Q, Zeng QP. Biotic/Abiotic Stress-Driven Alzheimer's Disease.. Front Cell Neurosci 2016;10:269.
      doi: 10.3389/fncel.2016.00269pubmed: 27932953google scholar: lookup
    30. Alkasir R, Li J, Li X, Jin M, Zhu B. Human gut microbiota: the links with dementia development.. Protein Cell 2017 Feb;8(2):90-102.
      doi: 10.1007/s13238-016-0338-6pubmed: 27866330google scholar: lookup
    31. Ghaisas S, Maher J, Kanthasamy A. Gut microbiome in health and disease: Linking the microbiome-gut-brain axis and environmental factors in the pathogenesis of systemic and neurodegenerative diseases.. Pharmacol Ther 2016 Feb;158:52-62.
    32. McGorum BC, Pirie RS, Glendinning L, McLachlan G, Metcalf JS, Banack SA, Cox PA, Codd GA. Grazing livestock are exposed to terrestrial cyanobacteria.. Vet Res 2015 Feb 25;46:16.
      doi: 10.1186/s13567-015-0143-xpubmed: 25828258google scholar: lookup
    33. Moneim AE. Oxidant/Antioxidant imbalance and the risk of Alzheimer's disease.. Curr Alzheimer Res 2015;12(4):335-49.
    34. Hill JM, Clement C, Pogue AI, Bhattacharjee S, Zhao Y, Lukiw WJ. Pathogenic microbes, the microbiome, and Alzheimer's disease (AD).. Front Aging Neurosci 2014;6:127.
      doi: 10.3389/fnagi.2014.00127pubmed: 24982633google scholar: lookup
    35. Tillisch K. The effects of gut microbiota on CNS function in humans.. Gut Microbes 2014 May-Jun;5(3):404-10.
      doi: 10.4161/gmic.29232pubmed: 24838095google scholar: lookup
    36. Hill JM, Bhattacharjee S, Pogue AI, Lukiw WJ. The gastrointestinal tract microbiome and potential link to Alzheimer's disease.. Front Neurol 2014;5:43.
      doi: 10.3389/fneur.2014.00043pubmed: 24772103google scholar: lookup
    37. Bhattacharjee S, Lukiw WJ. Alzheimer's disease and the microbiome.. Front Cell Neurosci 2013;7:153.
      doi: 10.3389/fncel.2013.00153pubmed: 24062644google scholar: lookup