Borna disease virus antibody and RNA from peripheral blood mononuclear cells of race horses and jockeys in Korea.
Abstract: During the last two decades, Borna disease virus (BDV) has received much attention as a possible zoonotic agent, particularly as a cause of psychiatric disease. Although several studies have shown that BDV is present in Asia, BDV has not been detected in Korea. This study was designed to further investigate the presence of BDV infection in Korea. Methods: Blood samples were taken from 39 race horses and 48 jockeys. Antibody to BDV was detected by indirect immunofluorescence antibody test and RNA of BDV by real time reverse transcriptase PCR (rRT-PCR). Results: No evidence of BDV was detected in either the horses or the jockeys group. Conclusions: Our results suggest that BDV infection may not be endemic in Korea. Further studies with novel diagnostic tools are required to clarify the prevalence of BDV infection in Korea.
Publication Date: 2010-11-27 PubMed ID: 21519538PubMed Central: PMC3079187DOI: 10.4306/pi.2011.8.1.58Google Scholar: Lookup
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Summary
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The research study investigates the presence of Borna disease virus (BDV) in race horses and jockeys in Korea and concludes there’s no evidence that BDV infection is prevalent in this region.
Research Background
- The study focuses on Borna disease virus (BDV), which over the last two decades has raised interest as a potential zoonotic agent – a disease transmissible from animals to humans. The virus is specifically being investigated for its potential as a cause of psychiatric disease.
- BDV has been detected in several parts of Asia, however, there were no recorded instances of it being found in Korea before this study. Hence, the researchers aimed to investigate the presence of the virus in Korea.
Research Methodology
- The researchers took blood samples from 39 race horses and 48 jockeys for the study.
- The investigation for signs of BDV infection took two forms: one, to detect BDV antibodies through an indirect immunofluorescence antibody test and second, to look for BDV RNA using a real-time reverse transcriptase PCR (rRT-PCR).
- These two methods are used to detect the presence of the virus in the sample. The detection of BDV RNA would indicate an active infection, while the presence of the antibody would indicate a previous or ongoing immune response to the virus.
Research Findings
- After conducting the tests on the samples, the researchers found no evidence of BDV in either the race horses or the jockeys’ group.
Research Conclusion and Further Study
- The study concluded that there might be no endemic BDV infection in Korea based on the conducted tests and findings.
- However, the researchers suggest further investigation using novel diagnostic tools to provide more clarity on the prevalence of BDV infection in Korea, expressing the need for continued monitoring and research in the area.
Cite This Article
APA
Song JW, Na KS, Tae SH, Kim YK.
(2010).
Borna disease virus antibody and RNA from peripheral blood mononuclear cells of race horses and jockeys in Korea.
Psychiatry Investig, 8(1), 58-60.
https://doi.org/10.4306/pi.2011.8.1.58 Publication
Researcher Affiliations
- Department of Microbiology, College of Medicine, Korea University, Seoul, Korea.
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