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The Veterinary clinics of North America. Equine practice1997; 13(1); 107-128; doi: 10.1016/s0749-0739(17)30259-6

Botulism.

Abstract: Equine botulism is being recognized with increasing frequency by veterinarians throughout North America. Muscular weakness and dysphagia that progress during a period of 1 to 4 days, in the absence of laboratory derangements that indicate the presence of systemic disease, are suggestive of botulism. A tentative diagnosis usually is based on the presence of the following findings on physical examination: delayed pupillary light response, mydriasis, ptosis, generalized weakness, decreased tail tone, and slow prehension of feed. Definitive diagnosis requires detection of botulinum toxin in plasma, serum, gastrointestinal contents, or body tissues. Early treatment with antitoxin generally results in a favorable outcome. Botulism in foals and adult horses can be prevented by vaccination.
Publication Date: 1997-04-01 PubMed ID: 9106347DOI: 10.1016/s0749-0739(17)30259-6Google Scholar: Lookup
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Summary

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This research article examines equine botulism, its increased recognition among North American veterinarians, and the physical symptoms to look for. The article also discusses the necessity for early diagnosis and treatment, along with a potential preventive measure through vaccination.

Symptoms and Diagnosis of Equine Botulism

  • The symptoms of equine botulism typically develop over a one- to four-day period.
  • These symptoms may include muscular weakness and difficulty swallowing.
  • These symptoms are often notable in the absence of lab results that would indicate a broader systemic disease.
  • A tentatively diagnosis is often based on a physical examination of the horse. Indicators could be a delayed response to light in the pupils, a condition known as mydriasis (excessive dilation of the pupil), drooping of the eyelids (ptosis), generalized weakness, decreased tail tone, and slow prehension (grasping) of feed.

Definitive Diagnosis and Treatment

  • A definitive diagnosis can be made by detecting botulinum toxin in the horse’s plasma, serum, contents of the gastrointestinal tract, or body tissues.
  • The article proposes that early treatment of equine botulism with an antitoxin generally yields favorable outcomes.

Prevention of Equine Botulism

  • Botulism can be prevented in both foals and adult horses through vaccination, highlighting the importance of preventive health practices in equine care.

Cite This Article

APA
Whitlock RH, Buckley C. (1997). Botulism. Vet Clin North Am Equine Pract, 13(1), 107-128. https://doi.org/10.1016/s0749-0739(17)30259-6

Publication

ISSN: 0749-0739
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 13
Issue: 1
Pages: 107-128

Researcher Affiliations

Whitlock, R H
  • Department of Clinical Studies, New Bolton Center, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, USA.
Buckley, C

    MeSH Terms

    • Animals
    • Anti-Bacterial Agents / therapeutic use
    • Antitoxins / therapeutic use
    • Bacterial Vaccines
    • Botulinum Toxins / blood
    • Botulism / etiology
    • Botulism / physiopathology
    • Botulism / veterinary
    • Clostridium botulinum / immunology
    • Clostridium botulinum / isolation & purification
    • Diagnosis, Differential
    • Horse Diseases / etiology
    • Horse Diseases / physiopathology
    • Horse Diseases / therapy
    • Horses
    • Prognosis

    Citations

    This article has been cited 5 times.
    1. Turin L, Piccione MM, Crosa F, Dall'Ara P, Filipe J, Zarucco L. Therapeutic Applications of Botulinum Neurotoxins in Veterinary Medicine. Vet Sci 2023 Jul 13;10(7).
      doi: 10.3390/vetsci10070460pubmed: 37505863google scholar: lookup
    2. Bischoff K, Moiseff J. Equine feed contamination and toxicology. Transl Anim Sci 2018 Feb;2(1):111-118.
      doi: 10.1093/tas/txy001pubmed: 32704694google scholar: lookup
    3. Rasetti-Escargueil C, Lemichez E, Popoff MR. Public Health Risk Associated with Botulism as Foodborne Zoonoses. Toxins (Basel) 2019 Dec 30;12(1).
      doi: 10.3390/toxins12010017pubmed: 31905908google scholar: lookup
    4. Lanci A, Rinnovati R, Anniballi F, Auricchio B, Scalfaro C, Menchetti M, Spadari A, Mariella J. The First Case of Botulism in a Donkey. Vet Sci 2019 May 15;6(2).
      doi: 10.3390/vetsci6020043pubmed: 31096593google scholar: lookup
    5. Slavik K, Whitlock R, Johnson A. Equine botulism. Equine Vet J 2026 Mar;58(2):333-347.
      doi: 10.1111/evj.14542pubmed: 40518698google scholar: lookup