Carbon dioxide laser photoablation adjunctive therapy following superficial lamellar keratectomy and bulbar conjunctivectomy for the treatment of corneolimbal squamous cell carcinoma in horses: a review of 24 cases.
Abstract: To determine the complications and nonrecurrence rates following superficial lamellar keratectomy, bulbar conjunctivectomy, and adjunctive carbon dioxide (CO(2)) photoablation for corneolimbal squamous cell carcinoma (SCC) in the horse. Methods: Retrospective study. Sample population Twenty-four horses with corneolimbal SCC. Methods: Medical records of horses diagnosed with corneolimbal SCC that was surgically excised and where CO(2) photoablation was used as an adjunctive therapy from 2000 to 2007 were reviewed. Signalment, prior therapy, tumor location and size, complications, and recurrence of SCC were recorded. Results: The Thoroughbred was the most commonly (25%) represented breed. Lesions were >10 mm in diameter in 70.8% of cases. Eight horses (33.3%) had neoplastic cells extending to the deep margin of the keratectomy. All horses were available for follow-up for an average ± standard deviation of 40.7 ± 25 months. Four horses (16.7%) developed a recurrence of SCC. Three of these four horses underwent repeat keratectomy and CO(2) photoablation, one each, at 4 months, 1, and 2 years following the initial procedure. One horse underwent enucleation 8 months following the initial procedure. Conclusions: As an adjunctive therapy, CO(2) photoablation was successful in 87.5% of the horses following a single procedure and in a total of 91.7% following a second therapeutic application. CO(2) photoablation appears to be effective as an adjunctive therapy following removal of large corneolimbal SCC in the horse and in cases in which all tumor cells were not excised.
© 2011 American College of Veterinary Ophthalmologists.
Publication Date: 2011-12-13 PubMed ID: 22151134DOI: 10.1111/j.1463-5224.2011.00977.xGoogle Scholar: Lookup
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- Journal Article
- Cancer
- Case Reports
- Clinical Findings
- Clinical Pathology
- Clinical Study
- Complications
- Diagnosis
- Disease
- Disease Diagnosis
- Disease Management
- Disease Treatment
- Equine Health
- Horses
- Retrospective Study
- Squamous Cell Carcinoma
- Surgery
- Thoroughbreds
- Veterinary Care
- Veterinary Medicine
- Veterinary Practice
- Veterinary Procedure
Summary
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The research paper evaluates the efficacy of using carbon dioxide (CO2) photoablation as additional treatment following superficial lamellar keratectomy and bulbar conjunctivectomy for corneolimbal squamous cell carcinoma (a type of cancer) in horses. It was found that CO2 photoablation proved successful in treating a significant number of cases.
Methodology of the Study
- The study is based on retrospective analysis, which means that researchers reviewed health records of horses from 2000 to 2007. The horses had been diagnosed with corneolimbal SCC and treated surgically. The procedure included excision of the cancerous mass and the use of CO2 photoablation as additional therapy.
- Various factors were recorded for each case. Those include the horse’s breed and previous treatments, the tumor’s location and size, any complications that occurred, and whether or not the SCC recurred.
Findings from the Study
- A significant percentage of the 24 studied cases (70.8%) had lesions greater than 10mm in diameter, meaning that the tumors were quite large.
- In 33.3% of the horses, tumor cells had spread to the deep margin of the keratectomy, a procedure that involves removing layers of the cornea.
- The horses were available for monitoring post-treatment for an average of 41 months. Recurrence of SCC was observed in only four cases, representing 16.7% of the studied cases.
- Out of the four cases where recurrence occurred, three underwent another round of keratectomy and CO2 photoablation, with recurrence times of 4 months, 1 year, and 2 years after the initial procedure. The fourth horse underwent enucleation, which means removing the eye, 8 months post-approach.
Conclusions of the Study
- CO2 photoablation as additional therapy after surgical removal of corneolimbal SCC proved successful in a majority of cases (87.5%) after a single procedure. This rate of success increased to 91.7% following a second treatment.
- The article suggests that CO2 photoablation is an effective supplementary treatment following the removal of large corneolimbal SCC, even in cases where all tumor cells were not initially excised.
Cite This Article
APA
Michau TM, Davidson MG, Gilger BC.
(2011).
Carbon dioxide laser photoablation adjunctive therapy following superficial lamellar keratectomy and bulbar conjunctivectomy for the treatment of corneolimbal squamous cell carcinoma in horses: a review of 24 cases.
Vet Ophthalmol, 15(4), 245-253.
https://doi.org/10.1111/j.1463-5224.2011.00977.x Publication
Researcher Affiliations
- Blue Pearl Veterinary Partners, 3000 Busch Lake Blvd, Tampa, FL 33624, USA. tmmichau@gmail.com
MeSH Terms
- Animals
- Carcinoma, Squamous Cell / surgery
- Carcinoma, Squamous Cell / veterinary
- Corneal Surgery, Laser / veterinary
- Eye Neoplasms / surgery
- Eye Neoplasms / veterinary
- Female
- Horse Diseases / surgery
- Horses
- Lasers, Gas / therapeutic use
- Male
- Ophthalmologic Surgical Procedures / methods
- Ophthalmologic Surgical Procedures / veterinary
- Retrospective Studies
Citations
This article has been cited 4 times.- Horvath S, Haghani A, Peng S, Hales EN, Zoller JA, Raj K, Larison B, Robeck TR, Petersen JL, Bellone RR, Finno CJ. DNA methylation aging and transcriptomic studies in horses.. Nat Commun 2022 Jan 10;13(1):40.
- Crausaz M, Launois T, Smith-Fleming K, McCoy AM, Knickelbein KE, Bellone RR. DDB2 Genetic Risk Factor for Ocular Squamous Cell Carcinoma Identified in Three Additional Horse Breeds.. Genes (Basel) 2020 Dec 5;11(12).
- Moshafi MH, Ranjbar M, Ilbeigi G. Eco-Friendly and Systematic Study for Synthesis of La(3+)/α-Al(2)O(3) Nanoparticles: Antibacterial Activity Against Pathogenic Microbial Strains.. Int J Nanomedicine 2019;14:10137-10146.
- Singer-Berk MH, Knickelbein KE, Lounsberry ZT, Crausaz M, Vig S, Joshi N, Britton M, Settles ML, Reilly CM, Bentley E, Nunnery C, Dwyer A, Lassaline ME, Bellone RR. Additional Evidence for DDB2 T338M as a Genetic Risk Factor for Ocular Squamous Cell Carcinoma in Horses.. Int J Genomics 2019;2019:3610965.
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