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Frontiers in veterinary science2022; 9; 1007345; doi: 10.3389/fvets.2022.1007345

Cardiovascular effects of intravenous morphine in anesthetized horse.

Abstract: To investigate whether morphine causes a change in mean arterial blood pressure (MAP) heart rate (HR) and oxygen extraction (OE) rate in healthy horses anesthetized with isoflurane and a dexmedetomidine infusion. Unassigned: The study design was prospective clinical, randomized, blinded two groups including 33 horses. All horses were sedated with romifidine IV, and anesthesia was induced with midazolam IV and ketamine IV and maintained with isoflurane in oxygen and medical air and a dexmedetomidine infusion. As a baseline venous and arterial blood, HR and MAP were sampled. Thereafter either morphine 0.1 mg kg IV or an equivalent volume of NaCl 0.9% IV was administered. HR and MAP were then further sampled for 5 min before venous and arterial blood was again sampled. OE was calculated based upon arterial and venous blood gas analysis. To evaluate the change in minimum MAP, mean HR, and OE, the differences between baseline and observation period values were further termed delta MAP, delta HR, and delta OE. Individual delta MAPs were normalized to the minimum baseline value and are reported as a percentage. Alpha was set to 0.05. Confidence intervals 95% (CI) were calculated for delta MAP, delta HR, and delta OE within groups, and for the difference between groups. Unassigned: The 95% CIs for delta MAP (%), delta HR (min), and delta OE (mL/dL) in the morphine group were -20.5 to -9.0, 0.6 to 3.1, and -0.1 to 0.6 and in the placebo group were -17.4 to -10.1, 0.2 to 2.0, and -0.2 to 0.3, respectively. The 95% CI for the differences in delta MAP (%), delta HR (min), and delta OE (mL/dL) were -5.5 to 7.6, -2.3 to 0.7, and -0.7 to 0.2, respectively. The minimum MAP of one horse in the morphine group decreased around 50% between baseline and observation period with almost unchanged OE and HR. Unassigned: The effects of morphine 0.1 mg kg IV on HR, MAP, and OE in healthy horses anesthetized with isoflurane and a CRI of dexmedetomidine are minimal.
Copyright © 2022 Hoeberg, Haga and Lervik.
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Publication Date: 2022-09-26 PubMed ID: 36225800PubMed Central: PMC9549263DOI: 10.3389/fvets.2022.1007345Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research investigated whether morphine affects arterial blood pressure, heart rate, and oxygen extraction in healthy, anesthetized horses. The study found minimal impact of morphine on these parameters.

Study Design and Methodology

  • The research was a prospective, randomized, blinded clinical study involving two groups of 33 horses each.
  • All the horses were sedated using romifidine intravenously. Anesthesia was then induced using midazolam and ketamine, both administered intravenously.
  • Anesthesia was maintained with isoflurane, supplemented by oxygen, medical air, and a dexmedetomidine infusion.
  • As a baseline, arterial and venous blood were sampled, heart rate and mean arterial blood pressure were recorded.
  • Post these baseline measurements, horses were either given morphine (at 0.1 mg/kg intravenously) or an equivalent volume of NaCl 0.9% intravenously.
  • After a further five minutes, the heart rate and mean arterial pressure were recorded again, followed by another sampling of arterial and venous blood.
  • Oxygen extraction was then determined based on the blood gas analysis from the arterial and venous blood samples.

Findings and Interpretations

  • The differences in the minimum mean arterial pressure (MAP), mean heart rate (HR), and oxygen extraction (OE) from the baseline to the observation period were termed delta MAP, delta HR, and delta OE.
  • The results established the 95% Confidence Intervals (CI) for the deltas in both the morphine and placebo groups.
  • In the morphine group, the 95% CIs for delta MAP, delta HR, and delta OE were reported to be -20.5 to -9.0, 0.6 to 3.1, and -0.1 to 0.6, respectively.
  • In the placebo group, these values were -17.4 to -10.1, 0.2 to 2.0, and -0.2 to 0.3, respectively.
  • The 95% CI for the differences in delta MAP, delta HR, and delta OE between the two groups were -5.5 to 7.6, -2.3 to 0.7, and -0.7 to 0.2, respectively.
  • It was noted that the minimum MAP reduced by around 50% between baseline and observation period in one horse from the morphine group, with almost unchanged OE and HR.
  • The overall findings suggested that morphine, at a dosage of 0.1 mg/kg administered intravenously, has minimal effect on the HR, MAP, and OE in healthy horses anesthetized with isoflurane and a dexmedetomidine infusion.

Cite This Article

APA
Hoeberg E, Haga HA, Lervik A. (2022). Cardiovascular effects of intravenous morphine in anesthetized horse. Front Vet Sci, 9, 1007345. https://doi.org/10.3389/fvets.2022.1007345

Publication

Frontiers in veterinary science
ISSN: 2297-1769
NlmUniqueID: 101666658
Country: Switzerland
Language: English
Volume: 9
Pages: 1007345
PII: 1007345

Researcher Affiliations

Hoeberg, Emma
  • Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences, Ås, Norway.
Haga, Henning Andreas
  • Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences, Ås, Norway.
Lervik, Andreas
  • Department of Companion Animal Clinical Sciences, Norwegian University of Life Sciences, Ås, Norway.

Conflict of Interest Statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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