Case-control study of risk factors associated with isolation of Salmonella saintpaul in hospitalized horses.
Abstract: In an investigation of a 1981-1982 outbreak of nosocomial Salmonella saintpaul infection in hospitalized horses at the University of California Veterinary Medical Teaching Hospital in Davis, California, a case-control study was performed using data gathered from the records of 33 cases and 132 controls. Multiple logistic regression risk analysis was used to identify factors associated with isolation of the organism, controlling for the effects of other, possibly confounding variables. Horses receiving parenteral antibiotics were at 10.9 times greater risk of having S. saintpaul isolated than were horses not receiving parenteral antibiotics. Horses intubated with nasogastric tubes were 3.9 times more likely to have had the organism isolated from fecal specimens than horses not intubated, and horses with a presenting complaint of colic were at 2.2 times greater risk of isolation than horses with other presenting complaints.
Publication Date: 1984-12-01 PubMed ID: 6507427DOI: 10.1093/oxfordjournals.aje.a113957Google Scholar: Lookup
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- Journal Article
Summary
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The research article analyzes the risk factors contributing to the outbreak of Salmonella saintpaul infection in hospitalized horses through a case-control study. The study revealed that horses given parenteral antibiotics, intubated with nasogastric tubes, or presented with colic were at higher risk of infection.
Study Background
- This research was conducted following an outbreak of Salmonella saintpaul infection in hospitalized horses at the University of California Veterinary Medical Teaching Hospital between 1981 and 1982.
- The study aimed to identify the risk factors that led to this outbreak by comparing data from both infected (33 cases) and uninfected horses (132 controls), making it a case-control study.
Methods and Statistical Analysis
- The researchers used multiple logistic regression risk analysis to pinpoint the factors associated with the infection. This method also enables them to account for other variables that could interfere with the results, therefore preventing confounding.
- Data were collected from hospital records, specifically looking at different conditions or treatments the horses received.
Key Findings
- The study found that horses that received parenteral (injectable) antibiotics were at an approximately 11 times greater risk of contracting S. saintpaul infection compared to horses that did not receive such antibiotics.
- Horses that were intubated with nasogastric tubes were about 4 times more likely to have the organism isolated from their fecal specimens, indicating greater susceptibility to infection.
- The risk was also 2.2 times greater in horses which presented with colic as their primary complaint, compared to horses with other complaints.
Conclusion
- This case-control study offers valuable insights into the risk factors associated with nosocomial (hospital-acquired) Salmonella saintpaul infection in hospitalised horses.
- The findings could help in formulating prevention strategies and modifying treatment plans for hospitalized horses to minimize the risk of infection.
Cite This Article
APA
Hird DW, Pappaioanou M, Smith BP.
(1984).
Case-control study of risk factors associated with isolation of Salmonella saintpaul in hospitalized horses.
Am J Epidemiol, 120(6), 852-864.
https://doi.org/10.1093/oxfordjournals.aje.a113957 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Anti-Bacterial Agents / therapeutic use
- California
- Cross Infection
- Disease Outbreaks / epidemiology
- Epidemiologic Methods
- Feces / microbiology
- Female
- Horse Diseases / drug therapy
- Horse Diseases / epidemiology
- Horses
- Hospitals, Animal
- Male
- Risk
- Salmonella / isolation & purification
- Salmonella Infections, Animal / drug therapy
- Salmonella Infections, Animal / epidemiology
Citations
This article has been cited 4 times.- Burgess BA, Morley PS. Risk factors for shedding of Salmonella enterica among hospitalized large animals over a 10-year period in a veterinary teaching hospital.. J Vet Intern Med 2019 Sep;33(5):2239-2248.
- Hoelzer K, Moreno Switt AI, Wiedmann M. Animal contact as a source of human non-typhoidal salmonellosis.. Vet Res 2011 Feb 14;42(1):34.
- Ravary B, Fecteau G, Higgins R, Paré J, Lavoie JP. [Control measures for contagious enteric diseases in a veterinary teaching hospital].. Can Vet J 1999 Dec;40(12):871-7.
- Ravary B, Fecteau G, Higgins R, Paré J, Lavoie JP. [Prevalence of infections caused by Salmonella spp. in cattle and horses at the Veterinary Teaching Hospital of the Faculty of Veterinary Medicine of the University of Montreal].. Can Vet J 1998 Sep;39(9):566-72.
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