[Cell-based therapeutic strategies for osteoarthritis in equine patients – Basic knowledge for clinical practitioners].
Abstract: Cell-based therapies for the treatment of osteoarthritis in equine patients experienced a real boom within the last few years. In every day medical practice, attending veterinary surgeons extract patient's blood or other autologous tissue samples and process the material for the purpose of administering the resulting product to the same patient under their own responsibility. Although being consistently classified as treatment option within the framework of regenerative medicine, the manufacturing processes, ingredients, and mechanisms of action remain highly diverse among cell-based therapies. Thus, sound knowledge about the latter ones forms the basis for therapeutic decision-making and best possible treatment regimes. In den letzten Jahren haben zellbasierte Therapeutika zur Behandlung von Osteoarthritiden in der Pferdemedizin einen regelrechten Boom erlebt. In der Praxis werden diese Therapeutika in Eigenverantwortung des Tierarztes aus Patientenblut oder anderen körpereigenen Geweben wie Fettgewebe oder Knochenmark hergestellt. Auch wenn diesen zellbasierten Therapiemethoden das einheitliche therapeutische Konzept der regenerativen Medizin gemein ist, unterscheiden sie sich maßgeblich hinsichtlich Herstellungsverfahren, Inhaltsstoffen und Funktionsweisen. Grundlegendes Wissen hierzu ermöglicht es dem praktizierenden Tierarzt, das für ihn und seine Pferdepatienten geeignete Produkt auszuwählen und bestmögliche Behandlungsstrategien zu erstellen.
Thieme. All rights reserved.
Publication Date: 2021-06-22 PubMed ID: 34157748DOI: 10.1055/a-1482-7752Google Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article discusses the increasing use of cell-based therapies for the treatment of osteoarthritis in horses, emphasizing the need for veterinarians to have a detailed understanding of the varied processes, components, and mechanisms involved in these therapies to make informed treatment decisions.
Understanding Cell-Based Therapies in Equine Osteoarthritis Treatment
- The paper notes a surge in the use of cell-based therapeutic strategies to treat osteoarthritis in horses over recent years. This rise is as a result of the benefits these therapies offer in terms of repairing and regenerating damaged tissues which conventional treatments may not establish.
- Often, these therapies involve the attending veterinary surgeons extracting autologous tissue samples, or blood from the horse, processing this material and then reintroducing the processed product back into the same animal.
Variability in Cell-Based Therapies
- The article highlights that, while all cell-based therapies are categorized within regenerative medicine, there are significant differences between the myriad therapies in terms of their components, manufacturing processes, and mechanisms of action.
- This diversity means that the effectiveness and suitability of each therapy can vary substantially, emphasizing the need for veterinary practitioners to have a thorough understanding of the varying therapies in order to select the most suitable one for their patient.
The Need for Detailed Knowledge
- The research points out that with the rising popularity and usage of cell-based therapies in treating equine osteoarthritis, it becomes vital for practitioners to have a solid understanding of these therapeutic strategies.
- This understanding includes knowledge of the diverse manufacturing processes, differing ingredients involved, and the various mechanisms of action of the therapies. Such knowledge can enable veterinarians to make informed decisions about the most effective treatment regimes for their equine patients suffering from osteoarthritis.
Cite This Article
APA
Roth SP, Brehm W, Troillet A.
(2021).
[Cell-based therapeutic strategies for osteoarthritis in equine patients – Basic knowledge for clinical practitioners].
Tierarztl Prax Ausg G Grosstiere Nutztiere, 49(3), 189-202.
https://doi.org/10.1055/a-1482-7752 Publication
Researcher Affiliations
- Klinik für Pferde, Veterinärmedizinische Fakultät, Universität Leipzig.
- Sächsischer Inkubator für Klinische Translation, Universität Leipzig.
- Klinik für Pferde, Veterinärmedizinische Fakultät, Universität Leipzig.
- Sächsischer Inkubator für Klinische Translation, Universität Leipzig.
- Klinik für Pferde, Veterinärmedizinische Fakultät, Universität Leipzig.
- Sächsischer Inkubator für Klinische Translation, Universität Leipzig.
MeSH Terms
- Animals
- Horse Diseases / therapy
- Horses
- Osteoarthritis / therapy
- Osteoarthritis / veterinary
Conflict of Interest Statement
Die Autoren bestätigen, dass kein Interessenkonflikt bezüglich der genannten Produkte oder Hersteller besteht.
Citations
This article has been cited 1 times.- Mayet A, Zablotski Y, Roth SP, Brehm W, Troillet A. Systematic review and meta-analysis of positive long-term effects after intra-articular administration of orthobiologic therapeutics in horses with naturally occurring osteoarthritis. Front Vet Sci 2023;10:1125695.
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
