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The Veterinary clinics of North America. Equine practice2011; 27(2); 315-333; doi: 10.1016/j.cveq.2011.06.001

Cell-based therapies for tendon and ligament injuries.

Abstract: Tendon and ligament injuries have proved difficult to treat effectively. Cell-based therapies offer the potential to harness the complex protein synthetic machinery of the cell to induce a regenerative response rather than fibrous scarring. This article reviews the current state of play with respect to the clinically used cell preparations for the treatment of tendon and ligaments overstrain injuries.
Copyright © 2011. Published by Elsevier Inc.
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Publication Date: 2011-08-30 PubMed ID: 21872761DOI: 10.1016/j.cveq.2011.06.001Google Scholar: Lookup
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  • Journal Article
  • Research Support
  • Non-U.S. Gov't

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research explores the use of cell-based therapies in treating tendon and ligament injuries, which have traditionally posed treatment challenges. It reviews all clinically used cell preparations for these types of injuries, suggesting that cell therapies may promote regenerative healing instead of fibrous scarring.

Understanding Tendon and Ligament Injuries

  • Tendon and ligament injuries are among the most difficult to treat effectively, often causing significant pain and requiring lengthy recovery durations.
  • Standard treatments typically result in the development of fibrous scar tissue, which can lead to future complications or a recurrence of the injury.
  • The healing process for these injuries remains complex, with the regenerative capabilities of tendons and ligaments being limited due to their low cellularity and vascularity.

Cell-Based Therapies: An Innovation

  • Cell-based therapies involve the use of cells to repair injured tissues, harnessing their protein-synthesizing capabilities to promote a regenerative response.
  • These therapies aim to induce repair, regeneration, or improvement of damaged tissues, which is a significant development from conventional approaches which usually lead to fibrous scarring.
  • They present an innovative solution for tendon and ligament injuries by manipulating the body’s natural healing process to preferentially favor regeneration over scarring.

Review of Clinically Used Cell Preparations

  • The research explores the various types of cell preparations currently utilized in clinical practice for treating tendon and ligament injuries.
  • These could include the use of stem cells, which have the ability to differentiate into various cell types including tenocytes and ligament cells, or autologous blood products such as platelet-rich plasma (PRP) that are rich in growth factors necessary for tissue repair.
  • The goal here is to understand the underlying mechanisms of each of these treatments, their effectiveness, and their potential side effects or limitations, in an effort to optimize cell-based therapeutics for tendon and ligament injuries.

Cite This Article

APA
Alves AG, Stewart AA, Dudhia J, Kasashima Y, Goodship AE, Smith RK. (2011). Cell-based therapies for tendon and ligament injuries. Vet Clin North Am Equine Pract, 27(2), 315-333. https://doi.org/10.1016/j.cveq.2011.06.001

Publication

The Veterinary clinics of North America. Equine practice
ISSN: 1558-4224
NlmUniqueID: 8511904
Country: United States
Language: English
Volume: 27
Issue: 2
Pages: 315-333

Researcher Affiliations

Alves, A G L
  • Department of Veterinary Surgery and Anesthesiology, School of Veterinary Medicine and Animal Science, São Paulo State University, Botucatu, São Paulo 18618970, Brazil.
Stewart, Allison A
    Dudhia, J
      Kasashima, Y
        Goodship, A E
          Smith, R K W

            MeSH Terms

            • Animals
            • Cell Transplantation / methods
            • Cell Transplantation / veterinary
            • Horse Diseases / therapy
            • Horses
            • Ligaments / injuries
            • Tendon Injuries / therapy
            • Tendon Injuries / veterinary

            Citations

            This article has been cited 14 times.
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