Cerebellar abiotrophy.
Abstract: Cerebellar abiotrophy is a degenerative condition of Arabian horses that produces signs of head tremors and ataxia. Affected foals demonstrate clinical signs between the time of birth and 6 months of age. The condition is untreatable, although some animals have reportedly improved to varying degrees. The disease is believed to be inherited; however, definitive evidence is lacking at this time.
Publication Date: 1987-08-01 PubMed ID: 3497695DOI: 10.1016/s0749-0739(17)30677-6Google Scholar: Lookup
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- Journal Article
Summary
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The research article discusses a degenerative health condition in Arabian horses, known as cerebellar abiotrophy, which causes symptoms such as head tremors and ataxia, usually observed in foals within their first six months. While the ailment is untreatable, some cases reported improvement to certain extents. The disease is suspected to be inherited but lacks definitive proof.
What is Cerebellar Abiotrophy?
- Cerebellar abiotrophy is a degenerative health condition present predominantly in Arabian horses. It affects the cerebellum, a part of the brain responsible for coordination and balance, causing the death of neurons that do not regenerate.
- It leads to symptoms such as head tremors (uncontrollable shaking) and ataxia (lack of voluntary coordination of muscle movements), predominantly observed in young horses, specifically foals. These symptoms usually start to manifest from birth up until the age of 6 months, impacting the overall health and quality of life of the affected horses.
Nature of the Disease
- The disease, as per the researchers, is currently incurable. There’s no confirmed treatment that can reverse or halt the progression of cerebellar abiotrophy. However, the study notes that some horses have demonstrated varying degrees of improvement over time, hinting at the possibility of natural adaptation or resistance to the ailment in some subjects.
- Despite the dearth of successful treatment measures, early diagnosis can help manage the condition— especially with respect to assuring the safety and relative comfort of the affected horses.
Possible Cause of Cerebellar Abiotrophy
- The researchers believe that this disease is inherited, that is, it is passed down from parents to offspring genetically. It suggests that some Arabian horses might possess and transmit specific genes causing cerebellar abiotrophy to their offspring.
- However, peculiarly, the study also acknowledges that there is currently no definitive scientific evidence backing this claim of inheritance; the theory is based on observed patterns and requires further research and genetic testing to establish solid proof.
Cite This Article
APA
DeBowes RM, Leipold HW, Turner-Beatty M.
(1987).
Cerebellar abiotrophy.
Vet Clin North Am Equine Pract, 3(2), 345-352.
https://doi.org/10.1016/s0749-0739(17)30677-6 Publication
Researcher Affiliations
MeSH Terms
- Animals
- Cerebellar Diseases / pathology
- Cerebellar Diseases / veterinary
- Female
- Horse Diseases / pathology
- Horses
- Male
Citations
This article has been cited 6 times.- Scott EY, Woolard KD, Finno CJ, Murray JD. Cerebellar Abiotrophy Across Domestic Species. Cerebellum 2018 Jun;17(3):372-379.
- Aleman M, Finno CJ, Weich K, Penedo MCT. Investigation of Known Genetic Mutations of Arabian Horses in Egyptian Arabian Foals with Juvenile Idiopathic Epilepsy. J Vet Intern Med 2018 Jan;32(1):465-468.
- Scott EY, Woolard KD, Finno CJ, Penedo MCT, Murray JD. Variation in MUTYH expression in Arabian horses with Cerebellar Abiotrophy. Brain Res 2018 Jan 1;1678:330-336.
- Sadaba SA, Madariaga GJ, Botto CM, Carino MH, Zappa ME, García PP, Olguín SA, Massone A, Díaz S. First report of cerebellar abiotrophy in an Arabian foal from Argentina. Open Vet J 2016;6(3):259-262.
- Scott EY, Penedo MCT, Murray JD, Finno CJ. Defining Trends in Global Gene Expression in Arabian Horses with Cerebellar Abiotrophy. Cerebellum 2017 Apr;16(2):462-472.
- Cavalleri JM, Metzger J, Hellige M, Lampe V, Stuckenschneider K, Tipold A, Beineke A, Becker K, Distl O, Feige K. Morphometric magnetic resonance imaging and genetic testing in cerebellar abiotrophy in Arabian horses. BMC Vet Res 2013 May 23;9:105.
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