Characterisation of Rhodococcus equi strains isolated from foals and from immunocompromised human patients.
Abstract: The cultural, morphological, biochemical, serological characteristics and antibiotic susceptibility of 25 Rhodococcus equi strains isolated from lungs and lung abscesses of pneumonic foals and 5 R. equi strains isolated from immuno-compromised human patients were examined. All R. equi strains showed common cultural, morphological and biochemical characteristics both with conventional tests and on the basis of their enzyme profile. The R. equi strains examined were resistant to penicillins with the exception of ampicillin, to sulphamethazine and several strains also to sulphamethoxazole-trimethoprim. All strains were susceptible to erythromycin and rifampicin. The strains isolated from humans showed somewhat higher rate of antibiotic resistance to penicillin, cefotaxime, kanamycin, streptomycin, lincomycin, and oxytetracycline. The overwhelming majority (96%) of the equine isolates belonged to serotype 1 in Prescott's serotyping system, while the human isolates could not be serotyped.
Publication Date: 2001-06-14 PubMed ID: 11402708
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- Comparative Study
- Journal Article
- Research Support
- Non-U.S. Gov't
Summary
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The research paper delves into the study of certain characteristics and antibiotic resistance of Rhodococcus equi strains, which originate from both pneumonic foals and immunocompromised human patients.
Research Background and Aim
- The research revolves around both the study and analysis of 25 Rhodococcus equi strains, which are bacteria predominantly isolated from pneumonic foals (young horses), as well as 5 R. equi strains from immunocompromised human patients.
- It examines different aspects such as cultural, morphological, and biochemical traits, besides serological characteristics and antibiotic resistance of these strains.
Findings of the Study
- All of the studied R. equi strains displayed common characteristics including culture, morphology, and biochemistry, which were established through conventional tests and enzyme profile analysis.
- The study explored how these strains demonstrated resistance to certain antibiotics namely, penicillins, barring ampicillin; sulphamethazine; and in the case of some strains, to sulphamethoxazole-trimethoprim.
- However, all strains were found to be susceptible to the antibiotics erythromycin and rifampicin.
- The strains originating from the human patients exhibited slightly higher antibiotic resistance, specifically to penicillin, cefotaxime, kanamycin, streptomycin, lincomycin, and oxytetracycline, compared to strains isolated from foals.
Serotyping and Antibiotic Susceptibility
- Prescott’s serotyping system was used to classify the bacterial strains. The results showed that an overwhelming majority(roughly 96 percent) of equine isolates were classified under serotype 1.
- Interestingly, the strains isolated from the human subjects could not be serotyped using this system, indicating a significant difference between the human and equine isolates.
Cite This Article
APA
Makrai L, Fodor L, Csivincsik A, Varga J, Senoner Z, Szabó B.
(2001).
Characterisation of Rhodococcus equi strains isolated from foals and from immunocompromised human patients.
Acta Vet Hung, 48(3), 253-259.
Publication
Researcher Affiliations
- Department of Microbiology and Infectious Diseases, Faculty of Veterinary Science, Szent István University, H-1581 Budapest, P.O. Box 22, Hungary. makrai@novell.vmri.hu
MeSH Terms
- Animals
- Drug Resistance, Microbial
- Horses / microbiology
- Humans
- Hungary
- Microbial Sensitivity Tests
- Rhodococcus equi / classification
- Rhodococcus equi / drug effects
- Rhodococcus equi / enzymology
- Serotyping
Citations
This article has been cited 5 times.- Erol E, Scortti M, Fortner J, Patel M, Vázquez-Boland JA. Antimicrobial Resistance Spectrum Conferred by pRErm46 of Emerging Macrolide (Multidrug)-Resistant Rhodococcus equi. J Clin Microbiol 2021 Sep 20;59(10):e0114921.
- Álvarez-Narváez S, Giguère S, Anastasi E, Hearn J, Scortti M, Vázquez-Boland JA. Clonal Confinement of a Highly Mobile Resistance Element Driven by Combination Therapy in Rhodococcus equi. mBio 2019 Oct 15;10(5).
- Vázquez-Boland JA, Meijer WG. The pathogenic actinobacterium Rhodococcus equi: what's in a name?. Mol Microbiol 2019 Jul;112(1):1-15.
- Anastasi E, MacArthur I, Scortti M, Alvarez S, Giguère S, Vázquez-Boland JA. Pangenome and Phylogenomic Analysis of the Pathogenic Actinobacterium Rhodococcus equi. Genome Biol Evol 2016 Oct 23;8(10):3140-3148.
- Letek M, González P, Macarthur I, Rodríguez H, Freeman TC, Valero-Rello A, Blanco M, Buckley T, Cherevach I, Fahey R, Hapeshi A, Holdstock J, Leadon D, Navas J, Ocampo A, Quail MA, Sanders M, Scortti MM, Prescott JF, Fogarty U, Meijer WG, Parkhill J, Bentley SD, Vázquez-Boland JA. The genome of a pathogenic rhodococcus: cooptive virulence underpinned by key gene acquisitions. PLoS Genet 2010 Sep 30;6(9):e1001145.
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