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Home / Equine Research Bank / Biochem Biophys Res Commun / Characterization and differentiation of equine umbilical cor...
Biochemical and biophysical research communications2007; 362(2); 347-353; doi: 10.1016/j.bbrc.2007.07.182

Characterization and differentiation of equine umbilical cord-derived matrix cells.

Abstract: Stem cells are being evaluated in numerous human clinical trials and are commercially used in veterinary medicine to treat horses and dogs. Stem cell differentiation, homing to disease sites, growth and cytokine factor modulation, and low antigenicity contribute to their therapeutic success. Bone marrow and adipose tissue are the two most common sources of adult-derived stem cells in animals. We report on the existence of an alternative source of primitive, multipotent stem cells from the equine umbilical cord cellular matrix (Wharton's jelly). Equine umbilical cord matrix (EUCM) cells can be cultured, cryogenically preserved, and differentiated into osteo-, adipo-, chondrogenic, and neuronal cell lineages. These results identify a source of stem cells that can be non-invasively collected at birth and stored for future use in that horse or used as donor cells for treating unrelated horses.
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Publication Date: 2007-08-13 PubMed ID: 17719011DOI: 10.1016/j.bbrc.2007.07.182Google Scholar: Lookup
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Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

This research article discusses the finding of a new source of primitive, multipotent stem cells from equine umbilical cord cellular matrix (known as Wharton’s jelly), which can be differentiated into various cell lineages and can be used non-invasively in treatments of horses.

Stem Cells in Clinical Trials and Veterinary Medicine

  • The article begins by outlining the importance of stem cells in human clinical trials and in veterinary medicine, particularly in treatments for horses and dogs. Stem cells offer various therapeutic benefits due to their ability to differentiate, attract to sites of disease, proliferate, modulate growth and cytokine factors, and offer low antigenicity (which helps to decrease immune responses).
  • The primary sources of adult-derived stem cells in animals are usually bone marrow and adipose (fat) tissue. However, these sources often require invasive procedures to extract.

Equine Umbilical Cord Matrix as a Stem Cell Source

  • However, this research identifies the equine umbilical cord cellular matrix (specifically, a substance called Wharton’s jelly) as an alternative source of primitive, multipotent stem cells.
  • The researchers suggest that the stem cells from this source, referred to as EUCM cells, can be non-invasively collected at birth and stored for future use.

Characteristics and Differentiation Capacity of EUCM Cells

  • The results of the research showed that EUCM cells can be cultivated in the lab and preserved through cryogenic methods (freezing at very low temperatures).
  • Hello, EUCM cells were found to be capable of differentiating into a number of different cell types, specifically osteogenic (bone-forming), adipogenic (fat-forming), chondrogenic (cartilage-forming), and neuronal (nerve) cell lineages.

Potential Applications of EUCM Cells

  • The discovery of this new source of stem cells could have significant therapeutic implications for the treatment of horses. For example, they could potentially be used to repair bone, cartilage, fat, or nerve tissue in injured or diseased horses.
  • Because these cells can be collected non-invasively at birth and stored, they can be available for use at any point in a horse’s life, providing a convenient and versatile medical resource.

Cite This Article

APA
Hoynowski SM, Fry MM, Gardner BM, Leming MT, Tucker JR, Black L, Sand T, Mitchell KE. (2007). Characterization and differentiation of equine umbilical cord-derived matrix cells. Biochem Biophys Res Commun, 362(2), 347-353. https://doi.org/10.1016/j.bbrc.2007.07.182

Publication

Biochemical and biophysical research communications
ISSN: 0006-291X
NlmUniqueID: 0372516
Country: United States
Language: English
Volume: 362
Issue: 2
Pages: 347-353

Researcher Affiliations

Hoynowski, Steven M
  • Department of Pharmacology and Toxicology, University of Kansas, 1251 Wescoe Hall Drive, Malott Rm 5064, Lawrence, KS 66045-7582, USA.
Fry, Madeline M
    Gardner, Bryn M
      Leming, Matthew T
        Tucker, Jeanell R
          Black, Linda
            Sand, Theodore
              Mitchell, Kathy E

                MeSH Terms

                • Adipocytes / chemistry
                • Adipocytes / cytology
                • Adipocytes / metabolism
                • Adipogenesis
                • Alkaline Phosphatase / metabolism
                • Animals
                • Anthraquinones / chemistry
                • Azo Compounds / chemistry
                • Cell Cycle
                • Cell Differentiation
                • Cell Proliferation
                • Cells, Cultured
                • Chondrocytes / chemistry
                • Chondrocytes / cytology
                • Chondrocytes / metabolism
                • Chondrogenesis
                • Female
                • Flow Cytometry
                • Horses
                • Immunohistochemistry
                • Multipotent Stem Cells / chemistry
                • Multipotent Stem Cells / cytology
                • Multipotent Stem Cells / metabolism
                • Neurons / chemistry
                • Neurons / cytology
                • Neurons / metabolism
                • Osteocytes / chemistry
                • Osteocytes / cytology
                • Osteocytes / metabolism
                • Osteogenesis
                • Umbilical Cord / cytology
                • Umbilical Cord / metabolism

                Citations

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