Clinical application of Patlak plot CT-GFR in animals with upper urinary tract disease.
Abstract: Glomerular filtration rate (GFR), an important parameter of renal function, is difficult to assess clinically. Serum creatinine and blood urea nitrogen measurements lack sensitivity, whereas radionuclide determination of GFR is not always available and requires postinjection patient isolation. GFR can be determined using computed tomography (CT), most commonly via Patlak plot analysis. Four adult cats, two adult dogs, and a foal underwent abdominal CT under general anesthesia for various diseases of the upper urinary tract. CT-GFR was measured with a single-slice dynamic acquisition and Patlak plot analysis. In five animals, the total CT-GFR appeared to be below normal, corresponding with mild (two animals) and moderate (two animals) increases of serum creatinine in four. In the two animals with normal or increased CT-GFR, serum creatinine was within the reference values. A significant negative logarithmic relationship was found between CT-GFR and serum creatinine values (P = 0.008; r2 = 0.75). No complications occurred during or following CT-GFR. CT examination provided clinically relevant information in 3/5 patients with possible ureteral obstruction and in 3/3 patients with suspected ureteral calculi. Single-slice dynamic CT-GFR was practical and provided clinically useful information in this small series of patients undergoing CT of the upper urinary tract. There was a significant relationship between CT-GFR and serum creatinine values, which supports the clinical potential of CT-GFR and justifies further investigation of this technique.
Publication Date: 2010-09-03 PubMed ID: 20806874DOI: 10.1111/j.1740-8261.2010.01670.xGoogle Scholar: Lookup
The Equine Research Bank provides access to a large database of publicly available scientific literature. Inclusion in the Research Bank does not imply endorsement of study methods or findings by Mad Barn.
- Journal Article
Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article explores the clinical application of a Computed Tomography method known as Patlak plot analysis to measure glomerular filtration rate (GFR) in animals with upper urinary tract diseases, demonstrating its feasibility and showing significant correlation with serum creatinine values.
Methodology
- The team of researchers applied Patlak plot analysis, an approach commonly used in Computed Tomography (CT), to determine the glomerular filtration rate (GFR) of seven animals with different diseases affecting their upper urinary tract.
- The subjects of the study were a group of animals consisting of four adult cats, two adult dogs, and a foal, each of which underwent abdominal CT scans while under general anesthesia.
- The CT-GFR of each animal was measured using a single-slice dynamic acquisition and Patlak plot analysis.
Results
- Five of the animals exhibited a total CT-GFR that appeared to be below the normal range. This was consistent with mild and moderate increases of serum creatinine observed in four of the subjects.
- Conversely, the two animals that presented normal or increased CT-GFR had serum creatinine within the normal reference values.
- Further, a significant negative logarithmic relationship was found between CT-GFR and serum creatinine values (P = 0.008; r2 = 0.75).
Conclusions
- The researchers reported no complications during or after the CT-GFR procedure, suggesting it to be a safe method.
- They noted that the information provided by the CT examination was clinically relevant for three out of five patients with possible ureteral obstruction and all three patients with suspected ureteral calculi.
- Thus, they concluded that single-slice dynamic CT-GFR is feasible and provides clinically useful information. It yielded a significant relationship between CT-GFR and serum creatinine values, indicating the potential usability of CT-GFR in clinical practice and justifying more extensive investigation into this technique.
Cite This Article
APA
Alexander K, Dunn M, Carmel EN, Lavoie JP, Del Castillo JR.
(2010).
Clinical application of Patlak plot CT-GFR in animals with upper urinary tract disease.
Vet Radiol Ultrasound, 51(4), 421-427.
https://doi.org/10.1111/j.1740-8261.2010.01670.x Publication
Researcher Affiliations
- Département de Sciences Cliniques, Faculté de médecine vétérinaire, Université de Montréal, PO Box 5000, St-Hyacinthe, QC, Canada J2S 7C6. kate.alexander@umontreal.ca
MeSH Terms
- Animals
- Anorexia / diagnostic imaging
- Anorexia / veterinary
- Cat Diseases / diagnostic imaging
- Cat Diseases / physiopathology
- Cats
- Dog Diseases / diagnostic imaging
- Dog Diseases / physiopathology
- Dogs
- Glomerular Filtration Rate / physiology
- Horse Diseases / diagnostic imaging
- Horse Diseases / physiopathology
- Horses
- Kidney Failure, Chronic / diagnostic imaging
- Kidney Failure, Chronic / physiopathology
- Kidney Failure, Chronic / veterinary
- Tomography, X-Ray Computed / methods
- Tomography, X-Ray Computed / veterinary
- Urography / methods
- Urography / veterinary
- Urologic Diseases / diagnostic imaging
- Urologic Diseases / physiopathology
- Urologic Diseases / veterinary
Use Nutrition Calculator
Check if your horse's diet meets their nutrition requirements with our easy-to-use tool Check your horse's diet with our easy-to-use tool
Talk to a Nutritionist
Discuss your horse's feeding plan with our experts over a free phone consultation Discuss your horse's diet over a phone consultation
Submit Diet Evaluation
Get a customized feeding plan for your horse formulated by our equine nutritionists Get a custom feeding plan formulated by our nutritionists
