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Home / Equine Research Bank / Can Vet J / Clinical effects of detomidine with or without atropine used...
The Canadian veterinary journal = La revue veterinaire canadienne1993; 34(5); 296-300;

Clinical effects of detomidine with or without atropine used for arthrocentesis in horses.

Abstract: The effectiveness of detomidine with or without atropine sulfate premedication in producing sedation and analgesia for arthrocentesis was studied in 12 horses. The effects were evaluated by monitoring heart and respiratory rates, borborygmi, distance from the lower lip to the floor, systolic blood pressure, and response to needle insertion. Either atropine or saline (as a placebo) was administered immediately prior to detomidine. All drugs were administered intravenously. Measurements were taken prior to drug injection and at 1, 5, 10, 15, 20, 25, 30, 40, 50, 60, 120, 180 and 240 minutes postinjection. Detomidine with atropine resulted in significantly higher heart rates than detomidine without atropine for the three hours of observation. Borborygmi were significantly decreased for four hours following detomidine with atropine and for three hours following detomidine without atropine, when compared to preinjection levels. Systolic blood pressure was significantly increased for 15 minutes following detomidine and atropine compared to the preinjection level. The head was markedly lowered for 60 minutes with either treatment. Atropine prevented the bradyarrhythmia and bradycardia induced by detomidine, but it induced a tachycardia. A satisfactory response for needle insertion and adequate synovial fluid aspiration was achieved in 95% of the trials with detomidine, with or without atropine sulfate premedication. The results suggest that, although atropine prevents bradyarrhythmia and bradycardia following detomidine, administering detomidine without atropine is satisfactory for arthrocentesis in untrained horses.
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Publication Date: 1993-05-01 PubMed ID: 17424223PubMed Central: PMC1686527
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  • Journal Article

Summary

This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.

The research paper studied the effect of detomidine, with or without atropine, on horses during arthrocentesis. It was found that while atropine can prevent heart rate abnormalities caused by detomidine, administering detomidine without atropine is enough for this procedure.

Methodology

  • The study involved 12 horses, which were subjected to arthrocentesis under the sedative effects of detomidine, sometimes complemented with the premedication of atropine sulfate.
  • The researchers observed the effects by checking various parameters such as the horses’ heart and respiratory rates, the occurrence of borborygmi (the rumbling noise made by the gut), the distance from the lower lip to the floor, the systolic blood pressure, and the response to needle insertion.
  • Each horse received either atropine or saline as a placebo before the detomidine was administered, all through intravenous injection.
  • Data was collected before the drug was administered and at 1, 5, 10, 15, 20, 25, 30, 40, 50, 60, 120, 180, and 240 minutes of post-injection.

Findings

  • Detomidine with atropine led to significantly higher heart rates than detomidine without atropine. The raised heart rates were observed for three hours post-injection.
  • The use of detomidine, whether with or without atropine, significantly reduced the horses’ borborygmi. The reduction followed for four hours with atropine and for three hours without it.
  • For 15 minutes post-injection, there was a significant increase in the systolic blood pressure when detomidine was used with atropine.
  • Both treatments caused the horse’s head to lower significantly for an hour.
  • Atropine was effective in helping to prevent the slow heart rate and irregular heart rhythm (bradyarrhythmia and bradycardia) that detomidine can induce. However, it was seen to cause a fast heart rate (tachycardia).
  • A successful response to needle insertion and adequate synovial fluid aspiration, which is essentially the aim of arthrocentesis, was achieved in 95% of all trials. This was the case regardless of whether detomidine was used with or without atropine.

Conclusion

  • From the observations made, the researchers concluded that while atropine can effectively prevent certain detomidine-related heart complications, it is not necessary for carrying out arthrocentesis in untrained horses. Detomidine alone appears to be satisfactory for this purpose.

Cite This Article

APA
Jones DL. (1993). Clinical effects of detomidine with or without atropine used for arthrocentesis in horses. Can Vet J, 34(5), 296-300.

Publication

The Canadian veterinary journal = La revue veterinaire canadienne
ISSN: 0008-5286
NlmUniqueID: 0004653
Country: Canada
Language: English
Volume: 34
Issue: 5
Pages: 296-300

Researcher Affiliations

Jones, D L

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    Citations

    This article has been cited 1 times.
    1. Ekstrand C, Michanek P, Gehring R, Sundell A, Källse A, Hedeland M, Ström L. Plasma atropine concentrations associated with decreased intestinal motility in horses.. Front Vet Sci 2022;9:951300.
      doi: 10.3389/fvets.2022.951300pubmed: 36118347google scholar: lookup
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