Clinical Pathology in the Adult Sick Horse: The Gastrointestinal System and Liver.
Abstract: The gastrointestinal tract and liver comprise key components of the equine digestive system and together have important functions in metabolism, digestion, absorption, detoxification, and synthesis. Disorders of the gastrointestinal tract and liver are common in clinical practice and can cause a variety of clinical signs. Hematologic and biochemical analysis can be helpful for identifying organ dysfunction, narrowing down the differential diagnostic list, and monitoring progress and response to treatment. This article details hematologic and biochemical tests that are important in the evaluation of intestinal and hepatic diseases and reviews bloodwork trends frequently observed in adult horses affected by enteropathy or hepatopathy.
Copyright © 2019 Elsevier Inc. All rights reserved.
Publication Date: 2020-01-22 PubMed ID: 31982231PubMed Central: PMC7127838DOI: 10.1016/j.cveq.2019.11.004Google Scholar: Lookup
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Summary
This research summary has been generated with artificial intelligence and may contain errors and omissions. Refer to the original study to confirm details provided. Submit correction.
The research article investigates hematologic and biochemical textures that are critical in assessing the liver and gastrointestinal disorders in adult horses. It also evaluates routine bloodwork trends in horses diagnosed with enteropathy and hepatopathy.
Significance of the Gastrointestinal Tract and Liver
- Both the gastrointestinal tract and liver play integral roles in a horse’s digestive system. They facilitate key processes like digestion, absorption, metabolism, detoxification, and synthesis.
- Any dysfunction in these organs can lead to various clinical signs and disorders. These disturbances are often observed in clinical practice, making the study of these functions extremely important.
Methods of Investigation
- The researchers use hematologic and biochemical analysis as research tools. These help in identifying any organ dysfunction, thus narrowing down the differential diagnostic list.
- Additionally, these tests can provide valuable data on the progression of the disorder and the horse’s response to treatment.
Adult Horses with Intestinal and Hepatic Diseases
- The study gives particular attention to hematologic and biochemical tests that can be used to evaluate conditions such as enteropathy (intestinal disease) and hepatopathy (liver disease) in adult horses.
- The researchers examine routine bloodwork trends associated with these two diseases, providing critical insight into their diagnosis and treatment.
Scope and Impact
- Through their analysis, the researchers aim to expand the current understanding of these ailments, which can potentially enhance treatment methodologies.
- This detailed investigation can also help future studies focusing on improving the quality of life for adult horses facing gastrointestinal and liver disorders.
Cite This Article
APA
DeNotta SL, Divers TJ.
(2020).
Clinical Pathology in the Adult Sick Horse: The Gastrointestinal System and Liver.
Vet Clin North Am Equine Pract, 36(1), 105-120.
https://doi.org/10.1016/j.cveq.2019.11.004 Publication
Researcher Affiliations
- Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 Southwest 16th Avenue, Gainesville, FL 32608, USA. Electronic address: s.denotta@ufl.edu.
- Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, 144 East Avenue, Ithaca NY 14853, USA.
MeSH Terms
- Animals
- Horse Diseases / diagnosis
- Horse Diseases / pathology
- Horses
- Intestinal Diseases / diagnosis
- Intestinal Diseases / pathology
- Intestinal Diseases / veterinary
- Liver Diseases / diagnosis
- Liver Diseases / pathology
- Liver Diseases / veterinary
- Pathology, Clinical
Conflict of Interest Statement
Disclosure The authors have nothing to disclose.
References
This article includes 53 references
- Gomez D.E., Arroyo L.G., Stampfli H.R.. Physiochemical interpretation of acid-base abnormalities in 54 adult horses with acute severe colitis and diarrhea.. J Vet Intern Med 2013;27(3):548–553.
- Bertin F.R., Reising A., Slovis N.M.. Clinical and clinicopathological factors associated with survival in 44 horses with equine neorickettsiosis (Potomac Horse Fever). J Vet Intern Med 2013;27(6):1528–1534.
- Latson K.M., Nieto J.E., Beldomenico P.M.. Evaluation of peritoneal fluid lactate as a marker of intestinal ischaemia in equine colic.. Equine Vet J 2005;37(4):342–346.
- Pye J., Espinosa-Mur P., Roca R.. Preoperative factors associated with resection and anastomosis in horses presenting with strangulating lesions of the small intestine.. Vet Surg 2019.
- Radcliffe R.M., Divers T.J., Fletcher D.J.. Evaluation of L-lactate and cardiac troponin I in horses undergoing emergency abdominal surgery.. J Vet Emerg Crit Care 2012;22(3):313–319.
- Johnston K., Holcombe S.J., Hauptman J.G.. Plasma lactate as a predictor of colonic viability and survival after 360 degrees volvulus of the ascending colon in horses.. Vet Surg 2007;36(6):563–567.
- Hashimoto-Hill S., Magdesian K.G., Kass P.H.. Serial measurement of lactate concentration in horses with acute colitis.. J Vet Intern Med 2011;25(6):1414–1419.
- Peterson M.B., Tolver A., Husted L.. Repeated measurements of blood lactate concentration as a prognostic indicator marker in horses with acute colitis evaluated with classification and regression trees (CART) and random forest analysis.. Vet J 2016;213:18–23.
- Tennent-Brown B.S., Wilkins P.A., Lindborg S.. Sequential plasma lactate concentrations as prognostic indicators in adult equine emergencies.. J Vet Intern Med 2010;24:198–205.
- Peloso J.G., Cohen N.D.. Use of serial measurements of peritoneal fluid lactate concentration to identify strangulating intestinal lesions in referred horses with signs of colic.. J Am Vet Med Assoc 2012;240(10):1208–1217.
- Nieto J.E., Dechant J.E., le Jeune S.S.. Evaluation of 3 handheld portable analyzers for measurement of L-lactate concentrations in blood and peritoneal fluid of horses with colic.. Vet Surg 2015;44(3):366–372.
- Dunkel B., Kapff J.E., Naylor R.J.. Blood lactate concentrations in ponies and miniature horses with gastrointestinal disease.. Equine Vet J 2013;45(6):666–670.
- Dunkel B., Mason C.J., Chang Y.M.. Retrospective evaluation of the association between admission blood glucose and l-lactate concentrations in ponies and horses with gastrointestinal disease (2008-2016): 545 cases.. J Vet Emerg Crit Care 2019.
- Gardner R.B., Nydam D.V., Mohammed H.O.. Serum gamma glutamyl transferase activity in horses with right or left displacements of the large colon.. J Vet Intern Med 2005;19(5):761–764.
- Davis J.L., Blikslager A.T., Catto K.. A retrospective analysis of hepatic injury in horses with proximal enteritis (1984-2002). J Vet Intern Med 2003;17(6):896–901.
- Dunkel B., Chaney K.P., Dallap-Schaer B.L.. Putative intestinal hyperammonemia in horses: 36 cases.. Equine Vet J 2011;43(2):133–140.
- Fielding C.L., Higgins J.K., Higgins J.C.. Disease associated with equine coronavirus infection and high case fatality rate.. J Vet Intern Med 2015;29(1):307–310.
- Giannitti F., Diab S., Mete A.. Necrotizing enteritis and hyperammonemic encephalopathy associated with equine coronavirus infection in equids.. Vet Pathol 2015;52(6):1148–1156.
- Lindner A., Bauer S.. Effect of temperature, duration of storage and sampling procedure on ammonia concentration in equine blood plasma.. Eur J Clin Chem Clin Biochem 1993;31(7):473–476.
- Boshuizen B., Ploeg M., Dewulf J.. Inflammatory bowel disease (IBD) in horses: a retrospective study exploring the value of different diagnostic approaches.. BMC Vet Res 2018;14(1):21.
- Divers T.J., Pelligrini-Masini A., McDonough S.. Diagnosis of inflammatory bowel disease in a Hackney pony by gastroduodenal endoscopy and biopsy and successful treatment with corticosteroids.. Equine Vet Educ 2006;18(6):284–287.
- Love S., Mair T.S., Hillyer M.H.. Chronic diarrhea in adult horses: a review of 51 cases.. Vet Rec 1992;130(11):217–219.
- Metcalfe L.V., More S.J., Duggan V.. A retrospective study of horses investigated for weight loss despite a good appetite (2002-2011). Equine Vet J 2013;45(3):340–345.
- McConnico R.S., Morgan T.W., Williams C.C.. Pathophysiologic effects of phenylbutazone on the right dorsal colon in horses.. Am J Vet Res 2008;69(11):1496–1505.
- Reed S.K., Messer N.T., Tessman R.K.. Effect of phenylbutazone alone or in combination with flunixin meglumine on blood protein concentrations in horses.. Am J Vet Res 2006;67(3):398–402.
- Hackett E.S., McCue P.M.. Evaluation of a veterinary glucometer for use in horses.. J Vet Intern Med 2010;24(3):617–621.
- Murphy D., Reid S.W.J., Love S.. Modified oral glucose tolerance test as an indicator of small intestinal pathology in horses.. Vet Rec 1997;140:342–343.
- Divers T.J.. The equine liver in health and disease.. Proceeding of the American Proc Am Assoc Equine Practit 2015;6:66–103.
- Curran J.M., Sutherland R.J., Peet R.L.. A screening test for subclinical liver disease in horses affected by pyrrolizidine alkaloid toxicosis.. Aust Vet J 1996;74:236–240.
- Bernard W.V., Divers T.J.. Variations in serum sorbitol dehydrogenase, aspartate transaminase, and isoenzyme 5 of lactate dehydrogenase activities in horses given carbon tetrachloride.. Am J Vet Res 1989;50(5):622–623.
- West H.J.. Clinical and pathological studies in horses with hepatic disease.. Equine Vet J 1996;28:146–156.
- Horney B.S., Honor D.J., MacKenzie A.. Stability of sorbitol dehydrogenase activity in bovine and equine sera.. Vet Clin Pathol 1993;22:5–9.
- McGorum B.C., Murphy D., Love S.. Clinicopathological features of equine primary hepatic disease: a review of 50 cases.. Vet Rec 1999;145:134–139.
- Noonan N.E.. Variations of plasma enzymes in the pony and the dog after carbon tetrachloride administration.. Am J Vet Res 1981;42(4):674–678.
- Durham A.E., Newton J.R., Smith K.C.. Retrospective analysis of historical, clinical, ultrasonographic, serum biochemical and haematological data in prognostic evaluation of equine liver disease.. Equine Vet J 2003;35:542–547.
- Underwood C., Southwood L.L., Walton R.M.. Hepatic and metabolic changes in surgical colic patients: a pilot study.. J Vet Emerg Crit Care 2010;20(6):578–586.
- Snow D.H., Harris P.. Enzymes as markers of physical fitness and training of racing horses.. Adv Clin Enzymol 1988;6:251–258.
- McGowan C.. Clinical pathology in the racing horse: the role of clinical pathology in assessing fitness and performance in the racehorse.. Vet Clin North Am Equine Pract 2008;24:405–422.
- Mack S.J., Kirkby K., Malalana F.. Elevations in serum muscle enzyme activities in racehorses due to unaccustomed exercise and training.. Vet Rec 2014;174:145.
- Leleu C., Haentjens F.. Morphological, haemato-biochemical and endocrine changes in young Standardbreds with 'maladaptation' to early training.. Equine Vet J Suppl 2010;38:171–178.
- Ramsay J.D., Evanoff R., Mealey R.H.. The prevalence of elevated gamma-glutamyltransferase and sorbitol dehydrogenase activity in racing Thoroughbreds and their associations with viral infection.. Equine Vet J 2019;51(6):738–742.
- Schendl M.J., Redhead D.N., Fearon K.C.H.. The value of residual liver volume as a predictor of hepatic dysfunction and infection after major liver resection.. Gut 2005;54(2):289–296.
- Durham A.E.. Hepatitis in horses.. In: Weber O., Protzer U., editors. Comparative hepatitis. Birkhauser Verlag; Basel (Switzerland): 2008. pp. 245–264.
- Peek S.F., Divers T.J.. Medical treatment of cholangiohepatitis and cholelithiasis in mature horses: 9 cases (1991-1998). Equine Vet J 2000;32:301–306.
- Divers T.J., Schappel K.A., Sweeney R.W.. Persistent hyperbilirubinemia in a healthy thoroughbred horse.. Cornell Vet 1993;83(3):237–242.
- Hoffmann W.E., Baker G., Rieser S.. Alterations in selected serum biochemical constituents in equids after induced hepatic disease.. Am J Vet Res 1987;48:1343–1347.
- Dunkel B., Jones S.A., Pinilla M.J.. Serum bile acid concentrations, histopathological features, and short-, and long-term survival in horses with hepatic disease.. J Vet Intern Med 2015;29(2):644–650.
- Dunkel B., McKenzie H.C., 3rd. Severe hypertriglyceridaemia in clinically ill horses: diagnosis, treatment and outcome.. Equine Vet J 2003;35:590–595.
- Parraga M.E., Carlson G.P., Thurmond M.. Serum protein concentrations in horses with severe liver disease: a retrospective study and review of the literature.. J Vet Intern Med 1995;9:154–161.
- Tennant B.C.. Hepatic function.. In: Kaneko J.J., Harvey J.W., Bruss M.L., editors. Clinical biochemistry of domestic animals. 6th edition. Elsevier Academic Press; Maryland Heights (MO): 1997. pp. 379–413.
- Johns I.C., Sweeney R.W.. Coagulation abnormalities and complications after percutaneous liver biopsy in horses.. J Vet Intern Med 2008;22:185–189.
- Tomlinson J.E., Kapoor A., Kumar A.. Viral testing of 18 consecutive cases of equine serum hepatitis: a prospective study (2014-2018). J Vet Intern Med 2019;33(1):251–257.
- Aleman M., Costa L.R.R., Crowe C.. Presumed neuroglycopenia caused by severe hypoglycemia in horses.. Vet Intern Med 2018;32(5):1731–1739.
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