Clinical Pathology in the Foal.
Abstract: The dynamic physiologic changes and unique diet during the neonatal period contribute to key differences in clinicopathologic test results of healthy foals relative to healthy adult horses. When reporting results, most diagnostic laboratories only provide reference intervals for mature horses. Thus, failure to recognize the unique differences that occur in foals relative to adult horses can lead to erroneous interpretation of neonatal clinical pathologic values. Thus, the main objective of this article was to review distinct features of common clinicopathologic tests in foals, relative to mature horses.
Copyright © 2019 Elsevier Inc. All rights reserved.
Publication Date: 2020-03-09 PubMed ID: 32145835DOI: 10.1016/j.cveq.2019.11.003Google Scholar: Lookup
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Summary
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This study highlights the physiological variations and distinct diet of newborn foals and how they cause differences in clinical pathology test results compared to mature horses. It aims to review these distinctions as many diagnostic labs only provide reference ranges for adult horses, which can lead to errors in clinical pathology evaluations for newborns.
Significance of the Study
- This research is critical in the field of veterinary medicine, as it probes the unique physiological differences between newborn foals and adult horses. Recognizing these dissimilarities is crucial for accurate interpretation of pathology tests.
- Most diagnostic laboratories tend to overlook these variations and use reference intervals meant for adult horses, which may lead to incorrect diagnosis or treatment for young foals.
- By focusing on these disparities, the study aims to foster more precise and specialist care for foals during their neonatal period.
Main Objective of the Study
- The primary goal of this research was to identify and delineate the distinct features of common clinicopathologic tests in foals compared to mature horses.
- This was done to prevent misinterpretation of neonatal clinical pathologic values that may arise due to their inherent differences from adult horses.
Unique Features of Foals
- Foals undergo dynamic physiological changes during their neonatal period that significantly affect their clinicopathologic test results.
- Contrasting dietary patterns between foals and adult horses also factor into these differing results.
- Without comprehensive understanding and recognition of these variances, veterinary practitioners may incorrectly interpret neonatal clinical pathologic values.
Implications of the study
- These findings call for diagnostic laboratories to develop and use specific reference intervals appropriate for newborn foals to foster accurate interpretation of clinicopathologic tests.
- Understanding how the unique physiological changes and diet of foals influence clinical pathology can lead to improved veterinary care during the critical neonatal stage.
- Better tailored diagnostic tools bring a higher chance for early detection and treatment of potential health issues, ultimately leading to better health outcomes for young foals.
Cite This Article
APA
Barton MH, Hart KA.
(2020).
Clinical Pathology in the Foal.
Vet Clin North Am Equine Pract, 36(1), 73-85.
https://doi.org/10.1016/j.cveq.2019.11.003 Publication
Researcher Affiliations
- Department of Large Animal Medicine, University of Georgia College of Veterinary Medicine, Veterinary Medical Center, 2200 College Station Road, Athens, GA 30602, USA.
- Department of Large Animal Medicine, University of Georgia College of Veterinary Medicine, Veterinary Medical Center, 2200 College Station Road, Athens, GA 30602, USA. Electronic address: khart4@uga.edu.
MeSH Terms
- Animals
- Animals, Newborn
- Horse Diseases / diagnosis
- Horse Diseases / pathology
- Horses
- Pathology, Clinical
Citations
This article has been cited 5 times.- Scalco R, de Oliveira GN, da Rosa Curcio B, Wooten M, Magdesian KG, Hidai ST, Pandit P, Aleman M. Red blood cell distribution width to platelet ratio in neonatal foals with sepsis. J Vet Intern Med 2023 Jul-Aug;37(4):1552-1560.
- Kinsella HM, Hostnik LD, Snyder HA, Mazur SE, Kamr AM, Burns TA, Mossbarger JC, Toribio RE. Comparison of insulin sensitivity between healthy neonatal foals and horses using minimal model analysis. PLoS One 2022;17(1):e0262584.
- Villalba-Orero M, Gómez CA, Valero-Gónzalez M, Venegas N, Criado G, Martín-Cuervo M. Blood parameters in neonatal foal and colostrum quality as possible early markers for increased risk of developing Rhodococcus equi pneumonia. Front Vet Sci 2025;12:1654052.
- Schaefer DMW, Videla R, Smith JS, Mulon PY, Flatland B, Zhu X. Hematology and clinical biochemistry reference intervals for companion pigs using the ADVIA 2120 and Cobas c501. PeerJ 2025;13:e18968.
- Hobbs KJ, Cooper BL, Dembek K, Sheats MK. Investigation of Extracted Plasma Cell-Free DNA as a Biomarker in Foals with Sepsis. Vet Sci 2024 Aug 1;11(8).
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